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Dietary supplement

Wild Lettuce Extract 450 mg Ingredients & Drug Interactions

by Indiana Botanic Gardens

Wild Lettuce Extract 450 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wild Lettuce Extract 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Wild Lettuce Extract 450 mg is a dietary supplement by Indiana Botanic Gardens with 1 active ingredient. Its ingredients are commonly taken for insomnia and trouble sleeping, anxiety and restlessness, pain relief.Based on those ingredients, 393 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Wild Lettuce 4:1 extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Wild Lettuce Extract 450 mg by Indiana Botanic Gardens

Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Lettuce Extract 450 mg by Indiana Botanic Gardens — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Wild Lettuce Extract 450 mg by Indiana Botanic Gardens

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: wild lettuce 4:1 extract, supplying 450 mg per capsule. A 4:1 extract means the raw plant is concentrated fourfold.

The capsule also holds inactive ingredients—microcrystalline cellulose, gum arabic, gelatin, magnesium stearate, and rice flour—which are fillers and binders used to form and stabilize the capsule.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Sleep support.
  • We looked for evidence on: Insomnia, Sleep quality, Sleep onset.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The product facts we hold do not include effectiveness ratings for wild lettuce extract. We cannot tell you from our data whether it works for any particular purpose.

The evidence, ingredient by ingredient Wild Lettuce

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Mature, properly harvested wild lettuce taken by mouth is generally well tolerated. However, limited human safety data exist, and the safety profile changes sharply at high doses.

Large amounts or prematurely harvested wild lettuce have been linked to serious effects: dizziness, racing heartbeat, pupil dilation, ringing in ears, vision problems, drowsiness, excitatory states, slowed breathing, coma, and in rare cases death. The extract is not recommended during pregnancy—there isn't enough safety information.

It should also be avoided while breastfeeding, as reliable safety data are lacking. Topically, wild lettuce can cause contact dermatitis in sensitive individuals.

Side effects, ingredient by ingredient Wild Lettuce

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wild Lettuce.
  • The most serious interaction on file is rated Moderate.
  • For scale: 393 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you use sedating medications—such as sleep aids, opioids, benzodiazepines, or certain antidepressants—or anticholinergic drugs (medications that dry the mouth, slow digestion, or affect urination). These are Moderate-severity interactions that could amplify side effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Wild lettuce extract at standard doses in properly harvested form appears generally well tolerated by mouth, but it carries real interaction risks with sedating and anticholinergic drugs, and safety at high doses is a legitimate concern. If you take any medication, especially anything that makes you sleepy or affects digestion and urination, check with your doctor or pharmacist before adding this supplement.

It is not recommended in pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wild Lettuce Extract 450 mg, straight from the product label.

Brand Indiana Botanic Gardens
Barcode (UPC) 703308010787
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Sep 21, 2017
DSLD ID 78519
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wild Lettuce Extract 450 mg by Indiana Botanic Gardens, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
703308010787
IngredientAmount% DV
Wild Lettuce 4:1 extract450 mg--

Other ingredients: Microcrystalline Cellulose, Gum Arabic, Gelatin Capsule, Magnesium Stearate, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Sleep support

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Take one (1) capsule daily, with a meal, as a dietary supplement, or as directed by a qualified health care professional.

Precautions

Warning: If you are taking any medications or are pregnant or nursing, do not use prior to consulting a physician.

For your protection, this container has an outer safety seal. (Do not accept if missing or broken.)

Keep out of reach of children

FDA Disclaimer Statement

This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a dry, cool place.

Brand IP Statement(s)

IBG Indiana Botanic Gardens

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wild Lettuce Extract 450 mg by Indiana Botanic Gardens label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wild Lettuce Extract 450 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wild Lettuce Extract 450 mg by Indiana Botanic Gardens

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Wild Lettuce 4:1 extract

Interacts with
393 drugs
450 mg per serving

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because i...

Wild Lettuce 4:1 extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Gum Arabic, Gelatin Capsule, Magnesium Stearate, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Wild Lettuce Extract 450 mg by Indiana Botanic Gardens Drug Interactions

Want to check YOUR meds against Wild Lettuce Extract 450 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
393Drugs
393 Moderate

Ingredients driving the most interactions

Wild Lettuce 4:1 extract 393

Individual Drug Interactions

The ingredients in Wild Lettuce Extract 450 mg interact with 393 drugs. Click any drug to see the details.

1 of the 1 ingredient in Wild Lettuce Extract 450 mg interact with drugs. Each result below shows which ingredient is responsible. Wild Lettuce 4:1 extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Wild Lettuce Extract 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Wild Lettuce 4:1 extract2 drug types · 393 drugs

Anticholinergic Drugs

Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug. If it does, it appears to be in very low amounts. Nevertheless, there have been case reports of individuals consuming large amounts of wild lettuce experiencing anticholinergic-related side effects, such as constipation, dry mouth, dizziness, and sweating. Therefore, if you are already taking a drug with anticholinergic effects, you should be cautious about combining it with wild lettuce as the risk of side effects may be increased.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.

Likelihood Possible Evidence D
Wild Lettuce 4:1 extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wild Lettuce Extract 450 mg, from the product label.

Indiana Botanic Gardens

See all Indiana Botanic Gardens products
Name
Indiana Botanic Gardens, Inc.
Street Address
3401 W. 37th Ave.
City
Hobart
State
IN
ZipCode
46342
Phone Number
1-800-644-8327
Web Address
www.botanicchoice.com
Pharmacist Counseling Corner

Wild Lettuce Extract 450 mg by Indiana Botanic Gardens: Common Questions

Does Wild Lettuce Extract 450 mg by Indiana Botanic Gardens interact with any medications?
Yes. Based on its ingredients, Wild Lettuce Extract 450 mg has a known interaction with 393 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wild Lettuce Extract 450 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What side effects might I see from wild lettuce?
At normal doses using mature, properly harvested plant, side effects are uncommon. At high doses or with prematurely harvested plant, people have reported dizziness, racing heartbeat, vision problems, drowsiness, ringing in the ears, and in rare severe cases, slowed breathing or coma. If you experience unusual symptoms, stop and call your doctor.
Can I take this if I'm pregnant or breastfeeding?
No. There isn't enough safety information to recommend wild lettuce in pregnancy, and reliable safety data are absent for breastfeeding. Talk with your doctor or pharmacist about alternatives.
Does wild lettuce work as a sleep aid?
Our data do not include effectiveness ratings for wild lettuce extract, so we cannot tell you whether it works for sleep or any other condition from the information we hold.
What's actually in this capsule besides the extract?
The capsule holds inactive ingredients used to form and stabilize it: microcrystalline cellulose, gum arabic, gelatin, magnesium stearate, and rice flour. None are active remedies.
Why does the label say 450 mg if it's a 4:1 extract?
The 450 mg is the total amount of the concentrated extract in each capsule. A 4:1 extract means that amount represents four parts of raw plant material condensed into one, so you're getting a more concentrated dose than you would from raw plant powder.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Wild Lettuce Extract 450 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wild Lettuce Extract 450 mg label
Go deeper

The Full Monographs Behind Wild Lettuce Extract 450 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wild Lettuce

Interacts with 393 drugs

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because its safety is not well studied, it should...

Read the full Wild Lettuce monograph →
Sources

Sources & How We Checked

Wild Lettuce Extract 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wild Lettuce 5 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Besharat S, Besharat M, Jabbari A. Wild lettuce (Lactuca virosa) toxicity. BMJ Case Rep. 2009;2009. pii: bcr06.2008.0134.
  5. Mullins ME, Horowitz BZ. The case of the salad shooters: intravenous injection of wild lettuce extract. Vet Hum Toxicol. 1998;40(5):290-1.

See these in context on the Wild Lettuce monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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