Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

White Willow with Feverfew Ingredients & Drug Interactions

by Nature's Answer

White Willow with Feverfew label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking White Willow with Feverfew against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

White Willow with Feverfew is a dietary supplement by Nature's Answer with 3 active ingredients. Its ingredients are commonly taken for migraine prevention, headache, fever (traditional).Based on those ingredients, 929 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Feverfew (Tanacetum parthenium) leaf and flower extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against White Willow with Feverfew by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with White Willow with Feverfew by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of White Willow with Feverfew by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 3 active ingredients: white willow (the herb and its bark extract) and feverfew leaf and flower extract. White willow has traditionally been used for pain and inflammation, while feverfew is commonly taken for headaches and inflammatory conditions.

The capsules also contain inactive ingredients — rice flour, cellulose, and calcium silicate — which are fillers and binders.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Feverfew product and its label doesn't state a use — see Feverfew's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we have doesn't support a reliable rating for feverfew's effectiveness in tension headaches, the condition it's most often used for. Similarly, the data we hold shows insufficient evidence to rate feverfew for rheumatoid arthritis, psoriasis, or prurigo nodularis.

We don't hold effectiveness ratings for the white willow ingredients in this product, so we can't speak to how well they work.

The evidence, ingredient by ingredient Feverfew

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Feverfew is generally well tolerated in the short term, but a few things to watch for: some people develop allergic reactions or mouth irritation, especially if they chew fresh leaves rather than taking a commercial preparation. The most common side effects are digestive — abdominal pain, bloating, constipation, diarrhea, flatulence, heartburn, and nausea.

A skin rash can occur in sensitive individuals. If you stop taking feverfew after long-term use, you may experience "post-feverfew syndrome" — anxiety, headaches, and insomnia.

During pregnancy, the safety data advises against feverfew because it may stimulate the uterus. While breastfeeding, there isn't enough reliable safety information, so it's best to avoid it.

Talk with your pharmacist or doctor before using this product if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Feverfew

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Feverfew.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 930 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check any blood thinners or antiplatelet drugs (such as warfarin or aspirin) — feverfew may increase your bleeding risk. Also verify medications metabolized by liver enzymes CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP3A4, or CYP2C8, as feverfew may raise their levels in your body.

Use the medication checker on this page to search your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines white willow and feverfew, both traditionally used for pain and inflammation. The main concern is feverfew's potential to increase bleeding risk with anticoagulants and antiplatelet drugs, and its theoretical effect on liver enzymes that metabolize hundreds of medications.

If you take any prescription medications — especially blood thinners, heart drugs, or psychiatric medicines — check them against the tool on this page before starting. Pregnant and breastfeeding women should talk with their pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about White Willow with Feverfew, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000164453
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 264129
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for White Willow with Feverfew by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
083000164453
IngredientAmount% DV
White Willow100 mg--
White Willow (Salix alba) bark extract200 mg--
Feverfew (Tanacetum parthenium) leaf and flower extract200 mg--

Other ingredients: Rice Flour, Cellulose, Calcium Silicate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Discover Nature's Answer and trust the Difference... The True Nature of Our Standards go way beyond the herb...

Nature's Answer Since 1972

Nature's Answer Discover Nature's Answer

Copyright 2018 Nature's Answer

Storage

Store in a cool, dry place.

Formula

Salix alba/Tanacetum parthenium

FDA Statement of Identity

Dietary Supplement

Formulation

Vegan

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one (1) capsule twice a day with food or water.

Precautions

Warning: Keep out of reach of children.

Do not use if safety seal is damaged or missing.

If you are pregnant, nursing, taking aspirin or other blood-thinning agents consult with your healthcare practitioner before use.

Discontinue 2 weeks prior to surgery, or if upset stomach occurs.

General Statements

For product information, call (800) 439-2324.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

White Willow with Feverfew by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

White Willow with Feverfew label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in White Willow with Feverfew by Nature's Answer

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

White Willow

100 mg per serving

White Willow (Salix alba) bark extract

200 mg per serving Form: Salicin

Feverfew (Tanacetum parthenium) leaf and flower extract

Interacts with
929 drugs
200 mg per serving

Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though...

Feverfew (Tanacetum parthenium) leaf and flower extract monograph & interactions

Other (inactive) ingredients: Rice Flour, Cellulose, Calcium Silicate. These complete the product’s ingredient list but are not active constituents.

Interaction report

White Willow with Feverfew by Nature's Answer Drug Interactions

Want to check YOUR meds against White Willow with Feverfew?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
929Drugs
929 Moderate

Ingredients driving the most interactions

Feverfew (Tanacetum parthenium) leaf and flower extract 929

Individual Drug Interactions

The ingredients in White Willow with Feverfew interact with 929 drugs. Click any drug to see the details.

1 of the 3 ingredients in White Willow with Feverfew interact with drugs. Each result below shows which ingredient is responsible. Feverfew (Tanacetum parthenium) leaf and flower extract

Each ingredient & the kinds of drugs it affects

For each ingredient in White Willow with Feverfew with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Feverfew (Tanacetum parthenium) leaf and flower extract7 drug types · 929 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, feverfew might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that feverfew may inhibit platelet aggregation. Additionally, in one case report, a 36-year-old patient taking feverfew 2400 mg daily for 3 months experienced vaginal bleeding and a prolonged menstrual cycle, with a modest increase in partial thromboplastin time (PTT) and prothrombin time (PT).

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Laboratory research shows that feverfew might inhibit CYP1A2. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C19.
Laboratory research shows that feverfew might inhibit CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C8.
Laboratory research shows that feverfew might inhibit CYP2C8. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C9.
Laboratory research shows that feverfew might inhibit CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.
Laboratory research shows that feverfew might inhibit CYP2D6. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Laboratory research shows that feverfew might inhibit CYP3A4. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Feverfew (Tanacetum parthenium) leaf and flower extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for White Willow with Feverfew, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
Street Address
85 Commerce Drive
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

White Willow with Feverfew by Nature's Answer: Common Questions

Does White Willow with Feverfew by Nature's Answer interact with any medications?
Yes. Based on its ingredients, White Willow with Feverfew has a known interaction with 929 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
White Willow with Feverfew contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on a blood thinner?
Not without talking to your pharmacist first. Feverfew may increase bleeding risk when combined with blood thinners or antiplatelet drugs. Your pharmacist can review your specific medication and dosage and help you decide whether it's safe.
What side effects should I expect?
Most people tolerate it well, but digestive upset is common — you might experience nausea, heartburn, bloating, diarrhea, or constipation. Some folks get a skin rash or mouth irritation, especially if chewing fresh leaves. If you stop taking it after long-term use, you may feel anxious, have headaches, or have trouble sleeping.
Can I take this while pregnant or breastfeeding?
No, not during pregnancy — feverfew may stimulate the uterus and its safety isn't established. There's also not enough safety information for breastfeeding, so it's best avoided. Talk with your doctor or pharmacist for personalized guidance.
Does this actually work for headaches?
The evidence we have on feverfew for tension headaches is insufficient to give it a reliable rating. That doesn't mean it doesn't help — just that we don't have solid research to confirm it does.
What are white willow and feverfew supposed to do?
White willow has been used traditionally for pain and inflammation. Feverfew is commonly taken for headaches and inflammatory conditions. Both are in this product to work together toward those goals, though feverfew's effectiveness for headaches hasn't been reliably established in the data we hold.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if White Willow with Feverfew is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

White Willow with Feverfew label
Go deeper

The Full Monographs Behind White Willow with Feverfew’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Feverfew

Interacts with 929 drugs

Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though the evidence is mixed. It is generally...

Read the full Feverfew monograph →
Sources

Sources & How We Checked

White Willow with Feverfew's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Feverfew 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Awang DVC. Prescribing therapeutic feverfew (Tancetum pathrnium (L.) Schultz Bip., syn. Chrysanthemumparthenium (L.) Bernh). Int Med 1998;1:11-3.
  3. Heptinstall S, Groenewegen WA, Spangenberg P, Loesche W. Extracts of feverfew may inhibit platelet behaviour via neutralization of sulphydryl groups. J Pharm Pharmacol 1987;39:459-65. PubMed
  4. Heptinstall S, White A, Williamson L, Mitchell JR. Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes. Lancet 1985;1:1071-4. PubMed
  5. Makheja AN, Bailey JM. A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium). Prostaglandins Leukot Med 1982;8:653-60.
  6. Groenewegen WA, Heptinstall S. A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro. J Pharm Pharmacol 1990;42:553-7. PubMed
  7. Heptinstall S, Groenewegen WA, Spangenberg P, Losche W. Inhibition of platelet behaviour by feverfew: a mechanism of action involving sulphydryl groups. Folia Haematol Int Mag Klin Morphol Blutforsch 1988;115:447-9.
  8. Biggs MJ, Johnson ES, Persaud NP, Ratcliffe DM. Platelet aggregation in patients using feverfew for migraine. Lancet 1982;2:776. PubMed
  9. Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5. PubMed
  10. Johnson ES, Kadam NP, Hylands DM, Hylands PJ. Efficacy of feverfew as prophylactic treatment of migraine. Br Med J (Clin Res Ed) 1985;291:569-73. PubMed
  11. Pittler MH, Ernst E. Feverfew for preventing migraine. Cochrane Database Syst Rev 2004;(1):CD002286. PubMed
  12. Ernst E, Pittler MH. The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review. Public Health Nutr 2000;3:509-14.
  13. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  14. Sil'vestrov VP, Kinitin AV, and Chesnokova, IV. [Immunological and metabolic disorders and the means for their correction in patients with chronic bronchitis]. Ter.Arkh. 1991;63:7-11.
  15. Cady RK, Goldstein J, Nett R, et al. A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic M) in the treatment of migraine. Headache 2011;51:1078-86.
  16. Jovanovic, M. and Poljacki, M. [Compositae dermatitis]. Med Pregl. 2003;56(1-2):43-49. PubMed
  17. Burry, J. N. Compositae dermatitis in South Australia: contact dermatitis from Chrysanthemum parthenium. Contact Dermatitis 1980;6(6):445.
  18. Alenzi KA, Alharbi FH, Tawhari FM, Fradees GS. Alteration of Coagulation Test Results and Vaginal Bleeding Associated With the Use of Feverfew (Tanacetum parthenium). J Med Cases 2021;12(1):9-12.

See these in context on the Feverfew monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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