Interactions on record — worth a quick check against your medications. Based on 9 of 15 ingredients. Check your meds →
Dietary supplement

SuperSilica Plus! Ingredients & Drug Interactions

by Harmonic Innerprizes

SuperSilica Plus! label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SuperSilica Plus! against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

SuperSilica Plus! is a dietary supplement by Harmonic Innerprizes with 15 active ingredients. Its ingredients are commonly taken for hair, skin, and nail health, bone health and osteoporosis, joint and connective tissue support.Based on those ingredients, 549 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dandelion, Horsetail, Nettles. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against SuperSilica Plus! by Harmonic Innerprizes

Ask about any prescription or over-the-counter medication and we check it for interactions with SuperSilica Plus! by Harmonic Innerprizes — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of SuperSilica Plus! by Harmonic Innerprizes

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 15 active ingredients.
  • “Proprietary Blend - Enzymes (Non-nutrient/Non-botanical)” is a proprietary blend — the label gives one combined amount (70 mg) without saying how much of each component you get.
  • “Proprietary Blend Herbal Extracts (Herb/Botanical)” is a proprietary blend — the label gives one combined amount (440 mg) without saying how much of each component you get.

SuperSilica Plus! contains 15 ingredients, including digestive enzymes (amylase, protease, lipase, cellulase, glucoamylase, pectinase, beta-glucanase, phytase, and hemicellulase), silica (a mineral), and several herbal extracts: bamboo, horsetail, nettles, barley grass, and dandelion. The inactive ingredients are silica mineral complex and water.

The product blends enzyme actives with botanical extracts meant to support digestion and overall wellness, though the evidence for many of these uses is limited or not yet established.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Hair, skin, nails, bones and soft tissue support.
  • We looked for evidence on: Aging skin, Androgenic alopecia, Osteoporosis, Joint pain, Osteoarthritis, Connective tissue health — and 2 related terms.
  • The strongest evidence on file: Silicon is rated "Possibly Effective" for Osteoporosis (Natural Medicines).
  • Also on file: Stinging Nettle is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis.
  • Also on file: Dandelion is rated "Insufficient Reliable Evidence To Rate" for Joint pain.

Evidence for this product's ingredients is mixed. Barley grass is likely effective for lowering cholesterol and supporting heart health.

Silica (silicon) is possibly effective for bone density. For the others—protease, lipase, phytase, horsetail, nettles, bamboo, and dandelion—the evidence we hold rates them as having insufficient reliable evidence for their stated uses.

That doesn't mean they don't work; it means the data aren't strong enough yet to say one way or the other.

The evidence, ingredient by ingredient Silicon Proteolytic Enzymes (proteases) Lipase Phytase Bamboo Horsetail Stinging Nettle Barley

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 9 of the 9 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 9 of 9.
  • General safety write-ups exist for 9 of 9.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated by adults when taken as directed, though individual responses vary. Protease, lipase, phytase, and horsetail may cause digestive upset.

Horsetail contains thiaminase, which with long-term use could theoretically lead to thiamine (vitamin B1) deficiency. Nettles and dandelion are generally well tolerated but can cause mild GI effects like constipation or diarrhea.

Silica from food and normal supplements is safe; occupational exposure to crystalline silica dust poses serious lung risks, which doesn't apply to oral supplements. Several ingredients carry allergenic potential—protease and phytase can trigger reactions in occupationally exposed individuals, and barley, dandelion, and nettles may cause allergic reactions in sensitive people.

Bamboo shoots contain cyanide compounds that are eliminated by cooking, but raw or improperly processed forms carry risk.

Side effects, ingredient by ingredient Silicon Proteolytic Enzymes (proteases) Lipase Phytase Bamboo Horsetail Stinging Nettle Barley

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 9 matched ingredients can interact with medications — Bamboo, Stinging Nettle, Dandelion, Barley, Horsetail.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 549 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take antidiabetes drugs, diuretic drugs (water pills), lithium, blood thinners or blood thinners (anticoagulants/antiplatelets), antithyroid drugs, or HIV reverse transcriptase inhibitors. These are the drug types with documented Moderate interactions from horsetail, nettles, dandelion, and bamboo.

Dandelion additionally affects certain antibiotics (quinolones) and drugs metabolized by liver enzyme CYP1A2.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product pairs digestive enzymes with herbal extracts aimed at supporting digestion and wellness. If you take blood thinners, diabetes medications, diuretics, lithium, or antithyroid drugs, you'll want to check this product against your exact prescriptions first—horsetail, nettles, and dandelion all have documented interactions with these types.

Talk with your pharmacist before adding it if you take any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SuperSilica Plus!, straight from the product label.

Brand Harmonic Innerprizes
Barcode (UPC) 640627481204
Net contents 120 Vegicap(s)
Market status On market
Date entered into DSLD Feb 23, 2018
DSLD ID 81641
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SuperSilica Plus! by Harmonic Innerprizes, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
UPC/BARCODE
640627481204
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Cellulase0 NP--
Glucoamylase0 NP--
Pectinase0 NP--
Beta-Glucanase0 NP--
Phytase0 NP--
Hemicellulase0 NP--
Silica85 mg--
Proprietary Blend - Enzymes (Non-nutrient/Non-botanical)70 mg--
Proprietary Blend Herbal Extracts (Herb/Botanical)440 mg--
Bamboo0 NP--
Horsetail0 NP--
Nettles0 NP--
organic Barley Grass0 NP--
Dandelion0 NP--

Other ingredients: Silica Mineral Complex, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Silica is a vital nutrient. It is a major component of hair, skin, nails, bones, and all the soft tissues of the body. Silica deficiency increases with age. Silica deficiency is a contributing factor in many age-related conditions such as increased brittleness of the skeletal system, chronically sore muscles and tendons, skin wrinkling, and even dementia.

Soft tissue integrity

120 vegicaps (500 mg ea) Skeletal support series

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Warning: Consult your physician before use if you are pregnant, lactating, have a medical condition or are taking any medication.

Keep out of reach of children.

Formulation

Hypoallergenic: This product does not contain milk, eggs, soy, fish, crustacean shellfish, tree nuts, peanuts, wheat, yeast, salt, preservatives, artificial color, flavor, or fragrances.

Brand IP Statement(s)

2015 HarmonicInnerprizes, Inc.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, depending on your state of health or nutritional goals take 1 or 2 capsules daily preferably with meals.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SuperSilica Plus! by Harmonic Innerprizes label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SuperSilica Plus! label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SuperSilica Plus! by Harmonic Innerprizes

These are the 15 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Silica

No known
interactions
85 mg per serving Form: Bamboo, Horsetail

Silicon is a trace mineral found in the body and in foods like oats, barley, and certain fruits and vegetables, and it is popular in supplements for h...

Silica monograph & interactions

Proprietary Blend - Enzymes (Non-nutrient/Non-botanical)

70 mg per serving
  • › Amylase
  • › Protease
  • › Lipase
  • › Cellulase
  • › Glucoamylase
  • › Pectinase
  • › Beta-Glucanase
  • › Phytase
  • › Hemicellulase

Proprietary Blend Herbal Extracts (Herb/Botanical)

440 mg per serving

Other (inactive) ingredients: Silica Mineral Complex, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

SuperSilica Plus! by Harmonic Innerprizes Drug Interactions

Want to check YOUR meds against SuperSilica Plus!?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
549Drugs
549 Moderate

Ingredients driving the most interactions

Dandelion 457
Horsetail 188
Nettles 164
Bamboo 5
organic Barley Grass 1

Individual Drug Interactions

The ingredients in SuperSilica Plus! interact with 549 drugs. Click any drug to see the details.

5 of the 15 ingredients in SuperSilica Plus! interact with drugs. Each result below shows which ingredient is responsible. Dandelion Horsetail Nettles Bamboo organic Barley Grass

Each ingredient & the kinds of drugs it affects

For each ingredient in SuperSilica Plus! with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dandelion7 drug types · 457 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro research suggests that dandelion root inhibits platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Laboratory research suggests that dandelion extract may have moderate alpha-glucosidase inhibitor activity and might also increase insulin secretion. Also, in a case report, a 58-year-old woman with type 2 diabetes who was being treated with insulin developed hypoglycemia 2 weeks after beginning to eat salads containing dandelion.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that dandelion might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, until more is known, watch for an increase in the levels of drugs metabolized by CYP1A2 in patients taking dandelion.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
There is some preliminary evidence that dandelion might induce UDP-glucuronosyltransferase, a phase II enzyme.

Likelihood Possible Evidence D
Lithium

Theoretically, through diuretic effects, dandelion might reduce excretion and increase levels of lithium.
Animal research suggests that dandelion has diuretic properties. As diuretics can increase serum lithium levels, the dose of lithium might need to be decreased when taken with dandelion.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Dandelion contains significant amounts of potassium.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, dandelion might lower fluoroquinolone levels.
Animal research shows that dandelion reduces absorption of ciprofloxacin and can lower levels by 73%. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Dandelion full monograph & interactions

Horsetail5 drug types · 188 drugs

Antidiabetes Drugs

Theoretically, taking horsetail with antidiabetes drugs might increase the risk of hypoglycemia.
Equisetum myriochaetum has demonstrated hypoglycemic activity in clinical research. In an animal diabetic model, Equisetum giganteum had hypoglycemic effects. It is unclear whether other horsetail species have hypoglycemic effects.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, taking horsetail with diuretic drugs might increase potassium loss and the risk of hypokalemia.
Laboratory research shows that various species of horsetail have diuretic properties. Due to its diuretic effects, there has been concern that taking horsetail along with potassium-depleting diuretics might increase the risk for hypokalemia. However, pharmacokinetic research in humans shows that taking horsetail 900 mg daily for 4 days does not affect urinary excretion of electrolytes, including potassium and sodium, despite having a diuretic effect similar to taking hydrochlorothiazide 25 mg daily. It is unclear if taking horsetail for a longer duration would affect electrolyte levels. Until more is known, use with caution.

Likelihood Possible Evidence D
Efavirenz (Sustiva)

Theoretically, horsetail might decrease the levels and clinical effects of efavirenz.
In two case reports, patients were found to have detectable viral loads when taking horsetail-containing supplements along with an antiretroviral regimen that included efavirenz. In one case, the antiretroviral regimen included zidovudine, lamivudine, and efavirenz; in the other case, the regimen consisted of emtricitabine, tenofovir disoproxil fumarate, and efavirenz. One month after discontinuing horsetail, the viral loads became undetectable in both cases. The exact mechanism of this interaction is unknown. It is also unclear if this interaction is specific to efavirenz or if it is related to various components of antiretroviral therapy.

Likelihood Possible Evidence D
Lithium

Theoretically, horsetail might increase the levels and adverse effects of lithium.
Animal research suggests that horsetail has diuretic properties. Theoretically, due to these potential diuretic effects, horsetail might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Nucleoside Reverse Transcriptase Inhibitors (Nrtis)

Theoretically, horsetail might decrease the levels and clinical effects of NRTIs.
In two case reports, patients were found to have detectable viral loads when taking horsetail-containing supplements along with an antiretroviral therapy. In one case, the antiretroviral regimen included zidovudine, lamivudine, and efavirenz; in the other case, the regimen consisted of emtricitabine, tenofovir disoproxil fumarate, and efavirenz. One month after discontinuing the supplement, the viral loads became undetectable in both cases. The exact mechanism of these interactions is unknown. It is also unclear if these interactions are specific to NRTIs or if they are related to various components of antiretroviral therapy.

Likelihood Possible Evidence D
Horsetail full monograph & interactions

Nettles4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D
Nettles full monograph & interactions

Bamboo1 drug type · 5 drugs

Antithyroid Drugs

Theoretically, long-term bamboo use might increase the effects and adverse effects of antithyroid drugs, possibly leading to hypothyroidism.
Animal research suggests that long-term consumption of bamboo shoot can decrease thyroid peroxidase activity, as well as levels of thyroxine (T4) and triiodothyronine (T3). This effect has not yet been reported in humans.

Likelihood Possible Evidence D
Bamboo full monograph & interactions

organic Barley Grass1 drug type · 1 drug

Triclabendazole (Egaten)

Theoretically, barley might decrease the clinical effects of triclabendazole.
Animal research suggests that a diet supplemented with barley can reduce the bioavailability of triclabendazole when taken concomitantly. This effect has not been shown in humans.

Likelihood Possible Evidence D
organic Barley Grass full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SuperSilica Plus!, from the product label.

Harmonic Innerprizes

See all Harmonic Innerprizes products
Name
Harmonic Innerprizes, Inc.
City
Henderson
State
NV
ZipCode
89063
Phone Number
1-888-667-4300
Web Address
Harmonicinnerprizes.com
Pharmacist Counseling Corner

SuperSilica Plus! by Harmonic Innerprizes: Common Questions

Does SuperSilica Plus! by Harmonic Innerprizes interact with any medications?
Yes. Based on its ingredients, SuperSilica Plus! has a known interaction with 549 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SuperSilica Plus! contains 15 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this product safe during pregnancy?
No. Several ingredients—protease, phytase, silica, horsetail, nettles, and dandelion—have insufficient safety data or are advised against in pregnancy. Bamboo supplements are also best avoided unless your doctor prescribes them. Talk with your doctor or pharmacist before use if you're pregnant or planning to become pregnant.
Can I take this while breastfeeding?
Safety data during breastfeeding are limited for most ingredients in this product. Protease, lipase, phytase, horsetail, nettles, and dandelion all carry cautions or lack studied safety. Check with your doctor or pharmacist first.
What do the digestive enzymes in this product actually do?
Digestive enzymes like protease, lipase, and amylase help break down proteins, fats, and carbohydrates in food. However, the evidence that supplemental enzymes improve digestion in healthy people is not yet established in our data. They may be useful if your body doesn't make enough of its own enzymes, but that's a conversation to have with your doctor.
Does barley grass have any proven benefits?
Yes—barley is likely effective for lowering cholesterol and supporting heart health. That said, the product contains barley grass, not whole barley, and concentrated barley grass products are less well studied than whole grain barley.
Will silica help my bones or skin?
Silica (silicon) is possibly effective for bone strength, but evidence for skin and hair is insufficient. Most of the silica in this product is from your food and water anyway—you get it naturally from a healthy diet.
Does this product contain gluten?
Barley contains gluten, so this product is not gluten-free. If you have celiac disease or gluten sensitivity, avoid this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SuperSilica Plus! label
Go deeper

The Full Monographs Behind SuperSilica Plus!’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Silicon

Silicon is a trace mineral found in the body and in foods like oats, barley, and certain fruits and vegetables, and it is popular in supplements for hair, skin, nail, and bone health. Some s...

Read the full Silicon monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Phytase

Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...

Read the full Phytase monograph → Herb & supplement monograph

Bamboo

Interacts with 5 drugs

Bamboo is a giant grass whose shoots are eaten as food and whose leaves and silica-rich extracts are sold as supplements, often for hair, skin, nail, and bone support. Solid human evidence f...

Read the full Bamboo monograph → Herb & supplement monograph

Horsetail

Interacts with 188 drugs

Horsetail is a traditional herb most often used as a mild diuretic and for hair, nail, and bone support, but high-quality human evidence is limited. It can cause thiamine (vitamin B1) loss w...

Read the full Horsetail monograph → Herb & supplement monograph

Stinging Nettle

Interacts with 164 drugs

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...

Read the full Stinging Nettle monograph → Herb & supplement monograph

Barley

Interacts with 1 drug

Barley is a nutritious whole grain that is a good source of soluble fiber called beta-glucan, which has solid evidence for modestly lowering LDL ('bad') cholesterol when eaten regularly. It...

Read the full Barley monograph → Herb & supplement monograph

Dandelion

Interacts with 457 drugs

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits...

Read the full Dandelion monograph →
Sources

Sources & How We Checked

SuperSilica Plus!'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 113 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Phytase 7 references
  1. Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
  2. Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
  3. van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
  4. Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
  5. Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
  6. Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
  7. Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.

See these in context on the Phytase monograph →

Silicon 19 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Jugdaohsingh R, Anderson SH, Tucker KL, et al. Dietary silicon intake and absorption. Am J Clin Nutr 2002;75:887-93. PubMed
  3. Ichiyanagi O, Sasagawa I, Adachi Y, et al. Silica urolithiasis without magnesium trisilicate intake. Urol Int 1998;61:39-42. PubMed
  4. Levison DA, Crocker PR, Banim S, Wallace DM. Silica stones in the urinary bladder. Lancet 1982;1:704-5. PubMed
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Bamboo 4 references
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Horsetail 14 references
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Stinging Nettle 23 references
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Dandelion 27 references
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