Interactions on record — worth a quick check against your medications. Based on 6 of 8 ingredients. Check your meds →
Dietary supplement

Super Papaya Enzyme Mint Flavored 45 mg Ingredients & Drug Interactions

by Nature's Bounty

Super Papaya Enzyme Mint Flavored 45 mg label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super Papaya Enzyme Mint Flavored 45 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Super Papaya Enzyme Mint Flavored 45 mg is a dietary supplement by Nature's Bounty with 8 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 517 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sodium Copper Chlorophyllin, Bromelain, Papaya. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Super Papaya Enzyme Mint Flavored 45 mg by Nature's Bounty

Ask about any prescription or over-the-counter medication and we check it for interactions with Super Papaya Enzyme Mint Flavored 45 mg by Nature's Bounty — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Super Papaya Enzyme Mint Flavored 45 mg by Nature's Bounty

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 8 of its 8 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This tablet contains 8 active ingredients: papain, bromelain, lipase, protease, sodium copper chlorophyllin, cellulase enzyme, alpha amylase, and papaya. The first four are digestive enzymes that break down proteins, fats, and carbohydrates in food.

Sodium copper chlorophyllin is a plant-derived compound, and papaya provides additional enzyme activity and nutrients. The product also contains inactive ingredients—sorbitol, mannitol, calcium carbonate, maltodextrin, vegetable stearic acid, vegetable magnesium stearate, silica, dicalcium phosphate, and peppermint oil—which serve as fillers, binders, and flavoring.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: promotes breakdown of food and digestive health.
  • We looked for evidence on: Dyspepsia, Flatulence, Constipation, Exercise-induced muscle soreness, Postoperative swelling, Sprains — and 4 related terms.
  • The closest evidence on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Wound healing.
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence supporting these ingredients is limited. For papain, the data we hold shows insufficient reliable evidence to rate its use for cancer, dental health, radiation burns, exercise muscle soreness, shingles, or intestinal parasites.

Bromelain similarly lacks solid evidence for hay fever, burns, cancer, nerve damage from chemotherapy, chronic venous insufficiency, or diabetes. Lipase and papaya also show insufficient evidence for their claimed uses in inflammatory bowel disease, poor digestion, and blood sugar control.

Sodium copper chlorophyllin is rated possibly ineffective for urinary odor and has insufficient evidence for acne, cancer, constipation, gas, and low white blood cell count.

The evidence, ingredient by ingredient Papain Bromelain Lipase Proteolytic Enzymes (proteases) Chlorophyllin Papaya

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain and bromelain are generally well tolerated at normal doses, but both can cause allergic reactions—including itchy watery eyes, runny nose, sneezing, stomach cramps, diarrhea, and in rare cases severe reactions—in people sensitive to them. High doses of papain are unsafe and may cause severe stomach inflammation or even perforation of the esophagus.

Bromelain commonly causes diarrhea, gas, and stomach upset. Sodium copper chlorophyllin is generally well tolerated short-term, but has caused photosensitization and a rare condition called pseudoporphyria (blistering on hands) in case reports of oral use.

Lipase and protease have minimal adverse effect data; lipase appears well tolerated in adults, and protease may rarely cause allergic reactions. For pregnancy, papain and the supplement form of papaya are possibly unsafe, and bromelain and sodium copper chlorophyllin should be avoided due to insufficient safety data; ripe papaya fruit itself is likely safe.

During breastfeeding, there isn't enough data on papain, bromelain, sodium copper chlorophyllin, lipase, or protease to know either way—talk it over with your healthcare provider.

Side effects, ingredient by ingredient Papain Bromelain Lipase Proteolytic Enzymes (proteases) Chlorophyllin Papaya

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 6 matched ingredients can interact with medications — Papain, Papaya, Chlorophyllin, Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 517 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Super Papaya Enzyme Mint Flavored, double-check with your doctor or pharmacist if you take warfarin or other blood thinners (anticoagulants) and antiplatelet drugs—moderate risk of increased bleeding. Also flag antidiabetes drugs, amiodarone, levothyroxine, photosensitizing drugs, and tetracycline antibiotics.

Altogether, these interactions span 517 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is an enzyme blend used to support digestion, but evidence that it works for any specific condition is not established in our data. If you take warfarin, any blood thinner, antidiabetes medication, amiodarone, levothyroxine, or photosensitizing drugs, you should check with your doctor or pharmacist before adding this supplement—the interactions are documented and could affect how your medications work.

Pregnant or breastfeeding people should also discuss it with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super Papaya Enzyme Mint Flavored 45 mg, straight from the product label.

Brand Nature's Bounty
Barcode (UPC) 074312006685
Net contents 90 Chewable Mint Tablet(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 277020
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super Papaya Enzyme Mint Flavored 45 mg by Nature's Bounty, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Tablet(s)
Maximum serving Sizes:
3 Tablet(s)
Servings per container
30
UPC/BARCODE
074312006685
IngredientAmount% DV
Papain45 mg--
Bromelain3 mg--
Lipase1.5 mg--
Protease3 mg--
Sodium Copper Chlorophyllin1.5 mg--
Cellulase Enzyme94.5 mg--
Alpha Amylase3 mg--
Papaya15 mg--

Other ingredients: Sorbitol, Mannitol, Calcium Carbonate, Maltodextrin, Vegetable Stearic Acid, Vegetable Magnesium Stearate, Silica, dicalcium phosphate, Peppermint Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

45 mg of papain per serving Contains 6 naturally sourced enzymes

Formulation

Promotes the breakdown of food Digestive health

Gluten free: Contains less than 20 ppm gluten.

Made in The USA with select ingredients from around the world

Guaranteed Quality Laboratory tested

Non-GMO, no artificial color, no artificial flavor, no sugar, no milk, no lactose, no soy, no gluten, no yeast, no fish.

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, chew three (3) tablets following a meal, one to three times daily.

Precautions

Contains wheat ingredients.

Warning: If you are pregnant, nursing, taking medications or have any medical condition, including a known sensitivity to latex, consult your doctor before use.

Warning: If you are pregnant, nursing, taking medications or have any medical condition, including a known sensitivity to latex, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Brand IP Statement(s)

Copyright 2019 Nature's Bounty, Inc.

General Statements

Nearly 50 years of Trusted Quality At Nature's Bounty, we are committed to your health. For nearly 50 years we have been making trusted products, backed by science, and made with only the purest ingredients...guaranteed. So you can get the most out of life every day.

Nutrition Questions or Comments? Call 1-800-433-2990 Mon. - Sat. 9 AM - 7 PM ET Sign up for News and Offers at NaturesBounty.com

Storage

Store at room temperature.

FDA Disclaimer Statement

This statement has nit been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super Papaya Enzyme Mint Flavored 45 mg by Nature's Bounty label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super Papaya Enzyme Mint Flavored 45 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super Papaya Enzyme Mint Flavored 45 mg by Nature's Bounty

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Papain

Interacts with
2 drugs
45 mg per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Bromelain

Interacts with
141 drugs
3 mg per serving

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early st...

Bromelain monograph & interactions

Lipase

No known
interactions
1.5 mg per serving

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase monograph & interactions

Protease

No known
interactions
3 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease monograph & interactions

Sodium Copper Chlorophyllin

Interacts with
335 drugs
1.5 mg per serving Form: Chlorophyll

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing....

Sodium Copper Chlorophyllin monograph & interactions

Cellulase Enzyme

94.5 mg per serving

Alpha Amylase

3 mg per serving

Papaya

Interacts with
92 drugs
15 mg per serving

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and m...

Papaya monograph & interactions

Other (inactive) ingredients: Sorbitol, Mannitol, Calcium Carbonate, Maltodextrin, Vegetable Stearic Acid, Vegetable Magnesium Stearate, Silica, Dicalcium phosphate, Peppermint Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super Papaya Enzyme Mint Flavored 45 mg by Nature's Bounty Drug Interactions

Want to check YOUR meds against Super Papaya Enzyme Mint Flavored 45 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
517Drugs
512 Moderate 5 Minor

Ingredients driving the most interactions

Sodium Copper Chlorophyllin 335
Bromelain 141
Papaya 92
Papain 2

Individual Drug Interactions

The ingredients in Super Papaya Enzyme Mint Flavored 45 mg interact with 517 drugs. Click any drug to see the details.

4 of the 8 ingredients in Super Papaya Enzyme Mint Flavored 45 mg interact with drugs. Each result below shows which ingredient is responsible. Sodium Copper Chlorophyllin Bromelain Papaya Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Super Papaya Enzyme Mint Flavored 45 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium Copper Chlorophyllin1 drug type · 335 drugs

Photosensitizing Drugs

Theoretically, concomitant use of chlorophyllin with photosensitizing drugs may have additive effects.
Chlorophyllin is a semi-synthetic derivative of chlorophyll. Chlorophyll has been reported to cause photosensitization. Orally, chlorophyll has also been associated with the development of pseudoporphyria in multiple case reports.

Likelihood Probable Evidence B
Sodium Copper Chlorophyllin full monograph & interactions

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions

Papaya4 drug types · 92 drugs

Amiodarone (Cordarone)

Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Antidiabetes Drugs

Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papaya full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super Papaya Enzyme Mint Flavored 45 mg, from the product label.

Nature's Bounty

See all Nature's Bounty products
Name
Nature's Bounty, Inc.
City
Bohemia
State
NY
ZipCode
11716
Phone Number
1-800-433-2990
Web Address
www.NaturesBounty.com
Pharmacist Counseling Corner

Super Papaya Enzyme Mint Flavored 45 mg by Nature's Bounty: Common Questions

Does Super Papaya Enzyme Mint Flavored 45 mg by Nature's Bounty interact with any medications?
Yes. Based on its ingredients, Super Papaya Enzyme Mint Flavored 45 mg has a known interaction with 517 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super Papaya Enzyme Mint Flavored 45 mg contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this supplement interfere with my warfarin?
Yes—there's a documented moderate interaction. Papain and papaya may increase warfarin's effects and bleeding risk; one patient's blood thinner level became dangerously high after taking a papain supplement. Check with your doctor or pharmacist before starting this product if you're on warfarin or any blood thinner.
Is papain safe to take every day?
At normal doses, papain is generally well tolerated, but it can cause allergic reactions (itchy eyes, runny nose, stomach cramps, diarrhea) in sensitive people. High doses are unsafe and may cause severe stomach damage. If you have a known papain or latex allergy, avoid it.
Does this help with digestion?
The evidence on file shows insufficient reliable data to rate these enzymes for indigestion or poor digestion. While they are digestive enzymes, we don't have strong clinical proof that this supplement works for digestive complaints.
Can I take this if I'm pregnant?
Papain and papaya in supplement form are rated possibly unsafe in pregnancy due to safety concerns. Bromelain and sodium copper chlorophyllin should also be avoided because there isn't enough safety data. Talk with your doctor or pharmacist before use if you're pregnant or planning to become pregnant.
What are the most common side effects?
Bromelain often causes diarrhea, gas, and stomach upset. Papain can trigger allergic reactions—itchy watery eyes, runny nose, sneezing, stomach cramps, and diarrhea—in sensitive individuals. Serious side effects are rare at normal doses but can occur at high doses.
Is this safe while breastfeeding?
There isn't enough reliable data on papain, bromelain, sodium copper chlorophyllin, lipase, or protease to know whether they're safe while breastfeeding. Check with your healthcare provider for personalized advice before taking it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Super Papaya Enzyme Mint Flavored 45 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super Papaya Enzyme Mint Flavored 45 mg label
Go deeper

The Full Monographs Behind Super Papaya Enzyme Mint Flavored 45 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Chlorophyllin

Interacts with 335 drugs

Chlorophyllin is a water-soluble, semi-synthetic form of chlorophyll most often used to help control body and fecal odor and to support wound healing. The best evidence is for its use as a d...

Read the full Chlorophyllin monograph → Herb & supplement monograph

Papaya

Interacts with 92 drugs

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is b...

Read the full Papaya monograph →
Sources

Sources & How We Checked

Super Papaya Enzyme Mint Flavored 45 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 54 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
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Lipase 1 reference
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Proteolytic Enzymes (proteases) 3 references
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Papaya 14 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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