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Refresh Digital Carboxymethylcellulose sodium, Glycerin, Polysorbate 80 5 mg/mL; 10 mg/mL; 80 5 mg/mL Solution/ Drops — NDC 00023-6952-10 package photo

Refresh Digital Carboxymethylcellulose sodium, Glycerin, Polysorbate 80 5 mg/mL; 10 mg/mL; 80 5 mg/mL Solution/ Drops

by Allergan, Inc. · 1 BOTTLE, DROPPER in 1 CARTON (0023-6952-10) / 10 mL in 1 BOTTLE, DROPPER
NDC 00023-6952-10
🏷️ FDA NDC (as labeled) 0023-6952-10 billing pads the labeler segment with a zero
This package
Contains10 mL in 1 bottle, dropper Cost per mL$1.03 NADAC Per package$10.32 / 10 ml Pack sizes2 compare ↓
Also priced by: Medicaid pays $1.39/unit — full pricing hub ↓
Also comes in: 2 mL 00023-6952-02
OTC On market Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

🆔 Identity & classification

FDA NDC (as labeled) 0023-6952-10
Product NDC 0023-6952
11-digit billing NDC 00023695210
NCPDP billing unit ML — per mL (volume)
RxCUI 1241471
UNII K679OBS311, PDC6A3C0OX, 6OZP39ZG8H
Application # M018
SPL Set ID b2bd34d4-fab9-4f4b-9be2-5d30b55f5b81
Established class (EPC) Non-Standardized Chemical Allergen
Physiologic effect Increased Histamine Release; Cell-mediated Immunity; Increased IgG Production
Chemical class Allergens; Glycerol
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2020-08-01
Route OPHTHALMIC
Dosage form SOLUTION/ DROPS
Substance CARBOXYMETHYLCELLULOSE SODIUM; GLYCERIN; POLYSORBATE 80
GPI-14 86209903202020
GPI class Refresh Digital
GCN Seq No 069132
GCN 32087
HICL code 038941
Ingredient (HICL) Carboxymethyl/Glycerin/Poly80
HIC1 code Q
Therapeutic class — broad (HIC1) Ear/Eye/Nose/Rectum/Topical/Vagina/Other
HIC2 code Q6
Therapeutic class — intermediate (HIC2) Ophthalmic Preparations
HIC3 code Q6T
Therapeutic class — specific (HIC3) Artificial Tears
AHFS code 52:92.00.00
AHFS class Eent Drugs, Miscellaneous
FDB label name REFRESH DIGITAL EYE DROPS
FDB brand name Refresh Digital
Legend status O — Over-the-counter (OTC) drug or device
Why two NDCs? The FDA registers this code as 0023-6952-10 — a 4-4-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the labeler segment → 00023-6952-10. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏭 Manufacturer & labeler

LabelerAllergan, Inc.
FDA applicationM018 (OTC MONOGRAPH DRUG)
Labeler code00023
First marketedAug 2020
Product typeHuman Otc Drug
Portfolio188 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

Label name REFRESH DIGITAL EYE DROPS Ingredient Carboxymethyl/Glycerin/Poly80
🧪 What is this product?

Refresh Digital is an over-the-counter eye drop solution containing carboxymethylcellulose sodium, glycerin, and polysorbate 80. It is applied directly to the eye and functions as an artificial tear product. Carboxymethylcellulose sodium and glycerin are lubricating agents typically used to relieve dry eye discomfort and irritation, while polysorbate 80 helps distribute and stabilize these ingredients in the solution.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII R57ZHV85D4
    Boric acid is a weak acid derived from boron. In medicines, it typically serves as a buffer to help maintain the product's pH level and may act as a preservative in certain formulations.
  • UNII 71DD5V995L
    A synthetic polymer derived from acrylic acid, crosslinked to form a gel-like substance. It thickens formulations, improves texture, and helps distribute active ingredients evenly in topical products like creams and gels.
  • UNII D5340Y2I9G
    Castor oil is a natural plant-based oil used in medicines as a lubricant, laxative agent, and solvent. It helps medicine ingredients dissolve or flow smoothly and can aid bowel movement in formulations designed for that purpose.
  • UNII RA96B954X6
    Erythritol is a sugar alcohol derived from fermented fruits or grains. It's used as a sweetener and bulking agent in medicines to improve taste without adding significant calories.
  • UNII 0G389FZZ9M
    Levocarnitine is an amino acid derivative that helps transport fatty acids in cells. In medications, it serves as an active nutritional component rather than a typical inactive binder or filler.
  • UNII G538EBV4VF
    Sodium chlorite is a white crystalline salt used as a preservative and antimicrobial agent in medications. It helps prevent bacterial and fungal growth to maintain product stability during storage.
  • UNII 55X04QC32I
    A strong alkaline chemical used to adjust and maintain the pH balance of liquid medicines. It helps keep the medicine stable and ensures it stays effective during storage.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

8 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesBoric acid; carbomer copolymer type A; castor oil; erythritol; levocarnitine; purified water; PURITE ® (stabilized oxychloro complex); and sodium hydroxide (to adjust pH).

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly $1.032 $10.32 / 10 ml
Medicaid paysCMS SDUD · 12 mo $1.39 $13.89 / 10 ml
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
NADAC price history (per mL) — tap or hover for the price & month
May 2021 Dec 2025 Mar 2026 Aug 2026 $1.033 $0.981
▲ Up 5% over the last 6 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Refresh Digital 5 mg/mL; 10 mg/mL; 80 5 mg/mLthis 00023-6952-10 Allergan, 1 bottle $1.032 — Availability likely —
Refresh Optive Mega-3 PF 5 mg/mL; 10 mg/mL; 80 5 mg/mL 00023-3988-05 Allergan, 1 vial — — FDA listed —
REFRESH Optive Mega-3 5 mg/mL; 10 mg/mL; 80 5 mg/mL 00023-4230-70 Allergan, 70 vials — — FDA listed —
REFRESH OPTIVE Advanced 5 mg/mL; 10 mg/mL; 80 5 mg/mL 00023-4307-02 Allergan, 1 bottle — — FDA listed —
REFRESH OPTIVE Advanced 5 mg/mL; 10 mg/mL; 80 5 mg/mL 00023-4491-05 Allergan, 5 vials — — FDA listed —
REFRESH Optive Mega-3 5 mg/mL; 10 mg/mL; 80 5 mg/mL 00023-5773-05 Allergan, 5 vials — — FDA listed —
Refresh Digital PF 5 mg/mL; 10 mg/mL; 80 5 mg/mL 00023-6954-05 Allergan, 1 vial — — FDA listed —
REFRESH Optive Mega-3 5 mg/mL; 10 mg/mL; 80 5 mg/mL 00023-7151-60 Allergan, 60 vials — — FDA listed —
Droptics Dry Eye Relief .5 g/100mL; 1 g/100mL; 80 .5 g/100mL 85211-0002-01 Droptics 1 bottle — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2020
On the market since
Aug 2020
📍
2026
Currently FDA-listed
6 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

🗺️ Medicaid utilization & spend

📍 This exact package only: Medicaid data is reported per full 11-digit NDC — labeler, product and pack size — so every number here is for 00023-6952-10, not the drug overall. Other pack sizes report separately.
💊 Pharmacy benefit only: These are Medicaid outpatient pharmacy claims, billed by NDC. They exclude the medical benefit — clinic- or hospital-administered drugs billed under HCPCS J-codes — so drugs used mostly that way (e.g. Avastin, Lucentis, Keytruda) can look low or missing here. That’s expected, not an error.
📅 Q1 2025 – Q4 2025 · 4 quarters of data
ⓘ The newest quarter is usually incomplete when first published; states restate recent quarters in later CMS releases, so the latest figures typically revise upward. State coverage-policy changes can also shift quarter-to-quarter totals.
Prescriptions last 4 qtrs
613
Units reimbursed last 4 qtrs
7.6K
Gross reimbursed last 4 qtrs
$10.6K
Avg / prescription
$17.31
Avg / unit
$1.3889
Latest quarter Q4 2025
151Rx
Medicaid pays / mL
$1.3889
gross reimbursed
vs
NADAC / mL
$1.0323
acquisition cost
=
Spread
+$0.3566
+35% vs cost
What Medicaid paid per mL (before rebates; includes the pharmacy’s dispensing fee) compared with NADAC — the average price pharmacies pay to buy the drug. A positive spread means Medicaid reimbursed more than the purchase price, before manufacturer rebates.
Fee-for-service vs managed care ⓘ
12% FFS 88% MCO
Fee-for-service · 71 Rx Managed care · 542 Rx
State Medicaid map
Alaska: no data reported AK Maine: no data reported ME Washington: no data reported WA Idaho: no data reported ID Montana: no data reported MT North Dakota: no data reported ND Minnesota: 200 units · 3.5 per 100k residents MN Wisconsin: no data reported WI Michigan: no data reported MI New York: no data reported NY Vermont: no data reported VT New Hampshire: no data reported NH Oregon: no data reported OR Nevada: no data reported NV Wyoming: no data reported WY South Dakota: no data reported SD Iowa: no data reported IA Illinois: no data reported IL Indiana: 110 units · 1.6 per 100k residents IN Ohio: 2,970 units · 25.2 per 100k residents OH Pennsylvania: no data reported PA New Jersey: 1,090 units · 11.7 per 100k residents NJ Massachusetts: no data reported MA California: no data reported CA Utah: no data reported UT Colorado: no data reported CO Nebraska: 340 units · 17.2 per 100k residents NE Missouri: no data reported MO Kentucky: no data reported KY West Virginia: no data reported WV Virginia: no data reported VA Maryland: no data reported MD Connecticut: 320 units · 8.8 per 100k residents CT Rhode Island: no data reported RI Arizona: no data reported AZ New Mexico: no data reported NM Kansas: no data reported KS Arkansas: no data reported AR Tennessee: no data reported TN North Carolina: no data reported NC South Carolina: no data reported SC Delaware: no data reported DE Oklahoma: no data reported OK Louisiana: no data reported LA Mississippi: no data reported MS Alabama: no data reported AL Georgia: no data reported GA D.C.: 110 units · 16.2 per 100k residents DC Hawaii: 2,500 units · 174 per 100k residents HI Texas: no data reported TX Florida: no data reported FL
Units reimbursed · per 100k residents
1.6174
gray = no data reported ⓘ
Colors are per 100,000 residents, so big states don’t automatically dominate. Tap or hover a state for its actual totals.
Tap or hover a state
…for its Medicaid breakdown
🏆 Top states by units · per 100k residents
1 Hawaii 174 /100k
2 Ohio 25.2 /100k
3 Nebraska 17.2 /100k
4 D.C. 16.2 /100k
5 New Jersey 11.7 /100k
6 Connecticut 8.8 /100k
7 Minnesota 3.5 /100k
8 Indiana 1.6 /100k
National units — by quarter
💵 About the dollar figures: “reimbursed” is what Medicaid paid pharmacies before confidential manufacturer rebates, so the program’s real net cost is lower than these numbers. Fee-for-service and managed-care claims are combined unless split above. Source: CMS State Drug Utilization Data; per-100k rates use 2023 Census population estimates.

💊 Medicaid utilization by pack size

Medicaid (SDUD) totals over the four most recent reported quarters for every package size of this drug — handy when a specific package (e.g. a starter/titration pack) carries little or no Medicaid volume on its own.
1 bottle this page00023-6952-10 613 Rx · $10,612
1 bottle00023-6952-02 No Medicaid data
Drug total (last 4 qtrs): 613 Rx · 7,640 units · $10,612 gross reimbursed
Tap a pack size to open its page. Source: CMS State Drug Utilization Data, last 4 quarters.

📦 Packaging — all sizes for this product

Package NDCDescription Per unit Per pack Marketing startStatus
00023-6952-02 1 BOTTLE, DROPPER in 1 CARTON (0023-6952-02) / 2 mL in 1 BOTTLE, DROPPER — — 2020-08-01 Active
00023-6952-10 You're viewing this 1 BOTTLE, DROPPER in 1 CARTON (0023-6952-10) / 10 mL in 1 BOTTLE, DROPPER $1.03 / mL $10.32 2020-08-01 Active

In Medicaid, this is the most-dispensed pack of this product — about 100% of fills over the last four reported quarters. See all packs ↓

Pack size FAQ

What quantity is in NDC 00023-6952-10?
NDC 00023-6952-10 is listed by the FDA — 1 bottle, dropper in 1 carton / 10 ml in 1 bottle, dropper.
What NDC number is used to bill for this package of Refresh Digital Carboxymethylcellulose sodium, Glycerin, Polysorbate 80 5 mg/mL; 10 mg/mL; 80 5 mg/mL Solution/ Drops?
Bill NDC 00023-6952-10 — the 11-digit billing format is 00023695210. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Prices are the latest CMS NADAC pharmacy acquisition cost per NDC; per-pack figures are per-unit × pack quantity, shown only when the pack is denominated in the same measure NADAC prices.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 31 words ▾

Uses For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun. May be used as a protectant against further irritation.

⏱️ Dosage and Administration 12 words ▾

Directions Instill 1 or 2 drops in the affected eye(s) as needed.

⚠️ Warnings 81 words ▾

Warnings For external use only. To avoid contamination, do not touch tip of container to any surface. Replace cap after using. If solution changes color, do not use . Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

🧪 Active Ingredient 11 words ▾

Active ingredient s Carboxymethylcellulose sodium 0.5% Glycerin 1% Polysorbate 80 0.5%

🧪 Inactive Ingredients 25 words ▾

Inactive ingredients Boric acid; carbomer copolymer type A; castor oil; erythritol; levocarnitine; purified water; PURITE ® (stabilized oxychloro complex); and sodium hydroxide (to adjust pH).

🎯 Purpose 7 words ▾

Purpose Eye lubricant Eye lubricant Eye lubricant

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 00023-6934-13 · Allergan, 00023-6954-05 · Allergan, →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.