Chlorpheniramine / Ibuprofen / Phenylephrine
Chlorpheniramine, ibuprofen, and phenylephrine is a triple-ingredient combination used to temporarily relieve cold, flu, and allergy symptoms including nasal congestion, runny nose, headache, fever, and body aches.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 4 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
📖 Chlorpheniramine / Ibuprofen / Phenylephrine: Patient Information Guide
A plain-language walkthrough of Chlorpheniramine / Ibuprofen / Phenylephrine — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.
🎯What it's used for▾
This combination ingredient page covers three products that treat overlapping but slightly different sets of symptoms.
- Advil Allergy and Congestion Relief and Advil Allergy Congestion Relief temporarily relieve symptoms of hay fever or other upper respiratory allergies, as well as the common cold: runny nose, itchy and watery eyes, itching of the nose or throat, sneezing, nasal congestion, sinus pressure, headache, minor body aches and pains, and fever.
- Advil Multi-Symptom Cold and Flu temporarily relieves symptoms of the common cold or flu: headache, fever, minor body aches and pains, nasal congestion, runny nose, sinus pressure, and sneezing.
- All three products reduce swelling of the nasal passages and temporarily restore freer breathing through the nose.
💊How it's taken▾
All three products come as oral tablets for adults and children 12 years of age and older. Take one tablet every 4 hours while symptoms persist, and do not exceed 6 tablets in a 24-hour period unless your doctor tells you otherwise. Children under 12 should not use any of these products.
- If the tablet causes stomach upset, take it with food or milk.
- Do not take more than directed — using more or for longer increases the risk of serious side effects.
🤒Side effects — in detail▾
Like any medication, this combination can cause side effects. Common ones include:
- Drowsiness
- Dizziness
- Nervousness or excitability (especially in children)
- Sleeplessness
- Stomach upset
Serious reactions — including signs of stomach bleeding, severe allergic reaction, or heart and stroke symptoms — require you to stop the medication immediately and seek medical help. See the warnings section for details on what to watch for.
⚠️Warnings & precautions▾
Stomach bleeding warning: Ibuprofen is an NSAID and can cause severe stomach bleeding. Your risk is higher if you are 60 or older, have a history of stomach ulcers or bleeding, take blood thinners or steroids, take other NSAIDs, drink 3 or more alcoholic beverages daily, or use more than directed.
Heart attack and stroke warning: NSAIDs (other than aspirin) increase the risk of heart attack, heart failure, and stroke — and these can be fatal. This risk is higher when the product is used in greater amounts or for longer than directed. Additionally, ibuprofen can cause a severe allergic reaction, particularly in people sensitive to aspirin; signs include hives, facial swelling, wheezing, blisters, or shock. Stop use and get emergency help if this happens.
🔀What it interacts with▾
This combination interacts with several medications and substances. Check with your pharmacist or doctor before combining it with:
- MAOIs (monoamine oxidase inhibitors — drugs for depression, Parkinson's disease, or certain psychiatric conditions): dangerous interaction; do not use together or within 2 weeks of stopping an MAOI.
- Aspirin for heart or stroke prevention: ibuprofen may reduce the protective effect of aspirin.
- Other NSAIDs (aspirin, naproxen, and others): raises the risk of serious stomach bleeding.
- Blood thinners (anticoagulants) or corticosteroids: significantly increases bleeding risk.
- Diuretics (water pills): ask a doctor before combining.
- Sedatives or tranquilizers: can intensify drowsiness.
- Other products with phenylephrine, chlorpheniramine, or any decongestant or antihistamine: risk of doubling up on ingredients.
- Alcohol: raises stomach bleeding risk and adds to drowsiness.
This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.
📋Before taking it▾
- Children under 12: do not use any of these products — the dose is too high for this age group.
- Pregnancy: ask a health professional before use; do not use ibuprofen at 20 weeks or later in pregnancy unless a doctor specifically directs it, as it may harm the unborn child or cause complications during delivery.
- Breastfeeding: ask a health professional before use.
- Allergic to aspirin or any pain reliever/fever reducer: do not use.
- Before or after heart surgery: do not use.
- Age 60 or older: at higher risk for serious stomach bleeding.
- History of stomach ulcers, bleeding problems, or heartburn: talk to your doctor first.
- High blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, thyroid disease, diabetes, glaucoma, or past stroke: ask your doctor before using.
- Enlarged prostate causing trouble urinating, or breathing problems such as emphysema or chronic bronchitis: ask your doctor first.
- Taking any other medication: ask a doctor or pharmacist — this combination has several important drug interactions.
🚑If you take too much▾
In case of overdose, get medical help or contact a Poison Control Center right away. Keep these products out of reach of children.
📦How to store it▾
store at 20-25°C (68-77°F) • avoid excessive heat above 40°C (104°F)
📄 Written from Chlorpheniramine / Ibuprofen / Phenylephrine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →
🩺 Pharmacist Counseling Corner
Quick, plain-English answers to the questions patients ask most about Chlorpheniramine / Ibuprofen / Phenylephrine — the kind of thing our pharmacy team would talk through with you at the counter.
What's the difference between Advil Allergy and Congestion Relief and Advil Multi-Symptom Cold and Flu? ▾
Can I give this to my child? ▾
I'm worried about stomach problems. What should I watch for? ▾
I take a daily aspirin for my heart. Is it okay to use this? ▾
I'm pregnant. Can I use this? ▾
This makes me really drowsy. Is that normal, and is it safe to drive? ▾
Is Chlorpheniramine / Ibuprofen / Phenylephrine available over the counter? ▾
When was Chlorpheniramine / Ibuprofen / Phenylephrine first available? ▾
Who makes Chlorpheniramine / Ibuprofen / Phenylephrine? ▾
💬 Answers drafted from Chlorpheniramine / Ibuprofen / Phenylephrine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →
🧰 Keep exploring
💊 How Chlorpheniramine / Ibuprofen / Phenylephrine comes
Chlorpheniramine / Ibuprofen / Phenylephrine is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Tablet
How this form is used
- Advil Allergy and Congestion Relief and Advil Allergy Congestion Relief: temporarily relieves symptoms of hay fever or other upper respiratory allergies and the common cold, including runny nose, itchy watery eyes, sneezing, nasal congestion, sinus pressure, headache, minor body aches, and fever
- Advil Multi-Symptom Cold and Flu: temporarily relieves symptoms of the common cold or flu, including headache, fever, minor body aches, nasal congestion, runny nose, sinus pressure, and sneezing
- All three products help reduce swelling of the nasal passages and temporarily restore freer breathing through the nose
- Adults and children 12 and older: take 1 tablet every 4 hours while symptoms persist; do not take more than 6 tablets in any 24-hour period unless directed by a doctor
- Children under 12: do not use — Advil Allergy and Congestion Relief, Advil Allergy Congestion Relief, and Advil Multi-Symptom Cold and Flu all contain too much medication for children under this age
- Take with food or milk if stomach upset occurs
- Do not take more than directed
📊 Chlorpheniramine / Ibuprofen / Phenylephrine across the U.S. market
How Chlorpheniramine / Ibuprofen / Phenylephrine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
🔍 Compare Chlorpheniramine / Ibuprofen / Phenylephrine products
A representative set of FDA-listed product records for Chlorpheniramine / Ibuprofen / Phenylephrine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Tablet | ||||
| 4; 200; 10 mg/1; mg/1; mg | Oral | GlaxoSmithKline Consumer Healthcare Holdings (US) LLC × 6 listings | NDA | View NDC → |
| CHLORPHENIRAMINE MALEATE 4 mg/1; IBUPROFEN 200 mg/1; PHENYLEPHRINE HYDROCHLORIDE 10 mg | Oral | Haleon US Holdings LLC × 3 listings | NDA | View NDC → |
| CHLORPHENIRAMINE MALEATE 4 mg/1; IBUPROFEN 200 mg/1; PHENYLEPHRINE HYDROCHLORIDE 10 mg | — | Haleon US Holdings LLC × 2 listings | DRUG FOR FURTHER PROCESSING | View NDC → |
| CHLORPHENIRAMINE MALEATE 4 mg/1; IBUPROFEN 200 mg/1; PHENYLEPHRINE HYDROCHLORIDE 10 mg | Oral | Navajo Manufacturing Company Inc. | NDA | View NDC → |
| 4; 200; 10 mg/1; mg/1; mg | Oral | Navajo Manufacturing Company Inc. | NDA | View NDC → |
| 4; 200; 10 mg/1; mg/1; mg | Oral | Select Corporation | OTC MONOGRAPH NOT FINAL | View NDC → |
Showing 14 of 14 products — FDA National Drug Code Directory. See every product, package size and price: browse all 14 Chlorpheniramine / Ibuprofen / Phenylephrine NDCs →
📈 What people report — real-world data (FDA FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Chlorpheniramine / Ibuprofen / Phenylephrine — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Chlorpheniramine / Ibuprofen / Phenylephrine in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
🏛️ The road to your pharmacy
How Chlorpheniramine / Ibuprofen / Phenylephrine went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
🚨 Recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
Source: openFDA drug enforcement (recall) reports.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one exact multiple-ingredient concept (MIN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). A product with a different ingredient combination belongs on a different page.
RxCUI 1310502 1 dose form · 1 strength
-
Dose form (SCDF) Oral Tablet RxCUI 1310501In current FDA listingsClinical drug / strength (SCD) chlorpheniramine maleate 4 MG / ibuprofen 200 MG / phenylephrine hydrochloride 10 MGRxCUI 1310503
Look up RxCUI 1310502 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
📦 Supply & shortage status
Whether Chlorpheniramine / Ibuprofen / Phenylephrine is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
🏷️ Sold under these brand names
🏭 Manufacturers & labelers
RxNorm drug class
Chlorpheniramine / Ibuprofen / Phenylephrine belongs to the Histamine-1 Receptor Antagonist class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
🔬 Where this comes from
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How we combine label and product data
HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 4 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.
For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. GlaxoSmithKline Consumer Healthcare Holdings (US) LLC is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.
This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.