Home › NDC Lookup › Ingredients › Onion, Apis Mellifera, Atropa Belladonna... › 00220-9049-42
Children Coldcalm ONION, APIS MELLIFERA, ATROPA BELLADONNA, EUPATORIUM PERFOLIATUM FLOWERING TOP, GELSEMIUM SEMPERVIRENS ROOT, POTASSIUM DICHROMATE, STRYCHNOS NUX-VOMICA SEED, PHYTOLACCA AMERICANA ROOT, PULSATILLA VULGARIS 3 [hp_C]/1; 5 [hp_C]/1; 6 [hp_C]/1; 3 [hp_C]/1; 6 [hp_C]/1; 6 [hp_C]/1; 3 [hp_C]/1 Pellet — NDC 00220-9049-42 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

Children Coldcalm ONION, APIS MELLIFERA, ATROPA BELLADONNA, EUPATORIUM PERFOLIATUM FLOWERING TOP, GELSEMIUM SEMPERVIRENS ROOT, POTASSIUM DICHROMATE, STRYCHNOS NUX-VOMICA SEED, PHYTOLACCA AMERICANA ROOT, PULSATILLA VULGARIS 3 [hp_C]/1; 5 [hp_C]/1; 6 [hp_C]/1; 3 [hp_C]/1; 6 [hp_C]/1; 6 [hp_C]/1; 3 [hp_C]/1 Pellet — NDC 0220-9049-42 (Billing 00220-9049-42)

by Laboratoires Boiron · 1 TUBE in 1 BOX / 80 PELLET in 1 TUBE

This is a package of Children Coldcalm ONION, APIS MELLIFERA, ATROPA BELLADONNA, EUPATORIUM PERFOLIATUM FLOWERING TOP, GELSEMIUM SEMPERVIRENS ROOT, POTASSIUM DICHROMATE, STRYCHNOS NUX-VOMICA SEED, PHYTOLACCA AMERICANA ROOT, PULSATILLA VULGARIS 3 [hp_C]/1; 5 [hp_C]/1; 6 [hp_C]/1; 3 [hp_C]/1; 6 [hp_C]/1; 6 [hp_C]/1; 3 [hp_C]/1 Pellet from Laboratoires Boiron, marketed since Sep 2008 and currently FDA-listed. It is this product's only package size.

NDC 00220-9049-42
🏷️ FDA NDC (as labeled) 0220-9049-42 billing pads the labeler segment with a zero
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 8, 2026 · this listing last changed Oct 8, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 0220-9049-42 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
0220 labeler · 9049 product · 42 package
Package marketed since
Sep 8, 2008
Sample package
No — commercial package
Listing certified through
Dec 31, 2026
Barcode (UPC-A, from the NDC)
3 0220904942 3
FDA record last changed
Oct 8, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 0220-9049-42
Product NDC 0220-9049
11-digit billing NDC 00220904942
SPL Set ID a0c35185-8ee5-4d7f-bfba-752503259cf9
Established class (EPC) Increased Hi
Physiologic effect Cell-mediated Immunity; Increased Histamine Release
Chemical class Allergens; Bee Venoms; Dietary Proteins
DEA schedule Non-controlled
Marketing category UNAPPROVED HOMEOPATHIC
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2008-09-08
Route ORAL
Dosage form PELLET
Substance ONION; APIS MELLIFERA; ATROPA BELLADONNA; EUPATORIUM PERFOLIATUM FLOWERING TOP; GELSEMIUM SEMPERVIRENS ROOT; POTASSIUM DICHROMATE; STRYCHNOS NUX-VOMICA SEED; PHYTOLACCA AMERICANA ROOT; PULSATILLA VULGARIS
Why two NDCs? The FDA registers this code as 0220-9049-42 — a 4-4-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the labeler segment → 00220-9049-42. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

Clinical

🧪 What is this product?

Children Coldcalm is an unapproved homeopathic oral pellet product containing nine plant and mineral ingredients used in homeopathic practice. These ingredients, including onion, gelsemium, eupatorium, and apis mellifera (honeybee), are traditionally selected in homeopathy for symptoms associated with common cold and respiratory discomfort. Homeopathic products are marketed based on homeopathic tradition rather than FDA evaluation for effectiveness. This product is not assessed by the FDA for safety or effectiveness like conventional over-the-counter medicines.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eachPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
00220-9049-42 You're viewing this Main listing 1 TUBE in 1 BOX / 80 PELLET in 1 TUBE 2008-09-08 — Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Children Coldcalm 3 [hp_C]/1; 5 [hp_C]/1; 6 [hp_C]/1; 3 [hp_C]/1; 6 [hp_C]/1; 6 [hp_C]/1; 3 [hp_C]this 00220-9049-42 Laboratoires 1 tube — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2008
On the market since
Sep 2008
📍
2026
Currently FDA-listed
18 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII J2B2A4N98G
    Lactose is a natural sugar derived from milk. In medications, it serves as a filler and binder to add bulk and help hold tablet or capsule ingredients together during manufacturing.
  • UNII C151H8M554
    A natural sugar derived from sugar cane or sugar beets. It's used as a sweetener, filler, and binder to improve taste, add bulk, and help hold tablet or capsule ingredients together.

2 inactive ingredients listed in the exact product block matched to this NDC.

The official label also stateslactose, sucrose

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerLaboratoires Boiron
Labeler code00220
First marketedSep 2008
Product typeHuman Otc Drug
Portfolio40 products on file

More NDCs from Laboratoires Boiron labeler code 00220

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 📦 How Supplied / Storage and Handling 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Ask a Doctor Before Use If 📄 Stop Use and Ask a Doctor If 📄 Keep Out of Reach of Children 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 15 words ▾

Temporary relieves cold symptoms such as sneezing, runny nose, nasal congestion and minor sore throat.

⏱️ Dosage and Administration 62 words ▾

Children 3 years of age and older: At the onset of symptoms, dissolve 5 pellets under the tongue every 15 minutes for 1 hour. Then, take 5 pellets every 6 hours. Decrease frequency with improvement. Children under 3 years of age: Ask a doctor. Turn tube upside down, twist until 5 pellets are dispensed, remove cap and pour pellets under the tongue.

⚠️ Warnings 17 words ▾

Do not use if glued carton end flaps are open or if pellet dispenser seal is broken.

📦 How Supplied / Storage and Handling 16 words ▾

2 Tubes Approx. 80 pellets each, 3.8g (0.133 oz.) 16 doses per tube Total 160 Pellets

🧪 Active Ingredient 92 words ▾

Allium cepa 3C HPUS (0.049.mg)** Apis mellifica 6C HPUS (0.049mg)** Belladonna 6C HPUS (0.049mg)** (contains less than 10 -15 mg atropine alkaloids. Eupatorium perfoliatum 3C (0.049mg)** Gelsemium sempervirens 6C (0.049mg)** (contains less an 10 -15 mg gelsemine alkaloids) Kali bichromicum 6C (0.049mg)** (contains less than 10 -13 mg chromium) Nux vomica 3C (0.049mg)** (contains less than 10 -8 mg strychnine alkaloids) Phytolacca decandra 6C (0.049mg)** Pulsatilla 6C (0.049mg)** (in each pellet) The letters "HPUS" indicate that the components in this product are officially monographed in the Homeopathic Pharmacopoeia of the United States.

🧪 Inactive Ingredients 2 words ▾

Lactose, Sucrose.

🎯 Purpose 94 words ▾

Allium cepa 3C HPUS (0.049.mg)* ... Relieves sneezing and runny nose Apis mellifica 6C HPUS (0.049mg)* ... Relieves nasal congestion Belladonna 6C HPUS (0.049mg)* ...

Relieves colds with a sudden onset Eupatorium perfoliatum 3C (0.049mg)* ... Relieves body aches associated with colds Gelsemium sempervirens 6C (0.049mg)* ... Relieves body aches associated with colds Kali bichromicum 6C (0.049mg)* ...

Relieves nasal discharge Nux vomica 3C (0.049mg)* ... Relieves sneezing attacks Phytolacca decandra 6C (0.049mg)* ... Relieves minor sore throat associated with colds Pulsatilla 6C (0.049mg)* ...

Relieves colds with a loss of taste and smell

📄 Ask a Doctor Before Use If 21 words ▾

Ask a doctor before use if sore throat is severe, accompanied or followed by a fever, headache, rash, nausea or vomiting.

📄 Stop Use and Ask a Doctor If 21 words ▾

Stop use and ask a doctor if symptoms persist for more than 2 days or worsen, or if new symptom occur.

📄 Keep Out of Reach of Children 22 words ▾

Keep out of reach of children. In case of accidental overdose, get medical help or contact a Poison Control Center right away.

📄 Questions or Comments 14 words ▾

ColdCalm.com www.boironusa.com 1-800-BOIRON-1 Made in France Distributed by Boiron, Inc. Newtown Square, PA 19073-3267

📄 Package Label / Principal Display Panel 6 words ▾

label label box tube tube box

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for ONION, APIS MELLIFERA, ATROPA BELLADONNA, EUPATORIUM PERFOLIATUM FLOWERING TOP, GELSEMIUM SEMPERVIRENS ROOT, POTASSIUM DICHROMATE, STRYCHNOS NUX-VOMICA SEED, PHYTOLACCA AMERICANA ROOT, PULSATILLA VULGARIS — the ingredient across all brands.

Top reported reactions

Abdominal Pain2
Cardiomegaly2
Constipation2
Cough2
Dry Skin2
Fatigue2
Hallucination2

Reporter sex

7 reports
Male · 17%
Female · 83%
Reports over time (by year) — tap or hover for the count & year
2019 2021 2023 2026 3 0
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

About this NDC listing & data coverage

Over-the-counter (OTC) product Homeopathic listing

About homeopathic listings

Children Coldcalm ONION, APIS MELLIFERA, ATROPA BELLADONNA, EUPATORIUM PERFOLIATUM FLOWERING TOP, GELSEMIUM SEMPERVIRENS ROOT, POTASSIUM DICHROMATE, STRYCHNOS NUX-VOMICA SEED, PHYTOLACCA AMERICANA ROOT, PULSATILLA VULGARIS 3 [hp_C]/1; 5 [hp_C]/1; 6 [hp_C]/1; 3 [hp_C]/1; 6 [hp_C]/1; 6 [hp_C]/1; 3 [hp_C]/1 PELLET is listed under the homeopathic marketing category. An NDC listing in this category does not by itself establish FDA approval, and FDA does not evaluate homeopathic products for effectiveness. This page reports the listing data as published.

What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Unapproved Homeopathic". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Laboratoires Boiron. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
Laboratoires Boiron is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 00220-9048-04 · Laboratoires 00220-9050-75 · Laboratoires →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.