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Dietary supplement

Una de Gato (Cat's Claw) Ingredients & Drug Interactions

by Energique

Una de Gato (Cat's Claw) label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Una de Gato (Cat's Claw) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Una de Gato (Cat's Claw) is a dietary supplement by Energique with 1 active ingredient. Its ingredients are commonly taken for osteoarthritis and rheumatoid arthritis, inflammation, immune support.Based on those ingredients, 962 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cat's Claw. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Una de Gato (Cat's Claw) by Energique

Ask about any prescription or over-the-counter medication and we check it for interactions with Una de Gato (Cat's Claw) by Energique — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Una de Gato (Cat's Claw) by Energique

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Una de Gato contains one active ingredient: cat's claw, a tropical plant traditionally used in herbal medicine. The capsules also contain inactive ingredients—hypromellose (a plant-based capsule material), magnesium stearate (a binder), and silica (an anti-caking agent).

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Cat's Claw product and its label doesn't state a use — see Cat's Claw's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for cat's claw isn't established in our data for the conditions listed—hay fever, Alzheimer's disease, asthma, osteoporosis, cancer, and chronic fatigue syndrome. All of these carry a rating of insufficient reliable evidence to know whether it works.

If you're considering this for one of these uses, talk with your doctor or pharmacist about what the broader research shows.

The evidence, ingredient by ingredient Cat's Claw

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cat's claw is generally well tolerated in the short term for healthy adults, but long-term safety hasn't been well studied. The safety data advises against using it during pregnancy (traditional use as an abortifacient raises concerns) and while breastfeeding due to lack of safety information.

In one clinical trial of people with advanced cancer, a small number experienced blood-count changes including anemia (12%), and smaller numbers had low white blood cells or low platelets (2% each). Several case reports link cat's claw to kidney injury, including acute kidney failure and kidney inflammation; symptoms resolved after stopping the supplement.

Other reported effects in that same cancer trial included headache, fatigue, insomnia, and nerve damage in a small number of patients, though the trial had no placebo group so it's unclear whether cat's claw caused these or the disease did.

Side effects, ingredient by ingredient Cat's Claw

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cat's Claw.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs.
  • For scale: 963 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using this if you take blood thinners or antiplatelet drugs (Moderate risk of increased bleeding), blood pressure medications or calcium channel blockers (Moderate risk of low blood pressure), nirmatrelvir/ritonavir (Paxlovid) (Moderate risk of reduced antiviral effect), immunosuppressant drugs (Moderate risk of interference), or any other medications broken down by the CYP3A4 liver enzyme pathway (Moderate risk of level changes).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood thinners, blood pressure drugs, immunosuppressants, or Paxlovid, check your exact medications with our tool before trying this. Pregnant or breastfeeding?

The safety data advises against it. For healthy adults using it short-term, it's generally well tolerated—but talk to your pharmacist if you have kidney disease or are on other medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Una de Gato (Cat's Claw), straight from the product label.

Brand Energique
Barcode (UPC) 363113900408
Net contents 100 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 318466
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Una de Gato (Cat's Claw) by Energique, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetable Capsule(s)
Maximum serving Sizes:
1 Vegetable Capsule(s)
Servings per container
100
UPC/BARCODE
363113900408
IngredientAmount% DV
Cat's Claw500 mg--

Other ingredients: Hypromellose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take one capsule 1 or more times daily or as directed by a health professional.

Precautions

Warnings: If pregnant, breast-feeding or have a medical condition, ask a health professional before use.

Consult a physician for use in children under 12 years of age. Keep out of reach of children.

Do not use if tamper evident seal is broken or missing.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

Energique Since 1987

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Una de Gato (Cat's Claw) by Energique label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Una de Gato (Cat's Claw) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Una de Gato (Cat's Claw) by Energique

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetable Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Cat's Claw

Interacts with
962 drugs
500 mg per serving

Cat's claw is a South American vine traditionally used for inflammation, joint pain, and immune support. Some small studies hint it may help with arth...

Cat's Claw monograph & interactions

Other (inactive) ingredients: Hypromellose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Una de Gato (Cat's Claw) by Energique Drug Interactions

Want to check YOUR meds against Una de Gato (Cat's Claw)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
962Drugs
962 Moderate

Ingredients driving the most interactions

Cat's Claw 962

Individual Drug Interactions

The ingredients in Una de Gato (Cat's Claw) interact with 962 drugs. Click any drug to see the details.

1 of the 1 ingredient in Una de Gato (Cat's Claw) interact with drugs. Each result below shows which ingredient is responsible. Cat's Claw

Each ingredient & the kinds of drugs it affects

For each ingredient in Una de Gato (Cat's Claw) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cat's Claw6 drug types · 962 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, cat's claw may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Cat's claw contains rhynchophylline and isorhynchophylline. Animal research suggests that these alkaloids can inhibit platelet aggregation. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking cat's claw with antihypertensive drugs might increase the risk of hypotension.
Cat's claw contains rhynchophylline. In vitro and animal research suggests that rhynchophylline can lower blood pressure. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Calcium Channel Blockers

Theoretically, taking cat's claw with calcium channel blockers might increase the risk of hypotension.
Cat's claw contains various alkaloids, including rhynchophylline, isorhynchophylline, corynoxeine, and isocorynoxiene. Animal research suggests that these alkaloids can lower blood pressure by acting as calcium channel blockers. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.
Cat's claw may affect the clearance of drugs metabolized by CYP3A4. In vitro research shows that cat's claw can inhibit CYP3A4 enzymes. In one case report, a patient taking cat's claw (at an unspecified dose) experienced increased serum levels of atazanavir, ritonavir, and saquinavir, all of which are CYP3A4 substrates. Levels returned to normal 15 days after discontinuation of the cat's claw supplement, suggesting inhibition of CYP3A4 by cat's claw. In contrast, animal research suggests that rhynchophylline, an alkaloid contained in cat's claw, induces CYP3A expression and accelerates the metabolism of nirmatrelvir, the active component in the nirmatrelvir/ritonavir combination product.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, cat's claw might interfere with immunosuppressive therapy.
In human and laboratory research, cat's claw has been shown to have immunostimulating activity. It stimulates phagocytosis and increases respiratory cellular activity and the mobility of leukocytes. Theoretically, this could interfere with the activity of immunosuppressant medications.

Likelihood Possible Evidence D
Nirmatrelvir/Ritonavir (Paxlovid)

Theoretically, cat's claw may decrease the levels of nirmatrelvir.
Cat's claw contains rhynchophylline. Animal research suggests that this alkaloid induces CYP3A expression, thereby accelerating the metabolism of nirmatrelvir, the active component in the nirmatrelvir/ritonavir combination product. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cat's Claw full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Una de Gato (Cat's Claw), from the product label.

Energique

See all Energique products
Name
Energique Inc
Street Address
201 Apple Blvd
City
Woodbine
State
IA
ZipCode
51579
Phone Number
800.869.8078
Pharmacist Counseling Corner

Una de Gato (Cat's Claw) by Energique: Common Questions

Does Una de Gato (Cat's Claw) by Energique interact with any medications?
Yes. Based on its ingredients, Una de Gato (Cat's Claw) has a known interaction with 962 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Una de Gato (Cat's Claw) contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant or breastfeeding?
The safety data advises against cat's claw during pregnancy because of its traditional use as an abortifacient and lack of modern safety studies. While breastfeeding, there isn't enough safety information either. Talk with your doctor or midwife for personalized advice.
Does cat's claw actually work for the conditions on the label?
The evidence isn't established in our data for hay fever, Alzheimer's disease, asthma, osteoporosis, cancer, or chronic fatigue syndrome. We don't have a rating that supports its use for these yet.
What are the side effects I should watch for?
In one trial, headache, fatigue, and insomnia each occurred in a small number of patients, and nerve damage in 8%. Case reports have linked cat's claw to kidney injury in some people. If you develop signs of kidney trouble (swelling, changes in urination) or unusual fatigue or numbness, stop it and talk to your doctor.
Is it safe to take long-term?
Long-term safety hasn't been well studied. We know it's generally well tolerated in the short term, but we don't have good data on what happens if you take it for months or years.
What is cat's claw and why is it called that?
Cat's claw is a tropical plant native to Central and South America. Its name comes from the curved thorns at the base of its leaves, which look like cat claws.
Can this affect how my other medications work?
Yes—cat's claw interacts with a wide range of drugs, especially blood thinners, blood pressure meds, and drugs your liver breaks down via the CYP3A4 pathway. Use the medication checker on this page with your full list of prescriptions before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Una de Gato (Cat's Claw) label
Go deeper

The Full Monographs Behind Una de Gato (Cat's Claw)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cat's Claw

Interacts with 962 drugs

Cat's claw is a South American vine traditionally used for inflammation, joint pain, and immune support. Some small studies hint it may help with arthritis symptoms, but the overall evidence...

Read the full Cat's Claw monograph →
Sources

Sources & How We Checked

Una de Gato (Cat's Claw)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cat's Claw 16 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  3. Sandoval M, Charbonnet RM, Okuhama NN, et al. Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection. Free Radic Biol Med 2000;29:71-78.
  4. Müller AC, Kanfer I. Potential pharmacokinetic interactions between antiretrovirals and medicinal plants used as complementary and African traditional medicines. Biopharm Drug Dispos. 2011;32(8):458-70. PubMed
  5. Sheng, Y., Bryngelsson, C., and Pero, R. W. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. J Ethnopharmacol. 2000;69(2):115-126. PubMed
  6. Lamm, S., Sheng, Y., and Pero, R. W. Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100. Phytomedicine 2001;8(4):267-274.
  7. Sheng, Y., Li, L., Holmgren, K., and Pero, R. W. DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study. Phytomedicine 2001;8(4):275-282.
  8. Chen, C. X., Jin, R. M., Li, Y. K., Zhong, J., Yue, L., Chen, S. C., and Zhou, J. Y. Inhibitory effect of rhynchophylline on platelet aggregation and thrombosis. Zhongguo Yao Li Xue.Bao. 1992;13(2):126-130.
  9. Flythe, J. E., Rueda, J. F., Riscoe, M. K., and Watnick, S. Silicate nephrolithiasis after ingestion of supplements containing silica dioxide. Am.J.Kidney Dis. 2009;54(1):127-130. PubMed
  10. Zhou, J. and Zhou, S. Antihypertensive and neuroprotective activities of rhynchophylline: the role of rhynchophylline in neurotransmission and ion channel activity. J.Ethnopharmacol. 10-28-2010;132(1):15-27. PubMed
  11. Zhou, J. Y. and Zhou, S. W. Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases. Fitoterapia 2012;83(4):617-626. PubMed
  12. Hemingway, S. R. and Phillipson, J. D. Proceedings: Alkaloids from S. American species of Uncaria (Rubiaceae). J.Pharm.Pharmacol. 1974;26 Suppl:113P.
  13. Hilepo, J. N., Bellucci, A. G., and Mossey, R. T. Acute renal failure caused by 'cat's claw' herbal remedy in a patient with systemic lupus erythematosus. Nephron 1997;77(3):361. PubMed
  14. De Paula LCL, Fonseca F, Perazzo F, et al. Uncaria tomentosa (cat's claw) improves quality of life in patients with advanced solid tumors. J Altern Complement Med. 2015;21(1):22-30.
  15. Portalatin G, Shettigar S, Carrion-Rodriguez A, et al. Ketogenic-Diet Shake Containing Uncaria tomentosa-Associated Acute Interstitial Nephritis. Case Rep Nephrol Dial 2022;12(3):219-225.
  16. Lei S, Guo A, Lu J, et al. Activation of PXR causes drug interactions with Paxlovid in transgenic mice. Acta Pharm Sin B 2023;13(11):4502-4510. PubMed

See these in context on the Cat's Claw monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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