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Dietary supplement

Wild Lettuce Leaf Powder Ingredients & Drug Interactions

by TerraVita Premium Collection

Wild Lettuce Leaf Powder label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wild Lettuce Leaf Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Wild Lettuce Leaf Powder is a dietary supplement by TerraVita Premium Collection with 1 active ingredient. Its ingredients are commonly taken for insomnia and trouble sleeping, anxiety and restlessness, pain relief.Based on those ingredients, 393 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Wild Lettuce, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Wild Lettuce Leaf Powder by TerraVita Premium Collection

Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Lettuce Leaf Powder by TerraVita Premium Collection — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Wild Lettuce Leaf Powder by TerraVita Premium Collection

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: wild lettuce powder. Traditionally used for its calming properties, wild lettuce leaf is the whole botanical in powder form with no added fillers or inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Wild Lettuce product and its label doesn't state a use — see Wild Lettuce's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We don't hold effectiveness data for wild lettuce in our system. That means the evidence for what it actually does isn't established in the research we have on file.

If you're considering it for a specific reason, check with your pharmacist about what the current evidence shows.

The evidence, ingredient by ingredient Wild Lettuce

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Wild lettuce comes with some caution. The safety data in humans is limited, and large doses have been tied to side effects.

In particular, taking big amounts of wild lettuce — or harvesting it before it's fully mature — has been reported to cause sweating, rapid breathing, dizziness, ringing in the ears, vision changes, pressure in the head, drowsiness, agitation, and in severe cases, trouble breathing or coma. Pregnancy and breastfeeding are off the table: there isn't enough safety information, so it's best avoided during both.

If you're pregnant or nursing, talk with your doctor or pharmacist before considering this product.

Side effects, ingredient by ingredient Wild Lettuce

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wild Lettuce.
  • The most serious interaction on file is rated Moderate.
  • For scale: 393 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against two categories before starting: first, any CNS depressants (sedatives, sleep aids, strong pain relievers) — the risk is moderate for added drowsiness and side effects. Second, anticholinergic drugs (medications that block nerve signals, used for conditions like overactive bladder or Parkinson's) — also moderate risk, with large doses of wild lettuce linked to anticholinergic side effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Wild Lettuce Leaf Powder is a single-ingredient botanical with limited human safety data and no established effectiveness in our files. It's not for use during pregnancy or breastfeeding, and large doses carry real risks.

Before taking it, check your current medications — especially anything that makes you drowsy or affects your nerves — with our tool below, or ask your pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wild Lettuce Leaf Powder, straight from the product label.

Brand TerraVita Premium Collection
Barcode (UPC) 064435146672
Net contents 1 Ounce(s)
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 282754
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wild Lettuce Leaf Powder by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.25 Teaspoon(s)
Maximum serving Sizes:
0.25 Teaspoon(s)
Servings per container
28
UPC/BARCODE
064435146672
IngredientAmount% DV
Wild Lettuce, Powder1000 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A Dietary Supplement

Brand IP Statement(s)

Copyright 2005 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Suggested/Recommended/Usage/Directions

Directions Stir 1/4 of a teaspoon into a glass of water and consume 3 times daily, with meals.

General Statements

TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.

Please recycle!

FDA Disclaimer Statement

Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wild Lettuce Leaf Powder by TerraVita Premium Collection label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wild Lettuce Leaf Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wild Lettuce Leaf Powder by TerraVita Premium Collection

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.25 Teaspoon(s) Dosage formPowder Servings per container28 Amounts shown are per serving.

Wild Lettuce, Powder

Interacts with
393 drugs
1000 mg per serving

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because i...

Wild Lettuce, Powder monograph & interactions
Interaction report

Wild Lettuce Leaf Powder by TerraVita Premium Collection Drug Interactions

Want to check YOUR meds against Wild Lettuce Leaf Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
393Drugs
393 Moderate

Ingredients driving the most interactions

Wild Lettuce, Powder 393

Individual Drug Interactions

The ingredients in Wild Lettuce Leaf Powder interact with 393 drugs. Click any drug to see the details.

1 of the 1 ingredient in Wild Lettuce Leaf Powder interact with drugs. Each result below shows which ingredient is responsible. Wild Lettuce, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Wild Lettuce Leaf Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Wild Lettuce, Powder2 drug types · 393 drugs

Anticholinergic Drugs

Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug. If it does, it appears to be in very low amounts. Nevertheless, there have been case reports of individuals consuming large amounts of wild lettuce experiencing anticholinergic-related side effects, such as constipation, dry mouth, dizziness, and sweating. Therefore, if you are already taking a drug with anticholinergic effects, you should be cautious about combining it with wild lettuce as the risk of side effects may be increased.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.

Likelihood Possible Evidence D
Wild Lettuce, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wild Lettuce Leaf Powder, from the product label.

TerraVita Premium Collection

See all TerraVita Premium Collection products
Name
TerraVita Fine Whole Herbs
City
Brampton
State
Ontario
Pharmacist Counseling Corner

Wild Lettuce Leaf Powder by TerraVita Premium Collection: Common Questions

Does Wild Lettuce Leaf Powder by TerraVita Premium Collection interact with any medications?
Yes. Based on its ingredients, Wild Lettuce Leaf Powder has a known interaction with 393 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wild Lettuce Leaf Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What side effects can wild lettuce cause?
Large amounts of wild lettuce, especially if harvested too early, can cause sweating, rapid breathing, dizziness, ringing in the ears, vision changes, pressure in the head, drowsiness, and agitation. In severe cases, respiratory depression and coma have been reported. Topically, it may cause contact dermatitis (skin irritation).
Is wild lettuce safe during pregnancy or breastfeeding?
No. There isn't enough safety information for either pregnancy or breastfeeding, so it's best avoided in both. Talk with your doctor or pharmacist if you're pregnant or nursing and thinking about taking it.
Can I take wild lettuce with my sleep medication?
That's a conversation you need to have with your pharmacist or doctor first. Wild lettuce may add to the drowsy effects of sedatives or sleep aids — potentially too much. Use the interaction checker on this page with your exact medication, or call your pharmacy.
How much wild lettuce is considered a large dose?
The safety data we have doesn't specify a cutoff, only that large amounts and prematurely harvested wild lettuce are tied to side effects. Because safety information is limited overall, talk with your pharmacist about appropriate dosing for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Wild Lettuce Leaf Powder is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wild Lettuce Leaf Powder label
Go deeper

The Full Monographs Behind Wild Lettuce Leaf Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wild Lettuce

Interacts with 393 drugs

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because its safety is not well studied, it should...

Read the full Wild Lettuce monograph →
Sources

Sources & How We Checked

Wild Lettuce Leaf Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wild Lettuce 5 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Besharat S, Besharat M, Jabbari A. Wild lettuce (Lactuca virosa) toxicity. BMJ Case Rep. 2009;2009. pii: bcr06.2008.0134.
  5. Mullins ME, Horowitz BZ. The case of the salad shooters: intravenous injection of wild lettuce extract. Vet Hum Toxicol. 1998;40(5):290-1.

See these in context on the Wild Lettuce monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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