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Dietary supplement

Lion's Mane 1,500 mg Ingredients & Drug Interactions

by Nature's Answer

Lion's Mane 1,500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lion's Mane 1,500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lion's Mane 1,500 mg is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Lion's Mane (Hericium erinaceus) fruiting body extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Lion's Mane 1,500 mg by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane 1,500 mg by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lion's Mane 1,500 mg by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: organic Lion's Mane mushroom fruiting body extract, 1,500 mg per capsule. The extract comes from Hericium erinaceus, a medicinal mushroom sometimes called lion's mane or hedgehog mushroom.

The capsule also contains inactive ingredients — vegetable cellulose (the capsule itself), Quik-Sorb, and calcium silicate — that help deliver and stabilize the extract.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Lion's Mane Mushroom product and its label doesn't state a use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence on lion's mane for any of its marketed uses is not yet established in the data we hold. The product is promoted for Alzheimer disease, anxiety, athletic performance, cancer, cognitive function, and cognitive impairment, but the available research rates all of these as having insufficient reliable evidence.

That doesn't mean lion's mane doesn't work — it means the science isn't solid enough yet to say either way. If you're considering it for a specific reason, talk with your doctor or pharmacist about what research exists and whether it makes sense for you.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, lion's mane mushroom is generally well tolerated when used as a food. The most common side effects in studies are gastrointestinal discomfort, nausea, and skin rash — usually mild.

Because long-term supplement safety hasn't been well studied, we don't have a full safety picture beyond that. There isn't enough safety data in pregnancy or while breastfeeding, so the data advises against use during those times.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before starting this product.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before starting if you take any blood thinner or antiplatelet drug (like warfarin or aspirin) — lion's mane may increase bleeding risk. Also double-check if you're on diabetes medication or any immunosuppressant.

No interactions are documented for any other medication categories, but the medication search tool below will help you verify your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's Mane by Nature's Answer may interest you if you're exploring natural cognitive support, but the science on its effectiveness is still developing. The main caution is with blood thinners, diabetes drugs, and immune-suppressing medications — all of which need a careful check before you add this product.

Talk with your doctor or pharmacist about your medications and whether lion's mane fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lion's Mane 1,500 mg, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000161728
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jan 22, 2021
DSLD ID 243175
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lion's Mane 1,500 mg by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
083000161728
IngredientAmount% DV
organic Lion's Mane (Hericium erinaceus) fruiting body extract1500 mg--

Other ingredients: Vegetable Cellulose, Quik-Sorb, Calcium Silicate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Discover Nature's Answer and trust the difference

Nature's Answer since 1972

Formulation

The true nature of our standards goes way beyond the herb...

Holistically balanced Cruelty-free not tested on animals

Gluten free

Vegan

With responsibly sourced ingredients from around the world

Promotes mental clarity, focus, and memory

Non-GMO Gluten-free Magnesium Stearate free

Vegan

FDA Statement of Identity

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Dietary Supplement

Seals/Symbols

100% Genuine Product Satisfaction Guaranteed Proudly made in the USA

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take three (3) capsules once a day with food or water.

Precautions

Warning: Keep out of reach of children.

Do not use if safety seal is damaged or missing.

If you are pregnant, nursing, taking any medications, planning any medical procedure or have a medical condition, consult with your healthcare practitioner before use.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

2020 Nature's Answer

Quick-Sorb is a registered trademark of Bio-Botanica, Inc.

Formula

Made with organic Lion's Mane Mushroom

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lion's Mane 1,500 mg by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lion's Mane 1,500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lion's Mane 1,500 mg by Nature's Answer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Organic Lion's Mane (Hericium erinaceus) fruiting body extract

Interacts with
327 drugs
1500 mg per serving

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Organic Lion's Mane (Hericium erinaceus) fruiting body extract monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Quik-Sorb, Calcium Silicate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lion's Mane 1,500 mg by Nature's Answer Drug Interactions

Want to check YOUR meds against Lion's Mane 1,500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

organic Lion's Mane (Hericium erinaceus) fruiting body extract 327

Individual Drug Interactions

The ingredients in Lion's Mane 1,500 mg interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lion's Mane 1,500 mg interact with drugs. Each result below shows which ingredient is responsible. organic Lion's Mane (Hericium erinaceus) fruiting body extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lion's Mane 1,500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Lion's Mane (Hericium erinaceus) fruiting body extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
organic Lion's Mane (Hericium erinaceus) fruiting body extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lion's Mane 1,500 mg, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
Street Address
85 Commerce Drive
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Lion's Mane 1,500 mg by Nature's Answer: Common Questions

Does Lion's Mane 1,500 mg by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Lion's Mane 1,500 mg has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lion's Mane 1,500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is lion's mane mushroom?
It's the fruiting body extract of Hericium erinaceus, a medicinal mushroom sometimes called hedgehog mushroom. This product gives you 1,500 mg of the extract per capsule.
Does lion's mane actually work for memory or brain health?
The science isn't yet solid enough to say. Research on lion's mane for Alzheimer disease, cognitive function, anxiety, and other brain-related uses rates all of them as having insufficient reliable evidence — meaning we need more studies before we can make a real claim.
What are the side effects?
Most commonly, gastrointestinal discomfort, nausea, and skin rash. These tend to be mild. Because long-term supplement safety hasn't been well studied, that's the main side-effect data we have.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data in pregnancy or while breastfeeding. The safety data advises against use during those times. Talk with your doctor or pharmacist for personalized advice before starting.
What are the inactive ingredients?
The capsule contains vegetable cellulose, Quik-Sorb, and calcium silicate — these are fillers and stabilizers that help deliver the extract.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lion's Mane 1,500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lion's Mane 1,500 mg label
Go deeper

The Full Monographs Behind Lion's Mane 1,500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Lion's Mane 1,500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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