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Dietary supplement

Tongkata Ali 1500 mg Ingredients & Drug Interactions

by aSquared Nutrition

Tongkata Ali 1500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tongkata Ali 1500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tongkata Ali 1500 mg is a dietary supplement by aSquared Nutrition with 1 active ingredient. Its ingredients are commonly taken for low testosterone or low libido in men, male fertility support, athletic performance and muscle strength.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tongkat Ali Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tongkata Ali 1500 mg by aSquared Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Tongkata Ali 1500 mg by aSquared Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tongkata Ali 1500 mg by aSquared Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Tongkat Ali Root Extract at 1500 mg per dose, also known by its botanical name Eurycoma longifolia. It's a plant extract traditionally used to support testosterone and sexual function.

The capsule itself is made with methylcellulose, an inactive binder.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: male vitality and sexual health support.
  • We looked for evidence on: Age-related testosterone deficiency, Athletic performance, Erectile dysfunction (ED), Male Infertility, Muscle strength, Sexual desire — and 3 related terms.
  • The strongest evidence on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire (Natural Medicines).
  • Also on file: Eurycoma Longifolia is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Eurycoma Longifolia is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Muscle strength, Age-related testosterone deficiency, Male Infertility.

The evidence shows Tongkat Ali is possibly effective for sexual desire. For athletic performance, the data suggests it's possibly ineffective.

The safety and effectiveness information we hold isn't established enough to rate it for back pain, osteoporosis, or diabetes—so if you're considering it for those reasons, the evidence isn't there yet.

The evidence, ingredient by ingredient Eurycoma Longifolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tongkat Ali is generally well tolerated in short-term studies, but long-term safety data are sparse and product quality can vary. The main concern is that it may increase testosterone levels: if your levels rise beyond the normal range, you could develop testosterone-related side effects including acne, insulin resistance, and liver problems.

Avoid it during pregnancy because there isn't enough safety data and the possible hormonal effects are a worry. While breastfeeding, there's no reliable safety information, so skip it.

Side effects, ingredient by ingredient Eurycoma Longifolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Tongkat Ali, double-check if you take propranolol or any other blood pressure beta-blockers (Moderate interaction). Also flag any medications processed by liver enzymes CYP1A2, CYP2C19, or CYP2A6, and let us know if you're on testosterone therapy—all Minor interactions, but worth confirming.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tongkat Ali might help if you're looking to boost sexual desire. If you take propranolol or any blood pressure medication, or if you're on testosterone therapy, you'll want to check with us before starting.

Pregnant people and those breastfeeding should avoid it. Talk to your pharmacist about your medications first—it's worth a quick conversation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tongkata Ali 1500 mg, straight from the product label.

Brand aSquared Nutrition
Barcode (UPC) X003ADPZL9
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 322078
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tongkata Ali 1500 mg by aSquared Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
X003ADPZL9
IngredientAmount% DV
Tongkat Ali Root Extract1500 mg--

Other ingredients: Methylcellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 2 capsules per day with a meal, or as directed by your qualified healthcare professional.

Precautions

Caution: Do not exceed the recommended dose. Do not use if safety seal is damaged or missing.

Not for use by children under 18 years of age. Keep out of the reach of children.

Pregnant or nursing mothers, individuals taking any medications, individuals with a known medical condition, and individuals planning a medical procedure should consult a physician before using this or any dietary supplement.

Seals/Symbols

Sourced from a GMP Certified Facility Good Manufacturing Practice Certified Facility

USA Formulated

General Statements

Please recycle.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Ultra strength Made with natural ingredients

Natural formulation Third-party tested Supports energy levels

No preservatives

Formula

Tongkata Ali 1500 mg with 300:1 extract

aSquared Nutrition is proud to offer an ultra-strength Tongkat Ali supplement that is extracted from the Eurycoma longifolia plant. Our formula contains 1500mg of Tongkat Ali root extract per serving.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tongkata Ali 1500 mg by aSquared Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tongkata Ali 1500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tongkata Ali 1500 mg by aSquared Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Tongkat Ali Root Extract

Interacts with
248 drugs
1500 mg per serving

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

Tongkat Ali Root Extract monograph & interactions

Other (inactive) ingredients: Methylcellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tongkata Ali 1500 mg by aSquared Nutrition Drug Interactions

Want to check YOUR meds against Tongkata Ali 1500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
3 Moderate 245 Minor

Ingredients driving the most interactions

Tongkat Ali Root Extract 248

Individual Drug Interactions

The ingredients in Tongkata Ali 1500 mg interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tongkata Ali 1500 mg interact with drugs. Each result below shows which ingredient is responsible. Tongkat Ali Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tongkata Ali 1500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tongkat Ali Root Extract5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Tongkat Ali Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tongkata Ali 1500 mg, from the product label.

aSquared Nutrition

See all aSquared Nutrition products
Name
aSquared Brands LLC
Street Address
382 NE 191st Street, #98406
City
Miami
State
Florida
ZipCode
33179
Phone Number
1-800-557-4120
Pharmacist Counseling Corner

Tongkata Ali 1500 mg by aSquared Nutrition: Common Questions

Does Tongkata Ali 1500 mg by aSquared Nutrition interact with any medications?
Yes. Based on its ingredients, Tongkata Ali 1500 mg has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tongkata Ali 1500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will Tongkat Ali actually boost my testosterone?
A clinical study in older men with low testosterone showed it raised levels by 8% to about 16% over 12 weeks. So yes, there's evidence it can increase testosterone—but the effect was modest and was tested in a specific population. If you're already on testosterone therapy, this could push levels higher.
Is it safe to use long-term?
Short-term use looks well tolerated in studies, but we don't have good long-term safety data. Product quality can also vary between brands. If you want to use it for months, talk with your pharmacist about monitoring.
What side effects might I see?
The main risk is if your testosterone climbs too high—that can bring on acne, insulin resistance, and liver problems. Stick to the dose, and if you notice acne, mood changes, or feel unusual, stop and check with us.
Can I take this if I'm pregnant or breastfeeding?
No—avoid it during pregnancy because there isn't enough safety data and the hormonal effects are a concern. While breastfeeding, there's no reliable safety information, so skip it too.
Does it work for back pain or osteoporosis?
The evidence we have isn't strong enough to rate it for either. If that's why you're thinking about it, there are other options with better data—ask your pharmacist what might work better.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tongkata Ali 1500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tongkata Ali 1500 mg label
Go deeper

The Full Monographs Behind Tongkata Ali 1500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph →
Sources

Sources & How We Checked

Tongkata Ali 1500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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