Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Terrific Zzzz Ingredients & Drug Interactions

by Terry Naturally

Softgel Capsule Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Terrific Zzzz is a dietary supplement by Terry Naturally with 4 active ingredients. Its ingredients are commonly taken for source of vitamin c, digestive support, aromatherapy and relaxation.Based on those ingredients, 1,014 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Mandarin (Citrus reticulata) zest Oil, Ravintsara (Cinnamomum camphora) leaf oil, Lemon Balm (Melissa officinalis) leaf CO2 extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Terrific Zzzz by Terry Naturally

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Formula” is a proprietary blend — the label gives one combined amount (250 mg) without saying how much of each component you get.

Terrific Zzzz is a softgel with 4 active ingredients: mandarin zest oil, lemon balm leaf CO2 extract, ravintsara (camphor) leaf oil, and lavender aerial oil. Each brings its own properties — mandarin for its citrus constituents, lemon balm for its traditional calming use, camphor for its warming and soothing effects, and lavender for its well-known aromatic profile.

The formula also contains inactive ingredients (extra virgin olive oil, gelatin, glycerol, water, and chlorophyll) that serve as the base and capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Relieves occasional sleeplessness and promotes rejuvenation.
  • We looked for evidence on: Insomnia, Anxiety, Stress, Restless legs syndrome (RLS), Sleep quality, Sleep onset — and 2 related terms.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Insomnia.
  • Also on file: Lavender is rated "Insufficient Reliable Evidence To Rate" for Perioperative anxiety, Insomnia, Pre-procedural anxiety, Restless legs syndrome (RLS).

The evidence for these ingredients varies. Camphor is likely effective for acute pain and cough, and possibly effective for itching.

Lemon balm is possibly effective for stress and depression, and also possibly effective for cold sores. Lavender shows possibly effective evidence for menstrual cramps, but possibly ineffective evidence for cancer-related pain; evidence for its other uses — including alopecia, anxiety before procedures, and cancer fatigue — is insufficient.

Mandarin's effectiveness for cancer has insufficient reliable evidence to rate. Because this is a sleep-support product, note that the individual effectiveness data we hold does not directly address sleep quality or insomnia.

The evidence, ingredient by ingredient Tangerine Lemon Balm Camphor Lavender

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Camphor is unsafe if swallowed in quantity and is generally used only topically in small regulated amounts — this softgel delivers camphor oil, so ingestion is the route here, which carries real risk if overused. Lemon balm is generally well tolerated for short-term use in healthy adults, but long-term safety and high-dose safety aren't well studied; it's best avoided in pregnancy unless your doctor advises otherwise, and caution is needed while breastfeeding.

Lavender is well tolerated in food amounts and seems well tolerated in larger doses, but medicinal amounts shouldn't be used without your doctor's approval, and safety data in pregnancy and breastfeeding are incomplete. Mandarin fruit is safe as food, but concentrated extracts and essential oils require caution and medical guidance.

Adverse effects reported across these ingredients are generally mild — headache, nausea, dizziness, and gastrointestinal upset — though topical contact dermatitis has been linked to tangerine and lavender oils, and rare cases of serious effects like cardiac arrhythmias have been associated with high-dose camphor ingestion.

Side effects, ingredient by ingredient Tangerine Lemon Balm Camphor Lavender

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Lemon Balm, Camphor, Lavender, Tangerine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1,015 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Terrific Zzzz, check your medications against these categories: CNS depressants (sedatives, sleeping pills, anti-anxiety drugs) — lemon balm and lavender both carry Moderate interactions. Thyroid hormone replacement therapy — lemon balm has a Moderate interaction.

Hepatotoxic drugs (medications that can stress the liver) — camphor carries a Moderate interaction. Medications metabolized by your liver's CYP3A4 enzyme system — mandarin zest oil has Minor interactions.

Use the interaction checker below with your exact drug names.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Terrific Zzzz combines four ingredients with traditional sleep and relaxation use, but because it contains camphor (which is unsafe if overused orally) and lemon balm and lavender (which can add to sedative effects), you'll want to talk with your pharmacist before taking it — especially if you're on any medication for sleep, anxiety, thyroid, or liver function. This product is not suitable for pregnancy, and safety data for breastfeeding are limited.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Terrific Zzzz, straight from the product label.

Brand Terry Naturally
Barcode (UPC) 367703271039
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Jun 24, 2019
DSLD ID 203512
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Terrific Zzzz by Terry Naturally, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
15
UPC/BARCODE
367703271039
IngredientAmount% DV
Proprietary Formula250 mg--
Mandarin (Citrus reticulata) zest Oil0 NP--
Lemon Balm (Melissa officinalis) leaf CO2 extract0 NP--
Ravintsara (Cinnamomum camphora) leaf oil0 NP--
Lavender (Lavandula angustifolia) aerial Oil0 NP--

Other ingredients: extra virgin Olive Oil, Gelatin, Glycerol, Water, Chlorophyll

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Money-back guarantee

Relieves occasional sleeplessness Helps you feel rejuvenated and refreshed

Non-habit forming No morning grogginess

For relief of occassional sleeplessness

Deep, sound sleep For your good health Terry

Product of Belgium

Get a great night's sleep! Many of us aren't getting enough sleep, and the consequences are profound - for our energy, focus, and long-term health. But getting a good night's sleep can be hard when we have so many demands on our day.

Terrific Zzzz helps you relax so sleep comes naturally and you wake up refreshed and ready to start your day!

European herbal blend

Feel rejuvenated and refreshed! This non-habit forming European blend features time-tested ingredients that work synergistically to support deep, sound sleep without morning grogginess.

Terrific Zzzz! Terrific sleep! Terrific day ahead!

JC 34 91 + 3(5,6)EP BX27103.03

Formulation

Free of valerian and melatonin

Non-GMO No sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial flavoring, artificial preservatives.

Suggested/Recommended/Usage/Directions

Recommendations: 1 to 2 softgels about an hour before bedtime.

Precautions

If pregnant or nursing, consult a healthcare practitioner before using.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

JC 34 91 + 3(5,6)EP L27103.02

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Terry Naturally EuroPharma

Formula

Lemon balm Lavender Mandarin Ravintsara

See for yourself

Terrific Zzzz by Terry Naturally label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Terrific Zzzz by Terry Naturally

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: Extra virgin Olive Oil, Gelatin, Glycerol, Water, Chlorophyll. These complete the product’s ingredient list but are not active constituents.

Interaction report

Terrific Zzzz by Terry Naturally Drug Interactions

Want to check YOUR meds against Terrific Zzzz?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker

Each ingredient & the kinds of drugs it affects

For each ingredient in Terrific Zzzz with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Mandarin (Citrus reticulata) zest Oil2 drug types · 643 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4). This suggests that tangeretin may stimulate CYP3A4 activity. However, in humans, drinking tangerine juice 200 mL slightly delayed the absorption, but did not affect the metabolism, of midazolam, a CYP3A4 substrate. Theoretically, tangerine juice might increase CYP3A4 activity and decrease levels of drugs metabolized by this enzyme. However, this effect is unlikely.
Some drugs metabolized by CYP3A4 include amitriptyline (Elavil), amiodarone (Cordarone), citalopram (Celexa), felodipine (Plendil), lansoprazole (Prevacid), ondansetron (Zofran), prednisone (Deltasone, Orasone), sertraline (Zoloft), sibutramine (Meridia), and many others.

Likelihood Unlikely Evidence B
Midazolam (Versed)

In vitro, tangeretin, a constituent of tangerine, appears to increase the metabolism of midazolam in human liver microsomes by up to 52%. However, in humans, drinking tangerine juice 200 mL slightly delayed the absorption, but did not affect the metabolism, of midazolam. Theoretically, tangerine juice might increase the metabolism and reduce the effects of midazolam. However, this effect is unlikely.

Likelihood Unlikely Evidence B

Ravintsara (Cinnamomum camphora) leaf oil1 drug type · 370 drugs

Hepatotoxic Drugs

Theoretically, concomitant use of camphor with other hepatotoxic drugs might increase the risk of liver damage.
There have been a few case reports of transient elevations in liver enzymes in adults after oral or topical use of camphor. There has also been one case of hepatotoxicity in an infant after topical camphor use.

Likelihood Possible Evidence D

Lemon Balm (Melissa officinalis) leaf CO2 extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D

Lavender (Lavandula angustifolia) aerial Oil1 drug type · 248 drugs

Cns Depressants

Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.
Laboratory research suggests that lavender has sedative effects. However, clinical studies in patients taking oral lavender oil (Silexan) 160 mg for 10 weeks or taking lavender flower powder 1 gram daily for 2 months have not reported side effects of drowsiness, sedation, or sleepiness. There is still some concern that higher doses or different preparations of lavender might have additive effects with CNS depressant medications.

Likelihood Unlikely Evidence D
The maker

Brand information

Manufacturer and brand details for Terrific Zzzz, from the product label.

Terry Naturally

See all Terry Naturally products
Name
EuroPharma, Inc.
City
Green Bay
State
WI
ZipCode
54311
Phone Number
(866) 807-2731
Web Address
EuroPharmaUSA.com
Pharmacist Counseling Corner

Terrific Zzzz by Terry Naturally: Common Questions

Does Terrific Zzzz by Terry Naturally interact with any medications?
Yes. Based on its ingredients, Terrific Zzzz has a known interaction with 1,014 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Terrific Zzzz contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Terrific Zzzz if I'm on a sleeping pill or anti-anxiety medication?
Not without checking first. Lemon balm and lavender in this product can add to the depressant effects of sleep and anxiety medications, which is a Moderate concern. Run your exact medication through our checker, and talk to your pharmacist or doctor before combining them.
Is this safe to take while I'm pregnant or breastfeeding?
No, not in pregnancy — lemon balm should be avoided during pregnancy unless your doctor says otherwise. While breastfeeding, lemon balm and lavender both have limited safety data, so caution is needed. Talk to your doctor or pharmacist for personalized advice.
What's ravintsara, and why is it in a sleep product?
Ravintsara is camphor leaf oil, a warming and soothing botanical traditionally used for comfort and relaxation. In this product it's meant to support the sleep blend, but camphor is unsafe if swallowed in high amounts, so stick to the recommended dose.
Does lemon balm really work for sleep?
Lemon balm is possibly effective for stress and depression, which can contribute to poor sleep, but we don't hold specific effectiveness data on lemon balm for sleep itself. Its calming properties are traditionally used for relaxation, though more research on sleep specifically would help clarify its role.
What side effects might I experience?
Most commonly, headache, nausea, dizziness, or mild digestive upset. Rare serious effects like cardiac arrhythmias have been reported with very high camphor doses, but these are uncommon at normal use. If you experience unusual symptoms, stop and contact your pharmacist.
Can I take this if I'm on thyroid medication?
Not without checking first. Lemon balm may theoretically interfere with thyroid hormone replacement therapy. Use our interaction checker and talk to your pharmacist before combining this product with any thyroid medication.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Terrific Zzzz is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Terrific Zzzz label
Sources

Sources & How We Checked

Terrific Zzzz's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 55 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tangerine 3 references
  1. Yuan, J. M., Wang, X. L., Xiang, Y. B., Gao, Y. T., Ross, R. K., and Yu, M. C. Preserved foods in relation to risk of nasopharyngeal carcinoma in Shanghai, China. Int J Cancer 2000;85(3):358-363. DOI
  2. Backman, J. T., Maenpaa, J., Belle, D. J., Wrighton, S. A., Kivisto, K. T., and Neuvonen, P. J. Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation. Clin Pharmacol Ther 2000; PubMed
  3. Vilaplana, J. and Romaguera, C. Contact dermatitis from the essential oil of tangerine in fragrance. Contact Dermatitis 2002;46(2):108. PubMed

See these in context on the Tangerine monograph →

Lemon Balm 12 references
  1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
  3. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
  4. Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
  5. Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
  6. Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
  7. Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86. DOI
  8. Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. PubMed
  9. Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5. PubMed
  10. Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11. PubMed
  11. Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207. PubMed
  12. Kucuk U, Pham M, Raza Raja MH, Saad Shaukat MH, Clark R. Transient complete atrioventricular block associated with herbal supplement use. S D Med 2023;76(7):311-313.

See these in context on the Lemon Balm monograph →

Camphor 20 references
  1. Uc A, Bishop WP, Sanders KD. Camphor hepatotoxicity. South Med J 2000;93:596-8. DOI
  2. Love JN, Sammon M, Smereck J. Are one or two dangerous? Camphor exposure in toddlers. J Emerg Med 2004;27:49-54.. PubMed
  3. Ruha AM, Graeme KA, Field A. Late seizure following ingestion of Vicks VapoRub. Acad Emerg Med 2003;10:691. . PubMed
  4. Gouin S, Patel H. Unusual cause of seizure. Pediatr Emerg Care 1996;12:298-300. DOI
  5. Ernst E. Adverse effects of herbal drugs in dermatology. Br J Dermatol 2000;143:923-9. PubMed
  6. Fung AE, Oxford KW. Microwave-superheated Vics Vapo Rub: an ocular public health danger. Am J Ophthalmol 2004;137:379-80. PubMed
  7. Emery, D. P. and Corban, J. G. Camphor toxicity. J.Paediatr.Child Health 1999;35(1):105-106.
  8. Rampini, S. K., Schneemann, M., Rentsch, K., and Bachli, E. B. Camphor intoxication after cao gio (coin rubbing). JAMA 7-3-2002;288(1):45.
  9. SMITH, A. G. and MARGOLIS, G. Camphor poisoning; anatomical and pharmacologic study; report of a fatal case; experimental investigation of protective action of barbiturate. Am.J.Pathol. 1954;30(5):857-869.
  10. Ragucci, K. R., Trangmar, P. R., Bigby, J. G., and Detar, T. D. Camphor ingestion in a 10-year-old male. South.Med.J. 2007;100(2):204-207. PubMed
  11. Agarwal, A. and Malhotra, H. S. Camphor ingestion: an unusual cause of seizure. J.Assoc.Physicians India 2008;56:123-124.
  12. Weiss, J. and Catalano, P. Camphorated oil intoxication during pregnancy. Pediatrics 1973;52(5):713-714. DOI
  13. Vasey, R. H. and Karayannopoulos, S. J. Camphorated oil. Br.Med.J. 1-8-1972;1(5792):112.
  14. Mascie-Taylor, B. H., Widdop, B., and Davison, A. M. Camphor intoxication treated by charcoal haemoperfusion. Postgrad.Med.J. 1981;57(673):725-726. PubMed
  15. Theis, J. G. and Koren, G. Camphorated oil: still endangering the lives of Canadian children. CMAJ. 6-1-1995;152(11):1821-1824.
  16. Skoglund, R. R., Ware, L. L., Jr., and Schanberger, J. E. Prolonged seizures due to contact and inhalation exposure to camphor. A case report. Clin.Pediatr.(Phila) 1977;16(10):901-902. PubMed
  17. Cordoba Torres IT, Marino-Nieto J, Barkin HB, Fort AC, Cobas M. Vicks VapoRub intoxication: an unusual presentation of multiorgan failure. J Clin Anesth 2018;48:46-7. PubMed
  18. Rahimi M, Shokri F, Hassanian-Moghaddam H, et al. Severe camphor poisoning, a seven-year observational study. Environ Toxicol Pharmacol 2017;52:8-13. PubMed
  19. Mathew T, John SK, Kamath V, et al. Essential oil related seizures (EORS): A multi-center prospective study on essential oils and seizures in adults. Epilepsy Res. 2021;173:106626. PubMed
  20. Camphor (synthetic): Immediately Dangerous to Life or Health Concentrations (IDLH). National Institute for Occupational Safety and Health. 1994. https://www.cdc.gov/niosh/idlh/76222.html. Assessed 5/6/2021.

See these in context on the Camphor monograph →

Lavender 20 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Akhondzadeh S, Kashani L, Fotouhi A, et al. Comparison of Lavandula angustifolia Mill. tincture and imipramine in the treatment of mild to moderate depression: a double-blind, randomized trial. Prog Neuropsychopharmacol Biol Psychiatry 2003;27:123-7. PubMed
  4. Varma S, Blackford S, Statham BN, Blackwell A. Combined contact allergy to tea tree oil and lavender oil complicating chronic vulvovaginitis. Contact Dermatitis 2000;42:309-10.
  5. Coulson IH and Khan AS. Facial 'pillow' dermatitis due to lavender oil allergy. Contact Dermatitis 1999;41(2):111. PubMed
  6. Woelk, H. and Schlafke, S. A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder. Phytomedicine. 2010;17(2):94-99. PubMed
  7. Kasper, S., Gastpar, M., Muller, W. E., Volz, H. P., Moller, H. J., Dienel, A., and Schlafke, S. Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of 'subsyndromal' anxiety disorder: a randomized, double-blind, plac
  8. Uehleke, B., Schaper, S., Dienel, A., Schlaefke, S., and Stange, R. Phase II trial on the effects of Silexan in patients with neurasthenia, post-traumatic stress disorder or somatization disorder. Phytomedicine. 6-15-2012;19(8-9):665-671. PubMed
  9. Brandao FM. Occupational allergy to lavender oil. Contact Dermatitis 1986;15(4):249-250. PubMed
  10. Rademaker M. Allergic contact dermatitis from lavender fragrance in Difflam gel. Contact Dermatitis 1994;31(1):58-59. PubMed
  11. Kasper S, Gastpar M, Müller WE, et al. Lavender oil preparation Silexan is effective in generalized anxiety disorder--a randomized, double-blind comparison to placebo and paroxetine. Int J Neuropsychopharmacol. 2014 Jun;17(6):859-69. PubMed
  12. Farshbaf-Khalili A, Kamalifard M, Namadian M. Comparison of the effect of lavender and bitter orange on anxiety in postmenopausal women: A triple-blind, randomized, controlled clinical trial. Complement Ther Clin Pract 2018;31:132-8. PubMed
  13. Bingham LJ, Tam MM, Palmer AM, Cahill JL, Nixon RL. Contact allergy and allergic contact dermatitis caused by lavender: A retrospective study from an Australian clinic. Contact Dermatitis. 2019;81(1):37-42. PubMed
  14. Donelli D, Antonelli M, Bellinazzi C, Gensini GF, Firenzuoli F. Effects of lavender on anxiety: A systematic review and meta-analysis. Phytomedicine. 2019;65:153099. PubMed
  15. Firoozeei TS, Feizi A, Rezaeizadeh H, Zargaran A, Roohafza HR, Karimi M. The antidepressant effects of lavender (Lavandula angustifolia Mill.): A systematic review and meta-analysis of randomized controlled clinical trials. Complement Ther Med 2021;59:102 PubMed
  16. Kodama T, Watanabe T, Mataki N, Kanoh S, Kichikawa Y. Acute eosinophilic pneumonia following aromatherapy with essential oil. Respir Med Case Rep 2022;37:101657. PubMed
  17. Barbaud A, Kurihara F, Raison-Peyron N, et al. Allergic contact dermatitis from essential oil in consumer products: Mode of uses and value of patch-tests with an essential oil series. Results of a French study of the DAG (dermato-allergy group of the Fren
  18. Ozer H, Sayan ZA, Baloglu I, Ozturk Y, Yonet F, Turkmen K. Unknown criminals for kidney: Acute interstitial nephritis due to lavender tea. Explore (NY) 2023. PubMed
  19. Kasper S, Volz HP, Möller HJ, et al. Lavender oil preparation Silexan is effective in mild-to-moderate major depression: a randomized, placebo- and reference-controlled trial. Eur Arch Psychiatry Clin Neurosci 2024. PubMed
  20. Simaei SR, Askari VR, Rostami M, et al. Lavender and metformin effectively propagate progesterone levels in patients with polycystic ovary syndrome: A randomized, double-blind clinical trial. Fitoterapia 2023;172:105720. PubMed

See these in context on the Lavender monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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