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Dietary supplement

Tested Ingredients & Drug Interactions

by Nutrex Research Clinical Edge

Tested label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tested against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tested is a dietary supplement by Nutrex Research Clinical Edge with 2 active ingredients. Its ingredients are commonly taken for bone health, joint and arthritis support, hormone (testosterone/estrogen) support.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are LJ100 standardized Eurycoma longifolia jack extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tested by Nutrex Research Clinical Edge

Ask about any prescription or over-the-counter medication and we check it for interactions with Tested by Nutrex Research Clinical Edge — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tested by Nutrex Research Clinical Edge

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 2 active ingredients. Boron citrate is a mineral form of boron, which your body needs in small amounts — it's established as effective for boron deficiency and is being studied for vaginal yeast infections and radiation skin damage, though evidence for those uses is still incomplete.

LJ100 standardized Eurycoma longifolia jack extract is a herbal concentrate from the roots of this Southeast Asian plant, used primarily for sexual desire, where current evidence rates it possibly effective. The product also contains inactive ingredients including glycerin, vegetable cellulose, purified water, and food colorings (titanium dioxide, FD&C Yellow 6, FD&C Red 40, and FD&C Blue 1).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Total testosterone support muscle and strength.
  • We looked for evidence on: Age-related testosterone deficiency, Athletic performance, Muscle strength, Sexual desire, Male Infertility, Libido — and 3 related terms.
  • The strongest evidence on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire (Natural Medicines).
  • Also on file: Boron is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Eurycoma Longifolia is rated "Possibly Ineffective" for Athletic performance.

Boron citrate is likely effective for preventing or correcting boron deficiency. For vaginal candidiasis (yeast infection) and radiation dermatitis (skin damage from radiation therapy), the evidence rates it possibly effective — meaning there's some promise, but more research is needed.

For athletic performance, the available evidence suggests it's probably not effective. Eurycoma longifolia extract is rated possibly effective for sexual desire based on current research.

For athletic performance, back pain, osteoporosis, and diabetes, we don't hold enough reliable evidence to rate it one way or the other.

The evidence, ingredient by ingredient Boron Eurycoma Longifolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Boron citrate is generally well tolerated when doses stay below 20 mg daily. At typical supplement doses, the most common side effects are anorexia (loss of appetite), dermatitis (skin irritation), erythema (redness), and indigestion.

High chronic doses or acute overdose can cause skin damage, hair loss, and in severe cases, nausea, vomiting, and diarrhea — but these risks are not a concern at normal supplement levels. Eurycoma longifolia is generally tolerated in short-term studies, though long-term safety and product quality consistency are uncertain.

Because the extract may increase testosterone, there is a theoretical risk of testosterone-related side effects like acne, insulin resistance, and liver stress if levels climb beyond the normal range. During pregnancy, the safety data advises against use; while breastfeeding, there isn't enough information to know if it's safe, so talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Boron Eurycoma Longifolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take propranolol (Inderal) for blood pressure or heart rhythm — Eurycoma longifolia can reduce how well it works (Moderate severity). Also double-check if you're on CYP1A2, CYP2C19, or CYP2A6 substrate drugs or testosterone therapy, though those interactions are theoretical at this point (Minor severity).

Your pharmacist can search your exact medications on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Nutrex Research Clinical Edge may be worth considering if you're looking to support sexual desire, correct a boron deficiency, or explore boron for other uses — but the interaction with propranolol and other blood-pressure or heart medications is real and worth checking first. If you're on any prescription medication, especially hormonal therapies or drugs your liver processes heavily, have a conversation with your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tested, straight from the product label.

Brand Nutrex Research Clinical Edge
Barcode (UPC) 857839006273
Net contents 60 Liquid Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2018
DSLD ID 176460
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tested by Nutrex Research Clinical Edge, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Liquid Capsule(s)
Maximum serving Sizes:
2 Liquid Capsule(s)
Servings per container
30
UPC/BARCODE
857839006273
IngredientAmount% DV
Boron Citrate100 mg--
LJ100 standardized Eurycoma longifolia jack extract200 mg--

Other ingredients: Glycerin, Vegetable Cellulose, purified Water, Titanium Dioxide, FD&C Yellow 6, FD&C Red 40, FD&C Blue 1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Warning: Tested is intended for healthy adults and not for use by individuals under the age of 18.

This product should not be taken without first consulting with your physician if you have any prior medical conditions or if you are pregnant or nursing.

Keep out of reach of children.

General

LBL-TESTED-60CT-V1-US

General Statements

Clinically dosed Total testosterone support Muscle & strength Increases vitality Enhances libido

Amplifies libido & sexual function Encourages a favorable anabolic to catabolic environment Increases physical & mental energy

Testosterone functions as a highly anabolic hormone in the body.

If building muscle, boosting energy and supporting strong sexual health is your desire, Tested will deliver beyond any natural expectation.

Regular exercise and proper nutrition are essential for achieving your physique goals. As individuals vary so may results from using this product.

FDA Statement of Identity

Dietary Supplement

Formula

LJ100

Helps achieve higher free testosterone levels in Men

Brand IP Statement(s)

Tested Product Highlights

Tested is a clinically dosed free testosterone and libido supporting formula.

Tested has patented LJ100 that has shown to increase and support free testosterone.

LJ100 is the registered trademark of HP ingredients. Worldwide Patent: WO/02/17946 Bioactive Fraction of Eurycoma longifolia.

Suggested/Recommended/Usage/Directions

Recommended Use: For general testosterone and libido support take 2 liquid capsules in the morning and 2 liquid capsules at night. On training days; Take 2 liquid capsules one hour before exercise and 2 liquid capsules either in the morning or before bed depending on the time of your training session.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tested by Nutrex Research Clinical Edge label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tested label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tested by Nutrex Research Clinical Edge

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Liquid Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Boron Citrate

No known
interactions
100 mg per serving

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence f...

Boron Citrate monograph & interactions

LJ100 standardized Eurycoma longifolia jack extract

Interacts with
248 drugs
200 mg per serving Form: Bioactive Eurypeptides, Eurycomanone, Glyco Saponins, Polysaccharides

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

LJ100 standardized Eurycoma longifolia jack extract monograph & interactions

Other (inactive) ingredients: Glycerin, Vegetable Cellulose, Purified Water, Titanium Dioxide, FD&C Yellow 6, FD&C Red 40, FD&C Blue 1. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tested by Nutrex Research Clinical Edge Drug Interactions

Want to check YOUR meds against Tested?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
3 Moderate 245 Minor

Ingredients driving the most interactions

LJ100 standardized Eurycoma longifolia jack extract 248

Individual Drug Interactions

The ingredients in Tested interact with 248 drugs. Click any drug to see the details.

1 of the 2 ingredients in Tested interact with drugs. Each result below shows which ingredient is responsible. LJ100 standardized Eurycoma longifolia jack extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tested with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

LJ100 standardized Eurycoma longifolia jack extract5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
LJ100 standardized Eurycoma longifolia jack extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tested, from the product label.

Nutrex Research Clinical Edge

See all Nutrex Research Clinical Edge products
Name
Nutrex Research, Inc.
City
Oviedo
State
FL
ZipCode
32765
Phone Number
1-888-368-8739
Web Address
Nutrex.com
Pharmacist Counseling Corner

Tested by Nutrex Research Clinical Edge: Common Questions

Does Tested by Nutrex Research Clinical Edge interact with any medications?
Yes. Based on its ingredients, Tested has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tested contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is boron safe to take every day?
Boron is generally well tolerated when you stay below the upper safe limit of 20 mg daily. At normal supplement doses, the main side effects are mild — things like loss of appetite, skin irritation, or indigestion. High chronic doses are where problems start.
Can I take this if I'm pregnant or breastfeeding?
For boron, the safety data advises against it during pregnancy because high amounts may be harmful to the fetus, and there isn't enough information to know it's safe while breastfeeding. For Eurycoma longifolia, avoid it during pregnancy, and there isn't enough safety information for breastfeeding either. Talk with your doctor or pharmacist about your specific situation.
Does this product actually work for sexual function?
The Eurycoma longifolia extract is rated possibly effective for sexual desire — meaning there's some research support, but we'd like more evidence. Results vary from person to person.
What is boron actually used for in the body?
Boron is a mineral your body needs in small amounts for normal function. This product's boron citrate is established as effective for correcting boron deficiency. It's also being studied for vaginal yeast infections and radiation skin damage, though the evidence for those uses is still developing.
Are there any fillers or junk in this product?
The product contains inactive ingredients that are standard capsule materials and colorings — glycerin, vegetable cellulose, purified water, and food dyes. These are excipients that help make the capsule work, not active ingredients.
I take propranolol for my heart. Can I take this?
Not without checking with your pharmacist first. The Eurycoma longifolia in this product can reduce propranolol's levels in your blood and make it less effective. Your doctor or pharmacist needs to know you're considering this before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tested label
Go deeper

The Full Monographs Behind Tested’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boron

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence for most of these uses is limited or prel...

Read the full Boron monograph → Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph →
Sources

Sources & How We Checked

Tested's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boron 6 references
  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Thai L, Hart LL. Boric acid vaginal suppositories. Ann Pharmacother 1993;27:1355-7.
  4. Acs N, Banhidy F, Puho E, Czeizel AE. Teratogenic effects of vaginal boric acid treatment during pregnancy. Int J Gynaecol Obstet 2006;93:55-6. PubMed
  5. Garabrant, D. H., Bernstein, L., Peters, J. M., and Smith, T. J. Respiratory and eye irritation from boron oxide and boric acid dusts. J Occup Med 1984;26(8):584-586. PubMed
  6. Hjelm C, Harari F, Vahter M. Pre- and postnatal environmental boron exposure and infant growth: results from a mother-child cohort in northern Argentina. Environ Res 2019;171:60-8. PubMed

See these in context on the Boron monograph →

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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