No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

TMG Ingredients & Drug Interactions

by SuperSmart

TMG label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
No known interaction
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TMG against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

TMG is a dietary supplement by SuperSmart with 1 active ingredient. Its ingredients are commonly taken for high homocysteine levels, liver health (fatty liver), exercise performance and strength.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of TMG by SuperSmart

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

SuperSmart TMG contains one active ingredient: betaine anhydrous, a compound your body naturally makes and that you also get from food sources like beets and spinach. Betaine plays a role in supporting cellular function and homocysteine metabolism — it helps break down an amino acid called homocysteine.

The tablet also contains acacia gum as an inactive ingredient (a binder).

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Betaine Anhydrous's overall clinical evidence instead.

Strong

Strong clinical evidence supports Betaine Anhydrous for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Homocystinuria — rated "Effective" (Natural Medicines).
  • On file: Hyperhomocysteinemia — rated "Possibly Effective" (Natural Medicines).

Betaine anhydrous is effective for homocystinuria (a genetic disorder affecting how your body processes the amino acid homocysteine). It's possibly effective for lowering elevated homocysteine levels (hyperhomocysteinemia) in people without that genetic condition.

For other uses listed — including fatty liver disease (NASH), colorectal adenoma risk, depression, and acid reflux — the evidence isn't strong enough yet to establish whether it works. Talk with your doctor about what you're hoping this supplement will do for you.

The evidence, ingredient by ingredient Betaine Anhydrous

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine anhydrous is generally well tolerated at the doses studied. The most common side effects are body odor, diarrhea, nausea, vomiting, stomach upset, and elevated cholesterol levels.

Cerebral edema (brain swelling) is a rare serious side effect. There isn't enough reliable safety data to know whether it's safe in pregnancy — talk with your doctor or midwife before using it if you're pregnant.

Safety while breastfeeding isn't well established, so caution is advised if you're nursing.

Side effects, ingredient by ingredient Betaine Anhydrous

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for betaine anhydrous. That said, run your exact medications through the checker on this page before you start — it's always the smart move.

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.

If you have homocystinuria or high homocysteine levels and your doctor recommends it, betaine anhydrous has solid evidence behind it. For other conditions, the research is still being sorted out.

Check your medications with the tool below, and because the safety data is limited, have a conversation with your pharmacist or doctor before starting, especially if you're pregnant, breastfeeding, or have any health concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TMG, straight from the product label.

Brand SuperSmart
Barcode (UPC) 5453003824237
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 332753
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TMG by SuperSmart, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
3 Tablet(s)
Servings per container
33
UPC/BARCODE
5453003824237
IngredientAmount% DV
Betaine Anhydrous2250 mg--

Other ingredients: Acacia Gum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults. Take 1 to 3 tablets per day preferably on an empty stomach.

Formula

Each tablet contains 750 mg of betaine anhydrous trimethylglycine (TMG).

Precautions

Precautions: Do not exceed the recommended daily dose. This product is a nutritional supplement and should not be used to replace a varied, balanced diet or healthy lifestyle.

Keep out of young childrens' reach.

As with all nutritional supplements, consult a health professional before taking if you are pregnant, breastfeeding or suffer from a health problem.

Storage

Store away from light, heat and humidity.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

TMG by SuperSmart label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TMG label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TMG by SuperSmart

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container33 Amounts shown are per serving.

Betaine Anhydrous

No known
interactions
2250 mg per serving Form: Trimethylglycine

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...

Betaine Anhydrous monograph & interactions

Other (inactive) ingredients: Acacia Gum. These complete the product’s ingredient list but are not active constituents.

Interaction report

TMG by SuperSmart Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in TMG. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for TMG, from the product label.

SuperSmart

See all SuperSmart products
Name
SN Worldwide Unipessoal, Lda
Street Address
Avenida Do Infante 66, Edificio Quinta Avenida 1 C
City
Funchal
ZipCode
9000-015
Pharmacist Counseling Corner

TMG by SuperSmart: Common Questions

Does TMG by SuperSmart interact with any medications?
We do not currently list a known interaction for the mapped ingredients in TMG. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
TMG contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is betaine anhydrous and why would I take it?
Betaine anhydrous is a compound that helps your body break down an amino acid called homocysteine. It's proven effective for homocystinuria, a genetic disorder, and possibly effective for lowering high homocysteine levels. Some people use it for fatty liver disease or other conditions, but the evidence for those uses isn't yet established.
What side effects might I get from betaine anhydrous?
The most common side effects are body odor, diarrhea, nausea, vomiting, stomach upset, and raised cholesterol levels. Brain swelling (cerebral edema) is rare but serious. Most people tolerate it well at studied doses, but tell your pharmacist if you notice anything unusual.
Is it safe to take if I'm pregnant?
There isn't enough reliable data to know whether betaine anhydrous is safe in pregnancy. Talk with your doctor or midwife before using it — they can weigh the pros and cons for your situation.
Can I take this while breastfeeding?
Safety while breastfeeding isn't well established. If you're nursing, check with your doctor or pharmacist before starting this product.
Does betaine anhydrous interact with my medications?
No interactions are documented in our data for betaine anhydrous. That said, run your exact medications through the interaction checker on this page, and if you take anything regularly, it's worth a quick call or visit to confirm.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if TMG is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TMG label
Go deeper

The Full Monographs Behind TMG’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph →
Sources

Sources & How We Checked

TMG's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Betaine Anhydrous 11 references
  1. Cystadane (betaine anhydrous for oral solution) Package insert. Orphan Medical, Inc. Minnetonka, MN. November 2005.
  2. Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol 2001;96:2711-7.. PubMed
  3. Schwab U, Torronen A, Toppinen L, et al. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr 2002;76:961-7. PubMed
  4. McGregor DO, Dellow WJ, Robson RA, et al. Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. Kidney Int 2002;61:1040-6. PubMed
  5. Olthof MR, van Vliet T, Verhoef P, et al. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PloS Med 2005;2:e135. PubMed
  6. Knopman, D. and Patterson, M. An open-label, 24-week pilot study of the methyl donor betaine in Alzheimer disease patients. Alzheimer Dis.Assoc.Disord. 2001;15(3):162-165. PubMed
  7. Moat, S. J., Madhavan, A., Taylor, S. Y., Payne, N., Allen, R. H., Stabler, S. P., Goodfellow, J., McDowell, I. F., Lewis, M. J., and Lang, D. High- but not low-dose folic acid improves endothelial function in coronary artery disease. Eur J Clin Invest 2 PubMed
  8. Abdelmalek, M. F., Sanderson, S. O., Angulo, P., Soldevila-Pico, C., Liu, C., Peter, J., Keach, J., Cave, M., Chen, T., McClain, C. J., and Lindor, K. D. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepa PubMed
  9. Ashtary-Larky D, Bagheri R, Ghanavati M, et al. Effects of betaine supplementation on cardiovascular markers: a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2021 Mar 25:1-18. PubMed
  10. Zawieja EE, Zawieja B, Chmurzynska A. Betaine supplementation moderately increases total cholesterol levels: a systematic review and meta-analysis. J Diet Suppl. 2021;18(1):105-117. PubMed
  11. Imbard A, Toumazi A, Magréault S, et al. Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial. Orphanet J Rare Dis 2022;17(1):417. PubMed

See these in context on the Betaine Anhydrous monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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