MEDICAL AIR 21 L/100L Gas, 625 l — NDC 49221-0025-1 (Billing 49221-0025-01)
by Strate Welding Supply Co., Inc. · 625 L in 1 CYLINDER
This is a package of 625 l of MEDICAL AIR 21 L/100L Gas from Strate Welding Supply Co., Inc., marketed since Jan 1949 and currently FDA-listed. It is the main listing for this product, which comes in 2 package sizes.
NDC 49221-0025-01
🏷️ FDA NDC (as labeled)
49221-0025-1
billing pads the package segment with a zero
This package
Contains625 l
Pack sizes2 compare ↓
Main listing for product 49221-0025 · Also comes in:
6620 l 49221-0025-3
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →
Identity & classification
Regulatory identifiers FDA, NLM and CMS codes for this package
FDA NDC (as labeled)
49221-0025-1
Product NDC
49221-0025
11-digit billing NDC
49221002501
RxCUI
347856
UNII
S88TT14065
Application #
NDA205765
SPL Set ID
a0bc2060-04d7-41f7-a657-1d2e0099abb9
DEA schedule
Non-controlled
Marketing category
NDA
Marketing status
On market
FDA listing status
Listed (active directory)
Marketing start
1949-01-01
Route
RESPIRATORY (INHALATION)
Dosage form
GAS
Substance
OXYGEN
Quick answers
- RxCUI (RxNorm): 347856
Why two NDCs?
The FDA registers this code as 49221-0025-1 — a 5-4-1 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the package segment → 49221-0025-01. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 1, 2026
- RxNorm (NLM RxNav) · catalog refreshed Oct 1, 2026
- Medi-Span GPI (licensed)
- First Databank (licensed) · refreshed Oct 1, 2026
RxNorm drug class
This medicine belongs to the Medical gases class.
Drug family (ATC)
Medical gases
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.
- RxClass (NLM) · catalog refreshed Oct 1, 2026
Clinical
📗 Our plain-language guide HelloPharmacist
- It is used during an ultrasound exam called sonohysterosalpingography. It helps your doctor see whether your fallopian tubes are open. It is used when infertility is known or suspe...
- No. A healthcare professional mixes the foam and places it into your uterus through a thin catheter during the exam. They infuse it slowly to keep you comfortable.
- Some women have pelvic or belly pain, nausea, faintness or light spotting afterward. Call your doctor if the pain is severe or you have signs of infection.
- No. It must not be used in pregnancy. You will need a negative pregnancy test within 24 hours before the exam, and the exam is timed for the first half of your cycle.
Patient education
Supplement & herbal interactions
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.
- MedlinePlus (NLM) · refreshed Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 1, 2026
💬 Questions about AIR?
Ask a pharmacist →
Ask a licensed pharmacist directly — free, answered by our team.
Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per each | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size:
6620 l
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.
- CMS NADAC weekly file
- CMS ASP pricing files · refreshed Sep 20, 2026
- CMS Medicaid State Drug Utilization Data · refreshed Oct 2, 2026
- CMS Part D plan pricing files · refreshed Sep 24, 2026
- VA National Acquisition Center price file
Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Marketing end | Status |
|---|---|---|---|---|
| 49221-0025-01 You're viewing this Main listing | 625 L in 1 CYLINDER | 1949-01-01 | — | Active |
| 49221-0025-03 49221-0025-3 | 6620 L in 1 CYLINDER | 1949-01-01 | — | Active |
You're viewing the smallest of 2 pack sizes for this product.
Pack size FAQ
What quantity is in this package?
This package contains 625 l — 625 l in 1 cylinder.
How does this package differ from NDC 49221-0025-03?
Both are MEDICAL AIR 21 L/100L Gas — the drug itself is identical. This page's package is the 625 l one, while NDC 49221-0025-03 is the 6620 l package.
What NDC number is used to bill for this package of MEDICAL AIR 21 L/100L Gas?
Use the 11-digit billing form listed in the identifiers section of this page. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.
Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Air 210 mL/L 10297-0103-01 | A-OX | 680 l | — | — | FDA listed | — |
| Air 210 mL/L 10451-0004-01 | General | 679 l | — | — | FDA listed | — |
| Air 210 mL/L 11054-0110-01 | AIRGAS | 105 l | — | — | Discontinued | — |
| Air 210 mL/L 11324-0006-01 | Linde | 8778 l | — | — | FDA listed | — |
| Air 210 mL/L 11564-0004-04 | Fresno | 623 l | — | — | FDA listed | — |
| Nitrogen Oxygen Mix 210 mL/L 12213-0733-12 | NexAir, | 5890 l | — | — | FDA listed | — |
| Air 210 mL/L 14961-0004-01 | Haun | 606 l | — | — | FDA listed | — |
| Air 210 mL/L 17575-0300-01 | AGL | 8637 l | — | — | FDA listed | — |
| Compressed Oxygen 21 kg/100L 18087-0007-01 | James | 170 l | — | — | FDA listed | — |
| Air 210 mL/L 21220-0152-01 | General | 8778 l | — | — | FDA listed | — |
| Medical Air 210 mL/L 48273-0012-01 | Keen | 385 l | — | — | FDA listed | — |
| Medical Air 21 L/100Lthis 49221-0025-01 | Strate | 625 l | — | — | FDA listed | — |
| Air 210 mL/L 50063-0004-01 | Andy-Oxy | 368 l | — | — | FDA listed | — |
| Air 210 mL/L 51486-0018-01 | ILMO | 8807 l | — | — | FDA listed | — |
| Air, Compressed 21 L/100L 52374-0006-03 | Messer | 3000 l | — | — | FDA listed | — |
| Air 210 mL/L 53452-0003-01 | Dale | 6598 l | — | — | FDA listed | — |
| Air 210 mL/L 55147-0004-03 | Minneapolis | 3030 l | — | — | FDA listed | — |
| Oxygen 210 mL/L 59400-0001-01 | BayCare | 670 l | — | — | Discontinued | — |
| Oxygen 210 mg/kg 59400-0005-01 | BayCare | 34168 kg | — | — | Discontinued | — |
| Air 210 mL/L 64169-0003-01 | EUGENE | 408 l | — | — | FDA listed | — |
| Reconstituted Air 210 mL/L 68877-0009-01 | United | 1133 l | — | — | Discontinued | — |
| Air 210 mL/L 70151-0003-01 | Central | 680 l | — | — | Discontinued | — |
| Air 210 mL/L 72276-0005-01 | MITCHELL | 190 l | — | — | FDA listed | — |
About this product: this is the brand-name version. We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA Orange Book · refreshed Sep 3, 2026
- CMS NADAC weekly file
Availability & generic status
🏛️
1949
On the market since
Jan 1949
📍
2026
Currently FDA-listed
77 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.
- FDA Orange Book · refreshed Sep 3, 2026
Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
-
UNII N762921K75
A colorless, odorless gas that makes up most of the air we breathe. In medicines, it's used as a packaging gas or propellant to protect products from oxidation and maintain freshness.
1 inactive ingredient listed in the exact product block matched to this NDC.
Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed —
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.- FDA label on DailyMed · label index refreshed Oct 1, 2026
- FDA openFDA NDC Directory · synced Oct 1, 2026
Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.
Manufacturer & labeler
LabelerStrate Welding Supply Co., Inc.
FDA applicationNDA205765 (NDA)
Labeler code49221
First marketedJan 1949
Product typeHuman Prescription Drug
Portfolio4 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.
- FDA openFDA NDC Directory · synced Oct 1, 2026
- Drugs@FDA
Full prescribing information FDA SPL
The complete FDA label for this product — the official prescribing information, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
📄 Package Label / Principal Display Panel ▾
AIR COMPRESSED USP LABEL LINDE AIR, COMPRESSED UN 1002 DO NOT REMOVE THIS LABEL L AND SP 7061E MG 812H 11/07 MADE IN USA NON-FLAMMABLE 2 MEDICAL AIR, U.S.P. CAUTION: HIGH PRESSURE GAS MAY ACCELERATE COMBUSTION. KEEP OIL AND GREASE AWAY.
USE ONLY WITH EQUIPMENT DESIGNED FOR COMPRESSED AIR SERVICE AND RATED FOR CYLINDER PRESSURE. USER SHALL SECURE CYLINDER IN USE AND IN STORAGE. USE IN UPRIGHT POSITION.
CLOSE VALVE AFTER EACH USE AND WHEN EMPTY. KEEP VALVE PROTECTIVE CAP IN PLACE WHEN NOT IN USE, IF SO EQUIPPED.USE IN ACCORDANCE WITH THE SPECIFIC MATERIAL SAFETY DATA SHEET (MSDS) FOR THIS PRODUCT. WWW.LINDEUS.COM WARNING: FOR BREATHING SUPPORT WHEN USED BY PROPERLY TRAINED PERSONNEL.
FOR MEDICAL APPLICATIONS Rx ONLY. ADMINISTRATION OF MEDICAL AIR MAY BE HAZARDOUS OR CONTRAINDICATED. FOR MEDICAL USE ONLY BY OR UNDER THE SUPERVISION OF A LICENSED PRACTITIONER WHO IS EXPERIENCED IN THE USE AND ADMINISTRATION OF MEDICAL AIR USP AND IS FAMILIAR WITH THE INDICATIONS, EFFECTS, DOSAGES, METHODS, AND FREQUENCY AND DURATION OF ADMINISTRATION, AND WITH THE HAZARDS, CONTRAINDICATIONS AND SIDE EFFECTS AND PRECAUTIONS TO BE TAKEN.
TO BE FILLED BY A LINDE AUTHORIZED FACILITY ONLY. RETURN WITH 25 PSIG. STRATE WELDING SUPPLY CO., INC.
101 COMET STREET BUFFALO, NY 14216 PRESSURE: PSIG AT 70 DEGREES F SIZE LITERS CONTENTS AIR LABEL
No label section mentions that — try another word, or open the full label on DailyMed below.
Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA.
Prefer the government’s original formatting? View this label on DailyMed ↗
About this NDC listing & data coverage
Finished prescription product
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | — Not published for this NDC No photo available yet for this listing. |
| Inactive ingredients (structured) | ✓ Available |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope. |
| HCPCS J-code billing crosswalk | — Not published for this NDC Most self-administered / retail products have no J-code — that is normal. |
| Medicaid utilization (CMS SDUD) | — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold. |
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.
Questions about this listing
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Strate Welding Supply Co., Inc.. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 1 other package presentation of this same product, including 6620 l (49221-0025-03). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
Strate Welding Supply Co., Inc. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as a prescription product, so it is dispensed under a prescriber's order. Your pharmacist can tell you whether any over-the-counter forms of the same medication exist.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
For educational and professional reference only — not medical advice. Pricing reflects published
NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.