Home › NDC Lookup › Ingredients › Infants Simethicone Drops › 00121-1094-03
Infants Simethicone Drops 20 mg/.3mL Liquid, 25 syringes — NDC 00121-1094-03 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

Infants Simethicone Drops 20 mg/.3mL Liquid, 25 syringes — NDC 0121-1094-03 (Billing 00121-1094-03)

by PAI Holdings, LLC dba PAI Pharma · 25 SYRINGE, PLASTIC in 1 CARTON / .3 mL in 1 SYRINGE, PLASTIC

This is a package of 25 syringes of Infants Simethicone Drops 20 mg/.3mL Liquid from PAI Holdings, LLC dba PAI Pharma, marketed since Jun 2026 and currently FDA-listed. It is this product's only package size.

NDC 00121-1094-03
🏷️ FDA NDC (as labeled) 0121-1094-03 billing pads the labeler segment with a zero
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 0121-1094-03 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
0121 labeler · 1094 product · 03 package
Package marketed since
Jun 8, 2026
Sample package
No — commercial package
Listing certified through
Dec 31, 2027
Billing quantity
25 EA per package
Barcode (UPC-A, from the NDC)
3 0121109403 2
FDA record last changed
Jul 24, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 0121-1094-03
Product NDC 0121-1094
11-digit billing NDC 00121109403
NCPDP billing unit EA — each (per item)
RxCUI 198857
UNII 92RU3N3Y1O
Application # M002
SPL Set ID 235f458e-c275-4bc1-9c0f-e007c4040649
Physiologic effect Skin Barrier Activity
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2026-06-08
Route ORAL
Dosage form LIQUID
Substance DIMETHICONE

Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification

GPI-14 52200020001810
GCN Seq No 082810
GCN 51467
HICL code 001224
Ingredient (HICL) Simethicone
HIC1 code D
Therapeutic class — broad (HIC1) Biliary System/Gastro-Intestinal System
HIC2 code D4
Therapeutic class — intermediate (HIC2) Drugs Acting Principally On The Alimentary Tract
HIC3 code D4N
Therapeutic class — specific (HIC3) Antiflatulents
AHFS code 56:10.00.00
AHFS class Antiflatulents
FDB label name INF SIMETHICONE 20MG/0.3ML ENF
FDB brand name Infants' Simethicone
Legend status O — Over-the-counter (OTC) drug or device
Quick answers
  • GSN (GCN sequence number): 082810
  • GCN: 51467
  • GPI-14 (Medi-Span): 52200020001810
  • HICL (First Databank): 001224
  • AHFS class code: 56:10.00.00
  • RxCUI (RxNorm): 198857
Why two NDCs? The FDA registers this code as 0121-1094-03 — a 4-4-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the labeler segment → 00121-1094-03. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

Clinical

Label name INF SIMETHICONE 20MG/0.3ML ENF Ingredient Simethicone
📖 What it is MedlinePlus · NLM

Simethicone is used to treat the symptoms of gas such as uncomfortable or painful pressure, fullness, and bloating. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Read the full MedlinePlus article ↗
📗 Our plain-language guide HelloPharmacist
  • It relieves the discomfort of gas. For adults, that means pressure, bloating and fullness. Infant drops are for baby gas, often caused by swallowed air or certain formulas or foods...
  • Shake the bottle well. Use only the syringe or dropper that came with it. Dispense it slowly toward the inner cheek. You can also mix it with 1 oz. of cool water, formula or anothe...
  • Doses can be repeated as needed after meals and at bedtime. Do not go over 12 doses in a day. Follow your product’s label and your doctor’s advice.
  • If you can, use your child’s weight. If not, use age. Check the chart on your product, and ask me or your doctor if you are unsure.
📖 Read our full Simethicone guide →

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
00121-1094-03 You're viewing this Main listing 25 SYRINGE, PLASTIC in 1 CARTON / .3 mL in 1 SYRINGE, PLASTIC 2026-06-08 — Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Infants 20 mg/.3mL 00536-1303-75 RUGBY 1 bottle $0.102 — Availability likely —
Infant Gas Relief 20 mg/.3mL 46122-0547-03 AMERISOURCEBERGEN 1 bottle $0.102 — Availability likely —
Cardinal Health Infants Gas Relief 20 mg/.3mL 70000-0051-01 CARDINAL 1 bottle $0.102 — Availability likely —
Foster and Thrive infants Gas relief 20 mg/.3mL 70677-1078-01 Strategic 1 bottle $0.102 — Availability likely —
SIMETHICONE INFANT Gas Relief Drops 20 mg/.3mL 82568-0017-03 AARNA 1 bottle $0.102 — Availability likely —
Quality Choice Infants Non-staining Gas relief 20 mg/.3mL 83324-0133-01 Chain 1 bottle $0.102 — Availability likely —
Infants Simethicone Drops 20 mg/.3mLthis 00121-1094-03 PAI 25 syringes — — FDA listed —
Childrens Simethicone Drops 40 mg/.6mL 00121-1095-03 PAI 25 syringes — — FDA listed —
Walgreens Infants Dye Free Gas Relief 20 mg/.3mL 00363-0790-30 WALGREEN 1 bottle — — FDA listed —
SIMETHICONE INFANT Gas Relief Drops 20 mg/.3mL 17856-1017-01 Atlantic 120 syringes — — FDA listed —
SIMETHICONE INFANT Gas Relief Drops 20 mg/.3mL 17856-1018-01 Atlantic 60 syringes — — FDA listed —
TEENY TUMMY Gas Relief Drops 20 mg/.3mL 17856-1141-01 ATLANTIC 120 syringes — — FDA listed —
TEENY TUMMY Gas Relief Drops 20 mg/.3mL 17856-1142-01 ALTANTIC 60 syringes — — FDA listed —
Infants 20 mg/.3mL 17856-1303-01 ATLANTIC 120 syringes — — FDA listed —
QUITA COLICOS Gas RELIEF Drops 20 mg/.3mL 24286-1533-08 DLC 1 bottle — — FDA listed —
Infants Gas Relief Dye Free 20 mg/.3mL 30142-0171-01 THE 1 bottle — — FDA listed —
Infants Gas relief 20 mg/.3mL 41163-0096-09 UNITED 1 bottle — — FDA listed —
Meijer Infants Gas Relief Drops 20 mg/.3mL 41250-0470-01 MEIJER 1 bottle — — FDA listed —
Publix Infants Dye Free Gas Relief 20 mg/.3mL 41415-0709-01 PUBLIX 1 bottle — — FDA listed —
Infants Gas Relief Drops 20 mg/.3mL 49035-0709-01 Wal-Mart 1 bottle — — FDA listed —
Infants Gas Relief Drops 20 mg/.3mL 55910-0790-01 DOLGENCORP 1 bottle — — FDA listed —
Infants Gas Relief 20 mg/.3mL 57896-0798-01 Geri-Care 1 bottle — — FDA listed —
Mylicon Infants Gas Relief Original 20 mg/.3mL 62372-0630-15 Infirst 1 bottle — — FDA listed —
Mylicon Infants Gas Relief Dye Free 20 mg/.3mL 62372-0650-15 Infirst 1 bottle — — FDA listed —
Little Remedies Gas Relief Drops 20 mg/.3mL 63029-0103-01 Medtech 1 bottle — — Discontinued —
Quality Choice Infants Dye Free Gas Relief 20 mg/.3mL 63868-0696-30 CHAIN 1 bottle — — FDA listed —
Best Choice 20 mg/.3mL 63941-0709-01 BEST 1 bottle — — FDA listed —
premier value infants gas relief 20 mg/.3mL 68016-0670-00 Chain 1 bottle — — FDA listed —
Infants Gas Relief Drops 20 mg/.3mL 69618-0059-51 RELIABLE 1 bottle — — FDA listed —
Gas-Aid Drops for infants 20 mg/.3mL 69626-5200-09 Leosons 1 bottle — — FDA listed —
CVS Health Anti gas 20 mg/.3mL 69842-0977-01 CVS 1 bottle — — FDA listed —
CVS Health Infant Gas Relief 20 mg/.3mL 69842-0979-15 CVS 1 bottle — — FDA listed —
TEENY TUMMY Gas Relief Drops 20 mg/.3mL 71399-0041-01 Akron 30 ml — — FDA listed —
simethicone gas relief 20 mg/.3mL 71444-0788-01 MOM 1 bottle — — FDA listed —
Infants Gas Relief 20 mg/.3mL 82179-0007-01 Mollec 1 bottle — — FDA listed —
Quality Choice Infants Gas Relief Dye Free 20 mg/.3mL 83324-0335-01 QUALITY 1 bottle — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2026
On the market since
Jun 2026
📍
2026
Currently FDA-listed
listed with the FDA
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII K679OBS311
    Carboxymethylcellulose sodium is a plant-derived thickening agent made from cellulose. In medicines, it acts as a binder to hold ingredients together, a disintegrant to help the tablet break apart, or a thickener in liquids.
  • UNII 2968PHW8QP
    A weak organic acid derived from citrus fruits or made through fermentation. It works as a buffer to control pH, a preservative to extend shelf life, and a flavoring agent in medications.
  • UNII D65DG142WK
    Maltitol is a sugar alcohol made by hydrogenating maltose. It's used as a sweetener and filler in medicines to improve taste and add bulk to tablets and capsules.
  • UNII OP1R32D61U
    Microcrystalline cellulose is a purified form of cellulose, a natural fiber from plant sources. It acts as a binder and filler in tablets and capsules, helping hold ingredients together and give the medicine its shape and size.
  • UNII OJ245FE5EU
    Sodium benzoate is a salt derived from benzoic acid, a preservative. It's added to medicines to prevent growth of bacteria, fungi, and other microorganisms that could spoil the product.
  • UNII 1Q73Q2JULR
    Sodium citrate is a salt derived from citric acid. It works as a buffer to maintain the medicine's pH level and may also help improve taste or act as a preservative in the formulation.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
  • UNII TTV12P4NEE
    Xanthan gum is a thickening and stabilizing ingredient made from fermented corn or other sugars. It's added to medicines to improve texture, prevent separation of liquids and solids, and help the product stay consistent.

8 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statescarboxymethylcellulose sodium, citric acid, flavor, maltitol, microcrystalline cellulose, purified water, sodium benzoate, sodium citrate, xanthan gum

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerPAI Holdings, LLC dba PAI Pharma
FDA applicationM002 (OTC MONOGRAPH DRUG)
Labeler code00121
First marketedJun 2026
Product typeHuman Otc Drug
Portfolio142 products on file

More NDCs from PAI Holdings, LLC dba PAI Pharma labeler code 00121

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Keep Out of Reach of Children 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 8 words ▾

Use relieves the symptoms referred to as gas

⏱️ Dosage and Administration 85 words ▾

Directions dose may be repeated as needed, after meals and at bedtime, or as directed by a physician only use the unit dose filled syringe. Do not use other syringe, dropper, spoon or dosing device when giving this medicine to a child do not exceed 12 doses per day dosage can also be mixed with 1 oz. of cool water, infant formula or other suitable liquids discard syringe after use mL = milliliter Age (years) Weight (lbs) Dose infants (under 2) under 24 0.3 mL

⚠️ Warnings 22 words ▾

Warnings Keep out of reach of children. In case of overdose, get medical help or contact a poison control center right away.

🧪 Active Ingredient 11 words ▾

Active ingredient (in each 0.3 mL filled syringe) Simethicone 20 mg

🧪 Inactive Ingredients 18 words ▾

Inactive ingredients carboxymethylcellulose sodium, citric acid, flavor, maltitol, microcrystalline cellulose, purified water, sodium benzoate, sodium citrate, xanthan gum

🎯 Purpose 2 words ▾

Purpose Antigas

📄 Keep Out of Reach of Children 21 words ▾

Keep out of reach of children. In case of overdose, get medical help or contact a poison control center right away.

📄 Questions or Comments 4 words ▾

Questions or comments? 1-800-845-8210

📄 Package Label / Principal Display Panel 51 words ▾

Principal Display Panel NDC 0121- 1094 -03 Compare to the ingredient of infants MYLICON®* Infants' Simethicone Drops DYE FREE 20 mg/0.3 mL Antigas Relieves the Symptoms Referred to as Gas PAI Pharma Each Box Contains 25 x 0.3 mL (0.01010 fl oz) Unit Dose Filled Syringes carton for Infants Simethicone Drops

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by PAI Holdings, LLC dba PAI Pharma. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
PAI Holdings, LLC dba PAI Pharma is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 00121-1091-55 · PAI 00121-1095-03 · PAI →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.