Dacomitinib

Generic name: Pronounced as (dak" oh mi' ti nib)
Brand names
  • Vizimpro®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 11/15/2018

Dacomitinib is used to treat a certain type of non-small-cell lung cancer (NSCLC) that has spread to other parts of the body. Dacomitinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells.

Dacomitinib comes as a tablet to take by mouth. It is usually taken once daily with or without food. Take dacomitinib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take dacomitinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you vomit after you take dacomitinib, do not immediately take another dose. Continue your regular dosing schedule.

Your doctor may temporarily or permanently stop your treatment or decrease your dose if you experience certain side effects of dacomitinib. Tell your doctor how you are feeling during your treatment. Continue to take dacomitinib even if you feel well. Do not stop taking dacomitinib without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking dacomitinib,

  • tell your doctor and pharmacist if you are allergic to dacomitinib, any other medications, or any of the ingredients in dacomitinib tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antidepressants such as amitriptyline, clomipramine (Anafranil), desipramine (Norpramin), duloxetine (Cymbalta), fluoxetine (Prozac), imipramine (Tofranil), paroxetine (Paxil, Pexeva), and venlafaxine (Effexor); antipsychotics such as aripiprazole (Abilify), haloperidol (Haldol), risperidone (Risperdal), and thioridazine; atomoxetine (Strattera); beta blockers such as carvedilol (Coreg), metoprolol (Dutoprol), and timolol; codeine; dextromethorphan (found in many cough medications; in Nuedexta); flecainide (Tambocar); mexiletine; ondansetron (Zofran, Zuplenz); oxycodone (Oxaydo, Xtampza ER); propafenone (Rythmol SR); proton-pump inhibitors such as dexlanspoprazole (Dexilant), esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (AcipHex); tamoxifen (Soltamox); and tramadol (Conzip, Ultram). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • if you are taking a medication for indigestion, heartburn, or ulcers such as cimetidine (Tagamet), famotidine (Pepcid, in Duexis), nizatidine (Axid), or ranitidine (Zantac), take dacomitinib at least 6 hours before or at least 10 hours after taking one of these medications.

  • tell your doctor if you have frequent diarrhea episodes, lung disease, breathing problems other than lung cancer, or liver or kidney disease.

  • tell your doctor if you are pregnant or plan to become pregnant. You must take a pregnancy test before starting treatment. You should not become pregnant while you are taking dacomitinib. You should use a reliable method of birth control while taking dacomitinib and for at least 17 days after your final dose. If you become pregnant while taking dacomitinib, call your doctor immediately. Dacomitinib may harm the fetus.

  • tell your doctor if you are breastfeeding. You should not breastfeed while you are taking dacomitinib and for 17 days after your final dose.

  • plan to use a moisturizer, avoid unnecessary or prolonged exposure to sunlight, and to wear protective clothing, sunglasses, and sunscreen. Dacomitinib may make your skin sensitive to sunlight.

Unless your doctor tells you otherwise, continue your normal diet.

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Dacomitinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • weight loss

    • loss of appetite

    • mouth sores

    • infection of the skin around the fingernails or toenails

    • hair loss

    • cough

    • lack of energy

    • difficulty falling asleep or staying asleep

    • red or swollen eyes ("pink eye")

    • taste changes

    • vomiting

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

    • diarrhea

    • shortness of breath, cough, and fever

    • dry skin, redness, rash, acne, itchy skin, and peeling or blistering of your skin

    • chest pain

  • Dacomitinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order a lab test before you begin your treatment to see whether your cancer can be treated with dacomitinib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Penbutolol Penbutolol The metabolism of Acebutolol can be decreased when combined with Dacomitinib.
Triamcinolone Triamcinolone The metabolism of Dacomitinib can be increased when combined with Triamcinolone.
Zidovudine Injection Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Dacomitinib.
Trimipramine Trimipramine The metabolism of Dacomitinib can be decreased when combined with Trimipramine.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Dacomitinib.
Tegaserod Tegaserod The metabolism of Tegaserod can be decreased when combined with Dacomitinib.
Infliximab Injection Infliximab Injection The metabolism of Dacomitinib can be increased when combined with Infliximab.
Voriconazole Voriconazole The metabolism of Dacomitinib can be decreased when combined with Voriconazole.
Darifenacin Darifenacin The metabolism of Darifenacin can be decreased when combined with Dacomitinib.
Tipranavir Tipranavir The metabolism of Tipranavir can be decreased when combined with Dacomitinib.
Dronabinol Dronabinol The metabolism of Dacomitinib can be decreased when combined with Dronabinol.
Budesonide Budesonide The metabolism of Dacomitinib can be increased when combined with Budesonide.
Tretinoin Tretinoin The metabolism of Dacomitinib can be decreased when combined with Tretinoin.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Dacomitinib.
Betaxolol Betaxolol The metabolism of Betaxolol can be decreased when combined with Dacomitinib.
Everolimus Everolimus The serum concentration of Everolimus can be increased when it is combined with Dacomitinib.
Acetaminophen Injection Acetaminophen Injection The metabolism of Acetaminophen can be increased when combined with Dacomitinib.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Dacomitinib.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Dacomitinib.
Roflumilast Roflumilast The metabolism of Dacomitinib can be decreased when combined with Roflumilast.
Linagliptin Linagliptin The serum concentration of Dacomitinib can be increased when it is combined with Linagliptin.
Rilpivirine Rilpivirine The metabolism of Dacomitinib can be decreased when combined with Rilpivirine.
Telaprevir Telaprevir The serum concentration of Glecaprevir can be increased when it is combined with Dacomitinib.
Abiraterone Abiraterone The metabolism of Dacomitinib can be decreased when combined with Abiraterone.
Rivaroxaban Rivaroxaban Dacomitinib may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ticagrelor Ticagrelor The serum concentration of Dacomitinib can be increased when it is combined with Ticagrelor.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Dacomitinib.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Dacomitinib.
Vandetanib Vandetanib The serum concentration of Dacomitinib can be increased when it is combined with Vandetanib.
Vemurafenib Vemurafenib The serum concentration of Dacomitinib can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Dacomitinib can be decreased when combined with Vismodegib.
Ivacaftor Ivacaftor The serum concentration of Dacomitinib can be increased when it is combined with Ivacaftor.
Axitinib Axitinib The serum concentration of Axitinib can be increased when it is combined with Dacomitinib.
Crizotinib Crizotinib The metabolism of Dacomitinib can be decreased when combined with Crizotinib.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Dacomitinib.
Enzalutamide Enzalutamide The serum concentration of Dacomitinib can be increased when it is combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Dacomitinib.
Regorafenib Regorafenib The serum concentration of Dacomitinib can be increased when it is combined with Regorafenib.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Dacomitinib.
Teriflunomide Teriflunomide Teriflunomide may decrease the excretion rate of Dacomitinib which could result in a higher serum level.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Dacomitinib can be decreased when combined with Cabozantinib.
Alogliptin Alogliptin The metabolism of Alogliptin can be decreased when combined with Dacomitinib.
Ponatinib Ponatinib The serum concentration of Ponatinib can be increased when it is combined with Dacomitinib.
Pomalidomide Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Dacomitinib.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Dacomitinib.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Dacomitinib.
Canagliflozin Canagliflozin The serum concentration of Dacomitinib can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The serum concentration of Dacomitinib can be increased when it is combined with Dabrafenib.
Ospemifene Ospemifene The metabolism of Dacomitinib can be decreased when combined with Ospemifene.
Trametinib Trametinib The metabolism of Dacomitinib can be increased when combined with Trametinib.
Dolutegravir Dolutegravir The metabolism of Dolutegravir can be decreased when combined with Dacomitinib.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Dacomitinib.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Dacomitinib.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Dacomitinib.
Perampanel Perampanel The metabolism of Dacomitinib can be increased when combined with Perampanel.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Dacomitinib.
Lomitapide Lomitapide The serum concentration of Dacomitinib can be increased when it is combined with Lomitapide.
Simeprevir Simeprevir The serum concentration of Dacomitinib can be increased when it is combined with Simeprevir.
Sofosbuvir Sofosbuvir Dacomitinib may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Dacomitinib.
Apremilast Apremilast The metabolism of Dacomitinib can be increased when combined with Apremilast.
Ceritinib Ceritinib The serum concentration of Ceritinib can be increased when it is combined with Dacomitinib.
Siltuximab Injection Siltuximab Injection The metabolism of Dacomitinib can be increased when combined with Siltuximab.
Eslicarbazepine Eslicarbazepine The metabolism of Eslicarbazepine can be increased when combined with Dacomitinib.
Belinostat Injection Belinostat Injection The metabolism of Belinostat can be decreased when combined with Dacomitinib.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Dacomitinib.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be increased when combined with Dacomitinib.
Oritavancin Injection Oritavancin Injection The metabolism of Dacomitinib can be increased when combined with Oritavancin.
Vorapaxar Vorapaxar The serum concentration of Dacomitinib can be increased when it is combined with Vorapaxar.
Suvorexant Suvorexant The serum concentration of Dacomitinib can be increased when it is combined with Suvorexant.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Dacomitinib.
Olaparib Olaparib The metabolism of Dacomitinib can be decreased when combined with Olaparib.
Tasimelteon Tasimelteon The metabolism of Dacomitinib can be decreased when combined with Tasimelteon.
Riociguat Riociguat Dacomitinib may decrease the excretion rate of Riociguat which could result in a higher serum level.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Dacomitinib.
Secukinumab Injection Secukinumab Injection The metabolism of Dacomitinib can be increased when combined with Secukinumab.
Palbociclib Palbociclib The serum concentration of Dacomitinib can be increased when it is combined with Palbociclib.
Lenvatinib Lenvatinib The metabolism of Lenvatinib can be increased when combined with Dacomitinib.
Naloxegol Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Dacomitinib.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Dacomitinib.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Dacomitinib can be increased when it is combined with Isavuconazonium.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Dacomitinib.
Flibanserin Flibanserin The serum concentration of Dacomitinib can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The metabolism of Dacomitinib can be decreased when combined with Rolapitant.
Daclatasvir Daclatasvir The serum concentration of Dacomitinib can be increased when it is combined with Daclatasvir.
Brexpiprazole Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Dacomitinib.
Ziprasidone Injection Ziprasidone Injection The metabolism of Dacomitinib can be decreased when combined with Ziprasidone.
Cariprazine Cariprazine The metabolism of Cariprazine can be decreased when combined with Dacomitinib.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Dacomitinib.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Dacomitinib.
Osimertinib Osimertinib The metabolism of Osimertinib can be increased when combined with Dacomitinib.
Alectinib Alectinib The metabolism of Dacomitinib can be decreased when combined with Alectinib.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Dacomitinib.
Lesinurad Lesinurad The metabolism of Dacomitinib can be increased when combined with Lesinurad.
Brivaracetam Injection Brivaracetam Injection The metabolism of Dacomitinib can be decreased when combined with Brivaracetam.
Venetoclax Venetoclax The serum concentration of Dacomitinib can be increased when it is combined with Venetoclax.
Cobicistat Cobicistat The serum concentration of Dacomitinib can be increased when it is combined with Cobicistat.
Selexipag Selexipag The serum concentration of Selexipag can be increased when it is combined with Dacomitinib.
Rucaparib Rucaparib The metabolism of Rucaparib can be decreased when combined with Dacomitinib.
Ribociclib Ribociclib The metabolism of Dacomitinib can be decreased when combined with Ribociclib.
Parathyroid Hormone Injection Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Dacomitinib.
Brigatinib Brigatinib The metabolism of Brigatinib can be increased when combined with Dacomitinib.
Deutetrabenazine Deutetrabenazine The serum concentration of the active metabolites of Deutetrabenazine can be increased when Deutetrabenazine is used in combination with Dacomitinib.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Dacomitinib.
Safinamide Safinamide The metabolism of Dacomitinib can be decreased when combined with Safinamide.
Sarilumab Injection Sarilumab Injection The metabolism of Dacomitinib can be increased when combined with Sarilumab.
Midostaurin Midostaurin The metabolism of Dacomitinib can be increased when combined with Midostaurin.
Neratinib Neratinib The serum concentration of Dacomitinib can be increased when it is combined with Neratinib.
Abaloparatide Injection Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Dacomitinib.
Enasidenib Enasidenib The metabolism of Enasidenib can be decreased when combined with Dacomitinib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Dacomitinib.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Dacomitinib can be increased when combined with Fosaprepitant.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Dacomitinib.
Delafloxacin Delafloxacin The metabolism of Delafloxacin can be increased when combined with Dacomitinib.
Abemaciclib Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Dacomitinib.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Dacomitinib.
Acalabrutinib Acalabrutinib The metabolism of Dacomitinib can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Letermovir can be decreased when combined with Dacomitinib.
Tetrabenazine Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Dacomitinib.
Ertugliflozin Ertugliflozin Dacomitinib may decrease the excretion rate of Ertugliflozin which could result in a higher serum level.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Dacomitinib.
Apalutamide Apalutamide The serum concentration of Dacomitinib can be decreased when it is combined with Apalutamide.
Fostamatinib Fostamatinib The metabolism of Dacomitinib can be decreased when combined with Fostamatinib.
Avatrombopag Avatrombopag The metabolism of Dacomitinib can be increased when combined with Avatrombopag.
Baricitinib Baricitinib The metabolism of Dacomitinib can be decreased when combined with Baricitinib.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Dacomitinib.
Encorafenib Encorafenib The metabolism of Dacomitinib can be decreased when combined with Encorafenib.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Dacomitinib.
Ivosidenib Ivosidenib The serum concentration of Ivosidenib can be increased when it is combined with Dacomitinib.
Lusutrombopag Lusutrombopag Dacomitinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Dacomitinib.
Tafenoquine Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Dacomitinib.
Cannabidiol Cannabidiol The metabolism of Dacomitinib can be decreased when combined with Cannabidiol.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Dacomitinib.
Stiripentol Stiripentol The metabolism of Dacomitinib can be decreased when combined with Stiripentol.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Dacomitinib can be decreased when combined with Drospirenone.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Dacomitinib.
Trazodone Trazodone The serum concentration of Trazodone can be decreased when it is combined with Dacomitinib.
Bromocriptine Bromocriptine The metabolism of Dacomitinib can be decreased when combined with Bromocriptine.
Tranylcypromine Tranylcypromine The metabolism of Dacomitinib can be decreased when combined with Tranylcypromine.
Tetracycline Tetracycline The metabolism of Dacomitinib can be decreased when combined with Tetracycline.
Thioridazine Thioridazine The metabolism of Dacomitinib can be decreased when combined with Thioridazine.
Sulfadiazine Sulfadiazine The metabolism of Dacomitinib can be decreased when combined with Sulfadiazine.
Benztropine Benztropine The metabolism of Benzatropine can be decreased when combined with Dacomitinib.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be increased when combined with Dacomitinib.
Warfarin Warfarin The metabolism of Warfarin can be increased when combined with Dacomitinib.
Calcitriol Calcitriol The metabolism of Dacomitinib can be increased when combined with Calcitriol.
Sulfinpyrazone Sulfinpyrazone The metabolism of Dacomitinib can be increased when combined with Sulfinpyrazone.
Valproic Acid Valproic Acid The metabolism of Valproic acid can be decreased when combined with Dacomitinib.
Tamoxifen Tamoxifen The serum concentration of Tamoxifen can be increased when it is combined with Dacomitinib.
Levothyroxine Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Dacomitinib.
Liothyronine Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Dacomitinib.
Tolbutamide Tolbutamide The metabolism of Dacomitinib can be decreased when combined with Tolbutamide.
Tolazamide Tolazamide The metabolism of Dacomitinib can be decreased when combined with Tolazamide.
Acetazolamide Acetazolamide The metabolism of Dacomitinib can be decreased when combined with Acetazolamide.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Dacomitinib.
Vincristine Injection Vincristine Injection The excretion of Vincristine can be decreased when combined with Dacomitinib.
Vinblastine Vinblastine The serum concentration of Dacomitinib can be increased when it is combined with Vinblastine.
Aspirin Aspirin The metabolism of Dacomitinib can be decreased when combined with Acetylsalicylic acid.
Trimethoprim Trimethoprim The metabolism of Dacomitinib can be decreased when combined with Trimethoprim.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Dacomitinib.
Verapamil Verapamil The serum concentration of Dacomitinib can be increased when it is combined with Verapamil.
Atenolol Atenolol The metabolism of Atenolol can be decreased when combined with Dacomitinib.
Buspirone Buspirone The metabolism of Buspirone can be decreased when combined with Dacomitinib.
Epoetin Alfa, Injection Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Dacomitinib.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be decreased when combined with Dacomitinib.
Bisoprolol Bisoprolol The serum concentration of Dacomitinib can be increased when it is combined with Bisoprolol.
Tramadol Tramadol The metabolism of Tramadol can be decreased when combined with Dacomitinib.
Lansoprazole Lansoprazole Lansoprazole can cause a decrease in the absorption of Dacomitinib resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Dacomitinib.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Dacomitinib.
Zafirlukast Zafirlukast The metabolism of Dacomitinib can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The metabolism of Mirtazapine can be decreased when combined with Dacomitinib.
Donepezil Donepezil The metabolism of Donepezil can be decreased when combined with Dacomitinib.
Nelfinavir Nelfinavir The metabolism of Dacomitinib can be decreased when combined with Nelfinavir.
Azithromycin Azithromycin The metabolism of Dacomitinib can be decreased when combined with Azithromycin.
Carvedilol Carvedilol The serum concentration of Carvedilol can be increased when it is combined with Dacomitinib.
Capecitabine Capecitabine The metabolism of Dacomitinib can be decreased when combined with Capecitabine.
Efavirenz Efavirenz The metabolism of Dacomitinib can be increased when combined with Efavirenz.
Abacavir Abacavir The metabolism of Abacavir can be decreased when combined with Dacomitinib.
Sildenafil Sildenafil The serum concentration of Sildenafil can be increased when it is combined with Dacomitinib.
Celecoxib Celecoxib The metabolism of Celecoxib can be decreased when combined with Dacomitinib.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Dacomitinib.
Thalidomide Thalidomide The metabolism of Dacomitinib can be decreased when combined with Thalidomide.
Rabeprazole Rabeprazole Rabeprazole can cause a decrease in the absorption of Dacomitinib resulting in a reduced serum concentration and potentially a decrease in efficacy.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists