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Dietary supplement

Vitamin K-2 100 mcg Ingredients & Drug Interactions

by GNC

Vitamin K-2 100 mcg label
See full label image
Other (e.g. Tea Bag) Category: Vitamin
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vitamin K-2 100 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Vitamin K-2 100 mcg is a dietary supplement by GNC with 1 active ingredient. Its ingredients are commonly taken for supporting normal blood clotting, bone health, heart and vascular health.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin K2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vitamin K-2 100 mcg by GNC

Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin K-2 100 mcg by GNC — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vitamin K-2 100 mcg by GNC

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: vitamin K2, a fat-soluble nutrient that plays a role in blood clotting and bone metabolism. It comes with a handful of inactive ingredients — cane sugar, rice syrup, palm oil, soy lecithin, natural flavors, fruit and vegetable juice blend, citric acid, malic acid, and glycerin — which are excipients that help deliver and stabilize the supplement.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Supports the bone-building process.
  • We looked for evidence on: Osteoporosis, Bone density, Bone mineralization, Fracture prevention.
  • The strongest evidence on file: Vitamin K is rated "Possibly Effective" for Osteoporosis (Natural Medicines).

Vitamin K2 is effective for treating vitamin K deficiency states, including low blood clotting factor levels and hemorrhagic disease (serious bleeding problems). It is also effective for reversing the effects of warfarin when that's medically necessary.

For bone health, the evidence rates it as possibly effective for osteoporosis, meaning the data suggests a potential benefit but isn't conclusive yet.

The evidence, ingredient by ingredient Vitamin K

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth, vitamin K is generally well tolerated. The most common side effects are mild: nausea, diarrhea, stomach upset, and abdominal pain — usually mild to moderate.

Serious adverse reactions are rare and have been linked mainly to intravenous dosing in infants, not oral supplements in adults. The supplement is rated likely safe in pregnancy and lactation, so if you're pregnant or nursing, the safety data doesn't advise against it — but do check with your doctor or midwife.

Side effects, ingredient by ingredient Vitamin K

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin K.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Blood thinners — especially warfarin (Coumadin) — are the main concern. Vitamin K can reduce how well these drugs work, putting you at risk for clots.

Check your exact medications with the tool on this page and flag any anticoagulant or blood thinner before taking this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Vitamin K-2 is a straightforward supplement if you're not on blood thinners. If you take warfarin or any blood thinner, don't start this without talking to your prescriber — vitamin K can blunt its effect.

Otherwise, it's generally well tolerated with only mild digestive side effects in some people.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitamin K-2 100 mcg, straight from the product label.

Brand GNC
Net contents 30 Delicious Soft Chew(s)
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 260153
Product type Vitamin
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitamin K-2 100 mcg by GNC, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Soft Chew(s)
Maximum serving Sizes:
1 Soft Chew(s)
Servings per container
30
IngredientAmount% DV
Calories20 Calorie(s)--
Total Carbohydrates5 Gram(s)2%
Added Sugars4 Gram(s)8%
Total Sugars4 Gram(s)--
Vitamin K2100 mcg--

Other ingredients: Cane Sugar, Raw, Rice Syrup, Palm Oil, Soy Lecithin, Natural Flavors, Fruit & Vegetable Juice Blend, Citric Acid, Malic Acid, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Supports the bone-building process

Gf gluten free

Vitamin K-2 soft chews are a convenient alternative to pills and a great addition to your daily nutrition and health regimen. Research indicates that vitamin K levels may decline with aging, and this lower amount of vitamin K is related to reduced bone density.

These delicious soft chews are gluten free.

Formula

Features superior menaquinone-7 Acai grape Natural flavor

Just one soft chew provides 100 mcg of vitamin K-2, which is good for the bone building process. What's more, our Vitamin K-2 soft chews feature menaquinone-7, a superior, highly absorbable form of vitamin K-2.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one soft chew daily.

Precautions

Contains: Soybeans.

Do not use if pregnant, nursing or allergic or contraindicated to aspirin. If you are taking aspirin or blood thinning or other medication, consult your physician before using this product.

Do not use if pregnant, nursing or allergic or contraindicated to aspirin.

Discontinue use two weeks prior to surgery or if stomach upset occurs.

Keep out of reach of children.

Storage

Store in a cool, dry place.

General Statements

For more information: 1-888-462-2548 GNC.com

Plus, they're individually wrapped, making them easy to take on the go.

Our quality commitment to you Since 1935, our mission as the industry leader has been to provide you with the highest-quality nutritional supplements. We continue to stand behind this mission. If you're not 100% satisfied with your purchase, return the unused portion of the product with your receipt within 30 days and we'll either refund your money or find a replacement product that is right for you.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vitamin K-2 100 mcg by GNC label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vitamin K-2 100 mcg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vitamin K-2 100 mcg by GNC

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Soft Chew(s) Dosage formOther (e.g. Tea Bag) Servings per container30 Amounts shown are per serving.

Vitamin K2

Interacts with
2 drugs
100 mcg per serving Form: Menaquinone-7

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K2 monograph & interactions

Other (inactive) ingredients: Cane Sugar, Raw, Rice Syrup, Palm Oil, Soy Lecithin, Natural Flavors, Fruit & Vegetable Juice Blend, Citric Acid, Malic Acid, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitamin K-2 100 mcg by GNC Drug Interactions

Want to check YOUR meds against Vitamin K-2 100 mcg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Major

Ingredients driving the most interactions

Vitamin K2 2

Individual Drug Interactions

The ingredients in Vitamin K-2 100 mcg interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Vitamin K-2 100 mcg interact with drugs. Each result below shows which ingredient is responsible. Vitamin K2

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitamin K-2 100 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin K21 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vitamin K-2 100 mcg, from the product label.

GNC

See all GNC products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Vitamin K-2 100 mcg by GNC: Common Questions

Does Vitamin K-2 100 mcg by GNC interact with any medications?
Yes. Based on its ingredients, Vitamin K-2 100 mcg has a known interaction with 2 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitamin K-2 100 mcg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this interfere with my warfarin?
Yes — this is a major interaction. Vitamin K can reverse warfarin's blood-thinning effect and raise your clot risk. Talk to your doctor or pharmacist before starting it; you may need a dose adjustment or lab work to stay safe.
What are the side effects?
Taken by mouth, vitamin K is generally well tolerated. The most common side effects are nausea, diarrhea, stomach upset, and abdominal pain — usually mild to moderate. Serious reactions are rare.
Is it safe to take while pregnant or breastfeeding?
Yes — the data rates vitamin K2 as likely safe in pregnancy and lactation. Still, check with your doctor or midwife before starting any supplement, especially during pregnancy.
What does vitamin K2 actually do?
It's a nutrient involved in blood clotting and bone metabolism. It's proven effective for treating vitamin K deficiency and bleeding problems, and it may help with osteoporosis, though the evidence for bone health isn't yet conclusive.
Are there fillers or additives in this?
The active ingredient is vitamin K2. It comes with inactive ingredients including cane sugar, rice syrup, palm oil, soy lecithin, natural flavors, and fruit and vegetable juice blend to help deliver and flavor the supplement.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vitamin K-2 100 mcg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitamin K-2 100 mcg label
Go deeper

The Full Monographs Behind Vitamin K-2 100 mcg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph →
Sources

Sources & How We Checked

Vitamin K-2 100 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin K 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150(5):293-300. PubMed
  4. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation? Nutr Rev. 2010;68(3):178-81. PubMed
  5. Kim JS, Nafziger AN, Gaedigk A, et al. Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe. J Clin Pharmacol. 2001 Jul;41(7):715-22. PubMed
  6. Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. PubMed
  7. Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. DOI
  8. Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. PubMed
  9. Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90.
  10. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. PubMed
  11. Hunnali CR, Devi U, Kitchanan S, Sethuraman G. Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial. J Pediatr 2023;255:98-104. PubMed

See these in context on the Vitamin K monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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