Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Synoplus Ingredients & Drug Interactions

by NewtonEverett

Synoplus label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Synoplus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Synoplus is a dietary supplement by NewtonEverett with 4 active ingredients. Its ingredients are commonly taken for skin hydration and aging, joint comfort and osteoarthritis, dry eyes.Based on those ingredients, 1,047 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Chinese Skullcap, Black Catechu, Glucosamine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Synoplus by NewtonEverett

Ask about any prescription or over-the-counter medication and we check it for interactions with Synoplus by NewtonEverett — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Synoplus by NewtonEverett

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 4 active ingredients.
  • “Synoflex Proprietary Herbal Extract” is a proprietary blend — the label gives one combined amount (250 mg) without saying how much of each component you get.

Synoplus contains four active ingredients. Hyaluronic acid is a natural compound used to help with dry eye and possibly venous leg ulcers (slow-healing sores from poor circulation).

Glucosamine hydrochloride is the form you'll find in joint supplements, used for osteoarthritis. Chinese skullcap (also called Baikal skullcap) is a traditional herbal ingredient, and black catechu is a plant extract used in some joint and inflammation formulas.

The tablet also contains several inactive ingredients—microcrystalline cellulose, vegetable magnesium stearate, silicon dioxide, stearic acid, vegetable coating, and titanium dioxide—which are common fillers and binders that give the tablet its form.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Joint health, comfort, protection and lubrication.
  • We looked for evidence on: Joint pain, Knee pain, Osteoarthritis, Rheumatoid arthritis (RA), Kashin-Beck Disease, Cartilage degradation — and 2 related terms.
  • The strongest evidence on file: Glucosamine is rated "Likely Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Catechu is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis.
  • Also on file: Glucosamine is rated "Insufficient Reliable Evidence To Rate" for Joint pain, Rheumatoid arthritis (RA), Knee pain, Kashin-Beck Disease.

The evidence for this product's ingredients is mixed. Glucosamine is likely effective for osteoarthritis, and hyaluronic acid is possibly effective for dry eye and venous leg ulcers.

For the other conditions listed in the data—aging skin, back pain, and various others—there isn't enough reliable evidence to say whether these ingredients work. Chinese skullcap and black catechu have insufficient evidence for their listed uses as well, including headache, anxiety, and exercise-induced muscle soreness.

If you're considering this product for a specific condition, talk with your pharmacist about what the science actually supports.

The evidence, ingredient by ingredient Hyaluronic Acid Glucosamine Baikal Skullcap Catechu

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

All four ingredients are generally well tolerated when taken by mouth. Hyaluronic acid and glucosamine appear well tolerated orally, though topical hyaluronic acid can occasionally cause eczema, itching, or erythema (redness).

Glucosamine's most common side effects are bloating, constipation, cramps, diarrhea, heartburn, and nausea. A small number of people have experienced allergic reactions to glucosamine, ranging from mild rashes to, rarely, anaphylaxis.

Chinese skullcap may cause abdominal pain, constipation, diarrhea, nausea, or vomiting. Black catechu has limited safety data on concentrated supplements.

Long-term safety of all these ingredients as supplements is not fully studied. During pregnancy, glucosamine and Chinese skullcap should be avoided due to insufficient safety data, while hyaluronic acid and black catechu lack clear safety information—talk with your doctor.

For breastfeeding, glucosamine and Chinese skullcap should be avoided, and black catechu's safety is unknown; hyaluronic acid has no lactation data on file.

Side effects, ingredient by ingredient Hyaluronic Acid Glucosamine Baikal Skullcap Catechu

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Catechu, Glucosamine, Baikal Skullcap.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,047 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Synoplus, double-check with your pharmacist if you take warfarin (a blood thinner)—glucosamine may increase its effect and bleeding risk. Also verify your use of blood pressure medications, diabetes drugs, blood thinners or antiplatelet drugs, thyroid medications, lithium, theophylline, or any drug metabolized by liver enzymes CYP1A2 or CYP2C19, since Chinese skullcap and black catechu may interact with these.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Synoplus may be worth considering if you have osteoarthritis or dry eye, since glucosamine and hyaluronic acid have some evidence behind them. However, you need to check your medications carefully before starting—especially if you take warfarin, blood pressure pills, diabetes drugs, or thyroid medication.

Talk with your pharmacist about your full medication list and whether this product is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Synoplus, straight from the product label.

Brand NewtonEverett
Barcode (UPC) 818423027852
Net contents 100 Vegetarian Tablet(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 248872
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Synoplus by NewtonEverett, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Tablet(s)
Maximum serving Sizes:
2 Vegetarian Tablet(s)
Servings per container
50
UPC/BARCODE
818423027852
IngredientAmount% DV
Hyaluronic Acid3.3 mg--
Glucosamine Hydrochloride1.5 Gram(s)--
Chinese Skullcap0 NP--
Black Catechu0 NP--
Synoflex Proprietary Herbal Extract250 mg--

Other ingredients: Microcrystalline Cellulose, Vegetable Magnesium Stearate, Silicon Dioxide, Stearic Acid, Vegetable Coating, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Joint health Protect Lubricate Nourish Joint comfort

Non-GMO Gluten free

FDA Statement of Identity

Dietary Supplement

Precautions

Contains: Shellfish (lobster, shrimp, crab).

Warning: Not for use by persons under the age of 18.

If pregnant nursing or taking a prescription drug, consult health care practitioner prior to use.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Three active ingredients in Synoplus give it a unique combination: Synofex - Deep-down joint comfort. Synoflex is a powerful, antioxidant formula that protects cartilage and joints from free radicals. This helps preserve and protect cartilage. Joint Fluid - Joint fluid (synovial) fluid is made of molecules of Hyaluronic Acid. These long and strong molecules let joint parts glide easily and smoothly. Glucosamine - Joint Builder, Glucosamine helps build, nourish, cushion, and protect cartilage.

Suggested/Recommended/Usage/Directions

Suggested Use: For best results, for the first 30 days take 2 tablets twice a day with meals (for a total of 4 tablets per day). After day 30, take 2 tablets once a day with a meal (for a total of 2 tablets per day).

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Synoplus by NewtonEverett label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Synoplus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Synoplus by NewtonEverett

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Vegetarian Tablet(s) Dosage formTablet Or Pill Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Hyaluronic Acid

No known
interactions
3.3 mg per serving

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...

Hyaluronic Acid monograph & interactions

Glucosamine Hydrochloride

Interacts with
170 drugs
1.5 Gram(s) per serving

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of...

Glucosamine Hydrochloride monograph & interactions

Synoflex Proprietary Herbal Extract

250 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetable Magnesium Stearate, Silicon Dioxide, Stearic Acid, Vegetable Coating, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Synoplus by NewtonEverett Drug Interactions

Want to check YOUR meds against Synoplus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,047Drugs
2 Major 722 Moderate 323 Minor

Ingredients driving the most interactions

Chinese Skullcap 946
Black Catechu 475
Glucosamine Hydrochloride 170

Individual Drug Interactions

The ingredients in Synoplus interact with 1,047 drugs. Click any drug to see the details.

3 of the 4 ingredients in Synoplus interact with drugs. Each result below shows which ingredient is responsible. Chinese Skullcap Black Catechu Glucosamine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Synoplus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Chinese Skullcap12 drug types · 946 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, Baikal skullcap might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Preliminary clinical research suggests that taking capsules containing a combination of astragalus, goldthread, and Baikal skullcap daily for 4 weeks inhibits platelet aggregation; the effect seems to be similar to that of aspirin 50 mg daily. It is unclear if this effect is due to Baikal skullcap, other ingredients, or the combination.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of Baikal skullcap with antidiabetes drugs might enhance blood glucose lowering effects.
Baicalein, a constituent of Baikal skullcap, has alpha-glucosidase inhibitory activity in vitro. Animal research also suggests that Baikal skullcap enhances the antidiabetic effects of metformin. However, in a small human study, taking Baikal skullcap extract did not enhance the antidiabetic effects of metformin, although it did modestly lower glucose levels during an oral glucose tolerance test (OGTT). Until more is known, use cautiously.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, concomitant use of Baikal skullcap with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Animal research suggests that baicalein, a constituent of Baikal skullcap, might lower blood pressure.

Likelihood Possible Evidence D
Antithyroid Drugs

Theoretically, concomitant use of Baikal skullcap and antithyroid drugs may result in additive activity and increase the risk of hypothyroidism.
In an animal hyperthyroid model, Baikal skullcap improved levels of triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH). The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
In vitro evidence suggests that constituents of Baikal skullcap inhibit the activity of CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Baikal skullcap might increase levels of drugs metabolized by CYP2C19 enzymes.
In vitro evidence suggest that wogonin, a constituent of Baikal skullcap, modestly inhibits the activity of CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of Baikal skullcap might interfere with hormone replacement therapy, due to competition for estrogen receptors.
In vitro evidence suggests that Baikal skullcap has estrogenic activity.

Likelihood Possible Evidence D
Lithium

Theoretically, Baikal skullcap might reduce lithium excretion and increase serum levels of lithium.
Baikal skullcap is thought to have diuretic properties, which may reduce lithium excretion. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Alcohol (Ethanol)

Theoretically, Baikal skullcap might potentiate the sedative effects of alcohol.
In vitro and animal research suggests that Baikal skullcap binds to GABA-A receptors and causes sedation. Theoretically, Baikal skullcap might potentiate the sedative effects of alcohol. Preliminary clinical research has not identified clinically relevant sedation after use of Baikal skullcap; however, a thorough evaluation of safety outcomes has not been conducted.

Likelihood Unlikely Evidence D
Cns Depressants

Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties.
In vitro and animal research suggests that Baikal skullcap binds to GABA-A receptors and causes sedation. Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties. Preliminary clinical research has not identified clinically relevant sedation after use of Baikal skullcap; however, a thorough evaluation of safety outcomes has not been conducted.

Likelihood Unlikely Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, Baikal skullcap might alter the levels and clinical effects of OATP substrates.
Some pharmacokinetic research shows that baicalin, a constituent of Baikal skullcap, can decrease plasma levels of rosuvastatin. The mechanism is thought to involve stimulation of the activity of the organic anion-transporting polypeptide 1B1 (OATP1B1), which transports rosuvastatin into the liver. This decreases plasma levels of the drug, but increases levels at the site of action in the liver. The degree to which rosuvastatin levels are affected depends on the OATP1B1 haplotype of the individual. Baikal skullcap might also affect other OATP1B1 substrates.

Likelihood Possible Evidence B
P-Glycoprotein Substrates

Theoretically, Baikal skullcap might increase levels of drugs transported by P-glycoprotein.
In vitro and animal research suggests that baicalein, oroxylin A, and wogonin, constituents of Baikal skullcap, can inhibit P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
Chinese Skullcap full monograph & interactions

Black Catechu4 drug types · 475 drugs

Antihypertensive Drugs

Theoretically, concomitant use with antihypertensive drugs might increase the risk of hypotension.
Catechu might lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black catechu may increase the levels and clinical effects of CYP1A2 substrates.
Animal research shows that black catechu can increase theophylline concentrations in the blood, possibly by inhibiting CYP1A2. Theophylline is a CYP1A2 substrate.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, catechu might interfere with immunosuppressant therapy.
Animal and in vitro studies suggest that catechu has immunomodulating effects.

Likelihood Possible Evidence D
Theophylline

Theoretically, black catechu may increase the levels and clinical effects of theophylline.
Animal research shows that black catechu can increase theophylline concentrations in the blood, possibly by inhibiting cytochrome P450 1A2.

Likelihood Possible Evidence D
Black Catechu full monograph & interactions

Glucosamine Hydrochloride4 drug types · 170 drugs

Warfarin (Coumadin)

Glucosamine might increase the anticoagulant effects of warfarin and increase the risk of bruising and bleeding.
In two individual case reports, glucosamine/chondroitin combinations were associated with a significant increase in international normalized ratio (INR) in patients previously stabilized on warfarin. In one case, the increase in INR occurred only after tripling the dose of a glucosamine/chondroitin supplement from 500 mg/400 mg daily to 1500/1200 mg daily. Additionally, 20 voluntary case reports to the U.S. Food & Drug Administration (FDA) have linked glucosamine plus chondroitin with increased INR, bruising, and bleeding in patients who were also taking warfarin. There have also been 20 additional case reports to the World Health Organization (WHO) that link glucosamine alone to increased INR in patients taking warfarin. The mechanism of this interaction is unclear. Glucosamine is a small component of heparin, but is not thought to have anticoagulant activity; however, animal research suggests that it might have antiplatelet activity.

Likelihood Probable Evidence D
Topoisomerase Ii Inhibitors

Theoretically glucosamine may induce resistance to topoisomerase II inhibitors.
In vitro research suggests that glucosamine might induce resistance to etoposide (VP16, VePesid) and doxorubicin (Adriamycin) by reducing inhibition of topoisomerase II, an enzyme required for DNA replication in tumor cells. This effect has not been reported in humans.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

Acetaminophen might interfere with the activity of glucosamine sulfate by interacting with the sulfate portion.
Anecdotal reports suggest that adding glucosamine to an acetaminophen regimen might decrease pain control in patients with osteoarthritis. Some research suggests that the sulfate portion of glucosamine sulfate might contribute to its effect in osteoarthritis. Since acetaminophen metabolism requires sulfur and reduces serum sulfate concentrations, acetaminophen could theoretically interfere with the action of glucosamine sulfate. Conversely, the administration of sulfate could theoretically decrease the effectiveness of acetaminophen in sulfate-deficient people by increasing its clearance.

Likelihood Possible Evidence B
Antidiabetes Drugs

Despite initial concerns, it is unlikely that glucosamine will interfere with the effects of antidiabetes drugs.
In vitro and animal research has suggested that glucosamine might increase insulin resistance or decrease insulin production. This has raised concerns that taking glucosamine might worsen diabetes and decrease the effectiveness of diabetes drugs. However, clinical research suggests that glucosamine does not have adverse effects on blood glucose or glycated hemoglobin (HbA1C) in healthy, obese, or type 2 diabetes patients.

Likelihood Unlikely Evidence B
Glucosamine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Synoplus, from the product label.

NewtonEverett

See all NewtonEverett products
Name
Newton-Everett Nutraceuticals
Street Address
9160 E. Bahia Dr.
City
Scottsdale
State
AZ
ZipCode
85260
Web Address
www.newton-everett.com
Pharmacist Counseling Corner

Synoplus by NewtonEverett: Common Questions

Does Synoplus by NewtonEverett interact with any medications?
Yes. Based on its ingredients, Synoplus has a known interaction with 1,047 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Synoplus contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is hyaluronic acid, and what does it do in this supplement?
Hyaluronic acid is a natural compound found in your body's connective tissues. In this product, it's included because it's possibly effective for dry eye and venous leg ulcers (slow-healing sores from poor circulation in your legs).
Is glucosamine safe to take if I have diabetes?
Glucosamine has a minor interaction with diabetes drugs. The good news is that despite early concerns, it's unlikely to interfere with how your diabetes medication works. That said, it's worth mentioning to your pharmacist or doctor, especially if your blood sugar control changes.
Can I take this while I'm pregnant or breastfeeding?
Glucosamine and Chinese skullcap should be avoided during pregnancy and while breastfeeding due to insufficient safety data. Hyaluronic acid and black catechu lack clear safety information for pregnancy and lactation. Talk with your doctor or pharmacist before taking Synoplus if you're pregnant, planning to become pregnant, or breastfeeding.
What are the most common side effects I might experience?
Glucosamine commonly causes bloating, constipation, cramps, diarrhea, heartburn, or nausea. Chinese skullcap may cause abdominal pain, constipation, diarrhea, or nausea. Hyaluronic acid is usually well tolerated. If you develop a rash or difficulty breathing, stop and contact your doctor.
How well does this product work for osteoarthritis?
Glucosamine hydrochloride, one of the active ingredients, is likely effective for osteoarthritis. The other ingredients don't have strong evidence for arthritis relief, though that's why the formula combines them.
Does it matter if I take this with acetaminophen (Tylenol)?
Acetaminophen might slightly interfere with the activity of glucosamine sulfate (a different form of glucosamine). This product contains glucosamine hydrochloride, so the interaction is less of a concern, but it's worth mentioning to your pharmacist if you regularly take acetaminophen.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Synoplus label
Go deeper

The Full Monographs Behind Synoplus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...

Read the full Hyaluronic Acid monograph → Herb & supplement monograph

Glucosamine

Interacts with 170 drugs

Glucosamine is a natural compound found in cartilage and joint fluid, and it is one of the most popular supplements for osteoarthritis, especially of the knee. The evidence is mixed, with so...

Read the full Glucosamine monograph → Herb & supplement monograph

Baikal Skullcap

Interacts with 946 drugs

Baikal skullcap is a traditional Chinese herb (Huang Qin) used for inflammation, allergies, and infections, with active compounds like baicalin and baicalein studied mostly in the lab. Human...

Read the full Baikal Skullcap monograph → Herb & supplement monograph

Catechu

Interacts with 475 drugs

Catechu is an astringent extract made from the heartwood of the Acacia (Senegalia) catechu tree, used traditionally for mouth sores, sore throat, diarrhea, and minor skin problems. Strong hu...

Read the full Catechu monograph →
Sources

Sources & How We Checked

Synoplus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 105 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

Glucosamine 58 references
  1. Adams ME. Hype about glucosamine. Lancet 1999;354:353-4. PubMed
  2. Balkan B, Dunning BE. Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats. Diabetes 1994;43:1173-9. PubMed
  3. Giaccari A, Morviducci L, Zorretta D, et al. In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat: possible relevance to the maladaptive responses to chronic hyperglycaemia. Diabetologia 1995;38:518-24. PubMed
  4. Holmang A, Nilsson C, Niklasson M, et al. Induction of insulin resistance by glucosamine reduces blood flow but not interstitial levels of either glucose or insulin. Diabetes 1999;48:106-11. PubMed
  5. Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol 1999;26:2423-30.
  6. Barclay TS, Tsourounis C, McCart GM. Glucosamine. Ann Pharmacother 1998;32:574-9.
  7. Shankar RR, Zhu JS, Baron AD. Glucosamine infusion in rats mimics the beta-cell dysfunction of non-insulin-dependent diabetes mellitus. Metabolism 1998;47:573-7.
  8. Almada A, Harvey P, Platt K. Effects of chronic oral glucosamine sulfate on fasting insulin resistance index (FIRI) in non-diabetic individuals. FASEB J 2000;14:A750.
  9. Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulfate on osteoarthritis progression: a randomised, placebo-controlled trial. Lancet 2001;357:251-6.
  10. Does glucosamine increase serum lipid levels and blood pressure? Pharmacist's Letter/Prescriber's Letter 2001;17(11):171115.
  11. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  12. Monauni T, Zenti MG, Cretti A, et al. Effects of glucosamine infusion on insulin secretion and insulin action in humans. Diabetes 2000;49:926-35. PubMed
  13. Pouwels MJ, Jacobs JR, Span PN, et al. Short-term glucosamine infusion does not affect insulin sensitivity in humans. J Clin Endocrinol Metab 2001;86:2099-103. DOI
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See these in context on the Glucosamine monograph →

Baikal Skullcap 34 references
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Catechu 9 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
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See these in context on the Catechu monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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