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Advil Targeted Relief camphor, capsaicin, menthol, methyl salicylate 31 mg/g; .25 mg/g; 100 mg/g; 150 mg/g Cream, 3 g — NDC 00573-6555-48 package photo

Advil Targeted Relief camphor, capsaicin, menthol, methyl salicylate 31 mg/g; .25 mg/g; 100 mg/g; 150 mg/g Cream, 3 g

by Haleon US Holdings LLC · 3 g in 1 POUCH (0573-6555-48)
NDC 00573-6555-48
🏷️ FDA NDC (as labeled) 0573-6555-48 billing pads the labeler segment with a zero
This package
Contains3 g Pack sizes4 compare ↓
Also comes in: 71 g 00573-6555-45 113.4 g 00573-6555-51 65 g 00573-6555-54
OTC On market Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

🆔 Identity & classification

FDA NDC (as labeled) 0573-6555-48
Product NDC 0573-6555
11-digit billing NDC 00573655548
RxCUI 2049725
UNII N20HL7Q941, S07O44R1ZM, L7T10EIP3A, LAV5U5022Y
Application # M017
SPL Set ID 16e6be21-7b43-443a-89ec-3bdf0ec0dfc1
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2024-03-06
Route TOPICAL
Dosage form CREAM
Substance CAMPHOR (NATURAL); CAPSAICIN; MENTHOL, UNSPECIFIED FORM; METHYL SALICYLATE
GCN Seq No 086994
GCN 56806
HICL code 005538
Ingredient (HICL) Capsaicin/M.salicyl/Menth/Camp
HIC1 code L
Therapeutic class — broad (HIC1) Skin/Subcutaneous Tissue
HIC2 code L6
Therapeutic class — intermediate (HIC2) Irritants
HIC3 code L6A
Therapeutic class — specific (HIC3) Irritants/Counter-Irritants
AHFS code 84:92.00.00
AHFS class Skin And Mucous Membrane Agents, Misc.
FDB label name ADVIL TARGETED RELIEF CREAM
FDB brand name Advil Targeted Relief
Legend status O — Over-the-counter (OTC) drug or device
Why two NDCs? The FDA registers this code as 0573-6555-48 — a 4-4-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the labeler segment → 00573-6555-48. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏭 Manufacturer & labeler

LabelerHaleon US Holdings LLC
FDA applicationM017 (OTC MONOGRAPH DRUG)
Labeler code00573
First marketedMar 2024
Product typeHuman Otc Drug
Portfolio404 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

Label name ADVIL TARGETED RELIEF CREAM Ingredient Capsaicin/M.salicyl/Menth/Camp
🧪 What is this product?

Advil Targeted Relief is a topical cream marketed under FDA's over-the-counter monograph rules for pain-relief products. It contains four active ingredients that work together: menthol and camphor produce a cooling sensation on the skin, capsaicin is derived from chili peppers and is commonly used in topical creams to reduce discomfort, and methyl salicylate (oil of wintergreen) is typically included in pain-relief creams. The combination is intended to be applied directly to the skin over areas where relief is sought.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

💊 What it looks like

Color white
One label can cover several strengths, so colors may be combined — always confirm a loose pill against the dispensed prescription label or a pharmacist.
Where does this data come from?
Physical description (imprint, shape, color, scoring, coating) from this product’s FDA Structured Product Labeling (SPL), mirrored from DailyMed / openFDA.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 0A5MM307FC
    A synthetic polymer that absorbs water and forms a thick, gel-like substance. In medicines, it works as a thickener and stabilizer to improve texture and help ingredients stay mixed together in creams, gels, and lotions.
  • UNII R12CBM0EIZ
    A natural wax derived from a Brazilian palm tree, used as a coating and polish on tablets and capsules. It creates a smooth, shiny finish that protects the medicine and improves appearance.
  • UNII 936JST6JCN
    Cetyl alcohol is a waxy, fatty substance derived from plant or animal sources. It acts as an emulsifier and thickener in medicines, helping blend oil and water components and giving products a smooth, creamy texture.
  • UNII D072FFP9GU
    Cetyl esters wax is a waxy substance made from natural or synthetic fatty acids. It's used as a binder, hardening agent, and coating material to give tablets and capsules their structure and texture.
  • UNII 3RJ7186O9W
    A waxy ester derived from plant or mineral sources. It works as an emollient and binder in topical products to help soften skin and hold ingredients together.
  • UNII 8Q0Z18J1VL
    A surfactant derived from oleic acid, a naturally occurring fatty acid. It helps mix oil and water-based ingredients together in formulations, improving product stability and texture.
  • UNII 55X04QC32I
    A strong alkaline chemical used to adjust and maintain the pH balance of liquid medicines. It helps keep the medicine stable and ensures it stays effective during storage.
  • UNII 4ELV7Z65AP
    Stearic acid is a fatty acid derived from plant or animal sources. It acts as a binder and lubricant in tablets and capsules, helping them hold together and flow smoothly during manufacturing.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

9 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statescarbomer homopolymer, cetyl alcohol, cetyl esters wax, emulsifying wax, oleth-3-phosphate, purified water, sodium hydroxide, stearic acid

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer gPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 71 g 113.4 g 65 g
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Advil Targeted Relief 31 mg/g; .25 mg/g; 100 mg/g; 150 mg/gthis 00573-6555-48 Haleon 3 g — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2024
On the market since
Mar 2024
📍
2026
Currently FDA-listed
2 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

🔬 Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Camphor, capsaicin, menthol, methyl salicylate — the ingredient across all brands.

Top reported reactions

Drug Effective For Unapproved Indication7
Drug Effect Less Than Expected4
Burning Sensation3
Application Site Burn2
Application Site Pain2
Pruritus2
Chemical Burn1

Reporter sex

26 reports
Male · 43%
Female · 57%
Reports over time (by year) — tap or hover for the count & year
2025 2026 3 0
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
00573-6555-45 1 TUBE, WITH APPLICATOR in 1 CARTON (0573-6555-45) / 71 g in 1 TUBE, WITH APPLICATOR 2024-03-06 Active
00573-6555-48 You're viewing this 3 g in 1 POUCH (0573-6555-48) 2024-03-06 Active
00573-6555-51 1 TUBE in 1 CARTON (0573-6555-51) / 113.4 g in 1 TUBE 2024-03-06 Active
00573-6555-54 1 TUBE in 1 CARTON (0573-6555-54) / 65 g in 1 TUBE 2024-03-06 Active

Pack size FAQ

What quantity is in NDC 00573-6555-48?
NDC 00573-6555-48 contains 3 g — 3 g in 1 pouch.
What is the difference between NDC 00573-6555-48 and NDC 00573-6555-51?
Both are Advil Targeted Relief camphor, capsaicin, menthol, methyl salicylate 31 mg/g; .25 mg/g; 100 mg/g; 150 mg/g Cream — the drug itself is identical. NDC 00573-6555-48 is the 3 g package, while NDC 00573-6555-51 is the 1 tube package.
What NDC number is used to bill for this package of Advil Targeted Relief camphor, capsaicin, menthol, methyl salicylate 31 mg/g; .25 mg/g; 100 mg/g; 150 mg/g Cream?
Bill NDC 00573-6555-48 — the 11-digit billing format is 00573655548. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

🧭 About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 0573-6555-48, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 00573-6555-48, written without dashes as 00573655548. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 00573-6555-48, the first segment (00573) is the labeler code FDA assigned to Haleon US Holdings LLC; the middle segment (6555) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (48) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Haleon US Holdings LLC. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 3 other package presentations of this same product, including 1 tube (00573-6555-45), 1 tube (00573-6555-51), 1 tube (00573-6555-54). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
Haleon US Holdings LLC is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 📦 Storage and Handling 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 19 words ▾

Uses Temporarily relieves minor aches and pains of muscles and joints associated with: arthritis strains simple backache bruises sprains

⏱️ Dosage and Administration 37 words ▾

Directions use only as directed adults and children 12 years and older: apply to affected area not more than 3 to 4 times daily children under 12 years of age: consult your doctor wash hands after applying

⚠️ Warnings 123 words ▾

Warnings For external use only avoid contact with eyes. If eye contact occurs, rinse thoroughly with water. Do not use on wounds or damaged skin with a heating pad if you are allergic to any ingredients in this product Ask a doctor before use if you have redness over the affected area When using this product do not bandage tightly Stop use and ask a doctor if condition worsens or if symptoms last for more than 7 days symptoms clear up and occur again within a few days rash, itching or skin irritation develops If pregnant or breast-feeding, ask a health professional before use Keep out of reach of children.

If swallowed, get medical help or contact a Poison Control Center right away.

📦 Storage and Handling 6 words ▾

Other information store between 20-25°C (68-77°F)

🧪 Active Ingredient 11 words ▾

Active ingredients Camphor 3.1% Capsaicin 0.025% Menthol 10% Methyl salicylate 15%

🧪 Inactive Ingredients 18 words ▾

Inactive ingredients carbomer homopolymer, cetyl alcohol, cetyl esters wax, emulsifying wax, oleth-3-phosphate, purified water, sodium hydroxide, stearic acid

🎯 Purpose 9 words ▾

Purposes Topical analgesic Topical analgesic Topical analgesic Topical analgesic

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 00573-2919-12 · Haleon 00574-0106-01 · Padagis →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.