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Dietary supplement

Wild Lettuce Ingredients & Drug Interactions

by L.A. Naturals

Wild Lettuce label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wild Lettuce against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Wild Lettuce is a dietary supplement by L.A. Naturals with 1 active ingredient. Its ingredients are commonly taken for insomnia and trouble sleeping, anxiety and restlessness, pain relief.Based on those ingredients, 393 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are selectively imported Wild Lettuce. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Wild Lettuce by L.A. Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Lettuce by L.A. Naturals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Wild Lettuce by L.A. Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: selectively imported wild lettuce. It's a liquid form, which means the herb is suspended in a base of grain alcohol and deionized water.

The alcohol serves as both a preservative and a way to extract and deliver the herb's compounds into your system.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Wild Lettuce product and its label doesn't state a use — see Wild Lettuce's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We don't hold effectiveness ratings for wild lettuce in our data, so we can't tell you from the research we have whether it works for any particular condition.

The evidence, ingredient by ingredient Wild Lettuce

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Wild lettuce has limited human safety data, and the facts on file raise several cautions. Large doses or prematurely harvested material have been linked to sweating, rapid breathing, dizziness, ringing in the ears, vision changes, head pressure, drowsiness, excitability, and in severe cases respiratory depression or coma.

A small amount of contact dermatitis has been reported with topical application. The safety data advises against wild lettuce during pregnancy and breastfeeding because there isn't enough information to know it's safe for your baby.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before using this product.

Side effects, ingredient by ingredient Wild Lettuce

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wild Lettuce.
  • The most serious interaction on file is rated Moderate.
  • For scale: 393 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, talk with your pharmacist or doctor about any CNS depressants you take — including sleep aids, sedatives, anxiety medications, opioids, and alcohol — because wild lettuce may intensify their drowsy or respiratory effects. Also mention any anticholinergic medications, as wild lettuce may theoretically add to dry mouth, constipation, or dizziness.

Altogether, these interactions span 393 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Wild Lettuce by L.A. Naturals may be worth a conversation if you're interested in herbal options, but it's not well studied in humans and carries real risks at higher doses — especially dizziness, drowsiness, and vision changes.

If you take any sedating medications, anticholinergic drugs, or anything else on prescription, check with your doctor or pharmacist first. It's not for use in pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wild Lettuce, straight from the product label.

Brand L.A. Naturals
Barcode (UPC) 641356102118
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Jul 25, 2014
DSLD ID 35008
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wild Lettuce by L.A. Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1 mL
Servings per container
30
UPC/BARCODE
641356102118
IngredientAmount% DV
selectively imported Wild Lettuce0 NP--

Other ingredients: Grain Alcohol, deionized Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

WARNINGS: Do not take during pregnancy.

Keep out of the reach of children.

Suggested/Recommended/Usage/Directions

Shake well before using.

SUGGESTED USE: 47 drops in water or juice, 1-3 times daily, or as needed.

General Statements

Plant # K-0001604

MADE IN THE USA

FAST ABSORPTION MEDICINAL BOTANICALS

Amount Per Serving 500 mg Herb Weight Equivalence

Herb Strength Ratio 1:2

Seals/Symbols

L.a.(TM)

K PARVE

FDA Statement of Identity

DIETARY SUPPLEMENT

Formula

SINGLE HERB IN ALCOHOL

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wild Lettuce by L.A. Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wild Lettuce label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wild Lettuce by L.A. Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Selectively imported Wild Lettuce

Interacts with
393 drugs
0 NP per serving

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because i...

Selectively imported Wild Lettuce monograph & interactions

Other (inactive) ingredients: Grain Alcohol, Deionized Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Wild Lettuce by L.A. Naturals Drug Interactions

Want to check YOUR meds against Wild Lettuce?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
393Drugs
393 Moderate

Ingredients driving the most interactions

selectively imported Wild Lettuce 393

Individual Drug Interactions

The ingredients in Wild Lettuce interact with 393 drugs. Click any drug to see the details.

1 of the 1 ingredient in Wild Lettuce interact with drugs. Each result below shows which ingredient is responsible. selectively imported Wild Lettuce

Each ingredient & the kinds of drugs it affects

For each ingredient in Wild Lettuce with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

selectively imported Wild Lettuce2 drug types · 393 drugs

Anticholinergic Drugs

Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug. If it does, it appears to be in very low amounts. Nevertheless, there have been case reports of individuals consuming large amounts of wild lettuce experiencing anticholinergic-related side effects, such as constipation, dry mouth, dizziness, and sweating. Therefore, if you are already taking a drug with anticholinergic effects, you should be cautious about combining it with wild lettuce as the risk of side effects may be increased.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.

Likelihood Possible Evidence D
selectively imported Wild Lettuce full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wild Lettuce, from the product label.

L.A. Naturals

See all L.A. Naturals products
Name
Palko Services
Street Address
4991 W. US Hwy 20
City
Michigan City
State
IN
ZipCode
46360
Pharmacist Counseling Corner

Wild Lettuce by L.A. Naturals: Common Questions

Does Wild Lettuce by L.A. Naturals interact with any medications?
Yes. Based on its ingredients, Wild Lettuce has a known interaction with 393 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wild Lettuce contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's actually in this liquid?
It's wild lettuce suspended in grain alcohol and deionized water. The alcohol extracts the herb's active compounds and keeps it fresh.
Is it safe to take a lot of it?
No — large doses or prematurely harvested material have caused serious side effects including dizziness, rapid heartbeat, vision problems, drowsiness, and in rare cases coma or breathing problems. Stick to the recommended dose on the label and don't exceed it.
Can I take it while pregnant or breastfeeding?
No — the safety data advises against it during both pregnancy and breastfeeding because there isn't enough information to know it's safe for your baby. Talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or nursing.
Does wild lettuce actually do anything?
We don't have effectiveness ratings for it in our data, so we can't tell you from the research we hold whether it works for any condition.
What side effects can happen?
At large doses, you may feel dizzy, sweaty, have ringing in your ears, dry mouth, constipation, or pressure in your head. In rare cases, high doses have caused drowsiness, excitability, or breathing problems. It can also cause contact dermatitis if it touches your skin.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Wild Lettuce is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wild Lettuce label
Go deeper

The Full Monographs Behind Wild Lettuce’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wild Lettuce

Interacts with 393 drugs

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because its safety is not well studied, it should...

Read the full Wild Lettuce monograph →
Sources

Sources & How We Checked

Wild Lettuce's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wild Lettuce 5 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Besharat S, Besharat M, Jabbari A. Wild lettuce (Lactuca virosa) toxicity. BMJ Case Rep. 2009;2009. pii: bcr06.2008.0134.
  5. Mullins ME, Horowitz BZ. The case of the salad shooters: intravenous injection of wild lettuce extract. Vet Hum Toxicol. 1998;40(5):290-1.

See these in context on the Wild Lettuce monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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