Dacomitinib
Generic name: Pronounced as (dak" oh mi' ti nib)
Medical Content Reviewed By HelloPharmacist Staff
Last Revised - 11/15/2018
On this page
- Why is this medication prescribed?
- How should this medicine be used?
- Other uses for this medicine
- What special precautions should I follow?
- What special dietary instructions should I follow?
- What should I do if I forget a dose?
- What side effects can this medication cause?
- What should I know about STORAGE and DISPOSAL of this medication?
- What should I do in case of OVERDOSE?
- What OTHER INFORMATION should I know?
- Drug interactions
Why is this medication prescribed?
Dacomitinib is used to treat a certain type of non-small-cell lung cancer (NSCLC) that has spread to other parts of the body. Dacomitinib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells.
How should this medicine be used?
Dacomitinib comes as a tablet to take by mouth. It is usually taken once daily with or without food. Take dacomitinib at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take dacomitinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
If you vomit after you take dacomitinib, do not immediately take another dose. Continue your regular dosing schedule.
Your doctor may temporarily or permanently stop your treatment or decrease your dose if you experience certain side effects of dacomitinib. Tell your doctor how you are feeling during your treatment. Continue to take dacomitinib even if you feel well. Do not stop taking dacomitinib without talking to your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking dacomitinib,
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tell your doctor and pharmacist if you are allergic to dacomitinib, any other medications, or any of the ingredients in dacomitinib tablets. Ask your pharmacist for a list of the ingredients.
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tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antidepressants such as amitriptyline, clomipramine (Anafranil), desipramine (Norpramin), duloxetine (Cymbalta), fluoxetine (Prozac), imipramine (Tofranil), paroxetine (Paxil, Pexeva), and venlafaxine (Effexor); antipsychotics such as aripiprazole (Abilify), haloperidol (Haldol), risperidone (Risperdal), and thioridazine; atomoxetine (Strattera); beta blockers such as carvedilol (Coreg), metoprolol (Dutoprol), and timolol; codeine; dextromethorphan (found in many cough medications; in Nuedexta); flecainide (Tambocar); mexiletine; ondansetron (Zofran, Zuplenz); oxycodone (Oxaydo, Xtampza ER); propafenone (Rythmol SR); proton-pump inhibitors such as dexlanspoprazole (Dexilant), esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (AcipHex); tamoxifen (Soltamox); and tramadol (Conzip, Ultram). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
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if you are taking a medication for indigestion, heartburn, or ulcers such as cimetidine (Tagamet), famotidine (Pepcid, in Duexis), nizatidine (Axid), or ranitidine (Zantac), take dacomitinib at least 6 hours before or at least 10 hours after taking one of these medications.
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tell your doctor if you have frequent diarrhea episodes, lung disease, breathing problems other than lung cancer, or liver or kidney disease.
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tell your doctor if you are pregnant or plan to become pregnant. You must take a pregnancy test before starting treatment. You should not become pregnant while you are taking dacomitinib. You should use a reliable method of birth control while taking dacomitinib and for at least 17 days after your final dose. If you become pregnant while taking dacomitinib, call your doctor immediately. Dacomitinib may harm the fetus.
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tell your doctor if you are breastfeeding. You should not breastfeed while you are taking dacomitinib and for 17 days after your final dose.
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plan to use a moisturizer, avoid unnecessary or prolonged exposure to sunlight, and to wear protective clothing, sunglasses, and sunscreen. Dacomitinib may make your skin sensitive to sunlight.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?
Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
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Dacomitinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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weight loss
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loss of appetite
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mouth sores
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infection of the skin around the fingernails or toenails
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hair loss
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cough
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lack of energy
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difficulty falling asleep or staying asleep
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red or swollen eyes ("pink eye")
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taste changes
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vomiting
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Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:
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diarrhea
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shortness of breath, cough, and fever
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dry skin, redness, rash, acne, itchy skin, and peeling or blistering of your skin
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chest pain
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Dacomitinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
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If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
What OTHER INFORMATION should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order a lab test before you begin your treatment to see whether your cancer can be treated with dacomitinib.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Drug interactions
Drug | Interaction |
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Penbutolol | Penbutolol The metabolism of Acebutolol can be decreased when combined with Dacomitinib. |
Triamcinolone | Triamcinolone The metabolism of Dacomitinib can be increased when combined with Triamcinolone. |
Zidovudine Injection | Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Dacomitinib. |
Trimipramine | Trimipramine The metabolism of Dacomitinib can be decreased when combined with Trimipramine. |
Tenofovir | Tenofovir The metabolism of Tenofovir can be decreased when combined with Dacomitinib. |
Tegaserod | Tegaserod The metabolism of Tegaserod can be decreased when combined with Dacomitinib. |
Infliximab Injection | Infliximab Injection The metabolism of Dacomitinib can be increased when combined with Infliximab. |
Voriconazole | Voriconazole The metabolism of Dacomitinib can be decreased when combined with Voriconazole. |
Darifenacin | Darifenacin The metabolism of Darifenacin can be decreased when combined with Dacomitinib. |
Tipranavir | Tipranavir The metabolism of Tipranavir can be decreased when combined with Dacomitinib. |
Dronabinol | Dronabinol The metabolism of Dacomitinib can be decreased when combined with Dronabinol. |
Budesonide | Budesonide The metabolism of Dacomitinib can be increased when combined with Budesonide. |
Tretinoin | Tretinoin The metabolism of Dacomitinib can be decreased when combined with Tretinoin. |
Bendamustine Injection | Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Dacomitinib. |
Betaxolol | Betaxolol The metabolism of Betaxolol can be decreased when combined with Dacomitinib. |
Everolimus | Everolimus The serum concentration of Everolimus can be increased when it is combined with Dacomitinib. |
Acetaminophen Injection | Acetaminophen Injection The metabolism of Acetaminophen can be increased when combined with Dacomitinib. |
Vilazodone | Vilazodone The metabolism of Vilazodone can be decreased when combined with Dacomitinib. |
Busulfan Injection | Busulfan Injection The metabolism of Busulfan can be decreased when combined with Dacomitinib. |
Roflumilast | Roflumilast The metabolism of Dacomitinib can be decreased when combined with Roflumilast. |
Linagliptin | Linagliptin The serum concentration of Dacomitinib can be increased when it is combined with Linagliptin. |
Rilpivirine | Rilpivirine The metabolism of Dacomitinib can be decreased when combined with Rilpivirine. |
Telaprevir | Telaprevir The serum concentration of Glecaprevir can be increased when it is combined with Dacomitinib. |
Abiraterone | Abiraterone The metabolism of Dacomitinib can be decreased when combined with Abiraterone. |
Rivaroxaban | Rivaroxaban Dacomitinib may decrease the excretion rate of Rivaroxaban which could result in a higher serum level. |
Ticagrelor | Ticagrelor The serum concentration of Dacomitinib can be increased when it is combined with Ticagrelor. |
Brentuximab Vedotin Injection | Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Dacomitinib. |
Ruxolitinib | Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Dacomitinib. |
Vandetanib | Vandetanib The serum concentration of Dacomitinib can be increased when it is combined with Vandetanib. |
Vemurafenib | Vemurafenib The serum concentration of Dacomitinib can be increased when it is combined with Vemurafenib. |
Vismodegib | Vismodegib The metabolism of Dacomitinib can be decreased when combined with Vismodegib. |
Ivacaftor | Ivacaftor The serum concentration of Dacomitinib can be increased when it is combined with Ivacaftor. |
Axitinib | Axitinib The serum concentration of Axitinib can be increased when it is combined with Dacomitinib. |
Crizotinib | Crizotinib The metabolism of Dacomitinib can be decreased when combined with Crizotinib. |
Carfilzomib Injection | Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Dacomitinib. |
Enzalutamide | Enzalutamide The serum concentration of Dacomitinib can be increased when it is combined with Enzalutamide. |
Mirabegron | Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Dacomitinib. |
Regorafenib | Regorafenib The serum concentration of Dacomitinib can be increased when it is combined with Regorafenib. |
Bosutinib | Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Dacomitinib. |
Teriflunomide | Teriflunomide Teriflunomide may decrease the excretion rate of Dacomitinib which could result in a higher serum level. |
Cabozantinib (thyroid cancer) | Cabozantinib (thyroid cancer) The metabolism of Dacomitinib can be decreased when combined with Cabozantinib. |
Alogliptin | Alogliptin The metabolism of Alogliptin can be decreased when combined with Dacomitinib. |
Ponatinib | Ponatinib The serum concentration of Ponatinib can be increased when it is combined with Dacomitinib. |
Pomalidomide | Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Dacomitinib. |
Ado-trastuzumab Emtansine Injection | Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Dacomitinib. |
Apixaban | Apixaban The metabolism of Apixaban can be decreased when combined with Dacomitinib. |
Canagliflozin | Canagliflozin The serum concentration of Dacomitinib can be increased when it is combined with Canagliflozin. |
Dabrafenib | Dabrafenib The serum concentration of Dacomitinib can be increased when it is combined with Dabrafenib. |
Ospemifene | Ospemifene The metabolism of Dacomitinib can be decreased when combined with Ospemifene. |
Trametinib | Trametinib The metabolism of Dacomitinib can be increased when combined with Trametinib. |
Dolutegravir | Dolutegravir The metabolism of Dolutegravir can be decreased when combined with Dacomitinib. |
Afatinib | Afatinib The serum concentration of Afatinib can be increased when it is combined with Dacomitinib. |
Levomilnacipran | Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Dacomitinib. |
Vortioxetine | Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Dacomitinib. |
Perampanel | Perampanel The metabolism of Dacomitinib can be increased when combined with Perampanel. |
Ibrutinib | Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Dacomitinib. |
Lomitapide | Lomitapide The serum concentration of Dacomitinib can be increased when it is combined with Lomitapide. |
Simeprevir | Simeprevir The serum concentration of Dacomitinib can be increased when it is combined with Simeprevir. |
Sofosbuvir | Sofosbuvir Dacomitinib may decrease the excretion rate of Sofosbuvir which could result in a higher serum level. |
Dapagliflozin | Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Dacomitinib. |
Apremilast | Apremilast The metabolism of Dacomitinib can be increased when combined with Apremilast. |
Ceritinib | Ceritinib The serum concentration of Ceritinib can be increased when it is combined with Dacomitinib. |
Siltuximab Injection | Siltuximab Injection The metabolism of Dacomitinib can be increased when combined with Siltuximab. |
Eslicarbazepine | Eslicarbazepine The metabolism of Eslicarbazepine can be increased when combined with Dacomitinib. |
Belinostat Injection | Belinostat Injection The metabolism of Belinostat can be decreased when combined with Dacomitinib. |
Idelalisib | Idelalisib The metabolism of Idelalisib can be decreased when combined with Dacomitinib. |
Testosterone Injection | Testosterone Injection The metabolism of Testosterone can be increased when combined with Dacomitinib. |
Oritavancin Injection | Oritavancin Injection The metabolism of Dacomitinib can be increased when combined with Oritavancin. |
Vorapaxar | Vorapaxar The serum concentration of Dacomitinib can be increased when it is combined with Vorapaxar. |
Suvorexant | Suvorexant The serum concentration of Dacomitinib can be increased when it is combined with Suvorexant. |
Edoxaban | Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Dacomitinib. |
Olaparib | Olaparib The metabolism of Dacomitinib can be decreased when combined with Olaparib. |
Tasimelteon | Tasimelteon The metabolism of Dacomitinib can be decreased when combined with Tasimelteon. |
Riociguat | Riociguat Dacomitinib may decrease the excretion rate of Riociguat which could result in a higher serum level. |
Nintedanib | Nintedanib The metabolism of Nintedanib can be decreased when combined with Dacomitinib. |
Secukinumab Injection | Secukinumab Injection The metabolism of Dacomitinib can be increased when combined with Secukinumab. |
Palbociclib | Palbociclib The serum concentration of Dacomitinib can be increased when it is combined with Palbociclib. |
Lenvatinib | Lenvatinib The metabolism of Lenvatinib can be increased when combined with Dacomitinib. |
Naloxegol | Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Dacomitinib. |
Panobinostat | Panobinostat The metabolism of Panobinostat can be decreased when combined with Dacomitinib. |
Isavuconazonium Injection | Isavuconazonium Injection The serum concentration of Dacomitinib can be increased when it is combined with Isavuconazonium. |
Sonidegib | Sonidegib The metabolism of Sonidegib can be decreased when combined with Dacomitinib. |
Flibanserin | Flibanserin The serum concentration of Dacomitinib can be increased when it is combined with Flibanserin. |
Rolapitant | Rolapitant The metabolism of Dacomitinib can be decreased when combined with Rolapitant. |
Daclatasvir | Daclatasvir The serum concentration of Dacomitinib can be increased when it is combined with Daclatasvir. |
Brexpiprazole | Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Dacomitinib. |
Ziprasidone Injection | Ziprasidone Injection The metabolism of Dacomitinib can be decreased when combined with Ziprasidone. |
Cariprazine | Cariprazine The metabolism of Cariprazine can be decreased when combined with Dacomitinib. |
Cobimetinib | Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Dacomitinib. |
Trabectedin Injection | Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Dacomitinib. |
Osimertinib | Osimertinib The metabolism of Osimertinib can be increased when combined with Dacomitinib. |
Alectinib | Alectinib The metabolism of Dacomitinib can be decreased when combined with Alectinib. |
Ixazomib | Ixazomib The metabolism of Ixazomib can be decreased when combined with Dacomitinib. |
Lesinurad | Lesinurad The metabolism of Dacomitinib can be increased when combined with Lesinurad. |
Brivaracetam Injection | Brivaracetam Injection The metabolism of Dacomitinib can be decreased when combined with Brivaracetam. |
Venetoclax | Venetoclax The serum concentration of Dacomitinib can be increased when it is combined with Venetoclax. |
Cobicistat | Cobicistat The serum concentration of Dacomitinib can be increased when it is combined with Cobicistat. |
Selexipag | Selexipag The serum concentration of Selexipag can be increased when it is combined with Dacomitinib. |
Rucaparib | Rucaparib The metabolism of Rucaparib can be decreased when combined with Dacomitinib. |
Ribociclib | Ribociclib The metabolism of Dacomitinib can be decreased when combined with Ribociclib. |
Parathyroid Hormone Injection | Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Dacomitinib. |
Brigatinib | Brigatinib The metabolism of Brigatinib can be increased when combined with Dacomitinib. |
Deutetrabenazine | Deutetrabenazine The serum concentration of the active metabolites of Deutetrabenazine can be increased when Deutetrabenazine is used in combination with Dacomitinib. |
Valbenazine | Valbenazine The metabolism of Valbenazine can be decreased when combined with Dacomitinib. |
Safinamide | Safinamide The metabolism of Dacomitinib can be decreased when combined with Safinamide. |
Sarilumab Injection | Sarilumab Injection The metabolism of Dacomitinib can be increased when combined with Sarilumab. |
Midostaurin | Midostaurin The metabolism of Dacomitinib can be increased when combined with Midostaurin. |
Neratinib | Neratinib The serum concentration of Dacomitinib can be increased when it is combined with Neratinib. |
Abaloparatide Injection | Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Dacomitinib. |
Enasidenib | Enasidenib The metabolism of Enasidenib can be decreased when combined with Dacomitinib. |
Inotuzumab Ozogamicin Injection | Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Dacomitinib. |
Aprepitant/Fosaprepitant Injection | Aprepitant/Fosaprepitant Injection The metabolism of Dacomitinib can be increased when combined with Fosaprepitant. |
Copanlisib Injection | Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Dacomitinib. |
Delafloxacin | Delafloxacin The metabolism of Delafloxacin can be increased when combined with Dacomitinib. |
Abemaciclib | Abemaciclib The serum concentration of Abemaciclib can be increased when it is combined with Dacomitinib. |
Betrixaban | Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Dacomitinib. |
Acalabrutinib | Acalabrutinib The metabolism of Dacomitinib can be decreased when combined with Acalabrutinib. |
Letermovir | Letermovir The metabolism of Letermovir can be decreased when combined with Dacomitinib. |
Tetrabenazine | Tetrabenazine The metabolism of Tetrabenazine can be decreased when combined with Dacomitinib. |
Ertugliflozin | Ertugliflozin Dacomitinib may decrease the excretion rate of Ertugliflozin which could result in a higher serum level. |
Buprenorphine Injection | Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Dacomitinib. |
Apalutamide | Apalutamide The serum concentration of Dacomitinib can be decreased when it is combined with Apalutamide. |
Fostamatinib | Fostamatinib The metabolism of Dacomitinib can be decreased when combined with Fostamatinib. |
Avatrombopag | Avatrombopag The metabolism of Dacomitinib can be increased when combined with Avatrombopag. |
Baricitinib | Baricitinib The metabolism of Dacomitinib can be decreased when combined with Baricitinib. |
Eliglustat | Eliglustat The metabolism of Eliglustat can be decreased when combined with Dacomitinib. |
Encorafenib | Encorafenib The metabolism of Dacomitinib can be decreased when combined with Encorafenib. |
Binimetinib | Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Dacomitinib. |
Ivosidenib | Ivosidenib The serum concentration of Ivosidenib can be increased when it is combined with Dacomitinib. |
Lusutrombopag | Lusutrombopag Dacomitinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level. |
Elagolix | Elagolix The serum concentration of Elagolix can be increased when it is combined with Dacomitinib. |
Tafenoquine | Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Dacomitinib. |
Cannabidiol | Cannabidiol The metabolism of Dacomitinib can be decreased when combined with Cannabidiol. |
Duvelisib | Duvelisib The metabolism of Duvelisib can be decreased when combined with Dacomitinib. |
Stiripentol | Stiripentol The metabolism of Dacomitinib can be decreased when combined with Stiripentol. |
Progestin-Only (drospirenone) Oral Contraceptives | Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Dacomitinib can be decreased when combined with Drospirenone. |
Theophylline | Theophylline The metabolism of Theophylline can be decreased when combined with Dacomitinib. |
Trazodone | Trazodone The serum concentration of Trazodone can be decreased when it is combined with Dacomitinib. |
Bromocriptine | Bromocriptine The metabolism of Dacomitinib can be decreased when combined with Bromocriptine. |
Tranylcypromine | Tranylcypromine The metabolism of Dacomitinib can be decreased when combined with Tranylcypromine. |
Tetracycline | Tetracycline The metabolism of Dacomitinib can be decreased when combined with Tetracycline. |
Thioridazine | Thioridazine The metabolism of Dacomitinib can be decreased when combined with Thioridazine. |
Sulfadiazine | Sulfadiazine The metabolism of Dacomitinib can be decreased when combined with Sulfadiazine. |
Benztropine | Benztropine The metabolism of Benzatropine can be decreased when combined with Dacomitinib. |
Carbamazepine | Carbamazepine The metabolism of Carbamazepine can be increased when combined with Dacomitinib. |
Warfarin | Warfarin The metabolism of Warfarin can be increased when combined with Dacomitinib. |
Calcitriol | Calcitriol The metabolism of Dacomitinib can be increased when combined with Calcitriol. |
Sulfinpyrazone | Sulfinpyrazone The metabolism of Dacomitinib can be increased when combined with Sulfinpyrazone. |
Valproic Acid | Valproic Acid The metabolism of Valproic acid can be decreased when combined with Dacomitinib. |
Tamoxifen | Tamoxifen The serum concentration of Tamoxifen can be increased when it is combined with Dacomitinib. |
Levothyroxine | Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Dacomitinib. |
Liothyronine | Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Dacomitinib. |
Tolbutamide | Tolbutamide The metabolism of Dacomitinib can be decreased when combined with Tolbutamide. |
Tolazamide | Tolazamide The metabolism of Dacomitinib can be decreased when combined with Tolazamide. |
Acetazolamide | Acetazolamide The metabolism of Dacomitinib can be decreased when combined with Acetazolamide. |
Thiotepa Injection | Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Dacomitinib. |
Vincristine Injection | Vincristine Injection The excretion of Vincristine can be decreased when combined with Dacomitinib. |
Vinblastine | Vinblastine The serum concentration of Dacomitinib can be increased when it is combined with Vinblastine. |
Aspirin | Aspirin The metabolism of Dacomitinib can be decreased when combined with Acetylsalicylic acid. |
Trimethoprim | Trimethoprim The metabolism of Dacomitinib can be decreased when combined with Trimethoprim. |
Timolol | Timolol The metabolism of Timolol can be decreased when combined with Dacomitinib. |
Verapamil | Verapamil The serum concentration of Dacomitinib can be increased when it is combined with Verapamil. |
Atenolol | Atenolol The metabolism of Atenolol can be decreased when combined with Dacomitinib. |
Buspirone | Buspirone The metabolism of Buspirone can be decreased when combined with Dacomitinib. |
Epoetin Alfa, Injection | Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Dacomitinib. |
Teniposide Injection | Teniposide Injection The metabolism of Teniposide can be decreased when combined with Dacomitinib. |
Bisoprolol | Bisoprolol The serum concentration of Dacomitinib can be increased when it is combined with Bisoprolol. |
Tramadol | Tramadol The metabolism of Tramadol can be decreased when combined with Dacomitinib. |
Lansoprazole | Lansoprazole Lansoprazole can cause a decrease in the absorption of Dacomitinib resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Ticlopidine | Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Dacomitinib. |
Gemcitabine Injection | Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Dacomitinib. |
Zafirlukast | Zafirlukast The metabolism of Dacomitinib can be decreased when combined with Zafirlukast. |
Mirtazapine | Mirtazapine The metabolism of Mirtazapine can be decreased when combined with Dacomitinib. |
Donepezil | Donepezil The metabolism of Donepezil can be decreased when combined with Dacomitinib. |
Nelfinavir | Nelfinavir The metabolism of Dacomitinib can be decreased when combined with Nelfinavir. |
Azithromycin | Azithromycin The metabolism of Dacomitinib can be decreased when combined with Azithromycin. |
Carvedilol | Carvedilol The serum concentration of Carvedilol can be increased when it is combined with Dacomitinib. |
Capecitabine | Capecitabine The metabolism of Dacomitinib can be decreased when combined with Capecitabine. |
Efavirenz | Efavirenz The metabolism of Dacomitinib can be increased when combined with Efavirenz. |
Abacavir | Abacavir The metabolism of Abacavir can be decreased when combined with Dacomitinib. |
Sildenafil | Sildenafil The serum concentration of Sildenafil can be increased when it is combined with Dacomitinib. |
Celecoxib | Celecoxib The metabolism of Celecoxib can be decreased when combined with Dacomitinib. |
Tolterodine | Tolterodine The metabolism of Tolterodine can be decreased when combined with Dacomitinib. |
Thalidomide | Thalidomide The metabolism of Dacomitinib can be decreased when combined with Thalidomide. |
Rabeprazole | Rabeprazole Rabeprazole can cause a decrease in the absorption of Dacomitinib resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists