Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Wild Lettuce Extract 500 mg Ingredients & Drug Interactions

by Zazzee Naturals

Wild Lettuce Extract 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wild Lettuce Extract 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Wild Lettuce Extract 500 mg is a dietary supplement by Zazzee Naturals with 1 active ingredient. Its ingredients are commonly taken for insomnia and trouble sleeping, anxiety and restlessness, pain relief.Based on those ingredients, 393 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Wild Lettuce. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Wild Lettuce Extract 500 mg by Zazzee Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Lettuce Extract 500 mg by Zazzee Naturals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Wild Lettuce Extract 500 mg by Zazzee Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Wild Lettuce” is listed as a grouped ingredient — the label gives one combined amount (500 mg) without saying how much of each component you get.

This product contains one active ingredient: Wild Lettuce Extract at 500 mg per capsule. Wild Lettuce has been used traditionally as a relaxation aid, though the exact mechanisms aren't fully established.

The capsule itself also contains inactive ingredients — cellulose, cellulose powder, and magnesium stearate — which are common binders and flow agents in supplement capsules.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: promote healthy sleep and physical stress recovery.
  • We looked for evidence on: insomnia, sleep quality, physical recovery.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We don't have effectiveness ratings on file for Wild Lettuce Extract. That means the evidence for what it's claimed to do hasn't been formally rated in our data — not that it doesn't work, but that you're working with limited published information on how well it performs.

The evidence, ingredient by ingredient Wild Lettuce

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Wild Lettuce has limited human safety data, and high doses have been linked to side effects. Large amounts — or prematurely harvested wild lettuce — can cause dizziness, pressure in the head, drowsiness, anxiety, headache, sweating, rapid breathing, and in severe cases, respiratory depression or coma.

Topically, it may cause contact dermatitis (skin irritation). The safety data advises against use during pregnancy.

There is no reliable safety data for breastfeeding, so it's best avoided then too. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this supplement.

Side effects, ingredient by ingredient Wild Lettuce

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wild Lettuce.
  • The most serious interaction on file is rated Moderate.
  • For scale: 393 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, check any CNS depressants (sleep aids, sedatives, pain relievers with sedative effects, anti-anxiety drugs) and anticholinergic medications (for overactive bladder, Parkinson's disease, and similar conditions) against the interaction checker below. Both carry Moderate interaction risk with this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Wild Lettuce Extract is worth a conversation with your pharmacist if you're looking for a traditional relaxation aid — but only after you've checked it against any sedative medications or anticholinergic drugs you take. If you're pregnant or breastfeeding, steer clear.

Large doses carry real risks, so stick to the label dose and don't exceed it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wild Lettuce Extract 500 mg, straight from the product label.

Brand Zazzee Naturals
Barcode (UPC) X001R1lGCV
Net contents 120 Veggie Cap(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 276131
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wild Lettuce Extract 500 mg by Zazzee Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
X001R1lGCV
IngredientAmount% DV
Wild Lettuce500 mg--
Wild Lettuce Extract125 mg--

Other ingredients: Cellulose, Cellulose powder, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested usage: Take 1 capsule daily with food, or as recommended by health care practitioner.

Formula

Zazzee Naturals Wild Lettuce Extract Is an all-natural herbal supplement commonly used to promote healthy sleep and recovery from physical stress. Our Wild Lettuce Extract features a powerful 4:1 standardized extract equivalent to 500 mg of whole leaf powder.

Premium strength herbal supplement

Wild Lettuce Extract 500 mg strength

Precautions

Warnings: Do not take this product if you are pregnant or nursing.

Do not exceed recommended dosage.

Consult your health care provider before use if you are taking prescription medications, especially CNS (central nervous system) depressants or sedatives, or if you have a medical condition, especially glaucoma or benign prostatic hyperplasia.

Allergen information: Not manufactured with yeast, corn, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Supports a healthy sleep cycle Supports healthy recovery from physical stress

Allergen information: Not manufactured with yeast, corn, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

Natural color variation may occur in this product.

GMP Good Manufacturing Practice Consistent Quality Made In USA

Made with non GMO ingredients

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place after opening.

General Statements

Please recycle.

Seals/Symbols

GMP Good Manufacturing Practice Consistent Quality Made In USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wild Lettuce Extract 500 mg by Zazzee Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wild Lettuce Extract 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wild Lettuce Extract 500 mg by Zazzee Naturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Wild Lettuce

Interacts with
393 drugs
500 mg per serving

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because i...

Wild Lettuce monograph & interactions

Other (inactive) ingredients: Cellulose, Cellulose powder, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Wild Lettuce Extract 500 mg by Zazzee Naturals Drug Interactions

Want to check YOUR meds against Wild Lettuce Extract 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
393Drugs
393 Moderate

Ingredients driving the most interactions

Wild Lettuce 393

Individual Drug Interactions

The ingredients in Wild Lettuce Extract 500 mg interact with 393 drugs. Click any drug to see the details.

1 of the 1 ingredient in Wild Lettuce Extract 500 mg interact with drugs. Each result below shows which ingredient is responsible. Wild Lettuce

Each ingredient & the kinds of drugs it affects

For each ingredient in Wild Lettuce Extract 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Wild Lettuce2 drug types · 393 drugs

Anticholinergic Drugs

Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug. If it does, it appears to be in very low amounts. Nevertheless, there have been case reports of individuals consuming large amounts of wild lettuce experiencing anticholinergic-related side effects, such as constipation, dry mouth, dizziness, and sweating. Therefore, if you are already taking a drug with anticholinergic effects, you should be cautious about combining it with wild lettuce as the risk of side effects may be increased.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.

Likelihood Possible Evidence D
Wild Lettuce full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wild Lettuce Extract 500 mg, from the product label.

Zazzee Naturals

See all Zazzee Naturals products
Name
Zazzee Naturals
Street Address
400 Rella Boulevard Suite 123 Dept. 182
City
Montebello
State
NY
ZipCode
10901
Pharmacist Counseling Corner

Wild Lettuce Extract 500 mg by Zazzee Naturals: Common Questions

Does Wild Lettuce Extract 500 mg by Zazzee Naturals interact with any medications?
Yes. Based on its ingredients, Wild Lettuce Extract 500 mg has a known interaction with 393 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wild Lettuce Extract 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Wild Lettuce Extract if I'm pregnant?
No. The safety data advises against it during pregnancy because there isn't enough information to know it's safe. Talk with your doctor or pharmacist before taking any supplement when you're pregnant or trying to conceive.
What happens if I take too much?
Large amounts of wild lettuce can cause dizziness, pressure in the head, drowsiness, anxiety, headache, sweating, and rapid breathing. In severe cases, it may cause respiratory depression or coma. Stick to the label dose and don't exceed it.
Is this safe to take with sleep medications?
Not without checking first. Wild Lettuce can add to the sedative effects of sleep aids and other CNS depressants, which could cause too much drowsiness. Run your exact medications through the checker on this page, then talk to your pharmacist before starting.
What is Wild Lettuce Extract used for?
Traditionally it's been used as a relaxation aid, but we don't have formal effectiveness ratings for it in our data. That means the published evidence on how well it works hasn't been formally rated.
Does this contain hyoscyamine?
Wild Lettuce may contain trace amounts of hyoscyamine, an anticholinergic compound. The amounts appear very low, but case reports exist of people taking large doses experiencing anticholinergic side effects like constipation, dry mouth, and dizziness.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Wild Lettuce Extract 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wild Lettuce Extract 500 mg label
Go deeper

The Full Monographs Behind Wild Lettuce Extract 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wild Lettuce

Interacts with 393 drugs

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because its safety is not well studied, it should...

Read the full Wild Lettuce monograph →
Sources

Sources & How We Checked

Wild Lettuce Extract 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wild Lettuce 5 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Besharat S, Besharat M, Jabbari A. Wild lettuce (Lactuca virosa) toxicity. BMJ Case Rep. 2009;2009. pii: bcr06.2008.0134.
  5. Mullins ME, Horowitz BZ. The case of the salad shooters: intravenous injection of wild lettuce extract. Vet Hum Toxicol. 1998;40(5):290-1.

See these in context on the Wild Lettuce monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team