Valerian Root Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Valerian Root against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Valerian Root is a dietary supplement by Nature's Harmony with 1 active ingredient. Its ingredients are commonly taken for insomnia and poor sleep, anxiety and stress, restlessness.Based on those ingredients, 902 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Valerian (Valeriana officinalis) root extract 9:1. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Valerian Root by Nature's Harmony
Ask about any prescription or over-the-counter medication and we check it for interactions with Valerian Root by Nature's Harmony — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Valerian Root by Nature's Harmony
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Nature's Harmony Valerian Root contains one active ingredient: valerian (Valeriana officinalis) root extract in a 9:1 concentration, meaning nine parts of the plant are concentrated into one part extract. This extract delivers the plant's active compounds, particularly valerenic acid, which is responsible for valerian's sedative effects.
The tablet also contains several inactive ingredients—cellulose, dicalcium phosphate, croscarmellose sodium, stearic acid, magnesium stearate, silicon dioxide, hypromellose, and glycerin—which are fillers, binders, and capsule materials that hold the supplement together.
Does it work?
Moderate evidence
Valerian is possibly effective for insomnia—the evidence supports that it may help you fall asleep or stay asleep, though results vary person to person. For restless legs syndrome (RLS), pre-procedural anxiety, stress, and menstrual cramps (dysmenorrhea), the evidence in our data is insufficient; we simply don't have reliable studies yet to say whether valerian works for those uses.
How safe is it?
Well-documented data
Valerian is generally well tolerated in the short term, but long-term safety hasn't been well studied. The most common side effects are dizziness, drowsiness, mental slowness, headache, upset stomach, and vivid dreams.
Some people report restlessness or excitability instead. If you take valerian for a while and then stop abruptly, you might experience withdrawal symptoms—anxiety, irritability, insomnia, or even agitation and hallucinations—so it's important to taper your dose slowly after extended use.
Rare but serious liver problems have been reported, though most cases involved multi-ingredient products. Safety has not been established in pregnancy, so it's best avoided.
There isn't enough safety information for breastfeeding, so avoid it then as well.
Meds to double-check
Moderate interaction found
Before taking Valerian Root, check with your pharmacist if you take any central nervous system depressants (sleeping pills, sedatives, anti-anxiety drugs, or anesthetics), alprazolam (Xanax) specifically, alcohol, or drugs broken down by the liver enzymes UGT1A1 or UGT2B7. The most serious interactions are Moderate in severity.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Valerian may help with insomnia if you're looking for a plant-based option. Don't combine it with sleeping pills, sedatives, anti-anxiety medications like Xanax, or alcohol—the sedative effects add up and can leave you dangerously drowsy.
If you take any prescription or over-the-counter medications, check them against the tool on this page before you start, and talk to your pharmacist about whether valerian fits your situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Valerian Root, straight from the product label.
| Brand | Nature's Harmony |
|---|---|
| Barcode (UPC) | 063047006114 |
| Net contents | 60 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | May 24, 2013 |
| DSLD ID | 21794 |
| Product type | Botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Valerian Root by Nature's Harmony, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Valerian (Valeriana officinalis) root extract 9:1 | 100 mg | -- |
Other ingredients: Cellulose, Dicalcium Phosphate, Croscarmellose Sodium, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Hypromellose, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Exercise caution if operating heavy machinery or driving a motor vehicle within two hours of consumption.
DO NOT USE IF SEAL UNDER CAP IS BROKEN.
Risk Information: Consult a health care practitioner prior to use if pregnant or breastfeeding, or if sleeplessness persists continuously for more than three weeks (chronic insomnia) or worsens. Do not consume with alcohol, drugs or natural health products with sedative properties.
KEEP OUT OF REACH OF CHILDREN.
General
400611.01-03
Seals/Symbols
SunOpta A healthy products company
General Statements
A Proud Canadian Company
Herbal Sleep Aid
{Tablet} Actual Size
Suggested/Recommended/Usage/Directions
Recommended Use: Helps to promote sleep/used as a sleep aid. Recommended Dose (Adults): Take 2 or 3 tablets 1/2 hour to 1 hour before bedtime. Take an earlier dose during the evening if necessary.
Formulation
This product does not contain corn, dairy, egg, gluten, shellfish, soy, sulfites, animal derivatives, or artificial colours, flavours, or preservatives.
Storage
STORE IN A COOL, DRY PLACE.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Valerian Root by Nature's Harmony label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Valerian Root by Nature's Harmony
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.
Valerian (Valeriana officinalis) root extract 9:1
Interacts with902 drugs
Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some...
Valerian (Valeriana officinalis) root extract 9:1 monograph & interactionsOther (inactive) ingredients: Cellulose, Dicalcium Phosphate, Croscarmellose Sodium, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Hypromellose, Glycerin. These complete the product’s ingredient list but are not active constituents.
Valerian Root by Nature's Harmony Drug Interactions
HelloPharmacist Interaction Report
Valerian Root by Nature's Harmony can interact with several medication types, most notably central nervous system depressants—drugs that slow brain activity like sedatives, sleeping pills, and anesthetics.
Valerian adds to their drowsy, mentally-slowing effects, which is a Moderate concern. The interaction is both from valerian's own sedative action and possibly a modest increase in drug levels.
Read the full breakdown — every affected drug type, severity by severity
Alprazolam (Xanax), a common anti-anxiety medication, carries the same Moderate risk: additive sedation and a small possibility of higher drug levels. Alcohol poses a parallel Moderate concern—valerian can amplify alcohol's sedative effect.
Additionally, valerian may weakly interfere with how your body breaks down certain drugs (those metabolized by the liver enzymes UGT1A1 and UGT2B7), a Moderate interaction. Drugs metabolized by two other liver enzymes, CYP2D6 and CYP3A4, show only Minor or no clinically significant interaction with valerian.
Altogether, these interactions span 891 individual medications. Use the medication checker below with your exact prescriptions and over-the-counter drugs before starting valerian.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Valerian Root?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Valerian Root interact with 902 drugs. Click any drug to see the details.
1 of the 1 ingredient in Valerian Root interact with drugs. Each result below shows which ingredient is responsible. Valerian (Valeriana officinalis) root extract 9:1
Acetaminophen, Phenyltoloxamine, SalicylamideLobac
How Acetaminophen, Phenyltoloxamine, Salicylamide interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Glucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Acetaminophen, Phenyltoloxamine, Salicylamide interactionAcetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic
How Acetaminophen, Propoxyphene interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Glucuronidated Drugs, Cns Depressants +1 Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Acetaminophen, Propoxyphene interactionAcetaminophen, PseudoephedrineChildren's Tylenol Sinus, Dristan N.D., Non-Aspirin Sinus, Ornex, Ornex-Max, Sinutab +5 more
How Acetaminophen, Pseudoephedrine interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Glucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Acetaminophen, Pseudoephedrine interactionAcetaminophen, Pseudoephedrine, TriprolidineActifed Plus ES
How Acetaminophen, Pseudoephedrine, Triprolidine interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Glucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Acetaminophen, Pseudoephedrine, Triprolidine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Acetazolamide interactionAlfentanilAlfenta
How Alfentanil interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Alfentanil interactionAlprazolamNiravam, Xanax
How Alprazolam interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Alprazolam interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAminoglutethimideCytadren
How Aminoglutethimide interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Aminoglutethimide interactionAminophylline, Amobarbital, EphedrineAmesec
How Aminophylline, Amobarbital, Ephedrine interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Aminophylline, Amobarbital, Ephedrine interactionAmitriptylineElavil
How Amitriptyline interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Amitriptyline, Perphenazine interactionAmobarbitalAmytal
How Amobarbital interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Amobarbital interactionAmobarbital, Ephedrine SulfateEphedrine & Amytal
How Amobarbital, Ephedrine Sulfate interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Amobarbital, Ephedrine Sulfate interactionAmobarbital, SecobarbitalTuinal
How Amobarbital, Secobarbital interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Amobarbital, Secobarbital interactionApomorphineAPO-go, APO-go Pen, APO-go PFS, Apokyn, Uprima
How Apomorphine interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Glucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Apomorphine interactionApomorphine HydrochlorideKynmobi
How Apomorphine Hydrochloride interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Glucuronidated Drugs Moderate
Interaction Summary
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Apomorphine Hydrochloride interactionAprobarbital, Butabarbital, PhenobarbitalTriple Barbital
How Aprobarbital, Butabarbital, Phenobarbital interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cns Depressants Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Aprobarbital, Butabarbital, Phenobarbital interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Aripiprazole Lauroxil interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Carisoprodol, Codeine PhosphateSoma Compound w/ Codeine
How Aspirin, Carisoprodol, Codeine Phosphate interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Aspirin, Carisoprodol, Codeine Phosphate interactionAspirin, Codeine PhosphateAspirin w/ Codeine
How Aspirin, Codeine Phosphate interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Aspirin, Codeine Phosphate interactionAspirin, Codeine Phosphate, MethocarbamolRobaxisal C
How Aspirin, Codeine Phosphate, Methocarbamol interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cns Depressants, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Aspirin, Codeine Phosphate, Methocarbamol interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with Valerian Root — through 1 ingredient. Tap an ingredient for the detail:
Valerian (valeriana Officinalis) Root Extract 9:1Cytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants Moderate
Interaction Summary
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Read the full Valerian (valeriana Officinalis) Root Extract 9:1 + Aspirin, Codeine Phosphate, Phenobarbital interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Valerian Root with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Valerian (Valeriana officinalis) root extract 9:1
Alcohol (Ethanol)
Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.
Alprazolam (Xanax)
Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.
Cns Depressants
Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.
Glucuronidated Drugs
Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.
Brand information
Manufacturer and brand details for Valerian Root, from the product label.
Nature's Harmony
See all Nature's Harmony products- Name
- SunOpta Inc.
- Street Address
- 6 Commerce Crescent
- City
- Acton
- State
- ON
- ZipCode
- L7J 2X3
Valerian Root by Nature's Harmony: Common Questions
Does Valerian Root by Nature's Harmony interact with any medications?
How can one product interact with so many drugs?
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Does valerian really work for sleep?
Can I take valerian with alcohol?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Valerian Root’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Valerian Root's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 37 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Valerian 37 references
- Willey LB, Mady SP, Cobaugh DJ, Wax PM. Valerian overdose: a case report. Vet Hum Toxicol 1995;37:364-5.
- Kuhlmann J, Berger W, Podzuweit H, Schmidt U. The influence of valerian treatment on "reaction time, alertness and concentration" in volunteers. Pharmacopsychiatry 1999;32:235-41. PubMed
- Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. PubMed
- Houghton PJ. The scientific basis for the reputed activity of Valerian. J Pharm Pharmacol 1999;51:505-12. PubMed
- Garges HP, Varia I, Doraiswamy PM. Cardiac complications and delirium associated with Valerian root withdrawal. [Letter to the Editor]. JAMA 1998;280:1566-7. PubMed
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- MacGregor FB, Abernethy VE, Dahabra S, et al. Hepatotoxicity of herbal remedies. BMJ 1989;299:1156-7. PubMed
- Leathwood PD, Chauffard F. Aqueous extract of valerian reduces latency to fall asleep in man. Planta Med 1985;2:144-8. PubMed
- Hadley S, Petry JJ. Valerian. Am Fam Physician 2003;67:1755-8..
- Glass JR, Sproule BA, Herrmann N, et al. Acute pharmacological effects of temazepam, diphenhydramine, and valerian in healthy elderly subjects. J Clin Psychopharmacol 2003;23:260-8. PubMed
- Lefebvre T, Foster BC, Drouin CE, et al. In vitro activity of commercial valerian root extracts against human cytochrome P450 3A4. J Pharm Pharmaceut Sci 2004;7:265-73.
- Yuan CS, Mehendale S, Xiao Y, et al. The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. Anesth Analg 2004;98:353-8. PubMed
- Donovan JL, DeVane CL, Chavin KD, et al. Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers. Drug Metab Dispos 2004;32:1333-6. PubMed
- Gurley BJ, Gardner SF, Hubbard MA, et al. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Clin Pharmacol Ther 2005;77:415-26. PubMed
- Gutierrez S, Ang-Lee MK, Walker DJ, Zacny JP. Assessing subjective and psychomotor effects of the herbal medication valerian in healthy volunteers. Pharmacol Biochem Behav 2004;78:57-64. PubMed
- Jacobs BP, Bent S, Tice JA, et al. An internet-based randomized, placebo-controlled trial of kava and valerian for anxiety and insomnia. Medicine (Baltimore) 2005;84:197-207. PubMed
- National Toxicology Program, US Department of Health and Human Services. Chemical Information Review Document for Valerian (Valeriana officinalis L.) [CAS No. 8057-49-6] and Oils [CAS No. 8008-88-6]. Supporting Nomination for Toxicological Evaluation by t
- Fernández-San-Martín MI, Masa-Font R, Palacios-Soler L, et al. Effectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trials. Sleep Med. 2010 Jun;11:505-11. PubMed
- Coxeter PD, Schluter PJ, Eastwood HL, et al. Valerian does not appear to reduce symptoms for patients with chronic insomnia in general practice using a series of randomised n-of-1 trials. Complement Ther Med. 2003 Dec;11:215-22. PubMed
- Diaper A, Hindmarch I. A double-blind, placebo-controlled investigation of the effects of two doses of a valerian preparation on the sleep, cognitive and psychomotor function of sleep-disturbed older adults. Phytother Res. 2004 Oct;18:831-6. PubMed
- Cuellar NG, Ratcliffe SJ. Does valerian improve sleepiness and symptom severity in people with restless legs syndrome? Altern Ther Health Med 2009;15:22-8.
- Chen D, Klesmer J, Giovanniello A, et al. Mental status changes in an alcohol abuser taking valerian and gingko biloba. Am J Addict. 2002 Winter;11:75-7. PubMed
- Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
- Carrasco MC, Vallejo JR, Pardo-de-Santayana M, et al. Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009 Dec;23:1795-6.
- Hellum BH, Nilsen OG. The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol. Basic Clin Pharmacol Toxicol. 2007 Nov;101:350-8.
- Hellum BH, Hu Z, Nilsen OG. The induction of CYP1A2, CYP2D6 and CYP3A4 by six trade herbal products in cultured primary human hepatocytes. Basic Clin Pharmacol Toxicol. 2007 Jan;100:23-30. PubMed
- Alkharfy, K. M. and Frye, R. F. Effect of valerian, valerian/hops extracts, and valerenic acid on glucuronidation in vitro. Xenobiotica 2007;37(2):113-123.
- Vassiliadis, T., Anagnostis, P., Patsiaoura, K., Giouleme, O., Katsinelos, P., Mpoumponaris, A., and Eugenidis, N. Valeriana hepatotoxicity. Sleep Med 2009;10(8):935. PubMed
- Muller, Z., Sarkany, A., Altorjay, A., Szilagyi, A., Tura, T., and Ozsvar, Z. [Liver failure a la Eastern Europe]. Orv.Hetil. 3-22-2009;150(12):555-557. PubMed
- National Toxicology Program, US Department of Health and Human Services. Chemical Information Review Document for Valerian (Valeriana officinalis L.) [CAS No. 8057-49-6] and Oils [CAS No. 8008-88-6]. 2009;
- Wells SR. International intravenous administration of a crude valerian root extract. NACCT 1995;33:542.
- Aydinoglu U, Özcan H, Yücel A, Yücel N, Mutlu M. Valerian induced hypomania: a case report. Bull Clin Psychopharma 2012;22(Suppl. 1):S63.
- Mirabi P, Mojab F. The effects of valerian root on hot flashes in menopausal women. Iran J Pharm Res 2013;12(1):217-22.
- Thomas K, Canedo J, Perry PJ, et al. Effects of valerian on subjective sedation, field sobriety testing and driving simulator performance. Accid Anal Prev. 2016 Jul;92:240-4. PubMed
- Kia YH, Alexander S, Dowling D, Standish R. A case of steroid-responsive valerian-associated hepatitis. Intern Med J. 2016 Jan;46(1):118-9. PubMed
- Burke H, Jiang S, Chatham P, Stern TA. Delirium After Withdrawal From Valerian Root: A Case Report. Psychosomatics. 2020;61(6):787-790. PubMed
- Hajizadeh I, Jamshidi M, Kazemi M, Kargar H, Sadeghi T. Comparison the effect of valerian and gabapentin on RLS and sleep quality in hemodialysis patients: A randomized clinical trial. Ther Apher Dial 2023.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC