Witch Hazel 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Witch Hazel 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Witch Hazel 500 mg is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for skin irritation and inflammation, hemorrhoids, minor cuts and bruises.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Witch Hazel 500 mg by Nature's Answer
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: witch hazel (Hamamelis virginiana) leaf extract at 500 mg per dose. It's formulated as a liquid for topical application.
The inactive ingredients are purified water, vegetable glycerin, and 12–15% certified organic alcohol, which serve as preservatives and delivery vehicles.
Does it work?
Moderate evidence
Witch hazel appears possibly effective for hemorrhoids based on the evidence we have. For atopic dermatitis (eczema), the data suggests it's possibly ineffective.
For varicose veins and postmenopausal conditions, there isn't enough reliable evidence to say one way or the other — the science on those uses just isn't established yet.
How safe is it?
Well-documented data
Topically, witch hazel is generally well tolerated, though a small number of people develop contact dermatitis — redness or burning where it's applied. The product is not meant to be taken by mouth; if you're considering oral use, check with your doctor first.
Witch hazel is high in tannins, and regular consumption of high-tannin herbs has been linked in some studies to increased esophageal or nasal cancer risk. During pregnancy and lactation, safety data are limited — topical use is likely low risk, but avoid applying it to the nipple area and talk with your doctor or pharmacist about whether it's right for you.
Meds to double-check
No known interactions
No interactions are documented in our data for witch hazel. Because this product is designed for topical use only, the chance of interacting with your medications is very low — but confirm your full medication list with your doctor or pharmacist if you have any concerns.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.
Witch hazel is a reasonable choice if you're looking for topical relief for hemorrhoids and tolerate it well on your skin. If you have eczema, the evidence doesn't support its use.
Because it's applied to skin rather than swallowed, medication interactions are unlikely, but run your exact medications through the tool below if you want to be sure. Talk with your doctor or pharmacist before use if you're pregnant, breastfeeding, or thinking about taking it by mouth.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 7, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Witch Hazel 500 mg, straight from the product label.
| Brand | Nature's Answer |
|---|---|
| Barcode (UPC) | 083000005428 |
| Net contents | 1 fl. Oz.; 30 mL |
| Market status | On market |
| Date entered into DSLD | Jan 7, 2019 |
| DSLD ID | 185065 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Kosher, Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Witch Hazel 500 mg by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Witch Hazel (Hamamelis virginiana) leaf extract | 500 mg | -- |
Other ingredients: purified Water, Vegetable Glycerin, 12-15% certified organic Alcohol
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Seals/Symbols
Gluten Free
K Parve
Bio-Chelated Cold Extraction Process
Formula
K Parve
Hamamelis virginiana
Low Alcohol
General
9300 Rev. 816 1156
General Statements
Since 1972
Super Concentrated
We follow good manufacturing practices. Our Facility is cGMP Certified.
Brand IP Statement(s)
Discover Nature's Answer
2016 Nature's Answer
Formulation
Gluten-Free
FDA Statement of Identity
Herbal Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 1 mL (28 drops) 1-2 times a day in a small amount of water. For short term use. Shake well.
Precautions
Keep out of reach of children.
Warning: Do not use if pregnant or nursing.
Do not use if safety seal is damaged or missing.
Consult your healthcare provider if you are taking any prescription medications.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Witch Hazel 500 mg by Nature's Answer label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Witch Hazel 500 mg by Nature's Answer
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.
Witch Hazel (Hamamelis virginiana) leaf extract
No knowninteractions
Witch hazel is a plant-based astringent used mostly on the skin for minor irritation, hemorrhoids, and oily skin. It is generally well tolerated as a...
Witch Hazel (Hamamelis virginiana) leaf extract monograph & interactionsOther (inactive) ingredients: Purified Water, Vegetable Glycerin, 12-15% certified organic Alcohol. These complete the product’s ingredient list but are not active constituents.
Witch Hazel 500 mg by Nature's Answer Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Witch Hazel 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Witch Hazel 500 mg, from the product label.
Nature's Answer
See all Nature's Answer products- Name
- Nature's Answer
- City
- Hauppauge
- State
- NY
- ZipCode
- 11788-3943
- Phone Number
- (800) 439-2324
- Web Address
- www.naturesanswer.com
Witch Hazel 500 mg by Nature's Answer: Common Questions
Does Witch Hazel 500 mg by Nature's Answer interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is witch hazel safe to use every day on my skin?
Can I swallow witch hazel?
Will witch hazel help my eczema?
Does this product have a lot of fillers?
Is this safe during pregnancy?
Why is there alcohol in this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Witch Hazel 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Witch Hazel 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Witch Hazel 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 7 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Witch Hazel 7 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
- Hormann HP, Korting HC. Evidence for the efficacy and safety of topical herbal drugs in dermatology: part I: anti-inflammatory agents. Phytomedicine 1994;1:161-71. PubMed
- Wolff, H. H. and Kieser, M. Hamamelis in children with skin disorders and skin injuries: results of an observational study. Eur.J.Pediatr. 2007;166(9):943-948. PubMed
- Khanna, N. and Datta, Gupta S. Rejuvenating facial massage--a bane or boon? Int J Dermatol. 2002;41(7):407-410. PubMed
- Theisen LL, Erdelmeier CA, Spoden GA, Boukhallouk F, Sausy A, Florin L, Muller CP. Tannins from Hamamelis virginiana bark extract: characterization and improvement of the antiviral efficacy against influenza A virus and human papillomavirus. PLoS One. 201 PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC