Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Testosterone Premium Ingredients & Drug Interactions

by Premier Research Labs

Testosterone Premium label
See full label image
Capsule Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Testosterone Premium against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Testosterone Premium is a dietary supplement by Premier Research Labs with 7 active ingredients. Its ingredients are commonly taken for low testosterone or low libido in men, male fertility support, athletic performance and muscle strength.Based on those ingredients, 734 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Testofen, Cordyceps Mycelia Extract, LJ100. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Testosterone Premium by Premier Research Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Testosterone Premium by Premier Research Labs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Testosterone Premium by Premier Research Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 7 active ingredients.
  • “Men's Multi-Botanical Blend” is a proprietary blend — the label gives one combined amount (296 mg) without saying how much of each component you get.

Testosterone Premium contains 7 active ingredients. Maca, American ginseng, cordyceps mycelia extract, pumpkin powder, saw palmetto, LJ100 (an extract of Eurycoma longifolia), and Testofen (fenugreek) are all intended to support testosterone levels and male sexual function.

The product also contains two inactive ingredients—cellulose and water—which serve as fillers and capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Support healthy testosterone levels and male sexual function.
  • We looked for evidence on: Age-related testosterone deficiency, Erectile dysfunction (ED), Male infertility, Benign prostatic hyperplasia (BPH), Fatigue, Muscle strength — and 4 related terms.
  • The strongest evidence on file: Pumpkin is rated "Possibly Effective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire.
  • Also on file: Fenugreek is rated "Possibly Ineffective" for Benign prostatic hyperplasia (BPH).

The evidence for testosterone support is mixed. Testofen (fenugreek) is possibly effective for sexual dysfunction and sexual arousal, and possibly effective for diabetes.

LJ100 (Eurycoma longifolia) is possibly effective for sexual desire. Pumpkin powder is possibly effective for benign prostate enlargement (BPH).

However, cordyceps is rated possibly ineffective for athletic performance, and saw palmetto is rated possibly ineffective for BPH. The remaining ingredients—maca, American ginseng, and cordyceps for most of their uses—lack sufficient evidence to rate.

If your goal is sexual function or prostate health, fenugreek and pumpkin have the most support; if you're chasing athletic gains, the evidence doesn't back cordyceps for that purpose.

The evidence, ingredient by ingredient Eurycoma Longifolia Fenugreek Maca American Ginseng Cordyceps Pumpkin Saw Palmetto

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients are generally well tolerated short-term, though long-term safety data is limited for several. Common mild side effects include abdominal discomfort, diarrhea, nausea, headache, and dizziness.

Fenugreek and cordyceps may cause gastrointestinal upset. Saw palmetto rarely causes a skin rash or heart rhythm changes.

Cordyceps carries a rare case report of liver inflammation (hepatitis) tied to a supplement containing it, though it's unclear whether cordyceps itself was the cause or a contaminant. If you have testosterone-related concerns (acne, insulin resistance, liver problems), Eurycoma longifolia may pose additional risk if it raises your testosterone beyond normal.

Maca from fresh, uncooked plant material may cause stomach pain. Avoid this product during pregnancy: most ingredients are rated unsafe or lack sufficient safety data, and saw palmetto has possible hormonal effects.

During breastfeeding, data is insufficient for most ingredients; fenugreek is sometimes used to boost milk supply but evidence is limited—talk to your provider first.

Side effects, ingredient by ingredient Eurycoma Longifolia Fenugreek Maca American Ginseng Cordyceps Pumpkin Saw Palmetto

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 7 matched ingredients can interact with medications — Cordyceps, Fenugreek, Pumpkin, American Ginseng, Saw Palmetto, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 734 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check blood thinners like warfarin, clopidogrel, and aspirin—American ginseng and fenugreek may interfere, and cordyceps and saw palmetto may increase bleeding risk. Diabetes medications are a concern: American ginseng and fenugreek can lower blood sugar further.

Birth control (estrogen-based) and estrogen therapy may be less effective with saw palmetto. Blood pressure drugs, especially propranolol and metoprolol, may be affected by LJ100 and fenugreek.

Seizure medications like phenytoin and asthma drugs like theophylline may be less effective with fenugreek. Monoamine oxidase inhibitors (MAOIs, older antidepressants) and lithium require caution with American ginseng and pumpkin respectively.

Sildenafil (Viagra) levels may drop with fenugreek.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is aimed at men seeking testosterone support and sexual function improvement, with the strongest evidence for fenugreek and pumpkin. If you take blood thinners, diabetes medications, birth control, any antidepressants, or heart drugs like propranolol or metoprolol, you need to check your exact medications with the tool on this page before starting—the interaction risks are real.

Pregnant women and those breastfeeding should talk to their provider. If you have heart, liver, or hormonal concerns, mention this product to your pharmacist before you use it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Testosterone Premium, straight from the product label.

Brand Premier Research Labs
Barcode (UPC) 807735020934
Net contents 90 Plant-Source Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 297572
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years), Seniors/Mature (>50 Years) - Men ONLY
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Testosterone Premium by Premier Research Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
807735020934
IngredientAmount% DV
Maca0 NP--
American Ginseng0 NP--
Cordyceps Mycelia Extract0 NP--
Pumpkin, Powder0 NP--
Saw Palmetto0 NP--
LJ100200 mg--
Testofen600 mg--
Men's Multi-Botanical Blend296 mg--

Other ingredients: Cellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take 3 capsules daily or as directed by a health professional.

Precautions

California Residents Only Prop 65 Warning Reproductive Harm www.P65Warnings.ca.gov

Use only if inner seal is intact.

Consult your health care practitioner if you are pregnant or nursing, taking medications or have a medical condition, before taking this or any other product.

Keep out of reach of children.

Formulation

Helps support healthy testosterone levels Helps reduce some andropause-related symptoms in men over age 40 such as reduced sexual desire Helps support healthy cortisol levels and immune function

Supports Healthy Testosterone Levels and Sexual Desire

PRL's Quality Guarantee Plant-Based Nutrients Potency Verified Purity Verified Clinically Studied Nutrients Botanical Species Confirmed Phytoforensic Tested for Adulterants Pathogen Tested by Microbiology Heavy Metal Tested

No radiation sterilization

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Testosterone Premium With Eurcyoma & Testofen

Helps promote sexual desire and vitality in men

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Testofen is the registered trademark of Gencor LJ100 is the registered trademark of HP Ingredients. US Patents No.: 7,132,117 B2

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Testosterone Premium by Premier Research Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Testosterone Premium label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Testosterone Premium by Premier Research Labs

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

LJ100

Interacts with
248 drugs
200 mg per serving Form: Eurycoma longifolia Root Extract

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

LJ100 monograph & interactions

Testofen

Interacts with
389 drugs
600 mg per serving Form: Fenugreek Seed Extract

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. So...

Testofen monograph & interactions

Men's Multi-Botanical Blend

296 mg per serving

Other (inactive) ingredients: Cellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Testosterone Premium by Premier Research Labs Drug Interactions

Want to check YOUR meds against Testosterone Premium?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
734Drugs
2 Major 405 Moderate 327 Minor

Ingredients driving the most interactions

Testofen 389
Cordyceps Mycelia Extract 249
LJ100 248
American Ginseng 217
Saw Palmetto 174

Individual Drug Interactions

The ingredients in Testosterone Premium interact with 734 drugs. Click any drug to see the details.

6 of the 7 ingredients in Testosterone Premium interact with drugs. Each result below shows which ingredient is responsible. Testofen Cordyceps Mycelia Extract LJ100 American Ginseng Saw Palmetto Pumpkin, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Testosterone Premium with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Testofen9 drug types · 389 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.

Likelihood Probable Evidence B
Clopidogrel (Plavix)

Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.

Likelihood Possible Evidence D
Metoprolol (Toprol)

Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.

Likelihood Possible Evidence C
Testofen full monograph & interactions

Cordyceps Mycelia Extract3 drug types · 249 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.

Likelihood Possible Evidence B
Testosterone

Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
Cordyceps Mycelia Extract full monograph & interactions

LJ1005 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
LJ100 full monograph & interactions

American Ginseng4 drug types · 217 drugs

Warfarin (Coumadin)

American ginseng seems to decrease the effectiveness of warfarin therapy.
Healthy patients receiving warfarin 5 mg daily, who also take American ginseng 1 gram twice daily, seem to have a significantly reduced international normalized ratio (INR).

Likelihood Likely Evidence B
Antidiabetes Drugs

Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
American ginseng seems to lower postprandial blood glucose. Theoretically, concomitant use with antidiabetes drugs might enhance blood glucose lowering effects and possibly cause hypoglycemia.

Likelihood Probable Evidence B
Immunosuppressants

Theoretically, American ginseng use might interfere with immunosuppressive therapy.
American ginseng seems to stimulate immune function. Theoretically, American ginseng might decrease the effectiveness of immunosuppressant drugs.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, American ginseng can interfere with MAOI therapy.
There is one case report of insomnia, headache, and tremors when an unspecified ginseng product was used with phenelzine (Nardil), an MAOI. There is also one case report of hypomania when an unspecified ginseng product was used with phenelzine. Theoretically, American ginseng may interfere with MAOI therapy.

Likelihood Possible Evidence D
American Ginseng full monograph & interactions

Saw Palmetto3 drug types · 174 drugs

Anticoagulant/Antiplatelet Drugs

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.

Likelihood Possible Evidence D
Contraceptive Drugs

Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.

Likelihood Possible Evidence B
Estrogens

Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.

Likelihood Possible Evidence B
Saw Palmetto full monograph & interactions

Pumpkin, Powder1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Pumpkin, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Testosterone Premium, from the product label.

Premier Research Labs

See all Premier Research Labs products
Name
Premier Research Labs
Pharmacist Counseling Corner

Testosterone Premium by Premier Research Labs: Common Questions

Does Testosterone Premium by Premier Research Labs interact with any medications?
Yes. Based on its ingredients, Testosterone Premium has a known interaction with 734 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Testosterone Premium contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually boost testosterone?
The evidence is incomplete. Fenugreek (Testofen) is possibly effective for sexual function, and LJ100 may increase testosterone levels in men with low baseline testosterone. The other ingredients either lack solid evidence or are rated ineffective for what they're claimed to do. Your best bet is to talk with your doctor about whether your testosterone is actually low before starting any supplement.
What are the most common side effects I should expect?
Stomach upset is most common—abdominal discomfort, diarrhea, nausea, or bloating. Headache, dizziness, and fatigue are also reported. Most people tolerate short-term use well, but these effects are real and can be worse on an empty stomach. Taking it with food may help.
Is this safe if I'm trying to get my partner pregnant?
Yes, this product is intended for male use and doesn't carry safety warnings for sperm or male fertility. However, if your partner is pregnant or breastfeeding, she should avoid this product—most ingredients are unsafe during pregnancy due to potential hormonal effects and lack of safety data.
Can I take this with my blood thinner (warfarin or aspirin)?
No—not safely without checking with your pharmacist first. American ginseng significantly reduces warfarin's effectiveness, and cordyceps, saw palmetto, and fenugreek may all increase bleeding risk. Your doctor may need to adjust your dose or you may need to skip this product. Check your exact medication with the tool on this page.
What is Testofen and does it actually work?
Testofen is a standardized extract of fenugreek seed. It's possibly effective for sexual dysfunction and sexual arousal, and has been shown to support sexual desire in clinical studies. It's also possibly effective for diabetes. If sexual function is your goal, fenugreek has more evidence than most other ingredients in this blend.
I'm on diabetes medication—is this safe?
Not without checking first. Both American ginseng and fenugreek can lower blood sugar, so adding them to your diabetes medication may cause your blood sugar to drop too low (hypoglycemia). Your doctor may need to adjust your medication dose. Use the checker below with your exact medication name and dose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Testosterone Premium label
Go deeper

The Full Monographs Behind Testosterone Premium’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph → Herb & supplement monograph

Fenugreek

Interacts with 389 drugs

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...

Read the full Fenugreek monograph → Herb & supplement monograph

Maca

Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire and some menopause symptoms, but the evide...

Read the full Maca monograph → Herb & supplement monograph

American Ginseng

Interacts with 217 drugs

American ginseng is an herbal root used as an 'adaptogen' to support energy, stress, immune function, and blood sugar. Some uses—such as reducing the chance or length of colds and modestly l...

Read the full American Ginseng monograph → Herb & supplement monograph

Cordyceps

Interacts with 249 drugs

Cordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...

Read the full Cordyceps monograph → Herb & supplement monograph

Pumpkin

Interacts with 1 drug

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...

Read the full Pumpkin monograph → Herb & supplement monograph

Saw Palmetto

Interacts with 174 drugs

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...

Read the full Saw Palmetto monograph →
Sources

Sources & How We Checked

Testosterone Premium's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 88 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maca 1 reference
  1. Valerio, L. G., Jr. and Gonzales, G. F. Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis. Toxicol.Rev 2005;24(1):11-35. PubMed

See these in context on the Maca monograph →

American Ginseng 12 references
  1. Shader RI, Greenblatt DJ. Phenelzine and the dream machine-ramblings and reflections. J Clin Psychopharmacol 1985;5:65. PubMed
  2. Jones BD, Runikis AM. Interaction of ginseng with phenelzine. J Clin Psychopharmacol 1987;7:201-2. PubMed
  3. Janetzky K, Morreale AP. Probable interaction between warfarin and ginseng. Am J Health Syst Pharm 1997;54:692-3. PubMed
  4. Vuksan V, Sievenpiper JL, Koo VY, et al. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med 2000;160:1009-13. PubMed
  5. Vuksan V, Stavro MP, Sievenpiper JL, et al. Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetes. Diabetes Care 2000;23:1221-6. PubMed
  6. Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8..
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Cordyceps 14 references
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Pumpkin 5 references
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Saw Palmetto 22 references
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Eurycoma Longifolia 4 references
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Fenugreek 30 references
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