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Dietary supplement

Vitamin B-1 250 mg Ingredients & Drug Interactions

by Puritan's Pride

Vitamin B-1 250 mg label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vitamin B-1 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Vitamin B-1 250 mg is a dietary supplement by Puritan's Pride with 1 active ingredient. Its ingredients are commonly taken for preventing or treating thiamine deficiency, beriberi, wernicke-korsakoff syndrome (alcohol-related).Based on those ingredients, 3 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Thiamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vitamin B-1 250 mg by Puritan's Pride

Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin B-1 250 mg by Puritan's Pride — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vitamin B-1 250 mg by Puritan's Pride

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: thiamine (also called vitamin B-1), a B vitamin your body needs to convert food into energy and keep your nervous system working properly. The 250 mg dose is well above what you need daily, so it's meant to correct a deficiency or treat a specific condition rather than for general nutrition.

The tablet also contains vegetable cellulose and a small amount of other inactive ingredients that help hold the pill together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: B vitamin supplementation.
  • We looked for evidence on: Thiamine deficiency, Wernicke-Korsakoff syndrome (WKS), Beriberi, Energy metabolism.
  • The strongest evidence on file: Thiamine is rated "Effective" for Thiamine deficiency (Natural Medicines).
  • Also on file: Thiamine is rated "Effective" for Wernicke-Korsakoff syndrome (WKS).

Thiamine supplementation is effective for treating thiamine deficiency and Wernicke-Korsakoff syndrome (a serious neurological condition caused by severe thiamine lack). It's possibly effective for dysmenorrhea (painful periods).

The evidence doesn't support its use as a mosquito repellent or for heart failure.

The evidence, ingredient by ingredient Thiamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Thiamine is generally very well tolerated when taken by mouth in normal amounts. Allergic reactions like dermatitis are rare.

Thiamine is a nutrient your body needs during pregnancy and breastfeeding; if you're supplementing at this dose, use it only as your doctor or midwife advises — don't guess at what you need on your own.

Side effects, ingredient by ingredient Thiamine

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Thiamine.
  • The most serious interaction on file is rated Minor.
  • For scale: 3 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take trimethoprim (Proloprim), a Minor interaction exists — your thiamine blood level may rise slightly. Check your full medication list with the interaction tool on this page to be thorough.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This supplement is right for someone correcting a documented thiamine deficiency or treating Wernicke-Korsakoff syndrome under medical guidance. If you take trimethoprim (an antibiotic), mention this supplement to your pharmacist.

Talk with your doctor before starting if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitamin B-1 250 mg, straight from the product label.

Brand Puritan's Pride
Barcode (UPC) 074312106309
Net contents 100 Easy To Swallow Coated Tablet(s)
Market status On market
Date entered into DSLD Jul 25, 2017
DSLD ID 76349
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitamin B-1 250 mg by Puritan's Pride, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
074312106309
IngredientAmount% DV
Thiamine250 mg20833%

Other ingredients: Vegetable Cellulose, Contains <2% of:

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

B

State-of-the-art manufacturing and packaging facilities ensure you the highest quality nutritional supplements money can buy. When it comes to your health...choose the best.

To reorder item # 630 www.puritan.com 1-800-645-1030

FDA Statement of Identity

Vegetarian Vitamin Supplement

Formulation

Vegetarian Vitamin Supplement

No artificial color, flavor or sweetener, no preservatives, no sugar, no starch, no milk, no lactose, no soy, no gluten, no wheat, no yeast, no fish. Sodium free.

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) tablet daily, preferably with a meal.

Brand IP Statement(s)

Puritan’s Pride supplements are produced from the finest raw materials under stringent quality control standards.

2016 Puritan’s Pride, Inc.

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Storage

Store at room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

QA Quality assured

General

Item # 630 B630 08D

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vitamin B-1 250 mg by Puritan's Pride label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vitamin B-1 250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vitamin B-1 250 mg by Puritan's Pride

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Thiamine

Interacts with
3 drugs
250 mg per serving Form: Thiamine Hydrochloride, Vitamin B1

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get eno...

Thiamine monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Contains <2% of:. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitamin B-1 250 mg by Puritan's Pride Drug Interactions

Want to check YOUR meds against Vitamin B-1 250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
3Drugs
3 Minor

Ingredients driving the most interactions

Thiamine 3

Individual Drug Interactions

The ingredients in Vitamin B-1 250 mg interact with 3 drugs. Click any drug to see the details.

1 of the 1 ingredient in Vitamin B-1 250 mg interact with drugs. Each result below shows which ingredient is responsible. Thiamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitamin B-1 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Thiamine1 drug type · 3 drugs

Trimethoprim (Proloprim)

Trimethoprim might increase blood levels of thiamine.
In vitro, animal, and clinical research suggest that trimethoprim inhibits intestinal thiamine transporter ThTR-2, hepatic transporter OCT1, and renal transporters OCT2, MATE1, and MATE2, resulting in paradoxically increased thiamine plasma concentrations.

Likelihood Probable Evidence B
Thiamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vitamin B-1 250 mg, from the product label.

Puritan's Pride

See all Puritan's Pride products
Name
Puritan's Pride, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
1-800-645-1030
Web Address
www.puritan.com
Pharmacist Counseling Corner

Vitamin B-1 250 mg by Puritan's Pride: Common Questions

Does Vitamin B-1 250 mg by Puritan's Pride interact with any medications?
Yes. Based on its ingredients, Vitamin B-1 250 mg has a known interaction with 3 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitamin B-1 250 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this B-1 supplement give me energy?
Thiamine helps your body convert food into energy, but taking extra won't boost energy unless you have a deficiency. This product is meant to correct a shortage, not to enhance energy in people who already get enough B-1 from food.
Can I take this while I'm pregnant?
Thiamine is a nutrient you need during pregnancy, and the safety rating is Likely Safe. But don't self-dose at 250 mg — talk with your doctor or midwife first about whether you need a supplement and what amount is right for you.
Are there any fillers I should know about?
The tablet contains vegetable cellulose (which helps hold the pill together) and a small amount of other inactive ingredients. That's pretty minimal, and none of them are problematic additives.
What is thiamine used for?
Thiamine corrects vitamin B-1 deficiency and treats Wernicke-Korsakoff syndrome, a serious nerve condition from severe thiamine lack. It's possibly helpful for painful periods but hasn't been proven to work as a mosquito repellent or for heart failure.
Is 250 mg a lot of B-1?
Yes — the daily recommendation is only 1.1–1.2 mg for adults. This 250 mg dose is a supplement intended to treat or correct a deficiency, not for everyday nutrition. Use it only under your doctor's guidance.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vitamin B-1 250 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitamin B-1 250 mg label
Go deeper

The Full Monographs Behind Vitamin B-1 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Thiamine

Interacts with 3 drugs

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get enough from food, but supplements are clear...

Read the full Thiamine monograph →
Sources

Sources & How We Checked

Vitamin B-1 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Thiamine 7 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  4. Rogovik, A. L., Vohra, S., and Goldman, R. D. Safety considerations and potential interactions of vitamins: should vitamins be considered drugs? Ann.Pharmacother. 2010;44(2):311-324. PubMed
  5. Arruti N, Bernedo N, Audicana MT, Villarreal O, Uriel O, Muñoz D. Systemic allergic dermatitis caused by thiamine after iontophoresis. Contact Dermatitis. 2013 Dec;69(6):375-6. PubMed
  6. Thiamine hydrochloride injection package insert. Lake Zurich, IL: Fresenius Kabi, LLC; September 2019.
  7. Vora B, Wen A, Yee SW, et al. The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction. Clin Pharmacol Ther 2023;114(2):381-392.

See these in context on the Thiamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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