Inactive ingredients by manufacturer

Lubiprostone inactive ingredients by manufacturer

Wondering whether your Lubiprostone has lactose, gluten, soy, a dye or gelatin in it? The medicine is the same, but the fillers, coatings and colors differ from one company to the next. This page shows what each Lubiprostone product's FDA label lists, so you can find a version that leaves out what you avoid and ask your pharmacist for it by its NDC.

We have read the FDA labels of 41 of the 43 current Lubiprostone products on the market today, from 19 companies listing it with the FDA, and lined them up side by side. 2 are still being read and will appear on a later visit.

Ask about your bottle

Is there something in your Lubiprostone? Ask in plain words.

Name the company, strength or the NDC on your bottle and the ingredient you avoid. The answer comes only from the FDA labels on this page.

Answers are drawn from the FDA label data on this page and checked against it. They are not medical advice: confirm with your pharmacist before relying on them.

The short answer

Which Lubiprostone products list lactose, a gluten source, soy, dyes or gelatin?

  1. LactoseNo checked product

    No checked Lubiprostone product lists lactose.

  2. Wheat or gluten sourceNo checked product

    No checked Lubiprostone product lists a wheat or gluten source.

  3. SoyDiffers by manufacturer

    10 of 41 checked products list soy; 31 do not. See the products

    Does not list it Advanced Rx of Tennessee Amneal Asclemed Direct Rx Dr. Reddy's Golden State Medical Supply Natco Par Health Proficient Rx SpecGx Sun Takeda Zydus Zydus Lifesciences
    Lists it American Health Packaging Camber Direct_Rx Northstar Rx Proficient Rx Teva
  4. Synthetic dyesDiffers by manufacturer

    21 of 41 checked products list synthetic dyes; 20 do not. See the products

    Does not list it Advanced Rx of Tennessee American Health Packaging Amneal Asclemed Direct_Rx Golden State Medical Supply Natco Par Health Proficient Rx SpecGx Sun Takeda Teva Zydus Zydus Lifesciences
    Lists it Advanced Rx of Tennessee American Health Packaging Amneal Asclemed Camber Direct Rx Dr. Reddy's Golden State Medical Supply Natco Northstar Rx Proficient Rx SpecGx Sun Takeda Teva
  5. GelatinEvery checked product

    Every checked Lubiprostone product (41) lists gelatin. See the products

Also listed by some products: Titanium dioxide 19 of 41 Carmine or shellac 6 of 41 Propylene glycol 16 of 41 Sorbitol or mannitol 41 of 41

Find a version without it

Every current Lubiprostone product and what its label lists

Hide products that list:

ProductListsInactive ingredients on the label
Advanced Rx of Tennessee, LLC 2 products
8 mcg capsuleNDC 80425-0354-02 Titanium dioxide Gelatin Sorbitol or mannitol
Show 6 ingredients

FERRIC OXIDE RED, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, TITANIUM DIOXIDE, WATER
24 mcg capsuleNDC 80425-0355-02 Synthetic dyes Gelatin Sorbitol or mannitol
Show 6 ingredients

D&C YELLOW NO. 10, FD&C RED NO. 40, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, WATER
American Health Packaging 2 products
8 mcg capsuleNDC 60687-0816-32 Soy Titanium dioxide Gelatin Propylene glycol Sorbitol or mannitol
Show 10 ingredients

FERRIC OXIDE RED, FERROSOFERRIC OXIDE, GELATIN, UNSPECIFIED, HYPROMELLOSE, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, PROPYLENE GLYCOL, SORBITOL SOLUTION, SOYBEAN LECITHIN, TITANIUM DIOXIDE, WATER
24 mcg capsuleNDC 60687-0827-32 Soy Synthetic dyes Gelatin Propylene glycol Sorbitol or mannitol
Show 10 ingredients

D&C YELLOW NO. 10, FD&C RED NO. 40, FERROSOFERRIC OXIDE, GELATIN, UNSPECIFIED, HYPROMELLOSE, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, PROPYLENE GLYCOL, SORBITOL SOLUTION, SOYBEAN LECITHIN, WATER
Amneal Pharmaceuticals LLC 2 products
8 mcg capsuleNDC 65162-0841-06 Titanium dioxide Gelatin Sorbitol or mannitol
Show 7 ingredients

FERRIC OXIDE RED, FERROSOFERRIC OXIDE, GELATIN, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, TITANIUM DIOXIDE, WATER
24 mcg capsuleNDC 65162-0842-06 Synthetic dyes Gelatin Sorbitol or mannitol
Show 6 ingredients

D&C YELLOW NO. 10, FD&C RED NO. 40, GELATIN, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, WATER
Asclemed USA, Inc. 4 products
8 mcg capsuleNDC 76420-0777-01 Titanium dioxide Gelatin Carmine or shellac Propylene glycol Sorbitol or mannitol
Show 10 ingredients

1,4-SORBITAN, FERRIC OXIDE RED, FERROSOFERRIC OXIDE, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, PROPYLENE GLYCOL, SHELLAC, SORBITOL, TITANIUM DIOXIDE, WATER
8 mcg capsuleNDC 76420-0906-01 Titanium dioxide Gelatin Sorbitol or mannitol
Show 6 ingredients

FERRIC OXIDE RED, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, TITANIUM DIOXIDE, WATER
24 mcg capsuleNDC 76420-0778-01 Gelatin Carmine or shellac Propylene glycol Sorbitol or mannitol
Show 8 ingredients

1,4-SORBITAN, FERROSOFERRIC OXIDE, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, PROPYLENE GLYCOL, SHELLAC, SORBITOL, WATER
24 mcg capsuleNDC 76420-0907-01 Synthetic dyes Gelatin Sorbitol or mannitol
Show 6 ingredients

D&C YELLOW NO. 10, FD&C RED NO. 40, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, WATER
Camber Pharmaceuticals, Inc. 2 products
0.008 mg capsuleNDC 31722-0403-60 Soy Synthetic dyes Titanium dioxide Gelatin Propylene glycol Sorbitol or mannitol
Show 10 ingredients

FD&C YELLOW NO. 6, FERROSOFERRIC OXIDE, GELATIN, HYPROMELLOSE 2910 (6 MPA.S), LECITHIN, SOYBEAN, MEDIUM-CHAIN TRIGLYCERIDES, PROPYLENE GLYCOL, SORBITOL SOLUTION, TITANIUM DIOXIDE, WATER
0.024 mg capsuleNDC 31722-0404-60 Soy Synthetic dyes Gelatin Propylene glycol Sorbitol or mannitol
Show 9 ingredients

FD&C YELLOW NO. 6, FERROSOFERRIC OXIDE, GELATIN, HYPROMELLOSE 2910 (6 MPA.S), LECITHIN, SOYBEAN, MEDIUM-CHAIN TRIGLYCERIDES, PROPYLENE GLYCOL, SORBITOL SOLUTION, WATER
Direct Rx 1 product
24 mcg capsuleNDC 72189-0607-60 Synthetic dyes Gelatin Sorbitol or mannitol
Show 6 ingredients

D&C YELLOW NO. 10, FD&C RED NO. 40, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, WATER
Direct_Rx 1 product
8 mcg capsuleNDC 72189-0410-60 Soy Titanium dioxide Gelatin Propylene glycol Sorbitol or mannitol
Show 10 ingredients

FERRIC OXIDE RED, FERROSOFERRIC OXIDE, GELATIN, UNSPECIFIED, HYPROMELLOSE, UNSPECIFIED, LECITHIN, SOYBEAN, MEDIUM-CHAIN TRIGLYCERIDES, PROPYLENE GLYCOL, SORBITOL SOLUTION, TITANIUM DIOXIDE, WATER
Dr. Reddy's Laboratories Inc. 2 products
8 mcg capsuleNDC 43598-0163-60 Still being read Not read yet
24 mcg capsuleNDC 43598-0168-60 Synthetic dyes Gelatin Sorbitol or mannitol
Show 6 ingredients

D&C YELLOW NO. 10, FD&C RED NO. 40, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, WATER
Golden State Medical Supply, Inc. 2 products
8 mcg capsuleNDC 51407-0744-60 Titanium dioxide Gelatin Sorbitol or mannitol
Show 6 ingredients

FERRIC OXIDE RED, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, TITANIUM DIOXIDE, WATER
24 mcg capsuleNDC 51407-0745-60 Synthetic dyes Gelatin Sorbitol or mannitol
Show 6 ingredients

D&C YELLOW NO. 10, FD&C RED NO. 40, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, WATER
Natco Pharma USA LLC 2 products
8 mcg capsuleNDC 69339-0162-17 Titanium dioxide Gelatin Sorbitol or mannitol
Show 6 ingredients

FERRIC OXIDE RED, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, TITANIUM DIOXIDE, WATER
24 mcg capsuleNDC 69339-0163-17 Synthetic dyes Gelatin Sorbitol or mannitol
Show 6 ingredients

D&C YELLOW NO. 10, FD&C RED NO. 40, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, WATER
Northstar Rx LLC 2 products
0.008 mg capsuleNDC 72603-0288-01 Soy Synthetic dyes Titanium dioxide Gelatin Propylene glycol Sorbitol or mannitol
Show 10 ingredients

FD&C YELLOW NO. 6, FERROSOFERRIC OXIDE, GELATIN, HYPROMELLOSE 2910 (6 MPA.S), LECITHIN, SOYBEAN, MEDIUM-CHAIN TRIGLYCERIDES, PROPYLENE GLYCOL, SORBITOL SOLUTION, TITANIUM DIOXIDE, WATER
0.024 mg capsuleNDC 72603-0289-01 Soy Synthetic dyes Gelatin Propylene glycol Sorbitol or mannitol
Show 9 ingredients

FD&C YELLOW NO. 6, FERROSOFERRIC OXIDE, GELATIN, HYPROMELLOSE 2910 (6 MPA.S), LECITHIN, SOYBEAN, MEDIUM-CHAIN TRIGLYCERIDES, PROPYLENE GLYCOL, SORBITOL SOLUTION, WATER
Par Health USA, LLC 2 products
8 mcg capsuleNDC 00254-3028-02 Titanium dioxide Gelatin Sorbitol or mannitol
Show 6 ingredients

FERRIC OXIDE RED, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, TITANIUM DIOXIDE, WATER
24 mcg capsuleNDC 00254-3029-02 Still being read Not read yet
Proficient Rx LP 5 products
8 mcg capsuleNDC 71205-0831-00 Titanium dioxide Gelatin Sorbitol or mannitol
Show 6 ingredients

FERRIC OXIDE RED, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, TITANIUM DIOXIDE, WATER
24 mcg capsuleNDC 82804-0001-30 Synthetic dyes Gelatin Sorbitol or mannitol
Show 6 ingredients

D&C yellow no. 10, FD&C red no. 40, gelatin, unspecified, medium-chain triglycerides, sorbitol, water
24 mcg capsuleNDC 82804-0304-60 Soy Synthetic dyes Gelatin Propylene glycol Sorbitol or mannitol
Show 10 ingredients

D&C YELLOW NO. 10, FD&C RED NO. 40, FERROSOFERRIC OXIDE, GELATIN, UNSPECIFIED, HYPROMELLOSE, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, PROPYLENE GLYCOL, SORBITOL SOLUTION, SOYBEAN LECITHIN, WATER
24 mcg capsuleNDC 71205-0834-00 Synthetic dyes Gelatin Sorbitol or mannitol
Show 6 ingredients

D&C yellow no. 10, FD&C red no. 40, gelatin, unspecified, medium-chain triglycerides, sorbitol, water
24 mcg capsuleNDC 71205-0832-00 Synthetic dyes Gelatin Sorbitol or mannitol
Show 6 ingredients

D&C YELLOW NO. 10, FD&C RED NO. 40, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, WATER
SpecGx LLC 4 products
8 mcg capsuleNDC 00406-6408-60 Titanium dioxide Gelatin Sorbitol or mannitol
Show 6 ingredients

FERRIC OXIDE RED, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, TITANIUM DIOXIDE, WATER
8 mcg capsuleNDC 23635-0508-60 Titanium dioxide Gelatin Sorbitol or mannitol
Show 6 ingredients

FERRIC OXIDE RED, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, TITANIUM DIOXIDE, WATER
24 mcg capsuleNDC 00406-6424-60 Synthetic dyes Gelatin Sorbitol or mannitol
Show 6 ingredients

D&C YELLOW NO. 10, FD&C RED NO. 40, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, WATER
24 mcg capsuleNDC 23635-0524-60 Synthetic dyes Gelatin Sorbitol or mannitol
Show 6 ingredients

D&C YELLOW NO. 10, FD&C RED NO. 40, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, WATER
Sun Pharmaceutical Industries, Inc. 2 products
8 mcg capsuleNDC 63304-0351-60 Titanium dioxide Gelatin Sorbitol or mannitol
Show 6 ingredients

FERRIC OXIDE RED, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, TITANIUM DIOXIDE, WATER
24 mcg capsuleNDC 63304-0352-60 Synthetic dyes Gelatin Sorbitol or mannitol
Show 6 ingredients

D&C YELLOW NO. 10, FD&C RED NO. 40, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, SORBITOL, WATER
Takeda Pharmaceuticals America, Inc. 2 products
8 mcg capsuleNDC 64764-0080-40 Titanium dioxide Gelatin Sorbitol or mannitol
Show 6 ingredients

ferric oxide red, GELATIN, UNSPECIFIED, medium-chain triglycerides, sorbitol, titanium dioxide, water
24 mcg capsuleNDC 64764-0240-40 Synthetic dyes Gelatin Sorbitol or mannitol
Show 6 ingredients

D&C yellow no. 10, FD&C red no. 40, GELATIN, UNSPECIFIED, medium-chain triglycerides, sorbitol, water
Teva Pharmaceuticals, Inc. 2 products
8 mcg capsuleNDC 00480-3479-06 Soy Titanium dioxide Gelatin Propylene glycol Sorbitol or mannitol
Show 10 ingredients

FERRIC OXIDE RED, FERROSOFERRIC OXIDE, GELATIN, UNSPECIFIED, HYPROMELLOSE, UNSPECIFIED, LECITHIN, SOYBEAN, MEDIUM-CHAIN TRIGLYCERIDES, PROPYLENE GLYCOL, SORBITOL SOLUTION, TITANIUM DIOXIDE, WATER
24 mcg capsuleNDC 00480-4138-06 Soy Synthetic dyes Gelatin Propylene glycol Sorbitol or mannitol
Show 10 ingredients

D&C YELLOW NO. 10, FD&C RED NO. 40, FERROSOFERRIC OXIDE, GELATIN, UNSPECIFIED, HYPROMELLOSE, UNSPECIFIED, LECITHIN, SOYBEAN, MEDIUM-CHAIN TRIGLYCERIDES, PROPYLENE GLYCOL, SORBITOL SOLUTION, WATER
Zydus Pharmaceuticals USA Inc. 2 products
8 mcg capsuleNDC 70710-1641-01 Titanium dioxide Gelatin Carmine or shellac Propylene glycol Sorbitol or mannitol
Show 10 ingredients

1,4-SORBITAN, FERRIC OXIDE RED, FERROSOFERRIC OXIDE, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, PROPYLENE GLYCOL, SHELLAC, SORBITOL, TITANIUM DIOXIDE, WATER
24 mcg capsuleNDC 70710-1642-01 Gelatin Carmine or shellac Propylene glycol Sorbitol or mannitol
Show 8 ingredients

1,4-SORBITAN, FERROSOFERRIC OXIDE, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, PROPYLENE GLYCOL, SHELLAC, SORBITOL, WATER
Zydus Lifesciences Limited 2 products
8 mcg capsuleNDC 70771-1763-01 Titanium dioxide Gelatin Carmine or shellac Propylene glycol Sorbitol or mannitol
Show 10 ingredients

1,4-SORBITAN, FERRIC OXIDE RED, FERROSOFERRIC OXIDE, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, PROPYLENE GLYCOL, SHELLAC, SORBITOL, TITANIUM DIOXIDE, WATER
24 mcg capsuleNDC 70771-1764-01 Gelatin Carmine or shellac Propylene glycol Sorbitol or mannitol
Show 8 ingredients

1,4-SORBITAN, FERROSOFERRIC OXIDE, GELATIN, UNSPECIFIED, MEDIUM-CHAIN TRIGLYCERIDES, PROPYLENE GLYCOL, SHELLAC, SORBITOL, WATER

A product with none of these listed is not certified to be without them: the label says what the manufacturer declared, and the source of a starch or a flavor is often not stated. The companies are the FDA's labelers, which include repackagers and distributors selling another company's product under their own label. The NDC opens the product's own page, with the full label and its inactive-ingredient notes.

Lubiprostone without soy

Soy: soybean oil or soy lecithin; a concern with soy allergy. 10 of 41 checked products list soy; 31 do not.

Does not list soy

Lists soy

Lubiprostone without synthetic dyes

Synthetic dyes: FD&C or D&C colorants and their aluminum lakes. 21 of 41 checked products list synthetic dyes; 20 do not.

Does not list synthetic dyes

Lists synthetic dyes

Lubiprostone and gelatin

Gelatin: animal-derived (usually bovine or porcine); a concern for vegetarian, kosher or halal needs. Every checked Lubiprostone product (41) lists gelatin.

Lists gelatin

Lubiprostone without titanium dioxide

Titanium dioxide: A white colorant some people choose to avoid. 19 of 41 checked products list titanium dioxide; 22 do not.

Does not list titanium dioxide

Lists titanium dioxide

Lubiprostone without carmine or shellac

Carmine or shellac: insect-derived red colorant or coating glaze. 6 of 41 checked products list carmine or shellac; 35 do not.

Does not list carmine or shellac

Lists carmine or shellac

Lubiprostone without propylene glycol

Propylene glycol: A solvent in liquids and capsules; a concern in kidney disease, for infants, and at high doses. 16 of 41 checked products list propylene glycol; 25 do not.

Does not list propylene glycol

Lists propylene glycol

Lubiprostone and sorbitol or mannitol

Sorbitol or mannitol: sugar alcohols that can cause bloating or diarrhea in larger amounts. Every checked Lubiprostone product (41) lists sorbitol or mannitol.

Lists sorbitol or mannitol

At the pharmacy counter

How to use this at the pharmacy counter

  1. Pick the company whose list suits you and copy the NDC from the table. Many pharmacies order from wholesalers that carry several companies' versions and can request a particular one if you ask before the prescription is filled; some buy from one contracted source only, and a few insurance plans cover only certain NDCs, so ask the pharmacist to check.
  2. Treat "does not list" as exactly that. The label is what the manufacturer declared; a flavor or a starch may have an unstated source, and lines change. For celiac disease or a serious allergy, ask the manufacturer's medical information line for a written statement about the lot you have.
  3. Check the bottle each refill. A different company usually means a different shape, color and inactive-ingredient list; the pharmacist can tell you who made it, and the two-NDC comparison shows the difference line by line.
  4. If you need one company's version kept constant, ask your prescriber to write that company or the NDC on the prescription and tell the pharmacy you need it held. Rules vary by state and plan, so confirm with the pharmacist.
Ask Dr. Staiger which Lubiprostone product suits you →

Common questions about Lubiprostone inactive ingredients

Is Lubiprostone gluten-free?
This page cannot certify any Lubiprostone product gluten-free; it reports what each label declares. Of the 41 products checked, none lists a wheat, barley, rye or gluten ingredient, and none lists a starch without a stated source. If you have celiac disease, ask the manufacturer's medical information line for a written gluten statement for the lot you have.
Does Lubiprostone contain lactose?
No checked Lubiprostone product lists lactose on its label. The lactose in a tablet or capsule is a small amount, but people with a milk allergy or a strong intolerance often prefer a version that does not list it.
Does Lubiprostone contain soy?
10 of 41 checked Lubiprostone products list a soy ingredient (soybean oil or soy lecithin); 31 do not: Advanced Rx of Tennessee (8 mcg capsule and 24 mcg capsule), Amneal (8 mcg capsule and 24 mcg capsule), Asclemed (8 mcg capsule and 24 mcg capsule) and Direct Rx (24 mcg capsule) and 10 other companies. Soy lecithin is the usual form and the amount is small, but people with a soy allergy often prefer a version that does not list it.
Is there a dye-free Lubiprostone?
21 of 41 checked Lubiprostone products list a synthetic dye (an FD&C or D&C colorant); 20 do not: Advanced Rx of Tennessee (8 mcg capsule), American Health Packaging (8 mcg capsule), Amneal (8 mcg capsule) and Asclemed (8 mcg capsule and 24 mcg capsule) and 11 other companies. Colorants often differ by strength within one company's line, so compare the lists above strength by strength.
Does Lubiprostone contain gelatin?
Every checked Lubiprostone product (41) lists gelatin on its label. Gelatin is usually bovine or porcine and the label rarely says which; for kosher, halal or vegetarian needs, ask the manufacturer.
Why do the inactive ingredients differ between manufacturers?
A generic must match the brand's active ingredient, strength, dose form and how it is absorbed; its fillers, binders, coatings and colorants are the manufacturer's own choice. That is why one Lubiprostone product can list lactose and a dye while another from a different company lists neither.
Can my pharmacy give me a specific manufacturer's version?
Often, if you ask before the prescription is filled: many pharmacies order from wholesalers that carry several companies' versions and can request a particular one. Some pharmacies buy a generic from one contracted source only, and a few insurance plans cover only certain NDCs, so ask the pharmacist to check. Give them the NDC from this page; the company name alone is often enough.
How current is this list?
The products are the ones in the FDA's current NDC directory as of October 6, 2026, and each inactive-ingredient list is the manufacturer's FDA label as our label sync last read it. Formulations change, so check the label on your own bottle and ask your pharmacist if a refill looks different.

Sources: the products are the finished Lubiprostone products in the FDA's current NDC directory (openFDA), as of October 6, 2026; each inactive-ingredient list is the manufacturer's FDA Structured Product Label via DailyMed, as our label sync last read it. The concern groups are HelloPharmacist's classification of the names the label declares. Educational information only, not medical advice; confirm with your pharmacist before relying on a list. ← Back to the Lubiprostone guide