Zendocrine Ingredients & Drug Interactions
by doTERRA
What is this page for?
First and foremost: checking Zendocrine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Zendocrine is a dietary supplement by doTERRA with 5 active ingredients. Its ingredients are commonly taken for water retention (diuretic), digestive upset and bloating, urinary tract support.Based on those ingredients, 1,265 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cilantro, Tangerine, Rosemary. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Zendocrine by doTERRA
Ask about any prescription or over-the-counter medication and we check it for interactions with Zendocrine by doTERRA — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Zendocrine by doTERRA
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
The stated purpose hasn't been mapped to our evidence data yet.
Why this rating?
- We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.
Why this rating?
- The label discloses an exact amount for 0 of its 5 active ingredients.
- “Zendocrine Detoxification Blend” is a proprietary blend — the label gives one combined amount (60 mg) without saying how much of each component you get.
The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.
Why this rating?
- 4 of the 4 matched ingredients can interact with medications — Coriander, Rosemary, Juniper, Tangerine.
- The most serious interaction on file is rated Moderate.
- Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
- For scale: 1,266 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.
Why this rating?
- We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
- Pregnancy & breastfeeding safety ratings cover 4 of 4.
- General safety write-ups exist for 4 of 4.
- Remember: this measures how much safety information exists. Thin data is not the same as being safe.
HelloPharmacist summaryFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 28, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Zendocrine, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Zendocrine by doTERRA, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Juniper | 0 NP | -- |
| Rosemary | 0 NP | -- |
| Tangerine | 0 NP | -- |
| Cilantro | 0 NP | -- |
| Zendocrine Detoxification Blend | 60 mg | -- |
| Geranium | 0 NP | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General
v7 31460001
Suggested/Recommended/Usage/Directions
For aromatic or topical use.
Diffuse aromatically or, to apply topically, dilute with a carrier oil to minimize skin sensitivity.
For internal use dilute 1 drop in 4 fl. oz. of liquid.
Precautions
Caution: Possible skin sensitivity.
Keep out of reach of children.
If pregnant or under a doctor's care, consult your physician.
Avoid contact with eyes, inner ears, and sensitive areas. Avoid UV rays for 12 hours after applying product.
Formula
Detoxification Blend
FDA Statement of Identity
Essential Oil Supplement
Brand IP Statement(s)
CPTG Certified Pure Therapeutic Grade
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Zendocrine by doTERRA label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Zendocrine by doTERRA
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Drop(s) Dosage formLiquid Servings per container250 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Zendocrine by doTERRA Drug Interactions
Zendocrine contains 5 ingredients, and 4 of them have known drug interactions. Altogether they interact with 1,265 medications. Here’s the picture, then you can look up your own drug.
Want to check YOUR meds against Zendocrine?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Zendocrine interact with 1,265 drugs. Click any drug to see the details.
4 of the 5 ingredients in Zendocrine interact with drugs. Each result below shows which ingredient is responsible. Cilantro Tangerine Rosemary Juniper
Aspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with Zendocrine — through 3 ingredients. Tap an ingredient for the detail:
CilantroCns Depressants Moderate
Interaction Summary
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Read the full Cilantro + Aspirin, Hydrocodone interactionRosemaryAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Read the full Rosemary + Aspirin, Hydrocodone interactionTangerineCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine + Aspirin, Hydrocodone interactionAspirin, MeprobamateMicrainin
How Aspirin, Meprobamate interacts with Zendocrine — through 1 ingredient. Tap an ingredient for the detail:
RosemaryAnticoagulant/antiplatelet Drugs, Aspirin Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary + Aspirin, Meprobamate interactionAspirin, MethocarbamolRobaxisal
How Aspirin, Methocarbamol interacts with Zendocrine — through 1 ingredient. Tap an ingredient for the detail:
RosemaryAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Read the full Rosemary + Aspirin, Methocarbamol interactionAspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with Zendocrine — through 2 ingredients. Tap an ingredient for the detail:
RosemaryAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary + Aspirin, Omeprazole interactionTangerineCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine + Aspirin, Omeprazole interactionAspirin, OxycodonePercodan
How Aspirin, Oxycodone interacts with Zendocrine — through 2 ingredients. Tap an ingredient for the detail:
RosemaryAnticoagulant/antiplatelet Drugs, Aspirin Moderate
Interaction Summary
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Rosemary + Aspirin, Oxycodone interactionCilantroCns Depressants Moderate
Interaction Summary
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Read the full Cilantro + Aspirin, Oxycodone interactionAspirin, PentazocineTalwin Compound
How Aspirin, Pentazocine interacts with Zendocrine — through 2 ingredients. Tap an ingredient for the detail:
RosemaryAspirin, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Read the full Rosemary + Aspirin, Pentazocine interactionCilantroCns Depressants Moderate
Interaction Summary
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Read the full Cilantro + Aspirin, Pentazocine interactionAtenololAtenix, Tenormin
How Atenolol interacts with Zendocrine — through 1 ingredient. Tap an ingredient for the detail:
CilantroAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Cilantro + Atenolol interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Zendocrine — through 2 ingredients. Tap an ingredient for the detail:
CilantroAntihypertensive Drugs, Photosensitizing Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Cilantro + Atenolol, Chlortalidone interactionJuniperDiuretic Drugs Minor
Interaction Summary
Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.
Read the full Juniper + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Zendocrine — through 2 ingredients. Tap an ingredient for the detail:
CilantroAntihypertensive Drugs, Photosensitizing Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Cilantro + Atenolol, Chlorthalidone interactionJuniperDiuretic Drugs Minor
Interaction Summary
Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.
Read the full Juniper + Atenolol, Chlorthalidone interactionAtropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, ScopolamineAtrohist Plus, Pro Tuss, Ru-tuss, Stahist
How Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interacts with Zendocrine — through 2 ingredients. Tap an ingredient for the detail:
CilantroPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Read the full Cilantro + Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interactionTangerineCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine + Atropine, Chlorpheniramine, Hyoscyamine, Phenylephrine, Phenylpropanolamine, Scopolamine interactionAtropine, Hyoscyamine, PhenobarbitalHypnaldyne
How Atropine, Hyoscyamine, Phenobarbital interacts with Zendocrine — through 1 ingredient. Tap an ingredient for the detail:
CilantroCns Depressants Moderate
Interaction Summary
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Read the full Cilantro + Atropine, Hyoscyamine, Phenobarbital interactionAtropine, Hyoscyamine, Phenobarbital, ScopolamineBarbidonna No. 2, Belladonna Phenobarbital
How Atropine, Hyoscyamine, Phenobarbital, Scopolamine interacts with Zendocrine — through 1 ingredient. Tap an ingredient for the detail:
CilantroCns Depressants Moderate
Interaction Summary
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Read the full Cilantro + Atropine, Hyoscyamine, Phenobarbital, Scopolamine interactionAtropine, Hyoscyamine, Scopolamine, PhenobarbitalBarbeloid, Donnatal #2, Donphen
How Atropine, Hyoscyamine, Scopolamine, Phenobarbital interacts with Zendocrine — through 1 ingredient. Tap an ingredient for the detail:
CilantroCns Depressants Moderate
Interaction Summary
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Read the full Cilantro + Atropine, Hyoscyamine, Scopolamine, Phenobarbital interactionAtropine, PhenobarbitalAnthrocol
How Atropine, Phenobarbital interacts with Zendocrine — through 1 ingredient. Tap an ingredient for the detail:
CilantroCns Depressants Moderate
Interaction Summary
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Read the full Cilantro + Atropine, Phenobarbital interactionAtropine, MeperidineAtropine, Meperidine
How Atropine, Meperidine interacts with Zendocrine — through 1 ingredient. Tap an ingredient for the detail:
CilantroCns Depressants Moderate
Interaction Summary
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Read the full Cilantro + Atropine, Meperidine interactionAtropine, Morphine SulfateAtropine, Morphine Sulfate
How Atropine, Morphine Sulfate interacts with Zendocrine — through 1 ingredient. Tap an ingredient for the detail:
CilantroCns Depressants Moderate
Interaction Summary
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Read the full Cilantro + Atropine, Morphine Sulfate interactionAuranofinRidaura
How Auranofin interacts with Zendocrine — through 1 ingredient. Tap an ingredient for the detail:
CilantroPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Read the full Cilantro + Auranofin interactionAzatadineOptimine
How Azatadine interacts with Zendocrine — through 1 ingredient. Tap an ingredient for the detail:
CilantroPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Read the full Cilantro + Azatadine interactionAzatadine, PseudoephedrineTrinalin
How Azatadine, Pseudoephedrine interacts with Zendocrine — through 1 ingredient. Tap an ingredient for the detail:
CilantroPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Read the full Cilantro + Azatadine, Pseudoephedrine interactionAzilsartanEdarbi
How Azilsartan interacts with Zendocrine — through 1 ingredient. Tap an ingredient for the detail:
CilantroAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Cilantro + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Zendocrine — through 2 ingredients. Tap an ingredient for the detail:
CilantroAntihypertensive Drugs, Photosensitizing Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of hypotension when taken with antihypertensive drugs.
Read the full Cilantro + Azilsartan, Chlorthalidone interactionJuniperDiuretic Drugs Minor
Interaction Summary
Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.
Read the full Juniper + Azilsartan, Chlorthalidone interactionAzithromycinAzasite, Zithromax, Zmax
How Azithromycin interacts with Zendocrine — through 1 ingredient. Tap an ingredient for the detail:
CilantroPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Read the full Cilantro + Azithromycin interactionBelladona Extract, PhenobarbitalChardonna-2
How Belladona Extract, Phenobarbital interacts with Zendocrine — through 1 ingredient. Tap an ingredient for the detail:
CilantroCns Depressants Moderate
Interaction Summary
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Read the full Cilantro + Belladona Extract, Phenobarbital interactionBelladonna Alkaloids, Chlorpheniramine, Phenylephrine, PhenylpropanolamineRespa ARM
How Belladonna Alkaloids, Chlorpheniramine, Phenylephrine, Phenylpropanolamine interacts with Zendocrine — through 2 ingredients. Tap an ingredient for the detail:
CilantroPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Read the full Cilantro + Belladonna Alkaloids, Chlorpheniramine, Phenylephrine, Phenylpropanolamine interactionTangerineCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine + Belladonna Alkaloids, Chlorpheniramine, Phenylephrine, Phenylpropanolamine interactionBelladonna Alkaloids, Ergotamine Tartrate, PhenobarbitalBel Tabs, Bellamine-S, Bellaphen-S, Duragal S, Phenarbal S, Spastrin
How Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interacts with Zendocrine — through 2 ingredients. Tap an ingredient for the detail:
CilantroCns Depressants Moderate
Interaction Summary
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Read the full Cilantro + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interactionTangerineCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interactionBelladonna Alkaloids, PhenobarbitalBarbidonna, Donnatal
How Belladonna Alkaloids, Phenobarbital interacts with Zendocrine — through 1 ingredient. Tap an ingredient for the detail:
CilantroCns Depressants Moderate
Interaction Summary
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Read the full Cilantro + Belladonna Alkaloids, Phenobarbital interactionBelladonna Extract, PhenobarbitalBelap
How Belladonna Extract, Phenobarbital interacts with Zendocrine — through 1 ingredient. Tap an ingredient for the detail:
CilantroCns Depressants Moderate
Interaction Summary
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Read the full Cilantro + Belladonna Extract, Phenobarbital interactionBelladonna, Caffeine, Ergotamine, PentobarbitalMicomp PB
How Belladonna, Caffeine, Ergotamine, Pentobarbital interacts with Zendocrine — through 3 ingredients. Tap an ingredient for the detail:
CilantroCns Depressants Moderate
Interaction Summary
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Read the full Cilantro + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionTangerineCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionRosemaryCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Rosemary + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionBelladonna, Ergotamine Tartrate, Phenobarbital
How Belladonna, Ergotamine Tartrate, Phenobarbital interacts with Zendocrine — through 2 ingredients. Tap an ingredient for the detail:
CilantroCns Depressants Moderate
Interaction Summary
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Read the full Cilantro + Belladonna, Ergotamine Tartrate, Phenobarbital interactionTangerineCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine + Belladonna, Ergotamine Tartrate, Phenobarbital interactionBelladonna, Ergotamine, PhenobarbitalBellergal-S
How Belladonna, Ergotamine, Phenobarbital interacts with Zendocrine — through 2 ingredients. Tap an ingredient for the detail:
CilantroCns Depressants Moderate
Interaction Summary
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Read the full Cilantro + Belladonna, Ergotamine, Phenobarbital interactionTangerineCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4).
Read the full Tangerine + Belladonna, Ergotamine, Phenobarbital interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Zendocrine with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Cilantro
Antidiabetes Drugs
Theoretically, coriander might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Evidence from animal research suggests that coriander fruit and coriander extract can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Antihypertensive Drugs
Theoretically, coriander might increase the risk of hypotension when taken with antihypertensive drugs.
Evidence from animal research suggests that coriander fruit can lower blood pressure.
Cns Depressants
Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.
Evidence from animal research suggests that coriander fruit extract has sedative effects.
Photosensitizing Drugs
Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Evidence from in vitro research suggests that coriandrin, a constituent of coriander, has photosensitizing effects.
Tangerine
Cytochrome P450 3A4 (Cyp3A4) Substrates
In vitro, tangeretin, a constituent of tangerine, induces a 52% increase in the metabolism of midazolam by cytochrome P450 3A4 (CYP3A4). This suggests that tangeretin may stimulate CYP3A4 activity. However, in humans, drinking tangerine juice 200 mL slightly delayed the absorption, but did not affect the metabolism, of midazolam, a CYP3A4 substrate. Theoretically, tangerine juice might increase CYP3A4 activity and decrease levels of drugs metabolized by this enzyme. However, this effect is unlikely.
Some drugs metabolized by CYP3A4 include amitriptyline (Elavil), amiodarone (Cordarone), citalopram (Celexa), felodipine (Plendil), lansoprazole (Prevacid), ondansetron (Zofran), prednisone (Deltasone, Orasone), sertraline (Zoloft), sibutramine (Meridia), and many others.
Midazolam (Versed)
In vitro, tangeretin, a constituent of tangerine, appears to increase the metabolism of midazolam in human liver microsomes by up to 52%. However, in humans, drinking tangerine juice 200 mL slightly delayed the absorption, but did not affect the metabolism, of midazolam. Theoretically, tangerine juice might increase the metabolism and reduce the effects of midazolam. However, this effect is unlikely.
Rosemary
Anticoagulant/Antiplatelet Drugs
Theoretically, rosemary may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that rosemary inhibits platelet aggregation.
Antidiabetes Drugs
Theoretically, taking rosemary with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that rosemary extract can decrease blood glucose levels in diabetic models. However, research in humans is conflicting. Although rosemary powder decreased blood glucose levels in healthy adults, no change in blood glucose levels was seen in adults with type 2 diabetes, most of whom were taking antidiabetes drugs.
Aspirin
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as aspirin.
Rosemary is reported to contain salicylates.
Choline Magnesium Trisalicylate (Trilisate)
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as choline magnesium trisalicylate.
Rosemary is reported to contain salicylate.
Salsalate (Disalcid)
Theoretically, rosemary might have additive effects with salicylate-containing drugs such as salsalate.
Rosemary is reported to contain salicylate.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, rosemary might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that rosemary induces CYP1A2 enzymes. This effect has not been reported in humans.
Juniper
Antidiabetes Drugs
Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.
Animal research shows that juniper berry can lower blood glucose.
Diuretic Drugs
Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.
Juniper berry is thought to have mild diuretic effects.
Lithium
Theoretically, juniper berry might reduce lithium excretion and increase serum levels of lithium.
Juniper berry is thought to have mild diuretic effects.
Brand information
Manufacturer and brand details for Zendocrine, from the product label.
doTERRA
See all doTERRA products- Name
- doTERRA Intl, LLC
- Street Address
- 389 South 1300 West
- City
- Pleasant Grove
- State
- UT
- ZipCode
- 84062
Zendocrine by doTERRA: Common Questions
Does Zendocrine by doTERRA interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Zendocrine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Zendocrine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Juniper
Interacts with 162 drugsJuniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid. Solid human evidence for its health benefits is limited, and it can irr...
Read the full Juniper monograph → Herb & supplement monographRosemary
Interacts with 372 drugsRosemary is a fragrant Mediterranean herb that is safe and flavorful in normal food amounts. Some early research suggests possible benefits for memory, mood, and hair growth, but the evidenc...
Read the full Rosemary monograph → Herb & supplement monographTangerine
Interacts with 643 drugsTangerine is a sweet citrus fruit that is a good source of vitamin C and other nutrients, and is widely enjoyed as food. While the peel and essential oil are used in traditional medicine and...
Read the full Tangerine monograph → Herb & supplement monographCoriander
Interacts with 717 drugsCoriander (also called cilantro) is a common cooking herb and spice that has long been used in traditional medicine for digestive complaints. As a food it is generally safe for most people,...
Read the full Coriander monograph →Sources & How We Checked
Zendocrine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 42 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Juniper 7 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
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