Alka-Seltzer Heartburn Plus Gas ReliefChews Tropical Punch CALCIUM CARBONATE AND SIMETHICONE 80 mg; 750 mg Tablet, Chewable, 180-count
by Bayer HealthCare LLC. · 180 TABLET, CHEWABLE in 1 BOTTLE, PLASTIC (0280-0225-05)
NDC 00280-0225-05
🏷️ FDA NDC (as labeled)
0280-0225-05
billing pads the labeler segment with a zero
This package
Contains180-count
Pack sizes7 compare ↓
Also comes in:
28 tablets 00280-0225-02
32 tablets 00280-0225-32
54 tablets 00280-0225-54
60 tablets 00280-0225-03
82 tablets 00280-0225-82
110 tablets 00280-0225-01
OTC
On market
Non-controlled
🗂️ Data synced Aug 27, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →
🆔 Identity & classification
FDA NDC (as labeled)
0280-0225-05
Product NDC
0280-0225
11-digit billing NDC
00280022505
RxCUI
1492387
UNII
92RU3N3Y1O, H0G9379FGK
Application #
M001
SPL Set ID
41d17406-3653-4889-81df-6270b7b5d3c7
Physiologic effect
Skin Barrier Activity
DEA schedule
Non-controlled
Marketing category
OTC MONOGRAPH DRUG
Marketing status
On market
FDA listing status
Listed (active directory)
Marketing start
2014-03-15
Route
ORAL
Dosage form
TABLET, CHEWABLE
Substance
DIMETHICONE; CALCIUM CARBONATE
GPI-14
48991002050553
GPI class
Alka-Seltzer Heartburn + Gas
Why two NDCs?
The FDA registers this code as 0280-0225-05 — a 4-4-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the labeler segment → 00280-0225-05. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.
🏷️ RxNorm drug class
This medicine belongs to the Calcium compounds class.
Drug family (ATC)
Calcium compounds, Calcium
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.
🏭 Manufacturer & labeler
LabelerBayer HealthCare LLC.
FDA applicationM001 (OTC MONOGRAPH DRUG)
Labeler code00280
First marketedMar 2014
Product typeHuman Otc Drug
Portfolio240 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.
🩺 Clinical
📖 About the active ingredient: Dimethicone; Calcium Carbonate MedlinePlus · NLM
General information about the ingredient itself — the description of this specific product follows below.
Calcium carbonate is a dietary supplement used when the amount of calcium taken in the diet is not enough. Calcium is needed by the body for healthy bones, muscles, nervous system, and heart. Calcium carbonate also is used as an antacid to relieve heartburn, acid indigestion, and upset stomach. It is available with or without a prescription. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Read the full MedlinePlus article ↗🧪 What is this product?
Alka-Seltzer Heartburn Plus Gas Relief Chews is a chewable tablet taken by mouth that combines two active ingredients. Calcium carbonate functions as an antacid, typically used to neutralize stomach acid and relieve heartburn. Dimethicone (also called simethicone) is an anti-gas ingredient commonly used to help break up gas bubbles in the digestive tract. This is an over-the-counter monograph product, meaning it is marketed under established FDA guidelines for this category of antacid and anti-gas products.
Patient education
Supplement & herbal interactions
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.
💬 Questions about CALCIUM CARBONATE AND SIMETHICONE?
Ask a pharmacist →
Ask a licensed pharmacist directly — free, answered by our team.
💊 What it looks like
Color
pink
ShapeRound
ImprintHG
Size18 mm
ScoringNot scored
FlavorTropical Fruit Punch
One label can cover several strengths, so colors may be combined — always confirm a loose pill against the dispensed prescription label or a pharmacist.
Where does this data come from?
Physical description (imprint, shape, color, scoring, coating) from this product’s FDA Structured Product Labeling (SPL), mirrored from DailyMed / openFDA.
🧪 Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured
IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.
💲 Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per each | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.
🔁 Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Tums Chewy Bites with Gas Relief 750 mg/1; 80 mg 00135-0624-01 | Haleon | 28 tablets | — | — | FDA listed | — |
| Alka-Seltzer Kids Tummy ReliefChews 750 mg/1; 80 mg 00280-0051-01 | Bayer | 28 tablets | — | — | FDA listed | — |
| Alka-Seltzer Heartburn Plus Gas ReliefChews Tropical Punch 80 mg/1; 750 mgthis 00280-0225-05 | Bayer | 180 tablets | — | — | FDA listed | — |
| Walgreens Cherry Berry Lime Antacid HBG 54ct 750 mg/1; 80 mg 00363-9953-54 | Walgreens | 54 tablets | — | — | FDA listed | — |
| Target Antacid - Anti-Gas Relief Chews 80 mg/1; 750 mg 11673-0052-54 | Target | 54 tablets | — | — | FDA listed | — |
| Target Berry Lime HBG Chews 80 mg/1; 750 mg 11673-0547-54 | Target | 54 tablets | — | — | FDA listed | — |
| Mixed Berry Antacid and Anti-Gas Chews 80 mg/1; 750 mg 49035-0058-54 | Walmart | 54 tablets | — | — | FDA listed | — |
| CVS Mixed Berry Antacid HBG 54ct 750 mg/1; 80 mg 51316-0050-54 | CVS | 54 tablets | — | — | FDA listed | — |
| CVS Mixed Berry Antacid HBG 28ct 80 mg/1; 750 mg 51316-0051-28 | CVS | 28 tablets | — | — | FDA listed | — |
| Heartburn and gas fruit chews 80 mg/1; 750 mg 69842-0362-36 | CVS | 36 tablets | — | — | FDA listed | — |
| Basic Care Berry Antacid HBG 80 mg/1; 750 mg 72288-0235-82 | Amazon.com | 82 tablets | — | — | FDA listed | — |
| TopCare Cherry Berry Lime Antacid HBG 80 mg/1; 750 mg 76162-0408-54 | TopCo | 54 tablets | — | — | FDA listed | — |
| Meijer Berry Lime Antacid HBG Chews 750 mg/1; 80 mg 79481-0093-01 | Meijer | 54 tablets | — | — | FDA listed | — |
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.
⏳ Availability & generic status
🏛️
2014
On the market since
Mar 2014
📍
2026
Currently FDA-listed
12 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.
📦 Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Status |
|---|---|---|---|
| 00280-0225-01 | 110 TABLET, CHEWABLE in 1 BOTTLE, PLASTIC (0280-0225-01) | 2020-03-01 | Active |
| 00280-0225-02 | 28 TABLET, CHEWABLE in 1 BOTTLE, PLASTIC (0280-0225-02) | 2014-03-15 | Active |
| 00280-0225-03 | 60 TABLET, CHEWABLE in 1 BOTTLE, PLASTIC (0280-0225-03) | 2020-03-01 | Active |
| 00280-0225-32 | 32 TABLET, CHEWABLE in 1 BOTTLE, PLASTIC (0280-0225-32) | 2014-03-15 | Active |
| 00280-0225-54 | 54 TABLET, CHEWABLE in 1 BOTTLE, PLASTIC (0280-0225-54) | 2014-03-15 | Active |
| 00280-0225-82 | 82 TABLET, CHEWABLE in 1 BOTTLE, PLASTIC (0280-0225-82) | 2017-03-01 | Active |
| 00280-0225-05 You're viewing this | 180 TABLET, CHEWABLE in 1 BOTTLE, PLASTIC (0280-0225-05) | 2020-03-01 | Active |
You're viewing the largest of 7 pack sizes for this product.
Pack size FAQ
What quantity is in NDC 00280-0225-05?
NDC 00280-0225-05 is a 180-count package — 180 tablet, chewable in 1 bottle, plastic.
What is the difference between NDC 00280-0225-05 and NDC 00280-0225-02?
Both are Alka-Seltzer Heartburn Plus Gas ReliefChews Tropical Punch CALCIUM CARBONATE AND SIMETHICONE 80 mg; 750 mg Tablet, Chewable — the drug itself is identical. NDC 00280-0225-05 is the 180-count package, while NDC 00280-0225-02 is the 28 tablets package.
What NDC number is used to bill for this package of Alka-Seltzer Heartburn Plus Gas ReliefChews Tropical Punch CALCIUM CARBONATE AND SIMETHICONE 80 mg; 750 mg Tablet, Chewable?
Bill NDC 00280-0225-05 — the 11-digit billing format is 00280022505. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.
🧭 About this NDC listing & data coverage
Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | ✓ Available |
| Inactive ingredients (structured) | — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available. |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope. |
| HCPCS J-code billing crosswalk | — Not published for this NDC Most self-administered / retail products have no J-code — that is normal. |
| Medicaid utilization (CMS SDUD) | — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold. |
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.
Questions about this listing
Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 0280-0225-05, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 00280-0225-05, written without dashes as 00280022505. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 00280-0225-05, the first segment (00280) is the labeler code FDA assigned to Bayer HealthCare LLC.; the middle segment (0225) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (05) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Bayer HealthCare LLC.. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 6 other package presentations of this same product, including 28 tablets (00280-0225-02), 32 tablets (00280-0225-32), 54 tablets (00280-0225-54). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
Bayer HealthCare LLC. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
📄 FDA label — Drug Facts FDA SPL
The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage
⏱️ Dosage and Administration
⚠️ Warnings
📦 Storage and Handling
🧪 Active Ingredient
🧪 Inactive Ingredients
🎯 Purpose
🎯 Indications and Usage ▾
Uses for the relief of: acid indigestion heartburn sour stomach upset stomach associated with these symptoms bloating, pressure, or stuffed feeling commonly referred to as gas
⏱️ Dosage and Administration ▾
Directions adults and children 12 years and over: chew and swallow 1-2 chewable tablets every 2 to 4 hours as symptoms occur, or as directed by a doctor children under 12 years: consult a doctor do not take more than 6 chewable tablets in a 24-hour period
⚠️ Warnings ▾
Warnings Do not use if you have ever had an allergic reaction to this product or any of its ingredients Ask a doctor or pharmacist before use if you are presently taking a prescription drug. Antacids may interact with certain prescription drugs. When using this product do not take more than 6 chewable tablets in a 24-hour period do not use the maximum dosage of this product for more than 2 weeks, except under the advice and supervision of a physician constipation may occur If pregnant or breast-feeding, ask a health professional before use.
Keep out of reach of children.
📦 Storage and Handling ▾
Other information each chewable tablet contains: calcium 330 mg store at room temperature. Avoid excessive heat above 40°C (104°F). close cap tightly after use
🧪 Active Ingredient ▾
Active ingredient (in each chewable tablet) Purpose Calcium carbonate 750 mg Antacid Simethicone 80 mg Antigas
🧪 Inactive Ingredients ▾
Inactive ingredients acacia, carmine, carnauba wax, citric acid, corn starch, corn syrup, FD&C red #40 aluminum lake, flavors, hydrogenated coconut oil, hydrogenated vegetable oil, lecithin, maltodextrin, methyl paraben, modified starch, potassium hydroxide, pregelatinized modified starch, propyl paraben, propylene glycol, shellac, sorbic acid, sorbitol, sugar, titanium dioxide, triacetin, water, white wax
🎯 Purpose ▾
Active ingredient (in each chewable tablet) Purpose Calcium carbonate 750 mg Antacid Simethicone 80 mg Antigas
No label section mentions that — try another word, or open the full label on DailyMed below.
Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA.
Prefer the government’s original formatting? View this label on DailyMed ↗
For educational and professional reference only — not medical advice. Pricing reflects published
NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.