FDA-filed SPL labeling · retrieved through openFDA

Aluminum Acetate

Aluminum acetate is a topical astringent used across several products to temporarily relieve minor skin irritations from poison ivy, poison oak, poison sumac, insect bites, athlete's foot, and rashes from soaps, detergents, cosmetics, or jewelry.

Brand names TricalmDermeleveZO Skin Health Post Procedure ProgramZO Skin Health Post Procedure Recovery SystemDermeleve Anti Itch Scalp Serum +4 more
OTC Forms 3 Route Topical
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Aug 3, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 7 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveMay 29, 2025
Clinical labels in scope 7
AvailabilityOTC
Earliest approval/marketing year 1976
FDA-listed product records 20
Boxed warningNone found in compared labels
How we combine label and product data →
No current FDA shortage listed · checked Sep 22, 2026
Aluminum Acetate at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Aluminum acetate is a well-established topical astringent that temporarily relieves common skin irritations — from poison ivy and insect bites to athlete's foot and soap rashes. Apply it only to the skin as directed, and see a doctor if things aren't improving within a week. Keep it away from eyes and out of reach of children.

📖 Aluminum Acetate: Patient Information Guide

A plain-language walkthrough of Aluminum Acetate — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for

Aluminum acetate is a topical astringent available in several product forms that relieve minor skin irritation and itching. Supported uses across the available products include:

  • Poison ivy, poison oak, and poison sumac irritation (Tricalm Hydrogel, TriCalm, Dermeleve cream)
  • Insect bites (Tricalm Hydrogel, TriCalm, Dermeleve cream)
  • Athlete's foot (Tricalm Hydrogel, TriCalm, Dermeleve cream)
  • Rashes caused by soaps, detergents, cosmetics, or jewelry (Tricalm Hydrogel, TriCalm, Dermeleve cream, ZO Skin Health Astringent Solution, ZO Skin Health Post Procedure Program, Dermeleve Anti Itch Scalp Serum)
  • Minor burns (Dermeleve cream)
  • Scalp itch (Dermeleve Anti Itch Scalp Serum)
💊How it's taken

Aluminum acetate products are all applied to the skin — the method depends on the specific product. Gels and creams (Tricalm Hydrogel, TriCalm, Dermeleve) are applied directly to the affected area as needed for adults and children two years and older. Dermeleve Anti Itch Scalp Serum is applied directly to the scalp using the twist-open cap, as needed.

  • ZO Skin Health powder products are mixed with water first: dissolve one packet in 12 oz of cool or warm water, stir until dissolved (do not strain), then use as a compress for 15–30 minutes at a time, repeating as needed
  • Always discard the powder solution after each use — do not save it for later
  • Children under two years of age: check with a doctor before using any of these products
🤒Side effects — in detail

Aluminum acetate is generally well tolerated, but there is one local skin reaction to be aware of:

  • Overdrying of the skin, particularly if the compress or wet dressing is left on too long

If your skin condition worsens or symptoms don't improve after 7 days of use, stop and contact your doctor.

⚠️Warnings & precautions
  • External use only — never swallow or place inside the body
  • Keep away from the eyes; if contact occurs, rinse thoroughly with water right away
  • When using as a compress, do not cover with plastic wrap — this traps moisture and prevents evaporation, which can interfere with the treatment
  • Soaking too long can overdry the skin in some conditions — stick to the recommended 15–30 minutes
  • Stop use and see a doctor if symptoms worsen or do not improve within 7 days
  • Keep out of reach of children — if swallowed, get medical help or call Poison Control immediately
🔀What it interacts with

The product labels do not identify specific drug, food, or supplement interactions for aluminum acetate.

    This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

    📋Before taking it
    • Children under two years of age should not use these products without first checking with a doctor
    • Avoid applying near or in the eyes
    • Do not cover a wet compress with plastic or airtight material
    • Use caution in skin conditions where prolonged soaking might overdry the area
    🚑If you take too much

    If aluminum acetate is swallowed, get medical help or contact a Poison Control Center right away. These products are meant for skin use only.

    📄 Written from Aluminum Acetate’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

    3

    Supplements & herbs that interact with Aluminum Acetate

    3 supplements and herbal products have documented interactions with Aluminum Acetate in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

    Severity mix
    • Moderate · 2
    • Minor · 1
    Every supplement checked against Aluminum Acetate — ranked by severity The full interaction hub: 2 moderate · 1 minor · every one linked to its full report. Check Aluminum Acetate against your exact supplements

    Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

    🩺 Pharmacist Counseling Corner

    Quick, plain-English answers to the questions patients ask most about Aluminum Acetate — the kind of thing our pharmacy team would talk through with you at the counter.

    What kind of skin problems does aluminum acetate actually help with?
    It's mainly for temporary relief of common skin irritations — things like poison ivy, poison oak, insect bites, athlete's foot, and rashes from soaps, detergents, or jewelry. Dermeleve cream also covers minor burns, and the Dermeleve Anti Itch Scalp Serum is made specifically for scalp itch. It's not a cure, but it can take the edge off itching and irritation while your skin heals.
    How do I use the powder form correctly?
    For the ZO Skin Health powder products, you mix one packet into 12 ounces of cool or warm water and stir until it's fully dissolved — no straining needed. Then soak a clean, soft cloth in the solution and hold it loosely against your skin for 15 to 30 minutes. Toss the leftover solution after each use — don't save it. And one important rule: don't cover the wet cloth with plastic wrap, as that traps moisture and can cause problems.
    Can my child use aluminum acetate products?
    The gels, creams, and scalp serum are approved for use in children two years of age and older. For kids under two, you'll need to check with your doctor before using any of these products. When in doubt, a quick call to your pediatrician is always the right move.
    How long can I keep using it before I should see a doctor?
    Give it up to 7 days. If your skin condition worsens or you're not seeing any improvement by then, stop using it and talk to your doctor. These products are meant for temporary relief, so persistent or worsening symptoms deserve a closer look.
    Is it okay if a little gets in my eyes by accident?
    It's not ideal, but if it happens, rinse your eyes thoroughly with water right away. Going forward, try to keep all aluminum acetate products well away from your eye area — that's true for every form, whether it's a gel, cream, or the compress solution.
    What happens if someone accidentally swallows it?
    These products are for skin use only. If someone swallows any of them, get medical help or call Poison Control right away. Keep them stored somewhere children can't reach to prevent this from happening.
    Is Aluminum Acetate available over the counter?
    Yes — Aluminum Acetate is available over the counter (without a prescription) in at least some forms, according to its FDA labeling. Follow the package directions and ask your pharmacist if you're unsure which product is right for you.
    When was Aluminum Acetate first available?
    Aluminum Acetate has been available in the United States since at least 1976, based on FDA approval history (Drugs@FDA) and product marketing records.
    Who makes Aluminum Acetate?
    Aluminum Acetate is supplied by 4 manufacturers listed in the FDA NDC Directory, including Advanced Derm Solutions LLC, ZO Skin Health, Inc., Modular Thermal Technologies LLC Dba Life Wear Technologies.

    💬 Answers drafted from Aluminum Acetate’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

    🧰 Keep exploring

    💊 How Aluminum Acetate comes

    Aluminum Acetate is available in 3 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

    Topical cream, ointment or gel

    On the skin
    Brands Dermaleve Dermeleve Domeboro TriCalm Tricalm Hydrogel
    How this form is used
    What it may be used for
    • Tricalm Hydrogel: temporary relief of minor skin irritations from poison ivy, poison oak, poison sumac, insect bites, athlete's foot, and rashes from soaps, detergents, cosmetics, or jewelry
    • TriCalm: temporary relief of minor skin irritations from poison ivy, poison oak, poison sumac, insect bites, athlete's foot, and rashes from soaps, detergents, cosmetics, or jewelry
    • Dermeleve cream: insect bites, minor burns, athlete's foot, poison ivy, poison oak, poison sumac, and rashes from soaps, detergents, cosmetics, or jewelry
    Important instructions
    • Tricalm Hydrogel, TriCalm, and Dermeleve cream: for adults and children two years of age and older, apply to the affected area as needed or as directed by a doctor
    • Consult a doctor before use in children under two years of age
    • For external use only — avoid contact with eyes
    Available strengths 3 strengths
    10 FDA-listed product records

    Topical powder

    On the skin
    Brands ZO Skin Health Astringent Solution
    How this form is used
    What it may be used for
    • ZO Skin Health Astringent Solution: temporary relief of minor skin irritations from rashes caused by soaps, detergents, cosmetics, or jewelry
    • ZO Skin Health Post Procedure Program: temporary relief of minor skin irritations from rashes caused by soaps, detergents, cosmetics, or jewelry
    Important instructions
    • ZO Skin Health Astringent Solution and ZO Skin Health Post Procedure Program: dissolve one packet in 12 oz of cool or warm water and stir until fully dissolved — do not strain or filter
    • Soak a clean, soft cloth in the solution and apply loosely to the affected area for 15 to 30 minutes; repeat as needed or as directed by a doctor
    • Discard the solution after each use — do not reuse
    • Do not cover the compress or wet dressing with plastic to prevent evaporation; avoid soaking too long as this may overdry some skin conditions
    Available strengths 1 strength
    2 FDA-listed product records

    Topical solution

    On the skin
    Brands Dermeleve Anti Itch Scalp Serum
    How this form is used
    What it may be used for
    • Dermeleve Anti Itch Scalp Serum: scalp itch and rashes caused by soaps, detergents, or cosmetics
    Important instructions
    • Dermeleve Anti Itch Scalp Serum: for adults and children two years of age and older, twist the flow-control cap to open and apply directly to the scalp, rubbing in if needed
    • Dermeleve Anti Itch Scalp Serum: use as needed or as directed by a doctor
    • Consult a doctor before use in children under two years of age
    Available strengths 1 strength
    2 FDA-listed product records

    📊 Aluminum Acetate across the U.S. market

    How Aluminum Acetate appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

    3
    Dose forms
    4
    Manufacturers
    8
    Brand names
    20
    FDA-listed product records
    1976
    First marketed

    FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

    Also listed with the FDA, not a patient dose form: Kit (6) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

    Advanced Derm Solutions LLC45%
    ZO Skin Health, Inc.40%
    Modular Thermal Technologies LLC Dba Life Wear Technologies10%
    Advantice Health, LLC.5%

    Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

    🔍 Compare Aluminum Acetate products

    A representative set of FDA-listed product records for Aluminum Acetate — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

    Strength Route Manufacturer / Labeler Category Details
    💊Topical cream, ointment or gel
    0.2 g/100 g Topical Advanced Derm Solutions LLC × 4 listings OTC MONOGRAPH DRUG View NDC →
    0.2 g/100 g Topical Advanced Derm Solutions LLC OTC MONOGRAPH NOT FINAL Find on DailyMed
    0.2 g/100 g Topical Advanced Derm Solutions LLC × 2 listings OTC MONOGRAPH FINAL View NDC →
    0.5 g/100 g Topical Advantice Health, LLC. OTC MONOGRAPH FINAL View NDC →
    2 mg/mL Topical Modular Thermal Technologies LLC Dba Life Wear Technologies OTC MONOGRAPH FINAL View NDC →
    0.2 g/100 g Topical Modular Thermal Technologies Llc Dba Life Wear Technologies OTC MONOGRAPH DRUG View NDC →
    💊Topical powder
    4866 mg/6 g Topical ZO Skin Health, Inc. OTC MONOGRAPH DRUG View NDC →
    4866 mg/6 g Topical ZO Skin Health, Inc. OTC MONOGRAPH FINAL View NDC →
    💊Topical solution
    0.2 g/100 mL Topical Advanced Derm Solutions LLC × 2 listings OTC MONOGRAPH DRUG View NDC →
    💊Kits
    ZO Skin Health, Inc. × 4 listings OTC MONOGRAPH DRUG View NDC →
    ZO Skin Health, Inc. × 2 listings OTC MONOGRAPH FINAL View NDC →

    Showing 20 of 20 products — FDA National Drug Code Directory. See every product, package size and price: browse all 20 Aluminum Acetate NDCs →

    RxNorm Concept Web — From Ingredient to Every Form and Strength

    This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

    Ingredient (IN) Aluminum Acetate RxCUI 17609 5 dose forms · 6 strengths
    1. Dose form (SCDF) Otic Solution RxCUI 377435 No current FDA listing
      Clinical drug / strength (SCD) 80 MG/ML RxCUI 106076 130 MG/ML RxCUI 106075
    2. Dose form (SCDF) Topical Cream RxCUI 2531531 In current FDA listings
      Clinical drug / strength (SCD) 2 MG/ML RxCUI 2531532
    3. Dose form (SCDF) Topical Gel RxCUI 1594641 In current FDA listings
      Clinical drug / strength (SCD) 0.002 MG/MG RxCUI 1594642
    4. Dose form (SCDF) Topical Lotion RxCUI 379450 In current FDA listings
      Clinical drug / strength (SCD) 6.5 MG/ML RxCUI 106400
    5. Dose form (SCDF) Topical Solution RxCUI 1361769 In current FDA listings
      Clinical drug / strength (SCD) 2 MG/ML RxCUI 2638676

    Look up RxCUI 17609 in the RxCUI Atlas →

    RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

    🏷️ Sold under these brand names

    Tricalm Dermeleve ZO Skin Health Post Procedure Program ZO Skin Health Post Procedure Recovery System Dermeleve Anti Itch Scalp Serum TriCalm Hydrogel ZO Skin Health Astringent Solution Dermaleve Domeboro

    🏭 Manufacturers & labelers

    Advanced Derm Solutions LLC 9 ZO Skin Health, Inc. 8 Modular Thermal Technologies LLC Dba Life Wear Technologies 2 Advantice Health, LLC. 1

    🔬 Where this comes from

    Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

    📄
    FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective May 29, 2025
    🏭
    Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Aluminum Acetate.
    📈
    Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
    🚨
    Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
    🧾 Clinical label set — FDA-filed SPL labels retained for Aluminum Acetate after exact ingredient or ingredient-combination matching and applicable route/form matching
    Clinical labels in scope
    7
    NDC products indexed
    20
    Distinct labelers/manufacturers represented
    4
    Linked representative label
    Advanced Derm Solutions LLC
    Linked label effective
    May 29, 2025
    Composite sections available
    7
    Linked SPL Set ID
    bc58b347-a3cb-4b36-8041-62d948438a81
    Linked SPL Document ID
    364c6f8f-dca5-cf27-e063-6294a90a99e6
    Open the linked representative label on DailyMed ↗

    How we combine label and product data

    HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 7 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

    For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Advanced Derm Solutions LLC is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

    This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.