Vigor 2nd Edition Apple Pie Moonshine Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Vigor 2nd Edition Apple Pie Moonshine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Vigor 2nd Edition Apple Pie Moonshine is a dietary supplement by Arms Race Nutrition with 10 active ingredients. Its ingredients are commonly taken for improving high-intensity exercise performance, building muscle strength and size, sports and athletic training.Based on those ingredients, 662 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Reishi, Lion's Mane, Shiitake. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Vigor 2nd Edition Apple Pie Moonshine by Arms Race Nutrition
Ask about any prescription or over-the-counter medication and we check it for interactions with Vigor 2nd Edition Apple Pie Moonshine by Arms Race Nutrition — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Vigor 2nd Edition Apple Pie Moonshine by Arms Race Nutrition
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This powder has 10 active ingredients. Creatine monohydrate and betaine anhydrous are included for muscle strength and performance support.
The product also contains several mushroom extracts — cordyceps, reishi, shiitake, and lion's mane — along with three other specialized ingredients: elevATP, SenActiv, and PeakO2 (which is a blend of several components). Turkey Tail and King Trumpet mushroom round out the ingredient list.
The powder also contains inactive ingredients including citric acid, natural and artificial flavors, silicon dioxide, sucralose, and acesulfame potassium (sweeteners and flow agents).
Does it work?
Moderate evidence
The evidence on effectiveness is mixed. Creatine monohydrate is possibly effective for sarcopenia (age-related muscle loss), muscle strength, and athletic performance, but possibly ineffective for Huntington disease and bone density.
Betaine anhydrous is effective for homocystinuria and possibly effective for high homocysteine levels, though evidence is insufficient to rate it for NASH, colorectal adenoma, depression, or GERD. For the mushroom ingredients — cordyceps, reishi, shiitake, and lion's mane — the evidence we hold shows insufficient reliable evidence to rate them for most of their claimed uses, including athletic performance, cognitive function, and various disease states.
Cordyceps is rated possibly ineffective for athletic performance.
How safe is it?
Well-documented data
Creatine is generally well tolerated in healthy adults, but people with kidney problems should be careful — the facts note rare case reports of kidney injury and muscle breakdown. Avoid creatine during pregnancy and nursing.
Betaine is generally well tolerated at studied doses but avoid it during pregnancy and use caution while breastfeeding due to insufficient data. Common side effects of creatine include dehydration, diarrhea, muscle cramps, and water retention; betaine may cause body odor, nausea, diarrhea, and GI upset.
Cordyceps, reishi, shiitake, and lion's mane are each generally well tolerated short-term, but avoid all of them during pregnancy and nursing because safety data is insufficient. Common side effects include gastrointestinal symptoms (diarrhea, nausea, upset stomach) and dizziness with reishi.
Meds to double-check
Moderate interaction found
Blood thinners (anticoagulants and antiplatelets) like warfarin, aspirin, and clopidogrel are a concern — cordyceps, reishi at higher doses, and lion's mane may all increase bleeding risk. Diabetes medications and blood pressure drugs may have additive effects with reishi and lion's mane.
Immunosuppressants could be affected by cordyceps, shiitake, and lion's mane. Additionally, certain drugs metabolized by a liver enzyme called CYP2D6 might be affected by shiitake.
Use the medication checker below to verify your specific prescriptions.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is designed for people interested in muscle support and athletic performance. If you take blood thinners, diabetes drugs, blood pressure medication, or immunosuppressants, talk to your pharmacist or doctor before starting — several ingredients here have documented interactions with those drug types.
Pregnant women and nursing mothers should avoid this product. Check your exact medications using the tool on this page.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 6 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Vigor 2nd Edition Apple Pie Moonshine, straight from the product label.
| Brand | Arms Race Nutrition |
|---|---|
| Barcode (UPC) | 672975063948 |
| Net contents | 13.65 Ounce(s); 387 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2025 |
| DSLD ID | 328373 |
| Product type | Other Combinations |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Vigor 2nd Edition Apple Pie Moonshine by Arms Race Nutrition, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Creatine Monohydrate | 5000 mg | -- |
| Betaine Anhydrous | 2500 mg | -- |
| elevATP | 150 mg | -- |
| SenActiv | 50 mg | -- |
| PeakO2 | 2000 mg | -- |
| Turkey Tail | 0 NP | -- |
| Cordyceps | 0 NP | -- |
| Reishi | 0 NP | -- |
| King Trumpet | 0 NP | -- |
| Shiitake | 0 NP | -- |
| Lion's Mane | 0 NP | -- |
Other ingredients: Citric Acid, Natural & Artificial Flavors, Silicon Dioxide, Sucralose, Acesulfame Potassium
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Vigor, formulated with proven ingredients such as creatine and betaine along with the cutting-edge, trademarked ingredients PeakO2, ElevATP, and SenActiv, is the ultimate natural strength formula. Key ingredients in Vigor have been shown to increase the anabolic response to resistance exercise, assist the healthy formation of lean mass, and increase key measures of athletic performance.
Advanced creatine and strength formula Apple pie moonshine Naturally & artificially flavored
elevATP Strength. Power. Performance. SenActiv PeakO2
Precautions
Warning: Consuming this product can expose you to chemicals including lead, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.
Warning: This product is only intended for use in healthy adults 18 years of age or older. Keep out of reach of children.
Pregnant or nursing women should not use this product. Consult your healthcare provider before using this product, especially if you are taking any prescription, over the counter medication, dietary supplement product, or if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you re taking a MAOI ( Monoamine Oxidase Inhibitor) or any other medication.
Immediately discontinue use and consult your health care professional if you experience adverse reaction to this product. Do not exceed recommended serving. Do not use if safety seal is broken or missing.
Suggested/Recommended/Usage/Directions
Directions: Mix 1 scoop with 12-20 ounces of water and shake well. Consume immediately before and during training. Additional servings can be taken throughout the day.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Seals/Symbols
Made in USA
Formulation
Anabolic Strength Power Endurance
Manufactured in a U.S. cGMP Facility.
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
elevATP is a registered trademark of VDF FutureCeuticals, Inc. elevATP products are protected by US patent no. 9,327,005 used under license SenActiv is a registered trademark of NuLiv Science USA. PeakO2 is protected by patents pending owned by Disruptive Nutrition, LLC and under exclusive global distribution by Compound Solutions, Inc.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Vigor 2nd Edition Apple Pie Moonshine by Arms Race Nutrition label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Vigor 2nd Edition Apple Pie Moonshine by Arms Race Nutrition
These are the 10 active ingredients this product is made of. Select any to open its full monograph.
Serving size12.9 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Creatine Monohydrate
No knowninteractions
Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity ac...
Creatine Monohydrate monograph & interactionsBetaine Anhydrous
No knowninteractions
Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...
Betaine Anhydrous monograph & interactionsElevATP
SenActiv
PeakO2
- › Turkey Tail
- › Cordyceps
- › Reishi
- › King Trumpet
- › Shiitake
- › Lion's Mane
Other (inactive) ingredients: Citric Acid, Natural & Artificial Flavors, Silicon Dioxide, Sucralose, Acesulfame Potassium. These complete the product’s ingredient list but are not active constituents.
Vigor 2nd Edition Apple Pie Moonshine by Arms Race Nutrition Drug Interactions
HelloPharmacist Interaction Report
Vigor 2nd Edition Apple Pie Moonshine by Arms Race Nutrition contains several mushroom and plant extracts that have documented interactions with medications.
The most serious interaction involves cordyceps and anticoagulant or antiplatelet drugs (blood thinners like warfarin or aspirin) — cordyceps may theoretically increase bleeding risk, though this hasn't been reported in humans yet.
Read the full breakdown — every affected drug type, severity by severity
Reishi mushroom interacts with three drug categories. It may lower blood pressure further when combined with blood pressure medications (antihypertensives), increase bleeding risk with blood thinners at higher doses, and theoretically have additive effects with diabetes medications.
Lion's mane mushroom also interacts with blood thinners, diabetes drugs, and immunosuppressants (medications that weaken your immune system). Shiitake mushroom may interfere with immunosuppressants and theoretically affect how your body processes certain drugs broken down by a liver enzyme called CYP2D6.
Creatine and betaine anhydrous, the first two ingredients, have no documented interactions in our data. We could not check elevATP, SenActiv, Turkey Tail, or King Trumpet — we hold no interaction data for these ingredients.
Altogether, these interactions span 655 individual medications. Use the medication checker on this page to look up your exact drugs before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Vigor 2nd Edition Apple Pie Moonshine?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Vigor 2nd Edition Apple Pie Moonshine interact with 662 drugs. Click any drug to see the details.
4 of the 10 ingredients in Vigor 2nd Edition Apple Pie Moonshine interact with drugs. Each result below shows which ingredient is responsible. Reishi Lion's Mane Shiitake Cordyceps
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Vigor 2nd Edition Apple Pie Moonshine — through 3 ingredients. Tap an ingredient for the detail:
Lion's ManeImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
Read the full Lion's Mane + 6-mercaptopurine interactionCordycepsImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps + 6-mercaptopurine interactionShiitakeImmunosuppressants Moderate
Interaction Summary
Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
Read the full Shiitake + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with Vigor 2nd Edition Apple Pie Moonshine — through 3 ingredients. Tap an ingredient for the detail:
CordycepsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps + Abciximab interactionReishiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi + Abciximab interactionLion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Vigor 2nd Edition Apple Pie Moonshine — through 4 ingredients. Tap an ingredient for the detail:
Lion's ManeAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Abrocitinib interactionReishiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi + Abrocitinib interactionShiitakeImmunosuppressants Moderate
Interaction Summary
Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
Read the full Shiitake + Abrocitinib interactionCordycepsAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Vigor 2nd Edition Apple Pie Moonshine — through 2 ingredients. Tap an ingredient for the detail:
Lion's ManeAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Read the full Lion's Mane + Acarbose interactionReishiAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Reishi + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ReishiAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Reishi + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Vigor 2nd Edition Apple Pie Moonshine — through 3 ingredients. Tap an ingredient for the detail:
Lion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Acenocoumarol interactionReishiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi + Acenocoumarol interactionCordycepsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Vigor 2nd Edition Apple Pie Moonshine — through 3 ingredients. Tap an ingredient for the detail:
CordycepsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps + Acetaminophen, Aspirin interactionReishiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi + Acetaminophen, Aspirin interactionLion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Vigor 2nd Edition Apple Pie Moonshine — through 3 ingredients. Tap an ingredient for the detail:
Lion's ManeAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Read the full Lion's Mane + Acetaminophen, Aspirin, Caffeine interactionReishiAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Reishi + Acetaminophen, Aspirin, Caffeine interactionCordycepsAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, DextromethorphanTylenol Cough Ex Strength
How Acetaminophen, Dextromethorphan interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Dextromethorphan interactionAcetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
How Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
How Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionAcetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
How Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with Vigor 2nd Edition Apple Pie Moonshine — through 1 ingredient. Tap an ingredient for the detail:
ShiitakeCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
Read the full Shiitake + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Vigor 2nd Edition Apple Pie Moonshine with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Reishi
Anticoagulant/Antiplatelet Drugs
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.
Antidiabetes Drugs
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.
Antihypertensive Drugs
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.
Lion's Mane
Anticoagulant/Antiplatelet Drugs
Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.
Antidiabetes Drugs
Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.
Immunosuppressants
Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.
Shiitake
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.
Immunosuppressants
Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.
Cordyceps
Anticoagulant/Antiplatelet Drugs
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.
Immunosuppressants
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.
Testosterone
Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.
Brand information
Manufacturer and brand details for Vigor 2nd Edition Apple Pie Moonshine, from the product label.
Arms Race Nutrition
See all Arms Race Nutrition products- Name
- Arms Race Nutrition, LLC
- City
- Statesville
- State
- NC
- ZipCode
- 28625
- Phone Number
- (833) 568-4321
- Web Address
- www.armsracenutrition.com
Vigor 2nd Edition Apple Pie Moonshine by Arms Race Nutrition: Common Questions
Does Vigor 2nd Edition Apple Pie Moonshine by Arms Race Nutrition interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does creatine affect kidney function?
Is this safe during pregnancy?
Can I use this while breastfeeding?
What are the most common side effects?
Does this actually improve athletic performance?
What does betaine anhydrous do?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Vigor 2nd Edition Apple Pie Moonshine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Vigor 2nd Edition Apple Pie Moonshine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Creatine
Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...
Read the full Creatine monograph → Herb & supplement monographBetaine Anhydrous
Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...
Read the full Betaine Anhydrous monograph → Herb & supplement monographCordyceps
Interacts with 249 drugsCordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...
Read the full Cordyceps monograph → Herb & supplement monographReishi Mushroom
Interacts with 375 drugsReishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...
Read the full Reishi Mushroom monograph → Herb & supplement monographShiitake Mushroom
Interacts with 312 drugsShiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly al...
Read the full Shiitake Mushroom monograph → Herb & supplement monographLion's Mane Mushroom
Interacts with 327 drugsLion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...
Read the full Lion's Mane Mushroom monograph →Sources & How We Checked
Vigor 2nd Edition Apple Pie Moonshine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 201 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Creatine 86 references
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- Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
- Greenhaff P. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;352:233-4. PubMed
- Vandenberghe K, Goris M, Van Hecke P, et al. Long-term creatine intake is beneficial to muscle performance during resistance training (abstract). J Appl Physiol 1997;83:2055-63. PubMed
- Hultman E, Soderlund K, Timmons JA, et al. Muscle creatine loading in men. J Appl Physiol 1996;81:232-7. PubMed
- Pritchard NR, Kalra PA. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;351:1252-3. PubMed
- Poortmans JR, Auquier H, Renaut V, et al. Effect of short-term creatine supplementation on renal responses in men (abstract). Eur J Appl Physiol Occup Physiol 1997;76:566-7. PubMed
- Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc 1999;31:1108-10. PubMed
- Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA. Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Med Sci Sports Exerc 2000;32:291-6. PubMed
- Rawson ES, Wehnert ML, Clarkson PM. Effects of 30 days of creatine ingestion in older men. Eur J Appl Physiol Occup Physiol 1999;80:139-44. PubMed
- Earnest CP, Almada AL, Mitchell TL. High-performance capillary electrophoresis-pure creatine monohydrate reduces blood lipids in men and women. Clin Sci (Colch) 1996;91:113-8. PubMed
- Juhn MS. Oral creatine supplementation. Separating fact from hype. Phys Sportsmed 1999;27:47-50,53-54,56,61,89. PubMed
- Juhn MS, O'Kane JW, Vinci DM. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J Am Diet Assoc 1999;99:593-5.
- Green AL, Hultman E, Macdonald IA, et al. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol 1996;271:E821-6. PubMed
- Balsom PD, Soderlund K, Sjodin B, Ekblom B. Skeletal muscle metabolism during short duration high-intensity exercise: influence of creatine supplementation. Acta Physiol Scand 1995;154:303-10. PubMed
- Snow RJ, McKenna MJ, Selig SE, et al. Effect of creatine supplementation on sprint exercise performance and muscle metabolism. (abstract) J Appl Physiol 1998;84:1667-73. PubMed
- McNaughton LR, Dalton B, Tarr J. The effects of creatine supplementation on high-intensity exercise performance in elite performers. (abstract) Eur J Appl Physiol Occup Physiol 1998;78:236-40. PubMed
- Groeneveld GJ, Veldink JH, van der Tweel I, et al. A randomized sequential trial of creatine in amyotrophic lateral sclerosis. Ann Neurol 2003;53:437-45. . PubMed
- Robinson SJ. Acute quadriceps compartment syndrome and rhabdomyolysis in a weight lifter using high-dose creatine supplementation. J Am Board Fam Pract 2000;13:134-7. PubMed
- Kammer RT. Lone atrial fibrillation associated with creatine monohydrate supplementation. Pharmacotherapy 2005;25:762-4. PubMed
- Gualano B, Ugrinowitsch C, Novaes RB, et al. Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial. Eur J Appl Physiol 2008;103:33-40. PubMed
- Pfeffer, G., Majamaa, K., Turnbull, D. M., Thorburn, D., and Chinnery, P. F. Treatment for mitochondrial disorders. Cochrane Database.Syst.Rev. 2012;4:CD004426. PubMed
- Boos, C. J., White, S. H., Bland, S. A., and McAllister, P. D. Dietary supplements and military operations: caution is advised. J R.Army Med Corps 2010;156(1):41-43. PubMed
- Kreider, R. B. Dietary supplements and the promotion of muscle growth with resistance exercise. Sports Med 1999;27(2):97-110. PubMed
- Juhn, M. S., O'Kane, J. W., and Vinci, D. M. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J Am.Diet.Assoc 1999;99(5):593-595.
- Volek, J. S., Duncan, N. D., Mazzetti, S. A., Putukian, M., Gomez, A. L., and Kraemer, W. J. No effect of heavy resistance training and creatine supplementation on blood lipids. Int J Sport Nutr.Exerc.Metab 2000;10(2):144-156. PubMed
- Robinson, T. M., Sewell, D. A., Casey, A., Steenge, G., and Greenhaff, P. L. Dietary creatine supplementation does not affect some haematological indices, or indices of muscle damage and hepatic and renal function. Br.J Sports Med 2000;34(4):284-288. PubMed
- Tarnopolsky, M. A. Potential benefits of creatine monohydrate supplementation in the elderly. Curr.Opin.Clin Nutr.Metab Care 2000;3(6):497-502. PubMed
- Tarnopolsky, M. A. and MacLennan, D. P. Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Int J Sport Nutr.Exerc.Metab 2000;10(4):452-463. PubMed
- Arciero, P. J., Hannibal, N. S., III, Nindl, B. C., Gentile, C. L., Hamed, J., and Vukovich, M. D. Comparison of creatine ingestion and resistance training on energy expenditure and limb blood flow. Metabolism 2001;50(12):1429-1434. PubMed
- Chrusch, M. J., Chilibeck, P. D., Chad, K. E., Davison, K. S., and Burke, D. G. Creatine supplementation combined with resistance training in older men. Med Sci.Sports Exerc. 2001;33(12):2111-2117. PubMed
- Cox, G., Mujika, I., Tumilty, D., and Burke, L. Acute creatine supplementation and performance during a field test simulating match play in elite female soccer players. Int J Sport Nutr.Exerc.Metab 2002;12(1):33-46. PubMed
- Kilduff, L. P., Vidakovic, P., Cooney, G., Twycross-Lewis, R., Amuna, P., Parker, M., Paul, L., and Pitsiladis, Y. P. Effects of creatine on isometric bench-press performance in resistance-trained humans. Med Sci.Sports Exerc. 2002;34(7):1176-1183. PubMed
- Brose, A., Parise, G., and Tarnopolsky, M. A. Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults. J Gerontol A Biol.Sci.Med Sci. 2003;58(1):11-19. PubMed
- Volek, J. S., Ratamess, N. A., Rubin, M. R., Gomez, A. L., French, D. N., McGuigan, M. M., Scheett, T. P., Sharman, M. J., Hakkinen, K., and Kraemer, W. J. The effects of creatine supplementation on muscular performance and body composition responses to
- Tyler, T. F., Nicholas, S. J., Hershman, E. B., Glace, B. W., Mullaney, M. J., and McHugh, M. P. The effect of creatine supplementation on strength recovery after anterior cruciate ligament (ACL) reconstruction: a randomized, placebo-controlled, double-b DOI
- Groeneveld, G. J., Beijer, C., Veldink, J. H., Kalmijn, S., Wokke, J. H., and van den Berg, L. H. Few adverse effects of long-term creatine supplementation in a placebo-controlled trial. Int J Sports Med 2005;26(4):307-313. PubMed
- Astorino, T. A., Marrocco, A. C., Gross, S. M., Johnson, D. L., Brazil, C. M., Icenhower, M. E., and Kneessi, R. J. Is running performance enhanced with creatine serum ingestion? J Strength.Cond.Res 2005;19(4):730-734. PubMed
- Cramer, J. T., Stout, J. R., Culbertson, J. Y., and Egan, A. D. Effects of creatine supplementation and three days of resistance training on muscle strength, power output, and neuromuscular function. J Strength.Cond.Res 2007;21(3):668-677. PubMed
- Young, P., De, Jonghe P., Stogbauer, F., and Butterfass-Bahloul, T. Treatment for Charcot-Marie-Tooth disease. Cochrane.Database.Syst.Rev. 2008;(1):CD006052. PubMed
- Ostojic, S. M. and Ahmetovic, Z. Gastrointestinal distress after creatine supplementation in athletes: are side effects dose dependent? Res.Sports Med. 2008;16(1):15-22. PubMed
- Whitt, K. N., Ward, S. C., Deniz, K., Liu, L., Odin, J. A., and Qin, L. Cholestatic liver injury associated with whey protein and creatine supplements. Semin.Liver Dis. 2008;28(2):226-231. PubMed
- Koenig CA, Benardot D Cody M Thompson WR. Comparison of creatine monohydrate and carbohydrate supplementation on repeated jump height performance. J Strength Cond Res. 2008;22(4):1081-1086. PubMed
- Gordon, P. H., Cheung, Y. K., Levin, B., Andrews, H., Doorish, C., Macarthur, R. B., Montes, J., Bednarz, K., Florence, J., Rowin, J., Boylan, K., Mozaffar, T., Tandan, R., Mitsumoto, H., Kelvin, E. A., Chapin, J., Bedlack, R., Rivner, M., McCluskey, L.
- Bender, A., Samtleben, W., Elstner, M., and Klopstock, T. Long-term creatine supplementation is safe in aged patients with Parkinson disease. Nutr.Res. 2008;28(3):172-178. PubMed
- Parness, J. You're "hot" from pumping iron? Anesth.Analg. 2009;108(3):711-713. PubMed
- Gualano, B., Ferreira, D. C., Sapienza, M. T., Seguro, A. C., and Lancha, A. H., Jr. Effect of short-term high-dose creatine supplementation on measured GFR in a young man with a single kidney. Am.J.Kidney Dis. 2010;55(3):e7-e9. PubMed
- Saidi, H. and Mani, M. Severe metabolic acidosis secondary to coadministration of creatine and metformin, a case report. Am.J.Emerg.Med. 2010;28(3):388-6. PubMed
- Gualano, B., de, Salles Painelli, V, Roschel, H., Lugaresi, R., Dorea, E., Artioli, G. G., Lima, F. R., da Silva, M. E., Cunha, M. R., Seguro, A. C., Shimizu, M. H., Otaduy, M. C., Sapienza, M. T., da Costa, Leite C., Bonfa, E., and Lancha Junior, A. H.
- Neves, M., Jr., Gualano, B., Roschel, H., Lima, F. R., Lucia, de Sa-Pinto, Seguro, A. C., Shimizu, M. H., Sapienza, M. T., Fuller, R., Lancha, A. H., Jr., and Bonfa, E. Effect of creatine supplementation on measured glomerular filtration rate in postmeno
- Gufford, B. T., Sriraghavan, K., Miller, N. J., Miller, D. W., Gu, X., Vennerstrom, J. L., and Robinson, D. H. Physicochemical characterization of creatine N-methylguanidinium salts. J.Diet.Suppl 2010;7(3):240-252.
- Lugaresi, R., Leme, M., de, Salles Painelli, V, Murai, I. H., Roschel, H., Sapienza, M. T., Lancha Junior, A. H., and Gualano, B. Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein di
- Poortmans, J. R. and Francaux, M. Renal dysfunction accompanying oral creatine supplements. Lancet 7-18-1998;352(9123):234. PubMed
- Maganaris, C. N. and Maughan, R. J. Creatine supplementation enhances maximum voluntary isometric force and endurance capacity in resistance trained men. Acta Physiol Scand. 1998;163(3):279-287. PubMed
- Vandebuerie, F., Vanden Eynde, B., Vandenberghe, K., and Hespel, P. Effect of creatine loading on endurance capacity and sprint power in cyclists. Int J Sports Med 1998;19(7):490-495. PubMed
- Juhn, M. S. and Tarnopolsky, M. Oral creatine supplementation and athletic performance: a critical review. Clin J Sport Med 1998;8(4):286-297. PubMed
- Vandenberghe K, Van Hecke P, Van Leemputte M, and et al. Inhibition of muscle phosphocreatine resynthesis by caffeine after creatine loading. Med Sci Sports Exerc 1997;29(5 Supplement):249.
- Ziegenfuss T, Lowery LM, and Lemon PW. Acute fluid volume changes in men during three days of creatine supplementation. J Exerc Physiol Online 1998;1(3): .
- Kuehl K, Goldberg L, and Elliot D. Renal insufficiency after creatine supplementation in a college football athlete. Med Sci Sports Exerc 1998;30(5 Suppl ):S235. DOI
- Balsom PD, Ekblom B, Soderlund K, and et al. Creatine supplementation and dynamic high-intensity intermittent excercise. Scand J Med Sci Sports 1993;3:143-149.
- Kirksey KB, Warren BJ, Stone MH, and et al. The effects of six weeks of creatine monohydrate supplementation in male and female track athletes. Med Sci Sports Exerc 1997;29(5 Suppl):S145.
- Kreider R, Ransom J, Rasmussen C, and et al. Creatine supplementation during pre-season football does not affect markers of renal function. 83rd Annual Experimental Biology Meeting 1999;
- Rasmussen C, Kreider R, Ransom J, and et al. Creatine supplementation during pre-season football training does not affect fluid or electrolyte status. 46th Annual American College of Sports Medicine Annual Meeting 1999; DOI
- Tan CW, Hae Tha M, Joo Ng H. Creatine supplementation and venous thrombotic events. Am J Med 2014;127(8):e7-8. PubMed
- Young C, Oladipo O, Frasier S, et al. Hemorrhagic stroke in young healthy male following use of sports supplement Jack3d. Mil Med 2012;177(12):1450-4. PubMed
- Vilella AL, Limsuwat C, Williams DR, Seifert CF. Cholestatic jaundice as a result of combination designer supplement ingestion. Ann Pharmacother 2013;47(7-8):e33. PubMed
- Li N, Hauser R, Holford T, et al. Muscle-building supplement use and increased risk of testicular germ cell cancer in men from Connecticut and Massachusetts. Br J Cancer 2015;112(7):1247-50. PubMed
- Centers for Disease Control and Prevention (CDC). Hyperthermia and dehydration-related deaths associated with rapid weight loss in three collegiate wrestlers - North Carolina, Wisconsin, and Michigan, November-December 1997. MMWR Morb Mortal Wkly Rep 1998
- Litsky F. Collegiate wrestling deaths raise fears about training. The New York Times. December 19, 1997. Available at: http://www.nytimes.com/1997/12/19/sports/wrestling-collegiate-wrestling-deaths-raise-fears-about-training.html.
- The Associated Press. Creatine ruled out in athletes' deaths. The New York Times. May 2, 1998. Available at: http://www.nytimes.com/1998/05/02/sports/plus-college-wrestling-creatine-ruled-out-in-athletes-deaths.html.
- Creatine in the dock. Men's Fitness Magazine (Australia). September 2013. Available at: http://www.mensfitnessmagazine.com.au/2013/09/creatine-in-the-dock/.
- Galvan E, Walker Dk, Simbo SY, et al. Acute and chronic safety and efficacy of dose dependent creatine nitrate supplementation and exercise performance. J Int Soc Sports Nutr. 2016 Mar 31;13:12. PubMed
- Deminice R, Rosa FT, Pfrimer K, Ferrioli E, Jorao AA, Freitas E. Creatine supplementation increases total body water in soccer players: a deuterium oxide dilution study. Int J Sports Med. 2016 Feb;37(2):149-53. PubMed
- Wilkinson TJ, Lemmy AB, Jones AG, et al. Can creatine supplementation improve body composition and objective physical function in Rheumatoid Arthritis patients? A randomized controlled trial. Arthritis Care Res (Hoboken). 2016 Jun;68(6):729-37. PubMed
- Kreider RB, Kalman DS, Antonio J, et al. International Society of Sports Nutrition position stand: safety and efficacy of creating supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr. 2017;14:18.
- de Guingand DL, Palmer KR, Snow RJ, Davies-Tuck ML, Ellery SJ. Risk of adverse outcomes in females taking oral creatine monohydrate: a systematic review and meta-analysis. Nutrients. 2020;12(6):E1780. PubMed
- Almeida D, Colombini A, Machado M. Creatine supplementation improves performance, but is it safe? Double-blind placebo-controlled study. J Sports Med Phys Fitness. 2020;60(7):1034-9. PubMed
- Mills S, Candow DG, Forbes SC, Neary JP, Ormsbee MJ, Antonio J. Effects of creatine supplementation during resistance training sessions in physically active young adults. Nutrients. 2020;12(6):1880. PubMed
- Whinton AK, Donahoe K, Gao R, et al. Repeated application of a novel creatine cream improves muscular peak and average power in male subjects. J Strength Cond Res. 2020;34(9):2482-2491. PubMed
- Dover S, Stephens S, Schneiderman JE, et al. The effect of creatine supplementation on muscle function in childhood myositis: A randomized, double-blind, placebo-controlled feasibility study. J Rheumatol. 2020:jrheum.191375. PubMed
- Chilibeck PD, Candow DG, Landeryou T, Kaviani M, Paus-Jenssen L. Effects of creatine and resistance training on bone health in postmenopausal women. Med Sci Sports Exerc. 2015;47(8):1587-95. PubMed
- Forbes SC, Candow DG, Ostojic SM, Roberts MD, Chilibeck PD. Meta-analysis examining the importance of creatine ingestion strategies on lean tissue mass and strength in older adults. Nutrients 2021;13(6):1912. PubMed
- Silva C, Fung AWS, Masson V, et al. Vitamin D toxicity from an unusual and unexpected source: a report of 2 cases. Horm Res Paediatr 2022. PubMed
- Delpino FM, Figueiredo LM, Forbes SC, Candow DG, Santos HO. Influence of age, sex, and type of exercise on the efficacy of creatine supplementation on lean body mass: A systematic review and meta-analysis of randomized clinical trials. Nutrition 2022;103- PubMed
- Todorovic N, Korovljev D, Stajer V, Jorga J, Ostojic SM. Creatine consumption and liver disease manifestations in individuals aged 12?years and over. Food Sci Nutr 2022;11(2):1134-1141. PubMed
- Robles EL, Pache KM, Gluck JS. Acute compartment syndrome of the leg caused by cocaine use, creatine supplementation and vigorous exercise. J Surg Case Rep 2022;2022(11):rjac502. PubMed
Betaine Anhydrous 11 references
- Cystadane (betaine anhydrous for oral solution) Package insert. Orphan Medical, Inc. Minnetonka, MN. November 2005.
- Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol 2001;96:2711-7.. PubMed
- Schwab U, Torronen A, Toppinen L, et al. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr 2002;76:961-7. PubMed
- McGregor DO, Dellow WJ, Robson RA, et al. Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. Kidney Int 2002;61:1040-6. PubMed
- Olthof MR, van Vliet T, Verhoef P, et al. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PloS Med 2005;2:e135. PubMed
- Knopman, D. and Patterson, M. An open-label, 24-week pilot study of the methyl donor betaine in Alzheimer disease patients. Alzheimer Dis.Assoc.Disord. 2001;15(3):162-165. PubMed
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- Abdelmalek, M. F., Sanderson, S. O., Angulo, P., Soldevila-Pico, C., Liu, C., Peter, J., Keach, J., Cave, M., Chen, T., McClain, C. J., and Lindor, K. D. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepa PubMed
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- Zawieja EE, Zawieja B, Chmurzynska A. Betaine supplementation moderately increases total cholesterol levels: a systematic review and meta-analysis. J Diet Suppl. 2021;18(1):105-117. PubMed
- Imbard A, Toumazi A, Magréault S, et al. Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial. Orphanet J Rare Dis 2022;17(1):417. PubMed
Cordyceps 14 references
- Zhu JS, Halpern GM, Jones K. The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med 1998;4:289-303.
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Lion's Mane Mushroom 6 references
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