Wild Lettuce Ingredients & Drug Interactions
by Hawaii Pharm
What is this page for?
First and foremost: checking Wild Lettuce against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Wild Lettuce is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for insomnia and trouble sleeping, anxiety and restlessness, pain relief.Based on those ingredients, 393 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are certified organic Wild Lettuce extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Wild Lettuce by Hawaii Pharm
Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Lettuce by Hawaii Pharm — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Wild Lettuce by Hawaii Pharm
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: certified organic Wild Lettuce extract. Wild lettuce is a plant traditionally used as a herbal remedy, and this version is delivered in liquid form for easy dosing.
The liquid also includes vegetable palm glycerin and pharmaceutical-grade alcohol as inactive ingredients to preserve and deliver the extract.
Does it work?
Couldn't assess
We don't have effectiveness ratings on file for wild lettuce. The evidence supporting its use isn't established in our data, so we can't tell you how well it actually works for any particular purpose.
How safe is it?
Well-documented data
Wild lettuce comes with important safety cautions. Limited human safety data exist, and high doses have been linked to side effects.
In large amounts or if harvested prematurely, wild lettuce can cause sweating, increased breathing, rapid heart rate, dilated pupils, dizziness, ringing in the ears, vision problems, head pressure, drowsiness, excitatory states, slowed breathing, and in severe cases, coma or death. Topically, it can trigger contact dermatitis (a skin rash).
The safety data advises against use during pregnancy and while breastfeeding—there isn't enough information to know it's safe in either situation.
Meds to double-check
Moderate interaction found
Before taking this product, check with your pharmacist if you're on any CNS depressants (sleep aids, anxiety drugs, opioids, antihistamines, or other sedating medications) or anticholinergic drugs. Both carry moderate-severity interaction risks with wild lettuce.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Wild lettuce is a traditional herbal product with limited human safety research and a documented potential to interact with sedating drugs and anticholinergic medications. If you take anything for sleep, anxiety, or pain, or any medication that affects nerve signals, talk with your pharmacist before adding this.
Pregnancy and breastfeeding require a conversation with your doctor or pharmacist.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Wild Lettuce, straight from the product label.
| Brand | Hawaii Pharm |
|---|---|
| Barcode (UPC) | 650905470936 |
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | Oct 23, 2020 |
| DSLD ID | 237839 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Organic, Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Wild Lettuce by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| certified organic Wild Lettuce extract | 970 mg | -- |
Other ingredients: Vegetable Palm Glycerin, pharmaceutical grade Alcohol
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Hawaii Pharm Herbal Extract Highest quality since 2008
Made with Aloha!
Formulation
Contains no GMO, gluten, artificial colors, heavy metals, preservatives, pesticides, fertilizers.
Super concentrated liquid herbal extract. Dry herb/menstruum ratio: 1:3.
Manufactured in an FDA registered facility.
Non GMO Gluten free
Made in USA, Hawaii
Suggested/Recommended/Usage/Directions
Directions for use: Shake well before using. Take about 20-30 drops (0.7-1 ml, one full squeeze of the dropper bulb) to 2-4 oz of juice or water up to 4 times per day.
Precautions
Warning: Keep out of the reach of children.
May have contraindications. We recommend to seek expert medical advice before taking.
Do not use if you are allergic to any ingredients.
Consult a physician before using during pregnancy, if nursing or taking any medications.
Do not use if seal is broken or missing.
Storage
Store in a cool dry place.
Formula
(Lactuca virosa)
FDA Statement of Identity
Herbal Dietary Supplement
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Seals/Symbols
FDA Registered Facility Made in United States of America USA
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Wild Lettuce by Hawaii Pharm label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Wild Lettuce by Hawaii Pharm
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.
Certified organic Wild Lettuce extract
Interacts with393 drugs
Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because i...
Certified organic Wild Lettuce extract monograph & interactionsOther (inactive) ingredients: Vegetable Palm Glycerin, Pharmaceutical grade Alcohol. These complete the product’s ingredient list but are not active constituents.
Wild Lettuce by Hawaii Pharm Drug Interactions
HelloPharmacist Interaction Report
Hawaii Pharm's Wild Lettuce extract has documented interactions with two major drug categories.
The most serious concern is with CNS depressants—drugs that slow down your central nervous system, like sleep aids, anxiety medications, and opioids. Taking wild lettuce with these could pile on the sedative effects and increase side effects, a moderate-severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Anticholinergic drugs (medications that block a nerve signal called acetylcholine) are the other documented interaction, also moderate severity. Wild lettuce may contain small amounts of hyoscyamine, an anticholinergic compound.
While the amounts appear very low, case reports describe people taking large doses of wild lettuce experiencing anticholinergic side effects like constipation, dry mouth, and dizziness.
Altogether, these interactions span 392 individual medications. Before you start this product, run your exact medications through the checker below—especially anything that makes you drowsy or any anticholinergic drugs your doctor has prescribed.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Wild Lettuce?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Wild Lettuce interact with 393 drugs. Click any drug to see the details.
1 of the 1 ingredient in Wild Lettuce interact with drugs. Each result below shows which ingredient is responsible. certified organic Wild Lettuce extract
Aspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Certified Organic Wild Lettuce Extract + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Certified Organic Wild Lettuce Extract + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Certified Organic Wild Lettuce Extract + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Certified Organic Wild Lettuce Extract + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Certified Organic Wild Lettuce Extract + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Carisoprodol, Codeine PhosphateSoma Compound w/ Codeine
How Aspirin, Carisoprodol, Codeine Phosphate interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Certified Organic Wild Lettuce Extract + Aspirin, Carisoprodol, Codeine Phosphate interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
How Aspirin, Chlorpheniramine, Phenylpropanolamine interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Certified Organic Wild Lettuce Extract + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAspirin, Codeine PhosphateAspirin w/ Codeine
How Aspirin, Codeine Phosphate interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Certified Organic Wild Lettuce Extract + Aspirin, Codeine Phosphate interactionAspirin, Codeine Phosphate, MethocarbamolRobaxisal C
How Aspirin, Codeine Phosphate, Methocarbamol interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Certified Organic Wild Lettuce Extract + Aspirin, Codeine Phosphate, Methocarbamol interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Certified Organic Wild Lettuce Extract + Aspirin, Codeine Phosphate, Phenobarbital interactionAspirin, Diphenhydramine, PhenylpropanolamineAlka Seltzer Plus Night Time Effervescent
How Aspirin, Diphenhydramine, Phenylpropanolamine interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractCns Depressants, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Certified Organic Wild Lettuce Extract + Aspirin, Diphenhydramine, Phenylpropanolamine interactionAspirin, Ethoheptazine, MeprobamateEquagesic
How Aspirin, Ethoheptazine, Meprobamate interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Certified Organic Wild Lettuce Extract + Aspirin, Ethoheptazine, Meprobamate interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Certified Organic Wild Lettuce Extract + Aspirin, Hydrocodone interactionAspirin, OxycodonePercodan
How Aspirin, Oxycodone interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Certified Organic Wild Lettuce Extract + Aspirin, Oxycodone interactionAspirin, PentazocineTalwin Compound
How Aspirin, Pentazocine interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Certified Organic Wild Lettuce Extract + Aspirin, Pentazocine interactionAtropineSal-Tropine
How Atropine interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Certified Organic Wild Lettuce Extract + Atropine interactionAtropine Methyl Nitrate, Digestive EnzymesFestalan
How Atropine Methyl Nitrate, Digestive Enzymes interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Certified Organic Wild Lettuce Extract + Atropine Methyl Nitrate, Digestive Enzymes interactionAtropine SulfateAtropine Sulfate, Isopto Atropine
How Atropine Sulfate interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Certified Organic Wild Lettuce Extract + Atropine Sulfate interactionAtropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, PhenylAtrosept
How Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Certified Organic Wild Lettuce Extract + Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl interactionAtropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl SalicylateUrinary Antiseptic 2, Urised
How Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Certified Organic Wild Lettuce Extract + Atropine, Benzoic Acid, Hyoscyamine, Methenamine, Methylene Blue, Phenyl Salicylate interactionAtropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, ScopolamineAtrohist Plus, Pro Tuss, Ru-tuss, Stahist
How Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Certified Organic Wild Lettuce Extract + Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interactionAtropine, DifenoxinMotofen
How Atropine, Difenoxin interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Certified Organic Wild Lettuce Extract + Atropine, Difenoxin interactionAtropine, DiphenoxylateLofene, Lomotil
How Atropine, Diphenoxylate interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Certified Organic Wild Lettuce Extract + Atropine, Diphenoxylate interactionAtropine, Hyoscyamine, PhenobarbitalHypnaldyne
How Atropine, Hyoscyamine, Phenobarbital interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractAnticholinergic Drugs, Cns Depressants Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Certified Organic Wild Lettuce Extract + Atropine, Hyoscyamine, Phenobarbital interactionAtropine, Hyoscyamine, Phenobarbital, ScopolamineBarbidonna No. 2, Belladonna Phenobarbital
How Atropine, Hyoscyamine, Phenobarbital, Scopolamine interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractCns Depressants, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Certified Organic Wild Lettuce Extract + Atropine, Hyoscyamine, Phenobarbital, Scopolamine interactionAtropine, Hyoscyamine, ScopolamineColytrol
How Atropine, Hyoscyamine, Scopolamine interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractAnticholinergic Drugs Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Certified Organic Wild Lettuce Extract + Atropine, Hyoscyamine, Scopolamine interactionAtropine, Hyoscyamine, Scopolamine, PhenobarbitalBarbeloid, Donnatal #2, Donphen
How Atropine, Hyoscyamine, Scopolamine, Phenobarbital interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractAnticholinergic Drugs, Cns Depressants Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Certified Organic Wild Lettuce Extract + Atropine, Hyoscyamine, Scopolamine, Phenobarbital interactionAtropine, PhenobarbitalAnthrocol
How Atropine, Phenobarbital interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractCns Depressants, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Certified Organic Wild Lettuce Extract + Atropine, Phenobarbital interactionAtropine, MeperidineAtropine, Meperidine
How Atropine, Meperidine interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractCns Depressants, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Certified Organic Wild Lettuce Extract + Atropine, Meperidine interactionAtropine, Morphine SulfateAtropine, Morphine Sulfate
How Atropine, Morphine Sulfate interacts with Wild Lettuce — through 1 ingredient. Tap an ingredient for the detail:
Certified Organic Wild Lettuce ExtractAnticholinergic Drugs, Cns Depressants Moderate
Interaction Summary
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.
Read the full Certified Organic Wild Lettuce Extract + Atropine, Morphine Sulfate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Wild Lettuce with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
certified organic Wild Lettuce extract
Anticholinergic Drugs
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug. If it does, it appears to be in very low amounts. Nevertheless, there have been case reports of individuals consuming large amounts of wild lettuce experiencing anticholinergic-related side effects, such as constipation, dry mouth, dizziness, and sweating. Therefore, if you are already taking a drug with anticholinergic effects, you should be cautious about combining it with wild lettuce as the risk of side effects may be increased.
Cns Depressants
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Brand information
Manufacturer and brand details for Wild Lettuce, from the product label.
Hawaii Pharm
See all Hawaii Pharm products- Name
- Hawaii Pharm LLC
- City
- Honolulu
- State
- HI
- ZipCode
- 96815
- Web Address
- www.hawaiipharm.com
Wild Lettuce by Hawaii Pharm: Common Questions
Does Wild Lettuce by Hawaii Pharm interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Wild Lettuce if I'm pregnant or breastfeeding?
What are the side effects of Wild Lettuce?
Is this product FDA-approved?
What is Wild Lettuce used for?
Can I take this with my sleep aid or anxiety medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Wild Lettuce is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Wild Lettuce’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Wild Lettuce's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Wild Lettuce 5 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Besharat S, Besharat M, Jabbari A. Wild lettuce (Lactuca virosa) toxicity. BMJ Case Rep. 2009;2009. pii: bcr06.2008.0134.
- Mullins ME, Horowitz BZ. The case of the salad shooters: intravenous injection of wild lettuce extract. Vet Hum Toxicol. 1998;40(5):290-1.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC