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Dietary supplement

Telezyme Ingredients & Drug Interactions

by Premier Nutritionals International

Telezyme label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Telezyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Telezyme is a dietary supplement by Premier Nutritionals International with 1 active ingredient.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Telezyme by Premier Nutritionals International

Ask about any prescription or over-the-counter medication and we check it for interactions with Telezyme by Premier Nutritionals International — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Telezyme by Premier Nutritionals International

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 10 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (400 mg) without saying how much of each component you get.
  • “Enzyme Enhanced Spirulina(TM) (Organic) GRBCF-77(TM) Enzyme & Mineral Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Telezyme is a 10-ingredient digestive enzyme blend. The active enzymes are bromelain (derived from pineapple), protease, lipase, lactase, cellulase, invertase, alpha-galactosidase, and maltase — together they're designed to help break down proteins, fats, carbohydrates, and dairy.

The blend also contains ionic minerals and enzyme-enhanced spirulina. Two inactive ingredients — magnesium stearate and a veggie capsule — help hold the formula together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • The label markets general wellness (“longevity support”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Lactose intolerance — rated "Effective" (Lactase) (Natural Medicines).

The evidence is thin for most of what these enzymes are used for. Bromelain shows insufficient reliable evidence for hay fever, burns, cancer support, nerve damage from chemotherapy, chronic vein problems, and diabetes.

Lipase is similarly unproven for inflammatory bowel disease and indigestion. Lactase is the exception — it's considered effective for lactose intolerance.

The other enzymes' effectiveness hasn't been rated in the data we hold.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bromelain is generally well tolerated short-term when taken by mouth, though evidence on long-term use is limited. The most common side effects are diarrhea, flatulence, stomach upset, and headache.

Some people may have allergic reactions (rare but possible, especially if inhaled). Protease and lipase are generally well tolerated, though both can occasionally cause digestive upset or allergic reactions.

Lactase is generally well tolerated. For pregnancy: bromelain safety data is not enough, so it's best avoided.

Protease and lipase have not been established as safe in pregnancy — use only if your doctor advises it. Lactase is likely safe.

For breastfeeding: bromelain and protease safety is unknown — avoid or ask your healthcare provider first. Lipase has limited data — check with your doctor or pharmacist.

Lactase has limited data; it acts only in the gut, so ask your provider first.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 4 matched ingredients can interact with medications — Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Telezyme, check with your pharmacist or doctor if you take blood thinners or antiplatelet drugs (like warfarin, clopidogrel, or aspirin) — bromelain may increase bleeding risk. Also check if you take tetracycline antibiotics, as bromelain may affect their absorption.

No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Telezyme is a multi-enzyme digestive supplement. It's generally well tolerated short-term, though most of its intended uses have insufficient evidence behind them — lactase for lactose intolerance is the exception.

If you take blood thinners, antiplatelet drugs, or tetracycline antibiotics, talk with your pharmacist or doctor before you start, because bromelain may affect how those drugs work. Anyone pregnant or breastfeeding should discuss it with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 27, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Telezyme, straight from the product label.

Brand Premier Nutritionals International
Net contents 120 Veggie Capsule(s)
Market status On market
Date entered into DSLD Oct 27, 2014
DSLD ID 38262
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Telezyme by Premier Nutritionals International, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
120
IngredientAmount% DV
Amylase0 NP--
Bromelain0 NP--
Protease0 NP--
Lipase0 NP--
Proprietary Blend400 mg--
Lactase0 NP--
Cellulase0 NP--
Invertase0 NP--
Alpha-Galactosidase0 NP--
Maltase0 NP--
Ionic Minerals0 NP--
Enzyme Enhanced Spirulina(TM) (Organic) GRBCF-77(TM) Enzyme & Mineral Blend0 NP--

Other ingredients: Veggie Capsule, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use 4 Capsules Daily (1 every 3 Hours). Can be taken with or without meals.

Precautions

Not recommended for individuals under the age of 21. Caution: Do not use this product if safety seal on lid is broken prior to first use.

Keep out of reach of infant children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

premier nutritionals international

FDA Statement of Identity

dietary supplement

General Statements

longevity support

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Telezyme by Premier Nutritionals International label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Telezyme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Telezyme by Premier Nutritionals International

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Proprietary Blend

400 mg per serving
  • › Enzyme Enhanced Spirulina(TM) (Organic) GRBCF-77(TM) Enzyme & Mineral Blend

Other (inactive) ingredients: Veggie Capsule, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Telezyme by Premier Nutritionals International Drug Interactions

Want to check YOUR meds against Telezyme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Telezyme interact with 141 drugs. Click any drug to see the details.

0 of the 1 ingredient in Telezyme interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Telezyme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Telezyme, from the product label.

Premier Nutritionals International

See all Premier Nutritionals International products
Name
Enriching Gifts International
City
Miles City
State
MT
ZipCode
59301
Phone Number
(406) 232-4414
Web Address
www.telezyme.com
Pharmacist Counseling Corner

Telezyme by Premier Nutritionals International: Common Questions

Does Telezyme by Premier Nutritionals International interact with any medications?
Yes. Based on its ingredients, Telezyme has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Telezyme contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will Telezyme help with my digestion?
The evidence isn't clear for most digestive complaints. Lactase — one of the enzymes in the blend — is proven effective for lactose intolerance, but the other enzymes and their combinations haven't been reliably tested for indigestion or general digestion support. Talk with your doctor if you're using it to manage a specific digestive condition.
Can I take Telezyme if I'm pregnant?
Bromelain shouldn't be used in pregnancy because safety data is insufficient. Protease and lipase also lack established safety data in pregnancy — use only if your doctor advises it. Lactase is likely safe. Talk with your pharmacist or doctor about whether Telezyme is right for you.
Can I take Telezyme if I'm breastfeeding?
Bromelain and protease safety while breastfeeding is unknown — avoid them or ask your healthcare provider. Lipase has limited data available — check with your doctor or pharmacist first. Lactase acts only in the gut, so safety is likely low; still, ask your provider.
What side effects does bromelain cause?
Most common are diarrhea, flatulence, stomach upset, and headache. Allergic reactions are possible but rare; if inhaled, it may trigger asthma or throat itching in sensitive people. Stop and contact your doctor if you have signs of an allergic reaction.
What do all these enzymes do?
Each breaks down different nutrients: bromelain, protease break down proteins; lipase breaks down fats; lactase breaks down milk sugar (lactose); the others break down various carbohydrates. Together they're meant to assist overall digestion, though the evidence for most uses is limited.
I take a tetracycline antibiotic. Can I use Telezyme?
Bromelain may increase how much tetracycline your body absorbs, which could affect how the drug works. Check with your pharmacist or doctor before you start Telezyme — they can help you decide whether it's safe for you or if you need to take it at a different time.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Telezyme is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Telezyme label
Sources

Sources & How We Checked

Telezyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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