Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

SuperBeets Heart Chews Pomegranate Berry Flavor Ingredients & Drug Interactions

by Human N

SuperBeets Heart Chews Pomegranate Berry Flavor label
See full label image
Other (e.g. Tea Bag) Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SuperBeets Heart Chews Pomegranate Berry Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

SuperBeets Heart Chews Pomegranate Berry Flavor is a dietary supplement by Human N with 2 active ingredients. Its ingredients are commonly taken for high blood pressure, exercise and athletic performance, heart and circulation support.Based on those ingredients, 1,025 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Enovita, Beet, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against SuperBeets Heart Chews Pomegranate Berry Flavor by Human N

Ask about any prescription or over-the-counter medication and we check it for interactions with SuperBeets Heart Chews Pomegranate Berry Flavor by Human N — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of SuperBeets Heart Chews Pomegranate Berry Flavor by Human N

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

SuperBeets Heart Chews contains 2 active ingredients: beet powder and Enovita, a grape extract. Beet powder is added for its nitrate content, which supports blood vessel function and oxygen use during exercise.

Enovita contributes polyphenols and other compounds found in grapes, traditionally used for circulation and vein health. The product also contains inactive ingredients — tapioca syrup, cane sugar, rice bran, natural flavors, sunflower lecithin, sunflower oil, malic acid, glycerin, citric acid, and rebaudioside A — which serve as sweeteners, binders, and flavoring.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Blood pressure support and heart health.
  • We looked for evidence on: Hypertension, Cardiovascular disease (CVD), Coronary heart disease (CHD), Atherosclerosis, Dyslipidemia, Hypercholesterolemia — and 4 related terms.
  • The strongest evidence on file: Grape is rated "Possibly Effective" for Chronic venous insufficiency (CVI) (Natural Medicines).
  • Also on file: Beet is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Dyslipidemia, Hypertension, Pregnancy-induced hypertension, and more.
  • Also on file: Grape is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis.

Beet powder is possibly effective for athletic performance and exercise-induced muscle soreness. The evidence for grape extract (Enovita) points to it being possibly effective for chronic venous insufficiency — a condition affecting blood flow in the legs.

The data we hold shows insufficient evidence to rate beet for cognitive function or dyslipidemia (cholesterol issues). For grape extract, there's also insufficient evidence for most other uses.

The evidence, ingredient by ingredient Beet Grape

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both ingredients are generally well tolerated when used short-term. Beet as a whole food is widely eaten and safe for most adults, but concentrated beet supplements lack long-term safety data, so use caution.

Grape as a whole food and grape seed extract are generally well tolerated, though concentrated grape supplements are not recommended during pregnancy due to limited safety data. Common side effects from beet include red or black stools (harmless coloring) and occasional gastrointestinal upset.

Grape extract may cause abdominal pain, diarrhea, dry mouth, headache, joint pain, or nausea in some people. Rare serious effects include low blood calcium (hypocalcemia) and kidney damage from very large beet doses, and anaphylaxis to grape skin (extremely rare).

Side effects, ingredient by ingredient Beet Grape

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Beet, Grape.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs.
  • For scale: 1,026 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking SuperBeets Heart Chews, check with your pharmacist if you're on CYP3A4 substrates (Moderate), blood thinners or antiplatelet drugs like aspirin or warfarin (Moderate), cyclosporine (Moderate), CYP1A2 or CYP2D6 substrates (Moderate), or antihypertensive drugs that lower blood pressure (Minor). No interactions are documented for CYP2E1 substrates in humans, but lab evidence suggests they may also be affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

These chews may help with athletic performance and leg circulation, but they interact with a significant number of medications — especially blood thinners, cyclosporine, and drugs processed through several liver enzyme pathways. If you take any prescription medication, check it against our search tool before you start.

Talk to your pharmacist about whether this product is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SuperBeets Heart Chews Pomegranate Berry Flavor, straight from the product label.

Brand Human N
Barcode (UPC) 813188020780
Net contents 60 Chew(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 323049
Product type Botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SuperBeets Heart Chews Pomegranate Berry Flavor by Human N, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Chew(s)
Maximum serving Sizes:
2 Chew(s)
Servings per container
30
UPC/BARCODE
813188020780
IngredientAmount% DV
Calories40 Calorie(s)--
Total Carbohydrates9 Gram(s)3%
Added Sugars4 Gram(s)8%
Total Sugars4 Gram(s)8%
Beet, Powder500 mg--
Enovita150 mg--

Other ingredients: Tapioca Syrup, Cane Sugar, Raw, Rice Bran, Natural Flavors, Sunflower Lecithin, Sunflower Oil, Malic Acid, Glycerin, Citric Acid, Rebaudioside A

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Blood pressure support Nearly 2x more effective blood pressure support Heart healthy energy support

Non GMO Gluten free

Plant based

SuperBeets Heart Chews features non-GMO beetroot plus clinically researched grape seed extract to support normal blood pressure, heart-healthy energy without caffeine or stimulants, and healthy circulation and blood flow.

No artificial sweeteners or synthetic colors

FDA Statement of Identity

Dietary Supplement

General Statements

#1 doctor, pharmacist & cardiologist recommended best brand for heart health support According to IQVIA ProVoice Survey June 2023

Join our community for exclusive giveaways, education, and access

For more information, visit HumanN.com

Formula

SuperBeets Heart Chews features non-GMO beetroot plus clinically researched grape seed extract to support normal blood pressure, heart-healthy energy without caffeine or stimulants, and healthy circulation and blood flow. Clinically researched grape seed extract as been shown to be nearly 2x more effective at supporting healthy blood pressure than diet and exercise alone.

From clinically researched grape seed extract In a 16-week, double-blind, placebo-controlled study involving 113 healthy men and women, Heart Chews polyphenol compound, taken as part as a healthy lifestyle was clinically shown nearly 2-times as effective at promoting normal blood pressure already in the normal range as a healthy lifestyle alone.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take two (2) chews daily.

Precautions

Precaution: For adult use only. Keep out of reach of children.

Consult with a physician if you are pregnant/nursing, taking medications or have a medical condition.

Brand IP Statement(s)

Copyright 2023 Human Power of N All Rights Reserved

Seals/Symbols

Made in the USA with globally sourced ingredients

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SuperBeets Heart Chews Pomegranate Berry Flavor by Human N label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SuperBeets Heart Chews Pomegranate Berry Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SuperBeets Heart Chews Pomegranate Berry Flavor by Human N

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Chew(s) Dosage formOther (e.g. Tea Bag) Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Beet, Powder

Interacts with
861 drugs
500 mg per serving

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some peopl...

Beet, Powder monograph & interactions

Enovita

Interacts with
910 drugs
150 mg per serving Form: Grape Seed Extract

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and b...

Enovita monograph & interactions

Other (inactive) ingredients: Tapioca Syrup, Cane Sugar, Raw, Rice Bran, Natural Flavors, Sunflower Lecithin, Sunflower Oil, Malic Acid, Glycerin, Citric Acid, Rebaudioside A. These complete the product’s ingredient list but are not active constituents.

Interaction report

SuperBeets Heart Chews Pomegranate Berry Flavor by Human N Drug Interactions

Want to check YOUR meds against SuperBeets Heart Chews Pomegranate Berry Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,025Drugs
868 Moderate 157 Minor

Ingredients driving the most interactions

Enovita 910
Beet, Powder 861

Individual Drug Interactions

The ingredients in SuperBeets Heart Chews Pomegranate Berry Flavor interact with 1,025 drugs. Click any drug to see the details.

2 of the 2 ingredients in SuperBeets Heart Chews Pomegranate Berry Flavor interact with drugs. Each result below shows which ingredient is responsible. Enovita Beet, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in SuperBeets Heart Chews Pomegranate Berry Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Enovita9 drug types · 910 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro evidence suggests that grape extracts might decrease platelet aggregation.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Ingesting grape juice with cyclosporine can reduce cyclosporine absorption.
A small pharmacokinetic study in healthy young adults shows that intake of purple grape juice 200 mL along with cyclosporine can decrease the absorption of cyclosporine by up to 30% when compared with water. Separate doses of grape juice and cyclosporine by at least 2 hours to avoid this interaction.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, grape juice might reduce the levels of CYP1A2 substrates.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of CYP1A2.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.
In vitro evidence suggests that grape seed extract might inhibit CYP2D6 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, grape seed extract might increase the levels of CYP2E1 substrates.
In vitro and animal research suggests that grape seed proanthocyanidin extract inhibits CYP2E1 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

It is unclear if grape seed extract inhibits or induces CYP3A4; research is conflicting.
In vitro evidence suggests that grape seed extract might inhibit CYP3A4 enzymes. However, evidence from animal research shows that grape seed extract may induce CYP3A4 in the liver. So far, these interactions have not been reported in humans.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, long-term intake of grape seed extract might decrease the effects of midazolam.
Animal research shows that subchronic ingestions of grape seed extract can increase the elimination of intravenous midazolam by increasing hepatic CYP3A4 activity. Single doses of grape seed extract do not appear to affect midazolam elimination.

Likelihood Possible Evidence D
Phenacetin

Grape juice might decrease phenacetin absorption.
A small pharmacokinetic study in healthy adults shows that ingestion of 200 mL of grape juice decreases phenacetin plasma levels. This is thought to be due to induction of cytochrome P450 1A2 (CYP1A2).

Likelihood Possible Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

It is unclear if grape juice or grape seed extract inhibits CYP2C9; research is conflicting.
In vitro evidence shows that grape seed extract or grape juice might inhibit CYP2C9 enzymes. However, a small pharmacokinetic study in healthy adults shows that drinking 8 ounces of grape juice once does not affect the clearance of flurbiprofen, a probe-drug for CYP2C9 metabolism. The effects of continued grape juice consumption are unclear.

Likelihood Unlikely Evidence D
Enovita full monograph & interactions

Beet, Powder3 drug types · 861 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.

Likelihood Possible Evidence D
Antihypertensive Drugs

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Beet, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SuperBeets Heart Chews Pomegranate Berry Flavor, from the product label.

Human N

See all Human N products
Name
Human Power of N
Street Address
1250 S. Capital of Texas Hwy, Building 1 Suite 360
City
Austin
State
TX
ZipCode
78746
Phone Number
855-636-4040
Web Address
HumanN.com
Pharmacist Counseling Corner

SuperBeets Heart Chews Pomegranate Berry Flavor by Human N: Common Questions

Does SuperBeets Heart Chews Pomegranate Berry Flavor by Human N interact with any medications?
Yes. Based on its ingredients, SuperBeets Heart Chews Pomegranate Berry Flavor has a known interaction with 1,025 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SuperBeets Heart Chews Pomegranate Berry Flavor contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will these chews actually help my workouts?
Beet powder is possibly effective for athletic performance and exercise-induced muscle soreness, so the evidence is promising but not definitive. If you're training or recovering from intense exercise, it's worth a try — the effect is tied to beet's nitrate content, which helps your body use oxygen better.
What's Enovita, and why is it in this product?
Enovita is a grape extract. It's included because the evidence shows it's possibly effective for chronic venous insufficiency — a condition where blood doesn't flow well back up from your legs. It contains polyphenols and other compounds from grape that may support circulation.
Why do these chews turn my stools red or black?
That's the beet. Red or black stools from beet are just the color of the pigment passing through — it's not harmful and it's not blood. If it bothers you, it'll clear once you stop taking the chews.
Can I take these while pregnant or breastfeeding?
The grape extract in this product is rated likely safe during pregnancy. We don't have safety data on file for beet powder during pregnancy or breastfeeding, so talk with your pharmacist or doctor for personalized advice — they can weigh what we know against your individual situation.
Are there any fillers or 'other stuff' in these chews I should know about?
Yes — there are inactive ingredients like tapioca syrup, cane sugar, sunflower lecithin, and others that serve as sweeteners, binders, and flavoring. If you have sensitivities to any of these, check the full ingredient list on the label.
Will these chews affect how my medications work?
Possibly. Both beet and grape can interact with many medications, especially blood thinners, drugs your liver processes through specific enzyme pathways, and cyclosporine. You must check your exact prescriptions with the search tool on this page — don't assume you're in the clear without looking them up.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if SuperBeets Heart Chews Pomegranate Berry Flavor is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SuperBeets Heart Chews Pomegranate Berry Flavor label
Go deeper

The Full Monographs Behind SuperBeets Heart Chews Pomegranate Berry Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Beet

Interacts with 861 drugs

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but s...

Read the full Beet monograph → Herb & supplement monograph

Grape

Interacts with 910 drugs

Grapes and grape products like grape seed extract contain antioxidant compounds such as resveratrol and proanthocyanidins that may support heart and blood vessel health. While the food is he...

Read the full Grape monograph →
Sources

Sources & How We Checked

SuperBeets Heart Chews Pomegranate Berry Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 48 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beet 14 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Clifford T, Berntzen B, Davison GW, et al. Effects of beetroot juice on recovery of muscle function and performance between bouts of repeated sprint exercise. Nutrients 2016;8. pii: E506. PubMed
  3. Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr 2013;143:818-26. PubMed
  4. Clifford T, Howatson G, West DJ, Stevenson EJ. Beetroot juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise. Appl Physiol Nutr Metab. 2017;42(11):1185-1191. PubMed
  5. Clifford T, Bell O, West DJ, Howatson G, Stevenson EJ. The effects of beetroot juice supplementation on indices of muscle damage following eccentric exercise. Eur J Appl Physiol. 2016;116(2):353-62. PubMed
  6. Wylie LJ, Kelly J, Bailey SJ, et al. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985). 2013;115(3):325-36. PubMed
  7. Garnacho-Castaño MV, Palau-Salvà G, Cuenca E, et al. Effects of a single dose of beetroot juice on cycling time trial performance at ventilatory thresholds intensity in male triathletes. J Int Soc Sports Nutr. 2018;15(1):49. PubMed
  8. Rasica L, Porcelli S, Marzorati M, et al. Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents. Am J Physiol Regul Integr Comp Physiol. 2018;315(3):R453-R460. PubMed
  9. Henrohn D, Björkstrand K, Lundberg JO, et al. Effects of oral supplementation with nitrate-rich beetroot juice in patients with pulmonary arterial hypertension-results from BEET-PAH, an exploratory randomized, double-blind, placebo-controlled, crosso
  10. Serra-Payá N, Garnacho-Castaño MV, Sánchez-Nuño S, et al. The relationship between resistance exercise performance and ventilatory efficiency after beetroot juice intake in well-trained athletes. Nutrients 2021;13(4):1094. PubMed
  11. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  12. Hemmatinafar M, Zaremoayedi L, Koushkie Jahromi M, et al. Effect of Beetroot Juice Supplementation on Muscle Soreness and Performance Recovery after Exercise-Induced Muscle Damage in Female Volleyball Players. Nutrients 2023;15(17):3763. PubMed
  13. Lim SH, Bae S, Lee HS, Han HK, Choi CI. Effect of Betanin, the Major Pigment of Red Beetroot (Beta vulgaris L.), on the Activity of Recombinant Human Cytochrome P450 Enzymes. Pharmaceuticals (Basel) 2023;16(9):1224. PubMed
  14. Oscherwitz M, Tamayo RM, Heudebert A, Centor R. A Case of Pseudo-Hematochezia from Beet Supplement Ingestion. Am J Med 2023;136(9):e177-e178. PubMed

See these in context on the Beet monograph →

Grape 34 references
  1. Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung
  2. Xiao Dong S, Zhi Ping Z, Zhong Xiao W, et al. Possible enhancement of the first-pass metabolism of phenacetin by ingestion of grape juice in Chinese subjects. Br J Clin Pharmacol 1999;48:638-40. PubMed
  3. Vaswani SK, Hamilton RG, Carey RN, et al. Anaphylaxis recurrent urticaria and angioedema from grape hypersensitivity. J Allergy Clin Immunol 1998;101:S31.
  4. Chevallier A. The Encyclopedia of Medicinal Plants. London, UK: Dorling Kindersley, Ltd., 1996.
  5. Bernstein DI, Bernstein CK, Deng C, et al. Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study. Ann Allergy Asthma Immunol 2002;88:272-8.. PubMed
  6. Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
  7. Ward NC, Hodgson JM, Croft KD, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427-34.. PubMed
  8. Ray, S. D., Parikh, H., Hickey, E., Bagchi, M., and Bagchi, D. Differential effects of IH636 grape seed proanthocyanidin extract and a DNA repair modulator 4-aminobenzamide on liver microsomal cytochrome 4502E1-dependent aniline hydroxylation. Mol Cell B PubMed
  9. O'Byrne, D. J., Devaraj, S., Grundy, S. M., and Jialal, I. Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin.Nutr. 2002;76(6):1367-1374.
  10. Schaefer, E., Peil, H., Ambrosetti, L., and Petrini, O. Oedema protective properties of the red vine leaf extract AS 195 (Folia vitis viniferae) in the treatment of chronic venous insufficiency. A 6-week observational clinical trial. Arzneimittelforschun PubMed
  11. Nishikawa, M., Ariyoshi, N., Kotani, A., Ishii, I., Nakamura, H., Nakasa, H., Ida, M., Nakamura, H., Kimura, N., Kimura, M., Hasegawa, A., Kusu, F., Ohmori, S., Nakazawa, K., and Kitada, M. Effects of continuous ingestion of green tea or grape seed extra
  12. de Lange, D. W., Scholman, W. L., Kraaijenhagen, R. J., Akkerman, J. W., and van de Wiel, A. Alcohol and polyphenolic grape extract inhibit platelet adhesion in flowing blood. Eur.J Clin.Invest 2004;34(12):818-824. PubMed
  13. Samet, J. M. and Coultas, D. B. Reduced forced vital capacity in California grape workers. What does it mean? Am Rev.Respir.Dis 1992;145(2 Pt 1):255-256. PubMed
  14. Gamsky, T. E., McCurdy, S. A., Samuels, S. J., and Schenker, M. B. Reduced FVC among California grape workers. Am Rev.Respir.Dis 1992;145(2 Pt 1):257-262. PubMed
  15. de Lange, D. W., Verhoef, S., Gorter, G., Kraaijenhagen, R. J., van de Wiel, A., and Akkerman, J. W. Polyphenolic grape extract inhibits platelet activation through PECAM-1: an explanation for the French paradox. Alcohol Clin.Exp.Res 2007;31(8):1308-1314 PubMed
  16. Etheridge, A. S., Black, S. R., Patel, P. R., So, J., and Mathews, J. M. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constitu
  17. Krikorian, R., Nash, T. A., Shidler, M. D., Shukitt-Hale, B., and Joseph, J. A. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr. 2010;103(5):730-734. PubMed
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See these in context on the Grape monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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