Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Wintergreen Oil Ingredients & Drug Interactions

by Pure Herbs

Wintergreen Oil label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wintergreen Oil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Wintergreen Oil is a dietary supplement by Pure Herbs with 1 active ingredient. Its ingredients are commonly taken for muscle and joint pain (topical), arthritis discomfort, headaches.Based on those ingredients, 37 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Wintergreen Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Wintergreen Oil by Pure Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Wintergreen Oil by Pure Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Wintergreen Oil by Pure Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: wintergreen oil. Wintergreen oil is a liquid extract that people have traditionally used for pain and muscle soreness.

There are no other inactive ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Wintergreen's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: beneficial for muscle and joint discomfort.
  • We looked for evidence on: Back pain, Joint pain, Muscle soreness, Arthritis, Inflammation.
  • The closest evidence on file: Wintergreen is rated "Insufficient Reliable Evidence To Rate" for Back pain (Natural Medicines).
  • Also on file: Wintergreen is rated "Insufficient Reliable Evidence To Rate" for Muscle soreness, Joint pain.

The evidence we hold doesn't establish that wintergreen oil works for back pain, muscle soreness, or joint pain. For all three uses, the data shows insufficient reliable evidence to rate it one way or the other.

The evidence, ingredient by ingredient Wintergreen

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Topical use of wintergreen oil is generally well tolerated on the skin for adults. The critical safety issue is swallowing it: the essential oil is extremely toxic if ingested and can cause salicylate poisoning (a buildup of salicylate compounds), with symptoms including headache, ringing in the ears, and confusion.

Wintergreen oil can also cause contact dermatitis (skin irritation or allergic rash). Never cover the area with a bandage or occlusive dressing after applying it, because that traps the oil and allows too much methyl salicylate to be absorbed through the skin.

Lactation safety data advises against use while breastfeeding; pregnancy safety data isn't on file for this ingredient.

Side effects, ingredient by ingredient Wintergreen

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wintergreen.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 37 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take warfarin or any blood thinner — the Major severity interaction is serious. Also double-check aspirin and any other salicylate-containing pain relievers or NSAIDs before you use this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product is a single-ingredient topical wintergreen oil meant for pain and soreness, but the evidence for those uses isn't established. If you take blood thinners or aspirin, talk to your pharmacist before using it — even topical application can interact.

Never swallow it, and don't cover the skin with a bandage afterward.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wintergreen Oil, straight from the product label.

Brand Pure Herbs
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 279859
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wintergreen Oil by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.25 mL
Maximum serving Sizes:
0.25 mL
Servings per container
480
IngredientAmount% DV
Wintergreen Oil0 NP--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, mix 0.25 mL (10-12 drops) of oil in 2 fl. oz (60 mL) water one time daily preferably with a meal.

Shake well before use

Formulation

Beneficial for muscle and joint discomfort.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: Not intended for use by pregnant or nursing women. If you have a medical condition or are taking medication, consult your doctor prior to use.

Discontinue use and consult with your doctor if any adverse reactions occur.

Keep out of reach of children

Brand IP Statement(s)

Pure Herbs, Ltd. Natural Herbal Extracts

FDA Statement of Identity

Dietary Supplement

General Statements

"No expense has been spared to provide the finest nature has to offer."

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wintergreen Oil by Pure Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wintergreen Oil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wintergreen Oil by Pure Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.25 mL Dosage formLiquid Servings per container480 Amounts shown are per serving.

Wintergreen Oil

Interacts with
37 drugs
0 NP per serving

Wintergreen is a low-growing North American plant whose oil is rich in methyl salicylate, an aspirin-like compound used in topical pain rubs. While it...

Wintergreen Oil monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Wintergreen Oil by Pure Herbs Drug Interactions

Want to check YOUR meds against Wintergreen Oil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
37Drugs
2 Major 35 Moderate

Ingredients driving the most interactions

Wintergreen Oil 37

Individual Drug Interactions

The ingredients in Wintergreen Oil interact with 37 drugs. Click any drug to see the details.

1 of the 1 ingredient in Wintergreen Oil interact with drugs. Each result below shows which ingredient is responsible. Wintergreen Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Wintergreen Oil with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Wintergreen Oil2 drug types · 37 drugs

Warfarin (Coumadin)

Using wintergreen oil topically might increase the effects and adverse effects of warfarin.
Several case reports show that concomitant use of topical wintergreen oil-containing products and warfarin can increase INR and bleeding risk due to systemic absorption of the methyl salicylate contained in wintergreen oil. Topical analgesic gels, lotions, creams, ointments, liniments, and sprays can contain up to 55% methyl salicylate.

Likelihood Probable Evidence D
Aspirin

Using wintergreen oil topically in large amounts, with occlusive dressings, or for prolonged periods of time might increase the risk of additive salicylate toxicity when used with aspirin.
Wintergreen oil contains methyl salicylate. Topical analgesic gels, lotions, creams, ointments, liniments, and sprays can contain up to 55% methyl salicylate.

Likelihood Probable Evidence D
Wintergreen Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wintergreen Oil, from the product label.

Pure Herbs

See all Pure Herbs products
Name
Pure Herbs, Ltd.
City
Sterling Heights
State
MI
Phone Number
(800) 860-4372
Web Address
www.pureherbs.com
Pharmacist Counseling Corner

Wintergreen Oil by Pure Herbs: Common Questions

Does Wintergreen Oil by Pure Herbs interact with any medications?
Yes. Based on its ingredients, Wintergreen Oil has a known interaction with 37 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wintergreen Oil contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is wintergreen oil safe to swallow?
No. The essential oil is extremely toxic if swallowed and can cause salicylate poisoning with symptoms like headache, ringing in your ears, and confusion. Use it only topically on the skin, and keep it away from children and pets.
Can I cover the skin with a bandage after applying wintergreen oil?
No. Don't use an occlusive dressing (a bandage or wrap that seals in moisture) because it traps the oil and allows too much methyl salicylate to be absorbed through your skin, which can be toxic.
Does wintergreen oil work for joint pain and muscle soreness?
The evidence we hold doesn't establish that it works for those uses. The data shows insufficient reliable evidence to rate its effectiveness for back pain, muscle soreness, or joint pain.
Can wintergreen oil irritate my skin?
Yes, it can cause contact dermatitis — either irritant or allergic rash. Topically, wintergreen oil is generally well tolerated, but skin reactions are possible.
Is wintergreen oil safe during pregnancy or breastfeeding?
Lactation safety data advises against use while breastfeeding. We don't have safety data on file for pregnancy, so talk with your doctor or pharmacist for personalized advice if you're pregnant or planning to become pregnant.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Wintergreen Oil is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wintergreen Oil label
Go deeper

The Full Monographs Behind Wintergreen Oil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wintergreen

Interacts with 37 drugs

Wintergreen is a low-growing North American plant whose oil is rich in methyl salicylate, an aspirin-like compound used in topical pain rubs. While it may help ease minor muscle and joint pa...

Read the full Wintergreen monograph →
Sources

Sources & How We Checked

Wintergreen Oil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wintergreen 7 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Gossel TA, Bricker JD. Principles of Clinical Toxicology. New York, NY:Raven Press, 1994.
  4. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  5. Chan TY. Potential dangers from topical preparations containing methyl salicylate. Hum Exp Toxicol 1996;15:747-50.
  6. Joss JD, LeBlond RF. Potentiation of warfarin anticoagulation associated with topical methyl salicylate. Ann Pharmacother 2000;34:729-33. PubMed
  7. Franceschi J, Darrigade AS, Jegou MH, Milpied B. First report of allergic contact dermatitis caused by Gaultheria procumbens (wintergreen) essential oil. Contact Dermatitis 2022;87(2):193-195.

See these in context on the Wintergreen monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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