HomeNDC LookupIngredientsPyrithione Zinc › 49967-0052-01
Matrix Biolage ScalpSync Antidandruff Pyrithione Zinc 10 mg/mL Shampoo, 400 mL — NDC 49967-0052-01 package photo

Matrix Biolage ScalpSync Antidandruff Pyrithione Zinc 10 mg/mL Shampoo, 400 mL

by L'Oreal USA Products Inc · 400 mL in 1 BOTTLE (49967-052-01)
NDC 49967-0052-01
🏷️ FDA NDC (as labeled) 49967-052-01 billing pads the product segment with a zero
This package
Contains400 mL Pack sizes3 compare ↓
OTC On market Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

🆔 Identity & classification

FDA NDC (as labeled) 49967-052-01
Product NDC 49967-052
11-digit billing NDC 49967005201
RxCUI 209884
UNII R953O2RHZ5
UPC 0801788438654
Application # M032
SPL Set ID 8564f2cf-b680-4e2c-8451-f345c9852c1a
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2014-05-01
Route TOPICAL
Dosage form SHAMPOO
Substance PYRITHIONE ZINC
Why two NDCs? The FDA registers this code as 49967-052-01 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 49967-0052-01. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏷️ RxNorm drug class

This medicine belongs to the Other dermatologicals class.

Drug family (ATC) Other dermatologicals
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

🏭 Manufacturer & labeler

LabelerL'Oreal USA Products Inc
FDA applicationM032 (OTC MONOGRAPH DRUG)
Labeler code49967
First marketedMay 2014
Product typeHuman Otc Drug
Portfolio197 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

🧪 What is this product?

Matrix Biolage ScalpSync is an over-the-counter antidandruff shampoo containing pyrithione zinc as its active ingredient. This is an OTC monograph product, meaning it is marketed under established FDA guidelines for antidandruff shampoos rather than as an individually reviewed drug application. Pyrithione zinc is typically used in shampoos to help reduce flaking and itching associated with dandruff and seborrheic dermatitis of the scalp. The product is applied topically by washing the hair and scalp.

Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII WC51CA3418
    A fragrance compound derived from cinnamon, used as a flavoring and scent agent in medicines to improve taste and aroma.
  • UNII 7X6O37OK2I
    A synthetic fragrance compound used as a flavoring agent or aromatic component in medicines. It adds pleasant taste or smell to make the medication more acceptable to patients.
  • UNII LKG8494WBH
    Benzyl alcohol is a clear liquid used as a preservative and solvent in medicines. It helps prevent bacterial and fungal growth and dissolves other ingredients to create uniform liquid formulations.
  • UNII 0A5MM307FC
    A synthetic polymer that absorbs water and forms a thick, gel-like substance. In medicines, it works as a thickener and stabilizer to improve texture and help ingredients stay mixed together in creams, gels, and lotions.
  • UNII K679OBS311
    Carboxymethylcellulose sodium is a plant-derived thickening agent made from cellulose. In medicines, it acts as a binder to hold ingredients together, a disintegrant to help the tablet break apart, or a thickener in liquids.
  • UNII 2968PHW8QP
    A weak organic acid derived from citrus fruits or made through fermentation. It works as a buffer to control pH, a preservative to extend shelf life, and a flavoring agent in medications.
  • UNII C80684146D
    A foaming agent and thickener derived from coconut oil. It helps create a smooth texture and stable foam in liquid or semi-solid medicines, improving how the product feels and applies.
  • UNII 03DH2IZ3FY
    A mild cleansing agent derived from coconut oil. It's used in medicines as a surfactant to help dissolve or distribute other ingredients evenly throughout the formulation.
  • UNII A4VZ22K1WT
    Coumarin is a fragrant organic compound derived from plants or made synthetically. It adds pleasant flavor and aroma to medicines and is used as a flavoring agent in some formulations.
  • UNII 92RU3N3Y1O
    Dimethicone is a silicone-based oil that acts as an anti-foaming agent and lubricant in medicines. It reduces gas bubbles in liquid formulations and helps coat and protect the stomach lining when ingested.
  • UNII 88XHZ13131
    Fumaric acid is an organic acid used in medications as a buffer and pH regulator. It helps maintain the proper acidity level in the medicine and may aid in tablet disintegration.
  • UNII PDC6A3C0OX
    Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
  • UNII 13W7MDN21W
    A waxy compound made from glycol and stearic acid. It's used as an emulsifier to help blend oil and water-based ingredients, and as a thickener to give the medicine its desired texture and consistency.
  • UNII B16G315W7A
    A plant-derived thickener made from guar gum that has been chemically modified to carry a positive charge. It's used in medicines as a thickening agent and to help keep ingredients evenly mixed throughout the product.
  • UNII KEH0A3F75J
    Hexylene glycol is a clear liquid alcohol used as a solvent and preservative in medicines. It helps dissolve other ingredients and keeps the product stable during storage.
  • UNII GFD7C86Q1W
    A natural oil extracted from citrus peels, (+)-limonene is used as a flavoring agent and solvent in medicines. It helps dissolve active ingredients and provides a lemon or orange taste.
  • UNII D81QY6I88E
    Linalool is a natural fragrant oil found in plants like lavender and citrus. It's used in medicines as a flavoring agent and to mask unpleasant tastes or smells.
  • UNII 79M2M2UDA9
    Mentha piperita is peppermint, a plant extract used in medicines as a flavoring agent and to provide a cooling or soothing taste. It helps make the medication more pleasant to take.
  • UNII L7T10EIP3A
    A cooling compound from mint plants used as a flavoring agent and to create a fresh sensation in medicines. It helps mask bitter tastes and improve how the product feels in the mouth.
  • UNII 229D0E1QFA
    Methylisothiazolinone is a synthetic chemical preservative that prevents bacterial and fungal growth in liquid medicines and topical products. It helps keep the medication safe and extends shelf life during storage.
  • UNII 50C1307PZG
    Pentylene glycol is a humectant and preservative helper derived from petroleum or plant sources. It draws moisture into the product and helps prevent bacterial growth, keeping medicines stable during storage.
  • UNII O414PZ4LPZ
    A beta hydroxy acid derived from willow bark or synthesized chemically. In topical medicines, it acts as a keratolytic agent that helps soften and shed dead skin cells, improving penetration of active ingredients.
  • UNII OJ245FE5EU
    Sodium benzoate is a salt derived from benzoic acid, a preservative. It's added to medicines to prevent growth of bacteria, fungi, and other microorganisms that could spoil the product.
  • UNII 451W47IQ8X
    Sodium chloride is common table salt. It's used in medicines as a buffer to maintain proper pH, as a filler to add bulk, or to adjust the osmotic balance in liquid formulations.
  • UNII 55X04QC32I
    A strong alkaline chemical used to adjust and maintain the pH balance of liquid medicines. It helps keep the medicine stable and ensures it stays effective during storage.
  • UNII BPV390UAP0
    Sodium laureth sulfate is a mild detergent and surfactant derived from coconut oil or petroleum. It helps mix oil and water in formulations and is often used as a cleaning or foaming agent in topical products like shampoos and cleansers.
  • UNII 368GB5141J
    A detergent and foaming agent derived from coconut or palm oil. In medications, it helps break down and mix oil and water-based ingredients, aids in tablet disintegration, and improves how the drug dissolves and spreads in the mouth or digestive system.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

28 inactive ingredients listed in the exact product block matched to this NDC.

The official label also stateswater, sodium laureth sulfate, sodium lauryl sulfate, glycerin, cocamide MEA, glycol distearate, sodium chloride, hexylene glycol, dimethicone, fragrance, citric acid, sodium benzoate, sodium hydroxide, coco-betaine, carbomer, menthol, guar hydroxypropyltrimonium chloride, limonene, sodium polynaphthalenesulfonate, salicylic acid, hexyl cinnamal, coumarin, benzyl alcohol, linalool, amyl cinnamal, pentylene glycol, mentha piperita (peppermint) extract, cellulose gum, fumaric acid, methylisothiazolinone

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMedingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer gPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 50 ml 1000 ml
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Walgreens Everyday Clean Dandruff Anti-Dandruff 10 mg/mL 00363-2606-01 Walgreen 700 ml FDA listed
Walgreens Dandruff Itchy Dry Scalp Defense Anti-dandruff 10 mg/mL 00363-4138-01 Walgreen 325 ml FDA listed
Walgreens Dandruff Conditioner 2 in 1 Itchy Scalp Anti-dandruff 10 mg/mL 00363-4288-01 Walgreen 400 ml FDA listed
Walgreens Dandruff Conditioner 2 in 1 Itchy Scalp Anti-dandruff 10 mg/mL 00363-4289-01 Walgreen 400 ml FDA listed
Walgreens Dandruff Plus Conditioner 2 in 1 Dry Scalp Anti-dandruff 10 mg/mL 00363-4666-01 Walgreen 1000 ml FDA listed
Walgreens Dandruff Plus Conditioner 2 in 1 Anti-dandruff 10 mg/mL 00363-4673-01 Walgreen 1000 ml FDA listed
American Crew 1 mg/mL 10967-0650-25 Revlon 250 ml FDA listed
Pyrithione Zinc 10 mg/mL 11344-0131-32 Nice-Pak 370 ml FDA listed
Dandruff 10 mg/mL 11344-0153-32 Nice-Pak 370 ml FDA listed
Everyday Clean Dandruff 10 mg/mL 11673-0153-35 Target 700.8 ml Discontinued
2 in 1 Dandruff 10 mg/mL 11673-0643-11 Target 651 ml FDA listed
Sulfur 8 Kids Anti-Dandruff 10 mg/mL 12022-0023-00 J. 222 ml FDA listed
Sulfur 8 Aqua Blue 10 mg/mL 12022-0024-00 J. 222 ml FDA listed
Sulfur 8 Scalp Therapy Medicated Dandruff Control 10 mg/mL 12022-0036-00 J. 280 ml FDA listed
Glovers Clinical Care Seborrheic Dermatitis Antidandruff 10 mg/mL 12022-0038-00 J. 118 ml FDA listed
Dandruff 10 mg/mL 21130-0153-15 Better 420 ml Discontinued
Dry Scalp Care 10 mg/mL 21130-0296-15 Better 420 ml Discontinued
2 in 1 Dandruff 10 mg/mL 21130-0942-15 Better 420 ml Discontinued
Everyday Clean Dandruff 10 mg/mL 30142-0153-15 The 42 l Discontinued
Dry Scalp Care 10 mg/mL 30142-0296-15 The 420 ml Discontinued
Everyday Clean 10 mg/mL 30142-0311-15 The 420 ml Discontinued
Clean Apple 10 mg/mL 30142-0788-15 The 420 ml Discontinued
Everyday Clean 10 mg/mL 36800-0087-15 Topco 419 ml Discontinued
Everyday Clean Dandruff 10 mg/mL 36800-0153-15 Topco 42 l Discontinued
Dandruff 10 mg/mL 36800-0281-15 Topco 420 ml Discontinued
Dry Scalp Care 10 mg/mL 36800-0497-15 Topco 420 ml Discontinued
Head and Shoulders 2in1 Classic Clean 1 g/100mL 37000-0070-12 The 1280 ml Discontinued
Head and Shoulders Classic Clean 1 g/100mL 37000-0071-01 The 10 ml Discontinued
Head and Shoulders Green Apple 1 g/100mL 37000-0077-02 The 2 bottles FDA listed
Head and Shoulders Green Apple 2in1 1 g/100mL 37000-0078-02 The 2 bottles FDA listed
Head and Shoulders Itchy Scalp 1 g/100mL 37000-0079-01 The 2 bottles FDA listed
Head and Shoulders Itchy Scalp 2in1 1 g/100mL 37000-0081-25 The 250 ml FDA listed
Head and Shoulders Dry Scalp Care 1 g/100mL 37000-0092-01 The 2 bottles FDA listed
Head and Shoulders Dry Scalp Care 2in1 1 g/100mL 37000-0093-01 The 2 bottles FDA listed
Head and Shoulders Smooth and Silky 1 g/100mL 37000-0094-10 The 10 ml FDA listed
Head and Shoulders Smooth and Silky 2in1 1 g/100mL 37000-0095-12 The 1280 ml Discontinued
Dandruff 10 mg/mL 37808-0070-15 H 420 ml Discontinued
Dandruff 10 mg/mL 37808-0153-15 H 420 ml Discontinued
Dry Scalp Dandruff 10 mg/mL 37808-0281-15 H 420 ml Discontinued
Dry Scalp Care 10 mg/mL 37808-0296-15 H 420 ml Discontinued
2 in 1 Dandruff 10 mg/mL 37808-0311-32 H 370 ml FDA listed
2 in 1 Dandruff 10 mg/mL 37808-0612-15 H 420 ml Discontinued
Dandruff 10 mg/mL 41163-0024-32 United 370 ml FDA listed
Dandruff 10 mg/mL 41163-0153-15 United 420 ml Discontinued
Dandruff 10 mg/mL 41163-0253-15 United 420 ml Discontinued
2 in 1 Dandruff 10 mg/mL 41163-0266-35 United 700 ml Discontinued
Dry Scalp Care 10 mg/mL 41163-0296-15 United 420 ml Discontinued
Everyday Clean Dandruff 10 mg/mL 41250-0153-15 Meijer, 420 ml Discontinued
Dandruff 10 mg/mL 41250-0281-15 Meijer, 420 ml Discontinued
Everyday Clean 10 mg/mL 41250-0311-15 Meijer, 420 ml FDA listed
Dry Scalp 10 mg/mL 41250-0952-15 Meijer, 420 ml Discontinued
Equate Everyday Clean 2 in 1 Dandruff Anti-Dandruff 10 mg/mL 49035-0184-01 Wal-Mart 701 ml FDA listed
Equate Everyday Clean Dandruff Anti-Dandruff 10 mg/mL 49035-0185-01 Wal-Mart 701 ml FDA listed
Equate Dry Scalp 2 in 1 Dandruff Anti-Dandruff 10 mg/mL 49035-0249-01 Wal-Mart 399 ml FDA listed
Equate Dry Scalp 2 in 1 Dandruff SH and COND Anti-Dandruff 10 mg/mL 49035-0250-01 Wal-Mart 399 ml FDA listed
Equate Everyday Clean Dandruff Anti-Dandruff 10 mg/mL 49035-0254-01 Wal-Mart 420 ml FDA listed
Equate Dry Scalp 2 in 1 Dandruff Anti-Dandruff 10 mg/mL 49035-0256-01 Wal-Mart 1000 ml FDA listed
Equate Everyday Clean Dandruff Anti-Dandruff 10 mg/mL 49035-0263-01 Wal-Mart 420 ml FDA listed
Equate Everyday Clean 2 in 1 Dandruff Anti-Dandruff 10 mg/mL 49035-0680-01 Wal-Mart 399 ml FDA listed
Equate Green Apple 2 in 1 Dandruff Anti-Dandruff 10 mg/mL 49035-0683-01 Wal-Mart 701 ml FDA listed
Equate Everyday Clean 2 in 1 Dandruff SH and COND Anti-Dandruff 10 mg/mL 49035-0728-01 Wal-Mart 399 ml FDA listed
Matrix Biolage ScalpSync Antidandruff 10 mg/mLthis 49967-0052-01 L'Oreal 400 ml FDA listed
LOreal Paris Ever Pure Dandruff Scalp Care and Detox 10 mg/mL 49967-0056-01 L'Oreal 250 ml FDA listed
CeraVe 2 in 1 Anti-Dandruff Hydrating Conditioner 10 mg/mL 49967-0266-01 LOreal 355 ml FDA listed
CeraVe Anti Dandruff Hydrating 10 mg/mL 49967-0298-01 L'Oreal 355 ml FDA listed
Mizani Scalp Care Antidandruff 10 mg/mL 49967-0388-01 L'Oreal 500 ml FDA listed
Mizani Scalp Care Conditioner Antidandruff Conditioner 10 mg/mL 49967-0389-01 L'Oreal 500 ml FDA listed
Redken 5th Avenue NYC Scalp Relief Dandruff Control 10 mg/mL 49967-0795-03 L'Oreal 250 ml FDA listed
Control Dandruff Therapy 10 mg/mL 50718-0021-01 Kamedis 200 ml FDA listed
CONTROL Dandruff- Free Beard Wash 10 mg/mL 50718-0035-01 Kamedis 1 bottle FDA listed
Everyday Clean 10 mg/mL 50804-0311-15 Perrigo 420 ml Discontinued
CVS Daily Dandruff Anti-dandruff 10 mg/mL 51316-0178-01 CVS 325 ml FDA listed
Dandruff 10 mg/mL 53942-0153-15 Demoulas 420 ml Discontinued
Dandruff 10 mg/mL 53942-0253-15 Demoulas 420 ml Discontinued
Dandruff 10 mg/mL 53942-0281-15 Demoulas 420 ml Discontinued
Dandruff 10 mg/mL 53942-0311-15 Demoulas 420 ml Discontinued
MOISTURIZING DANDRUFF 1% Pyrithione Zinc 1 g/100mL 54111-0169-50 Bentley 236 ml FDA listed
Dandruff 10 mg/mL 55301-0153-15 Your 420 ml Discontinued
Dandruff 10 mg/mL 55301-0281-15 Your 420 ml Discontinued
Equate Mens Bold Scent 2 in 1 Dandruff SH and COND Anti-Dandruff 10 mg/mL 55319-0320-01 FAMILY 928.5 ml FDA listed
FAMILY Wellness EVERYDAY CLEAN 2 IN 1 DANDRUFF PLUS CONDITIONER Anti-Dandruff 10 mg/mL 55319-0386-01 FAMILY 700 ml FDA listed
Walgreens Dandruff Conditioner 2 in 1 Itchy Scalp Anti-dandruff 10 mg/mL 55319-0444-01 FAMILY 369 ml FDA listed
FAMILY WELLNESS DRY SCALP 2 IN 1 DANDRUFF PLUS CONDITIONER Anti-Dandruff 10 mg/mL 55319-0691-01 FAMILY 400 ml FDA listed
FAMILY Wellness FRESH and CLEAN DANDRUFF PLUS CONDITIONER 2 IN 1 Anti-Dandruff 10 mg/mL 55319-0768-01 FAMILY 400 ml FDA listed
Simply Clean Dandruff 10 mg/mL 55910-0153-15 Old 420 ml Discontinued
2 in 1 Dandruff 10 mg/mL 55910-0311-15 Old 420 ml Discontinued
2 in 1 Dandruff 10 mg/mL 55910-0496-32 Old 369.7 ml Discontinued
Dry Scalp Care 10 mg/mL 55910-0898-15 Old 420 ml Discontinued
2 in 1 Dandruff 10 mg/mL 55910-0921-15 Old 420 ml Discontinued
2 in 1 Dandruff 10 mg/mL 55910-0942-15 Old 420 ml Discontinued
Dandruff 10 mg/mL 56062-0153-15 Publix 420 ml Discontinued
Dandruff 10 mg/mL 56062-0311-15 Publix 420 ml FDA listed
Everyday Clean Dandruff 10 mg/mL 59779-0153-15 CVS 420 ml Discontinued
Dry Scalp Care 10 mg/mL 59779-0296-15 CVS 420 ml Discontinued
Everyday Clean 10 mg/mL 59779-0311-32 CVS 370 ml FDA listed
J1002902 Jason Dandruff Relief 2in1 Treatment 1.1 g/100g 61995-2439-08 The 355 g FDA listed
Zincon Medicated Anti-Dandruff .01 g/mL 62673-0017-94 Neoteric 118 ml FDA listed
Mens Sport 1000 mg/100mL 63148-0208-20 Apollo 612 ml FDA listed
Pyrithione Zinc 10 mg/mL 63148-0211-12 Apollo 355 ml FDA listed
Cvs Anti Dandruff 10 mg/mL 63148-0212-12 Apollo 355 ml FDA listed
CVS Itchy Scalp 10 mg/mL 63148-0214-12 Apollo 370 ml FDA listed
Everyday Clean 10 mg/mL 63148-0417-40 Apollo 400 ml FDA listed
Classic Clean 1000 mg/100mL 63148-0580-14 Apollo 400 ml FDA listed
KeraCare Dry and Itchy Scalp Anti-Dandruff 10 mg/mL 63766-0002-01 Avlon 240 ml FDA listed
KeraCare Dry and Itchy Scalp Anti-Dandruff 10 mg/mL 63766-0003-01 Avlon 240 ml FDA listed
Everyday Clean Dandruff 10 mg/mL 63941-0153-15 Valu 420 ml Discontinued
Dry Scalp Care 10 mg/mL 63941-0296-32 Valu 370 ml FDA listed
Dandruff 10 mg/mL 63941-0311-18 Valu 420 ml Discontinued
Dry Scalp 10 mg/mL 63941-0952-15 Valu 420 ml Discontinued
Simply Clean Dandruff 10 mg/mL 64024-0153-92 Aldi, 399 ml Discontinued
2 in 1 Dandruff 10 mg/mL 64024-0311-92 Aldi, 400 ml Discontinued
Suave Professionals Men 2 in 1 Classic Clean AntiDandruff 1 g/100mL 64942-1353-01 Conopco 828 ml FDA listed
Dove 1 g/100mL 64942-1622-01 Conopco, 355 ml FDA listed
Dove 1 g/100mL 64942-2441-01 Conopco 355 ml FDA listed
Dove Men Care 1 g/100mL 64942-2442-01 Conopco 532 ml FDA listed
Dove 1 g/100mL 64942-2443-01 Conopco 532 ml FDA listed
Dove Men Care 1 g/100mL 64942-2444-01 Conopco 828 ml FDA listed
Dove Men Care 1 g/100mL 64942-2445-01 Conopco 530 ml FDA listed
Dove Men Care 1 g/100mL 64942-2446-01 Conopco 355 ml FDA listed
Everyday Clean 2 in 1 10 mg/mL 67091-0176-02 WinCo 370 ml FDA listed
Everyday Clean Dandruff 10 mg/mL 67091-0178-14 WinCo 420 ml Discontinued
Dry Scalp 10 mg/mL 67091-0179-02 WinCo 370 ml FDA listed
Head and Shoulders Classic Clean Dandruff 1 g/100mL 67751-0053-01 Navajo 1 bottle FDA listed
Marcs 2 in 1 Everyday Care Dandruff Anti-Dandruff 10 mg/mL 68998-0132-01 Mark 399 ml FDA listed
Marcs Dry Scalp Care Dandruff Anti-Dandruff 10 mg/mL 68998-0133-01 Mark 399 ml FDA listed
Marcs Everyday Care Dandruff Anti-Dandruff 10 mg/mL 68998-0134-01 Mark 399 ml FDA listed
Divine Dandrene 1% 1 g/100mL 69188-0100-07 DS 205 ml FDA listed
Dandrene Anti-Dandruff Conditioner 1 g/100mL 69188-0300-07 DS 205 ml FDA listed
Head and Shoulders Deep Moisture 1 g/100mL 69423-0247-38 The 380 ml Discontinued
Head and Shoulders Charcoal Daily 1 g/100mL 69423-0278-37 The 370 ml FDA listed
Head and Shoulders 2in1 Men Advanced Series Pure Sport Old Spice 1 g/100mL 69423-0293-01 The 2 bottles Discontinued
Head and Shoulders MEN Old Spice Pure Sport 1 g/100mL 69423-0294-38 The 380 ml Discontinued
Head and Shoulders Men Advanced Series Refreshing Menthol 1 g/100mL 69423-0311-37 The 370 ml FDA listed
Head and Shoulders Men Advanced Series Refreshing 2in1 Menthol 1 g/100mL 69423-0312-37 The 370 ml FDA listed
Head and Shoulders Coconut Daily 1 g/100mL 69423-0315-25 The 250 ml FDA listed
Head and Shoulders Coconut 2in1 1 g/100mL 69423-0316-01 The 2 bottles Discontinued
Head and Shoulders Men Advanced Series Swagger Old Spice 1 g/100mL 69423-0326-37 The 370 ml FDA listed
Head and Shoulders 2in1 Men Advanced Series Swagger Old Spice 1 g/100mL 69423-0327-01 The 2 bottles FDA listed
Head and Shoulders 2in1 Men Advanced Series Full and Thick 1 g/100mL 69423-0329-38 The 380 ml Discontinued
Head and Shoulders Supreme Detox and Hydrate 1 g/100mL 69423-0343-35 The 350 ml FDA listed
Head and Shoulders Supreme Nourish and Smooth 1 g/100mL 69423-0344-35 The 350 ml FDA listed
Head and Shoulders Supreme Soothe and Strengthen 1 g/100mL 69423-0345-35 The 350 ml FDA listed
Head and Shoulders Supreme Color Protect 1 g/100mL 69423-0346-35 The 350 ml FDA listed
Head and Shoulders MEN Advanced Series Bourbon 2in1 1 g/100mL 69423-0412-38 The 380 ml Discontinued
Head and Shoulders MEN Advanced Series Sandalwood 2in1 1 g/100mL 69423-0415-38 The 380 ml Discontinued
Head and Shoulders Tea Tree Oil Daily 1 g/100mL 69423-0416-01 The 2 bottles Discontinued
Head and Shoulders Tea Tree Oil 2in1 1 g/100mL 69423-0417-12 The 1280 ml Discontinued
Head and Shoulders Apple Cider Vinegar 1 g/100mL 69423-0521-37 The 370 ml FDA listed
Head and Shoulders Apple Cider Vinegar 2in1 1 g/100mL 69423-0522-12 The 1280 ml Discontinued
Head and Shoulders Moisturizing Avocado Oil 1 g/100mL 69423-0589-38 The 380 ml FDA listed
First Aid Beauty Anti-Dandruff 1 g/100mL 69423-0591-23 The 236.5 ml FDA listed
Royal Oils by Head and Shoulders Sulfate Free Scalp Care 1 g/100mL 69423-0608-38 The 380 ml FDA listed
Head and Shoulders MEN Advanced Series Lavender Mint 2in1 1 g/100mL 69423-0619-38 The 380 ml Discontinued
Head and Shoulders Lemon Oil 2in1 1 g/100mL 69423-0620-40 The 400 ml Discontinued
Head and Shoulders Scalp Restore 1 g/100mL 69423-0646-11 The 1150 ml FDA listed
Head and Shoulders Classic Clean with Vitamin E 1 g/100mL 69423-0647-11 The 1150 ml FDA listed
Head and Shoulders 2in1 Dry Scalp Care with Almond and Coconut Oil 1 g/100mL 69423-0648-11 The 1150 ml FDA listed
Head and Shoulders Ginger 2in1 1 g/100mL 69423-0670-37 The 370 ml FDA listed
Head and Shoulders Shea Butter 1 g/100mL 69423-0671-37 The 370 ml FDA listed
Head and Shoulders Deep Scalp Hydration Daily 1 g/100mL 69423-0672-37 The 370 ml FDA listed
Head and Shoulders Deep Scalp Hydration 2in1 1 g/100mL 69423-0696-37 The 370 ml FDA listed
Head and Shoulders Deep Scalp Cleanse Daily 1 g/100mL 69423-0697-37 The 370 ml FDA listed
Head and Shoulders Deep Scalp Cleanse 2in1 1 g/100mL 69423-0698-37 The 370 ml FDA listed
Head and Shoulders Bare Minimal Ingredients 1 g/100mL 69423-0721-40 The 350 ml FDA listed
Head and Shoulders Bare Minimal Ingredients Soothing Hydration 1 g/100mL 69423-0722-40 The 400 ml FDA listed
Dandruff 10 mg/mL 70000-0748-01 CARDINAL 369 ml FDA listed
Zinc Pyrithione 10 mg/mL 70533-0003-02 Harry's 59 ml FDA listed
Zinc Pyrithione 20 mg/2mL 70533-0004-02 Harry's 59 ml FDA listed
ion 2 in 1 anti-dandruff Anti-dandruff 10 mg/mL 71990-0712-01 Arcadia 310 ml FDA listed
Everyday Clean Dandruff 10 mg/mL 72036-0153-15 Harris 420 ml Discontinued
Everyday Clean 10 mg/mL 72288-0911-15 Amazon.com 420 ml Discontinued
Dandruff 10 mg/mL 72288-0953-15 Amazon.com 420 ml Discontinued
As I Am Dry and Itchy Scalp Care 10 mg/mL 72474-0100-01 Salon 355 ml FDA listed
As I Am Dry and Itchy Scalp Care Conditioner 10 mg/mL 72474-0101-01 Salon 355 ml FDA listed
As I Am Dry and Itchy Scalp Care Co Wash 10 mg/g 72474-0103-01 Salon 454 g FDA listed
Everyday Clean Dandruff 10 mg/mL 72476-0153-15 Retail 420 ml Discontinued
Dandruff 10 mg/mL 72476-0253-15 Retail 420 ml Discontinued
Dry Scalp Dandruff 10 mg/mL 72476-0281-15 Retail 420 ml Discontinued
Dry Scalp Care 10 mg/mL 72476-0296-15 Retail 420 ml Discontinued
Dandruff 10 mg/mL 72476-0311-15 Retail 420 ml Discontinued
2 in 1 Dandruff 10 mg/mL 72476-0362-01 Retail 420 ml Discontinued
2 in 1 Dandruff 10 mg/mL 72476-0612-15 Retail 420 ml Discontinued
Aloe Coal by T Spruill 1 g/100mL 73324-0001-01 T. 237 ml FDA listed
Aloe Coal by T Spruill 1 g/100mL 73324-0002-01 T. 1 ml FDA listed
Aloe Coal 02 Conditioner 10 mg/mL 73324-0090-08 T. 237 ml FDA listed
Aloe Coal 01 10 mg/mL 73324-0091-08 T. 237 ml FDA listed
Balancing 1 g/100mL 73528-0100-01 Zero 280 ml FDA listed
Balancing 1 g/100mL 73528-0110-01 Zero 280 ml FDA listed
Royal Dandruff Dry Scalp 1 g/100g 73597-0020-10 Mission 273.06 g Discontinued
Quality Choice Dandruff Everyday Clean 10 mg/mL 75376-0320-13 Guangzhou 399 ml FDA listed
Quality Choice Dandruff 2 in 1 10 mg/mL 75376-0321-13 Guangzhou 399 ml FDA listed
Quality Choice Dandruff Dry Scalp Care 10 mg/mL 75376-0322-13 Guangzhou 399 ml FDA listed
Paul Mitchell Dandruff 1 g/100mL 75593-0001-10 John 300 ml FDA listed
Pyrithione zinc 10 mg/mL 75712-0470-32 Old 370 ml FDA listed
Dandruff 10 mg/mL 76162-0353-32 Topco 370 ml FDA listed
2 in 1 Dandruff 10 mg/mL 76162-0362-32 Topco 370 ml FDA listed
Pyrithione zinc 10 mg/mL 76162-0970-32 Topco 370 ml FDA listed
Equate Mens Bold Scent 2 in 1 Dandruff SH and COND Anti-Dandruff 10 mg/mL 79903-0002-01 Wal-Mart 928.5 ml FDA listed
Equate Mens Ultra Sport 2 in 1 Dandruff SH and COND Anti-Dandruff 10 mg/mL 79903-0003-01 Wal-Mart 928.5 ml FDA listed
Equate Soft and Smooth 2 in 1 Dandruff SH and COND Anti-Dandruff 10 mg/mL 79903-0004-01 Wal-Mart 928.5 ml FDA listed
Dandruff 10 mg/mL 79903-0332-01 Walmart 834 ml FDA listed
Dry Scalp 10 mg/mL 79903-0333-01 Walmart 834 ml FDA listed
Pert Plus 2 in 1 Anti-Dandruff 1 g/100mL 81277-0801-13 TCP 400 ml FDA listed
Matrix Biolage Scalp Sync Antidandruff 10 mg/mL 82046-0077-01 L'Oreal 400 ml FDA listed
CeraVe Developed with Dermatologists Anti-Dandruff Hydrating 10 mg/mL 82046-0228-01 LOreal 562 ml FDA listed
CeraVe 2 in1 Anti Dandruff Hydrating Conditioner 10 mg/mL 82046-0266-01 L'Oreal 355 ml FDA listed
Nioxin PRO CLINICAL SCALP RECOVERY purifying 1 g/100mL 82157-0011-10 Wella 1000 ml FDA listed
Dzul Anti-Dandruff 1 g/100mL 83037-0001-08 Caball 236 ml FDA listed
Quality Choice Dandruff Everyday Clean 10 mg/mL 83324-0320-13 CHAIN 399 ml FDA listed
Quality Choice Dandruff 2 in 1 10 mg/mL 83324-0321-13 CHAIN 399 ml FDA listed
Quality Choice Dandruff Dry Scalp Care 10 mg/mL 83324-0322-13 CHAIN 399 ml FDA listed
Suave Men 2 IN1 Scalp Defense 1 g/100mL 83711-0305-28 Suave 828 ml FDA listed
Suave Men Antidandruff 2 IN 1 Classic Clean 1 g/100mL 83711-0306-28 Suave 828 ml FDA listed
Suave Antidandruff 2 IN 1 Classic Clean 1 g/100mL 83711-0307-28 Suave 828 ml FDA listed
Suave Anti dandruff Coconut Moisture 1 g/100mL 83711-0308-28 Suave 828 ml FDA listed
Head and Shoulders 2in1 Advanced Scalp Care 2in1 1 g/100mL 84126-0022-11 The 1180 ml FDA listed
Head and Shoulders 2in1 MEN Citrus and Cedar 1 g/100mL 84126-0023-37 The 370 ml FDA listed
Head and Shoulders 2in1 Men Coastal Tide 1 g/100mL 84126-0024-37 The 370 ml FDA listed
Head and Shoulders Aloe Vera Soothing Relief Daily 1 g/100mL 84126-0053-37 The 370 ml FDA listed
Head and Shoulders Aloe Vera Soothing Relief 2in1 1 g/100mL 84126-0054-37 The 370 ml FDA listed
Head and Shoulders Moisturizing Avocado Oil 2in1 1 g/100mL 84126-0055-37 The 370 ml FDA listed
Head and Shoulders Bare Minimal Ingredients Pure Clean 2in1 1 g/100mL 84126-0073-01 The 2 bottles FDA listed
Head and Shoulders Bare Minimal Ingredients Itchy Scalp Relief 1 g/100mL 84126-0074-40 The 400 ml FDA listed
Head and Shoulders 2in1 Men Vanilla and Amber 1 g/100mL 84126-0082-37 The 370 ml FDA listed
Head and Shoulders 2in1 MenTimber Old Spice 1 g/100mL 84126-0089-37 The 370 ml FDA listed
Head and Shoulders Bare Minimal Ingredients Sensitive Scalp Care 1 g/100mL 84126-0154-01 The 2 bottles FDA listed
Head and Shoulders Dry Scalp Complete Hydration 2in1 1 g/100mL 84126-0180-11 The 1150 ml FDA listed
Head and Shoulders Hydrating Coconut 1 g/100mL 84126-0218-25 The 250 ml FDA listed
Head and Shoulders Hydrating Coconut 2in1 1 g/100mL 84126-0219-37 The 370 ml FDA listed
Mielle Lavender and Lychee Scalp Moisturizing 1 g/100mL 84126-0256-35 The 355 ml FDA listed
Head and Shoulders Bare Minimal Ingredients Total Scalp Care 1 g/100mL 84126-0259-83 The 835 ml FDA listed
anti dandruff SHAMPOOS 1 g/100mL 85434-0001-01 Guangdong 1 bottle FDA listed
anti dandruff SHAMPOOS 1 g/100mL 85434-0002-01 Guangdong 1 bottle FDA listed
ANTI DANDRUFF SHAMPOO473ml .01 g/mL 85434-0004-01 Guangdong 473 ml FDA listed
anti dandruff SHAMPOO473ml .01 g/mL 85434-0005-01 Guangdong 473 ml FDA listed
Structure of Skin Soothing Anti-Dandruff 10 mg/mL 85567-0323-01 STRUCTURE 237 ml FDA listed
Leader Classic Clean Dandruff 10 mg/mL 70000-0775-01 CARDINAL 369 ml FDA listed
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2014
On the market since
May 2014
📍
2026
Currently FDA-listed
12 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

🔬 Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Matrix Biolage ScalpSync Antidandruff (this brand).

Top reported reactions

Alopecia2
Death2
Dehydration2
Drug Interaction2
Headache2
Nausea2
Periproctitis2

Age at onset

Adult2
Elderly2

Reporter sex

30 reports
Male · 67%
Female · 33%

Serious outcomes

Hospitalization10
Death2
Life-threatening1
Disabling1
Reports over time (by year) — tap or hover for the count & year
2022 2023 2024 2026 8 0
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
49967-0052-01 You're viewing this 400 mL in 1 BOTTLE (49967-052-01) 2014-05-01 Active
49967-0052-02 1000 mL in 1 BOTTLE (49967-052-02) 2014-05-01 Active
49967-0052-03 50 mL in 1 BOTTLE (49967-052-03) 2024-02-01 Active

You're viewing one of 3 pack sizes for this product.

Pack size FAQ

What quantity is in NDC 49967-0052-01?
NDC 49967-0052-01 contains 400 mL — 400 ml in 1 bottle.
What is the difference between NDC 49967-0052-01 and NDC 49967-0052-03?
Both are Matrix Biolage ScalpSync Antidandruff Pyrithione Zinc 10 mg/mL Shampoo — the drug itself is identical. NDC 49967-0052-01 is the 400 mL package, while NDC 49967-0052-03 is the 50 ml package.
What NDC number is used to bill for this package of Matrix Biolage ScalpSync Antidandruff Pyrithione Zinc 10 mg/mL Shampoo?
Bill NDC 49967-0052-01 — the 11-digit billing format is 49967005201. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

🧭 About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 49967-052-01, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 49967-0052-01, written without dashes as 49967005201. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 49967-0052-01, the first segment (49967) is the labeler code FDA assigned to L'Oreal USA Products Inc; the middle segment (0052) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (01) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by L'Oreal USA Products Inc. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 2 other package presentations of this same product, including 50 ml (49967-0052-03), 1000 ml (49967-0052-02). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
L'Oreal USA Products Inc is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage 10 words

Use fights scalp scaling, itching and flaking due to dandruff

⏱️ Dosage and Administration 36 words

Directions - for best results use at least twice a week or as directed by a physician - shake well; apply evenly onto scalp - leave on 1 - 3 minutes; rinse - repeat if necessary

⚠️ Warnings 5 words

Warnings For external use only

🧪 Active Ingredient 5 words

Active ingredient Pyrithione zinc 1%

🧪 Inactive Ingredients 56 words

Inactive ingredients water, sodium laureth sulfate, sodium lauryl sulfate, glycerin, cocamide MEA, glycol distearate, sodium chloride, hexylene glycol, dimethicone, fragrance, citric acid, sodium benzoate, sodium hydroxide, coco-betaine, carbomer, menthol, guar hydroxypropyltrimonium chloride, limonene, sodium polynaphthalenesulfonate, salicylic acid, hexyl cinnamal, coumarin, benzyl alcohol, linalool, amyl cinnamal, pentylene glycol, mentha piperita (peppermint) extract, cellulose gum, fumaric acid, methylisothiazolinone

🎯 Purpose 2 words

Purpose Antidandruff

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.