Wu Jia Pi Ingredients & Drug Interactions
by Herbal Terra
What is this page for?
First and foremost: checking Wu Jia Pi against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Wu Jia Pi is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for fatigue and low energy, physical and athletic performance, stress resistance (adaptogen).Based on those ingredients, 1,140 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Wu Jia Pi dried root liquid extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Wu Jia Pi by Herbal Terra
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HelloPharmacist Scorecard of Wu Jia Pi by Herbal Terra
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Wu Jia Pi by Herbal Terra is a single-ingredient liquid extract: Wu Jia Pi dried root liquid extract, also known as eleuthero. The product contains one inactive ingredient, menstruum, which is the liquid base used in the extract.
Eleuthero is the root of Eleutherococcus senticosus, sometimes called Siberian ginseng, and has been used in traditional herbal practice.
Does it work?
Moderate evidence
The evidence we hold shows eleuthero is possibly effective for genital herpes. For other conditions—familial Mediterranean fever, bipolar disorder, osteoporosis, and chronic fatigue syndrome—the reliable evidence isn't established in the data we have.
If you're considering Wu Jia Pi for a specific condition, talk with your doctor or pharmacist about whether the current evidence supports its use for you.
How safe is it?
Well-documented data
Eleuthero is generally well tolerated when used short-term, but long-term safety data is limited. The most common side effects reported with short-term use are diarrhea, nausea, heartburn, headache, and a rash.
Some people have reported nervousness, anxiety, irritability, or low mood—effects that seem more likely at higher doses. In one study, about 7 in 100 people taking eleuthero reported nervousness.
There's also a report of increased blood pressure in children taking eleuthero, though it's unclear whether eleuthero or a contaminant in some products was responsible. During pregnancy, there isn't enough safety data, so eleuthero is best avoided.
The same applies to breastfeeding. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before taking this product.
Meds to double-check
Moderate interaction found
Before taking Wu Jia Pi, check with your pharmacist or doctor if you take digoxin (for heart rhythm), blood thinners or antiplatelet drugs, diabetes medications, immunosuppressant drugs, or any medication your liver breaks down—including many psychiatric, heart, and pain medications. Eleuthero may raise levels of some of these drugs or interfere with their effects.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Wu Jia Pi may be worth considering if you're interested in eleuthero's traditional use and you're not taking digoxin, blood thinners, diabetes medications, or drugs your liver metabolizes. However, because eleuthero interacts with so many medication types, you'll need to check your exact prescriptions first.
Pregnant or breastfeeding? Skip this and talk with your doctor.
Run your medications through the tool on this page, and discuss Wu Jia Pi with your own pharmacist or doctor before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Wu Jia Pi, straight from the product label.
| Brand | Herbal Terra |
|---|---|
| Barcode (UPC) | 606595922071 |
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2020 |
| DSLD ID | 235344 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Wu Jia Pi by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Wu Jia Pi dried root liquid extract | 970 mg | -- |
Other ingredients: Menstruum
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Direction Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz of juice or water up to 4 times a day. We recommend to seek expert medical advice before taking this or any other herbal supplements.
FDA Disclaimer Statement
Notice This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.
Formulation
Manufactured in the USA in an FDA registered facility
Alcohol free
Dried herb/menstruum ratio: 1:3 Expertly extracted Laboratory tested 330 mg/1 mL Premium product Alcohol-free liquid herbal extract
Non GMO
No artificial ingredients, GMO, gluten, color additives, fillers, preservatives or binders. Natural Gluten Free
Precautions
Caution May have contraindications.
Do not use if you are allergic to any ingredients.
Consult a physician before using during pregnancy, if nursing, or if you are on any medications.
Keep out of the reach of children.
Storage
Store in a cool, dry, dark place.
Formula
Eleutherococcus gracilistylus
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
Made in USA Made in an FDA registered facility Natural Gluten Free
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Wu Jia Pi by Herbal Terra label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Wu Jia Pi by Herbal Terra
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.
Wu Jia Pi dried root liquid extract
Interacts with1,140 drugs
Eleuthero is an herb traditionally used as an 'adaptogen' to fight fatigue, boost energy, and help the body handle stress. The scientific evidence beh...
Wu Jia Pi dried root liquid extract monograph & interactionsOther (inactive) ingredients: Menstruum. These complete the product’s ingredient list but are not active constituents.
Wu Jia Pi by Herbal Terra Drug Interactions
HelloPharmacist Interaction Report
Wu Jia Pi by Herbal Terra contains eleuthero, which has documented interactions with multiple medication types.
The most serious concern is a moderate-severity interaction with digoxin (a heart medication), where eleuthero may raise digoxin levels in your blood and increase the risk of side effects—a risk supported by a case report of a patient whose digoxin level climbed after starting eleuthero and returned to normal when he stopped.
Read the full breakdown — every affected drug type, severity by severity
Moderate interactions are also documented with blood thinners and antiplatelet drugs (which reduce clotting), where eleuthero may increase bleeding risk; with three classes of drugs your liver metabolizes (CYP1A2, CYP2C9, and CYP2D6 substrates)—where eleuthero might raise their levels; with P-glycoprotein substrates (a group of medications transported by a protein in your cells); with diabetes medications, where eleuthero might lower blood sugar additively; and with immunosuppressants, where eleuthero's immune-boosting activity might work against them. A minor interaction exists with some CYP2D6 substrates, though human studies suggest this risk may be smaller than animal data suggested.
Altogether, these interactions span 1,141 individual medications. Because many common drugs fall into these categories—including heart meds, blood thinners, diabetes drugs, and psychiatric medications—you'll want to check your exact prescriptions with the search tool on this page before starting Wu Jia Pi.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Wu Jia Pi?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Wu Jia Pi interact with 1,140 drugs. Click any drug to see the details.
1 of the 1 ingredient in Wu Jia Pi interact with drugs. Each result below shows which ingredient is responsible. Wu Jia Pi dried root liquid extract
EfalizumabRaptiva
How Efalizumab interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Wu Jia Pi Dried Root Liquid Extract + Efalizumab interactionEffientPrasugrel
How Effient interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates +1 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Wu Jia Pi Dried Root Liquid Extract + Effient interactionEfgartigimod Alfa-fcabVyvgart
How Efgartigimod Alfa-fcab interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Wu Jia Pi Dried Root Liquid Extract + Efgartigimod Alfa-fcab interactionElagolix SodiumOrilissa
How Elagolix Sodium interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Wu Jia Pi Dried Root Liquid Extract + Elagolix Sodium interactionElagolix, Estradiol Norethindrone Acetate, ElagolixOriahnn
How Elagolix, Estradiol Norethindrone Acetate, Elagolix interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
Read the full Wu Jia Pi Dried Root Liquid Extract + Elagolix, Estradiol Norethindrone Acetate, Elagolix interactionElranatamabElrexfio
How Elranatamab interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Wu Jia Pi Dried Root Liquid Extract + Elranatamab interactionEmapalumab-lzsgGamifant
How Emapalumab-lzsg interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Wu Jia Pi Dried Root Liquid Extract + Emapalumab-lzsg interactionEmpagliflozinJardiance
How Empagliflozin interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Read the full Wu Jia Pi Dried Root Liquid Extract + Empagliflozin interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractAntidiabetes Drugs, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Read the full Wu Jia Pi Dried Root Liquid Extract + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Read the full Wu Jia Pi Dried Root Liquid Extract + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Read the full Wu Jia Pi Dried Root Liquid Extract + Empagliflozin, Metformin Hydrochloride interactionEmtricitabine, Rilpivirine, Tenofovir AlafenamideOdefsey
How Emtricitabine, Rilpivirine, Tenofovir Alafenamide interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Wu Jia Pi Dried Root Liquid Extract + Emtricitabine, Rilpivirine, Tenofovir Alafenamide interactionEmtricitabine, Tenofovir Alafenamide FumarateDescovy
How Emtricitabine, Tenofovir Alafenamide Fumarate interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
Read the full Wu Jia Pi Dried Root Liquid Extract + Emtricitabine, Tenofovir Alafenamide Fumarate interactionEnasidenibIdhifa
How Enasidenib interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Wu Jia Pi Dried Root Liquid Extract + Enasidenib interactionEnoxaparinLovenox
How Enoxaparin interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Wu Jia Pi Dried Root Liquid Extract + Enoxaparin interactionEnsartinibEnsacove
How Ensartinib interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Wu Jia Pi Dried Root Liquid Extract + Ensartinib interactionEpcoritamab-byspEpkinly
How Epcoritamab-bysp interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Read the full Wu Jia Pi Dried Root Liquid Extract + Epcoritamab-bysp interactionEphedrine Sulfate, Hydroxyzine, TheophyllineHydroxy Compound
How Ephedrine Sulfate, Hydroxyzine, Theophylline interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Wu Jia Pi Dried Root Liquid Extract + Ephedrine Sulfate, Hydroxyzine, Theophylline interactionEphedrine, Guaifenesin, Phenobarbital, TheophyllineMudrane GG
How Ephedrine, Guaifenesin, Phenobarbital, Theophylline interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Wu Jia Pi Dried Root Liquid Extract + Ephedrine, Guaifenesin, Phenobarbital, Theophylline interactionEphedrine, Hydroxyzine, TheophyllineAmi Rax, Marax
How Ephedrine, Hydroxyzine, Theophylline interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
Read the full Wu Jia Pi Dried Root Liquid Extract + Ephedrine, Hydroxyzine, Theophylline interactionEptifibatideIntegrilin
How Eptifibatide interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Wu Jia Pi Dried Root Liquid Extract + Eptifibatide interactionErdafitinibBalversa
How Erdafitinib interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Wu Jia Pi Dried Root Liquid Extract + Erdafitinib interactionErtugliflozinSteglatro
How Ertugliflozin interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Read the full Wu Jia Pi Dried Root Liquid Extract + Ertugliflozin interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Read the full Wu Jia Pi Dried Root Liquid Extract + Ertugliflozin, Metformin Hydrochloride interactionErythromycinE-Mycin, Ery-Tab, Eryc, EryPed Chewable, Erythro Base, Erythro E-C +6 more
How Erythromycin interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
Read the full Wu Jia Pi Dried Root Liquid Extract + Erythromycin interactionErythromycin EthylsuccinateE.E.S. 400, E.E.S. Chewable, Wyamycin S
How Erythromycin Ethylsuccinate interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Wu Jia Pi Dried Root Liquid Extract + Erythromycin Ethylsuccinate interactionErythromycin Ethylsuccinate, SulfisoxazolePediazole
How Erythromycin Ethylsuccinate, Sulfisoxazole interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
Read the full Wu Jia Pi Dried Root Liquid Extract + Erythromycin Ethylsuccinate, Sulfisoxazole interactionErythromycin GluceptateErythromycin Gluceptate
How Erythromycin Gluceptate interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
Read the full Wu Jia Pi Dried Root Liquid Extract + Erythromycin Gluceptate interactionErythromycin LactobionateErythromycin Lactobionate
How Erythromycin Lactobionate interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
Read the full Wu Jia Pi Dried Root Liquid Extract + Erythromycin Lactobionate interactionErythromycin StearateErythro-S, Erythrocin, Ethril
How Erythromycin Stearate interacts with Wu Jia Pi — through 1 ingredient. Tap an ingredient for the detail:
Wu Jia Pi Dried Root Liquid ExtractP-glycoprotein Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
Read the full Wu Jia Pi Dried Root Liquid Extract + Erythromycin Stearate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Wu Jia Pi with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Wu Jia Pi dried root liquid extract
Anticoagulant/Antiplatelet Drugs
Theoretically, eleuthero may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research shows that a constituent of eleuthero, dihydroxybenzoic acid, appears to inhibit platelet aggregation. Concomitant use with anticoagulant or antiplatelet drugs might increase the risk of bleeding. This effect has not been reported in humans.
Antidiabetes Drugs
Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.
Animal research suggests that certain constituents of eleuthero have hypoglycemic activity in both healthy and diabetic animals. A small study in adults with type 2 diabetes also shows that taking eleuthero for 3 months can lower blood glucose levels. However, one very small study in healthy individuals shows that taking powdered eleuthero 3 grams, 40 minutes prior to a 75-gram oral glucose tolerance test, significantly increases postprandial blood glucose levels when compared with placebo. These contradictory findings might be due to patient-specific variability and variability in active ingredient ratios.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP1A2.
In vitro and animal research suggest that standardized extracts of eleuthero inhibit CYP1A2. This effect has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2C9.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2C9. This effect has not been reported in humans.
Digoxin (Lanoxin)
Eleuthero might increase serum digoxin levels and increase the risk of side effects.
In one case report, a 74-year-old male who was stabilized on digoxin presented with an elevated serum digoxin level after starting an eleuthero supplement, without symptoms of toxicity. After stopping the supplement, serum digoxin levels returned to normal. It is not clear whether this was due to a pharmacokinetic interaction or to interference with the digoxin assay. Although the product was found to be free of digoxin and digitoxin, it was not tested for other contaminants.
Immunosuppressants
Theoretically, eleuthero might interfere with immunosuppressive drugs because of its immunostimulant activity.
Animal and in vitro research shows that eleuthero extracts have immunomodulatory effects, including increasing cellular and humoral activity.
P-Glycoprotein Substrates
Theoretically, eleuthero might increase levels of P-glycoprotein substrates.
In vitro research suggests that eleuthero can inhibit the multi-drug transporter protein, P-glycoprotein. However, it is too soon to tell if this is clinically important. This interaction has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP2D6. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP2D6 drug metabolism.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP3A4. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP3A4 drug metabolism.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Theoretically, eleuthero might decrease levels of drugs metabolized by OATP.
In vitro research suggests that eleuthero inhibits OATP2B1, which might reduce the bioavailability of oral drugs that are substrates of OATP2B1. Due to the weak inhibitory effect identified in this study, this interaction is not likely to be clinically significant.
Brand information
Manufacturer and brand details for Wu Jia Pi, from the product label.
Wu Jia Pi by Herbal Terra: Common Questions
Does Wu Jia Pi by Herbal Terra interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Wu Jia Pi if I'm pregnant or breastfeeding?
What are the most common side effects?
Is eleuthero effective for fatigue or energy?
Can I take Wu Jia Pi long-term?
What is eleuthero, and why is it called Siberian ginseng?
Does Wu Jia Pi have any fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Wu Jia Pi is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Wu Jia Pi’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Wu Jia Pi's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 24 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Eleuthero 24 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- McRae S. Elevated serum digoxin levels in a patient taking digoxin and Siberian ginseng. CMAJ 1996;155:293-5.
- Awang DVC. Siberian ginseng toxicity may be case of mistaken identity (letter). CMAJ 1996;155:1237.
- Mills S, Bone K. Principles and Practice of Phytotherapy. London: Churchill Livingstone, 2000.
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- Hikino H, Takahashi M, Otake K, Konno C. Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots. J Nat Prod 1986;49:293-7. PubMed
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