Tussin DM Daytime Nighttime Dextromethorphan HBr, Doxylamine Succinate, Guaifenesin Kit — NDC 51316-434-19 (Billing 51316-0434-19)
This is a package of Tussin DM Daytime Nighttime Dextromethorphan HBr, Doxylamine Succinate, Guaifenesin Kit from CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED, marketed since Apr 2023 and currently FDA-listed, this package's marketing is listed to end Mar 2028. It is this product's only package size.
NDC database record
One package, one record: these facts belong to NDC 51316-434-19 alone.
- Record
- FDA NDC Directory package listing · Human OTC drug
- Code segments
- 51316 labeler · 434 product · 19 package
- Package marketed since
- Apr 18, 2023
- Package marketing ended
- Mar 31, 2028
- Sample package
- No — commercial package
- Barcode (UPC-A, from the NDC)
- 3 5131643419 6
- FDA record last changed
- Aug 27, 2026
Identity & classification
Regulatory identifiers FDA, NLM and CMS codes for this package
- RxCUI (RxNorm): 1020138
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 5, 2026
- RxNorm (NLM RxNav) · catalog refreshed Oct 1, 2026
- Medi-Span GPI (licensed)
- First Databank (licensed) · refreshed Oct 1, 2026
RxNorm drug class
This medicine belongs to the Uncompetitive N-methyl-D-aspartate Receptor Antagonist class.
Where does this data come from?
- RxClass (NLM) · catalog refreshed Oct 1, 2026
Clinical
Dextromethorphan is used to temporarily relieve cough caused by the common cold, the flu, or other conditions. Dextromethorphan will relieve a cough but will not treat the cause of the cough or speed recovery. Dextromethorphan is in a class of medications called antitussives. It works by decreasing activity in the part of the brain that causes coughing.
Read the full MedlinePlus article ↗- It helps loosen mucus and makes coughs more productive. It also temporarily eases cough from minor throat and bronchial irritation, like with a cold or inhaled irritants.
- Swallow them whole with a full glass of water. Don’t crush, chew or break them. You can take them with or without food, about every 12 hours as your label directs.
- How do I take the extended-release tablets?
- The extended-release tablets are not for children under 12. Some liquid products are made for children, so check that product’s label and ask me if you’re unsure.
Patient education
Supplement & herbal interactions
Where does this data come from?
- MedlinePlus (NLM) · refreshed Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 5, 2026
Ask a licensed pharmacist directly — free, answered by our team.
Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per each | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
Where does this data come from?
- CMS NADAC weekly file
- CMS ASP pricing files · refreshed Sep 20, 2026
- CMS Medicaid State Drug Utilization Data · refreshed Oct 5, 2026
- CMS Part D plan pricing files · refreshed Sep 24, 2026
- VA National Acquisition Center price file
Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Marketing end | Status |
|---|---|---|---|---|
| 51316-0434-19 You're viewing this Main listing | 1 KIT in 1 PACKAGE, COMBINATION * 118 mL in 1 BOTTLE, PLASTIC * 118 mL in 1 BOTTLE, PLASTIC | 2023-04-18 | Mar 31, 2028 | Active |
Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Tussin DM Daytime Nighttimethis 51316-0434-19 | CVS | 1 kit | — | — | FDA listed | — |
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA Orange Book · refreshed Oct 3, 2026
- CMS NADAC weekly file
Availability & generic status
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
- FDA Orange Book · refreshed Oct 3, 2026
What it looks like
Where does this data come from?
- FDA label on DailyMed · label index refreshed Oct 5, 2026
Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
🧪 Avoiding an ingredient? See Dextromethorphan / Guaifenesin inactive ingredients by manufacturer: every current product's list side by side, so you can ask your pharmacy for the version that does not list it.
This is label-wide narrative text, not a normalized exact-product ingredient list. A label can cover multiple strengths or packages.
Where does this data come from?
IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.- FDA label on DailyMed · label index refreshed Oct 5, 2026
- FDA openFDA NDC Directory · synced Oct 1, 2026
Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
Why might an inactive ingredient be missing?
Can inactive ingredients matter?
Manufacturer & labeler
More NDCs from CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED labeler code 51316
- nighttime severe cold and flu Acetaminophen, Dextromethorphan HBr, Doxylamine Succinate, Phenylephrine HCl 650 mg/30mL; 20 mg/30mL; 12.5 mg/30mL; 10 mg/30mL Solution NDC 51316-415-40
- Daytime Cold and Flu Acetaminophen, Dextromethorphan HBr 325 mg/15mL; 10 mg/15mL Liquid NDC 51316-421-12
- Ivermectin 5 mg/g Lotion NDC 51316-423-08
- CHILDRENS 12 HR COUGH RELIEF dextromethorphan polistirex 30 mg/5mL Suspension NDC 51316-429-21
- Tussin DM Nighttime Dextromethorphan HBr, Doxylamine Succinate 30 mg/20mL; 12.5 mg/20mL Solution NDC 51316-430-36
- Cough DM Nighttime Dextromethorphan HBr, Doxylamine Succinate 30 mg/20mL; 12.5 mg/20mL Solution NDC 51316-431-36
- CVS Adult Mucus plus Chest Congestion Guaifenesin 200 mg/10mL Syrup NDC 51316-437-08
- Cough and Chest Congestion DN, Cough DM Daytime, Nighttime Dextromethorphan HBr, Doxylamine Succinate, Guaifenesin Kit NDC 51316-439-36
- Motion Sickness Meclizine HCl 25 mg Tablet, Chewable NDC 51316-441-21
- CVS Health MAXIMUM STRENGTH Therapeutic Dandruff Anti-dandruff, anti-seborrheic dermatitis, anti-psoriasis SALICYLIC ACID 30 mg/mL Shampoo NDC 51316-443-01
- Extra Strength Mini Softgels Pain Reliever Acetaminophen 500 mg Capsule, Liquid Filled NDC 51316-444-18
- Pain and Fever Childrens Acetaminophen 160 mg Tablet, Chewable NDC 51316-449-08
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- Drugs@FDA
FDA label — Drug Facts FDA SPL
🎯 Indications and Usage ▾
Uses temporarily relieves cough due to minor throat and bronchial irritation as may occur with a cold helps loosen phlegm (mucus) and thin bronchial secretions to drain bronchial tubes
Uses temporarily relieves cough due to minor throat and bronchial irritation as may occur with a cold temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: itching of the nose or throat itchy, watery eyes runny nose sneezing controls the impulse to cough to help you sleep
⏱️ Dosage and Administration ▾
Directions do not take more than directed do not take more than 6 doses in any 24-hour period mL = milliliter only use the dose cup provided adults and children 12 years and over: 20 mL in dosing cup provided every 4 hours children under 12 years: do not use
Directions do not take more than directed do not take more than 4 doses in any 24-hour period mL = milliliter only use the dose cup provided adults and children 12 years and over: 20 mL in dosing cup provided every 6 hours children under 12 years: do not use
⚠️ Warnings ▾
Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. Ask a doctor before use if you have cough that occurs with too much phlegm (mucus) persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis, or emphysema Stop use and ask a doctor if cough persists more than 7 days, tends to recur, or is accompanied by a fever, rash, or persistent headache.
These could be signs of a serious condition. If pregnant or breast-feeding ask a health professional before use. Keep out of reach of children.
In case of overdose, get medical help or contact a Poison Control Center right away.
Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. Ask a doctor before use if you have a cough that occurs with too much phlegm (mucus) glaucoma difficulty in urination due to enlargement of the prostate gland a breathing problem or persistent or chronic cough as occurs with smoking, asthma, chronic bronchitis, or emphysema Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers.
When using this product marked drowsiness may occur avoid alcoholic drinks alcohol, sedatives, and tranquilizers may increase drowsiness use caution when driving a motor vehicle or operating machinery excitability may occur, especially in children Stop use and ask a doctor if cough persists more than 7 days, tends to recur, or is accompanied by a fever, rash, or persistent headache. These could be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use.
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.
📦 Storage and Handling ▾
Other information each 20 mL contains: sodium 16 mg store at 25°C (77°F); excursions permitted between 15°-30°C (59°-86°F) see end flap for expiration date and lot number
Other information each 20 mL contains: sodium 14 mg store at 25ºC (77ºF); excursions permitted between 15º-30ºC (59º-86ºF) see end flap for expiration date and lot number
🧪 Active Ingredient ▾
Active ingredients (in each 20 mL) Dextromethorphan HBr 20 mg Guaifenesin 400 mg
Active ingredients (in each 20 mL) Dextromethorphan HBr 30 mg Doxylamine Succinate 12.5 mg
🧪 Inactive Ingredients ▾
Inactive ingredients anhydrous citric acid, FD&C blue #1, FD&C red #40, flavors, glycerin, high fructose corn syrup, microcrystalline cellulose, polyethylene glycol, propylene glycol, purified water, sodium benzoate, sodium chloride, sodium citrate dihydrate, sorbitol, sucralose, xanthan gum
Inactive ingredients anhydrous citric acid, FD&C blue #1, FD&C red #40, flavors, glycerin, high fructose corn syrup, polyethylene glycol, propylene glycol, purified water, sodium benzoate, sodium chloride, sodium citrate dihydrate, sucralose, sugar, xanthan gum
🎯 Purpose ▾
Purpose Cough suppressant Expectorant
Purpose Cough suppressant Antihistamine
📄 Do Not Use ▾
Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
📄 Ask a Doctor Before Use If ▾
Ask a doctor before use if you have cough that occurs with too much phlegm (mucus) persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis, or emphysema
Ask a doctor before use if you have a cough that occurs with too much phlegm (mucus) glaucoma difficulty in urination due to enlargement of the prostate gland a breathing problem or persistent or chronic cough as occurs with smoking, asthma, chronic bronchitis, or emphysema
📄 Ask a Doctor or Pharmacist Before Use If ▾
Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers.
📄 When Using This Product ▾
When using this product marked drowsiness may occur avoid alcoholic drinks alcohol, sedatives, and tranquilizers may increase drowsiness use caution when driving a motor vehicle or operating machinery excitability may occur, especially in children
📄 Stop Use and Ask a Doctor If ▾
Stop use and ask a doctor if cough persists more than 7 days, tends to recur, or is accompanied by a fever, rash, or persistent headache. These could be signs of a serious condition.
Stop use and ask a doctor if cough persists more than 7 days, tends to recur, or is accompanied by a fever, rash, or persistent headache. These could be signs of a serious condition.
🤰 If Pregnant or Breast-Feeding ▾
If pregnant or breast-feeding ask a health professional before use.
If pregnant or breast-feeding, ask a health professional before use.
📄 Keep Out of Reach of Children ▾
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.
Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.
📄 Questions or Comments ▾
Questions or comments? 1-800-426-9391
📄 Package Label / Principal Display Panel ▾
Principal Display Panel DAY & NIGHT COMBO PACK ♥CVS Health ® Compare to the active ingredients in Robitussin ® Maximum Strength Cough + Chest Congestion DM* MAXIMUM STRENGTH MAXIMUM STRENGTH FOR MUCUS RELIEF Daytime Non-Drowsy Tussin DM DEXTROMETHORPHAN HBr Cough suppressant GUAIFENESIN Expectorant Cough & Chest Congestion Relieves: • Cough • Chest congestion • Mucus Menthol-Berry Flavor Dosage cup provided For Ages 12 & Over Actual Bottle Size on Side Panel 4 FL OZ (118 mL) + 4 FL OZ (118 mL) TOTAL 8 FL OZ (236 mL) ♥CVS Health ® Compare to the active ingredients in Robitussin ® Maximum Strength Nighttime Cough DM* MAXIMUM STRENGTH MAXIMUM STRENGTH Nighttime Tussin DM DEXTROMETHORPHAN HBr Cough suppressant DOXYLAMINE SUCCINATE Antihistamine Cough & Antihistamine Relieves: • Cough • Runny nose • Sneezing Menthol-Berry Flavor Dosage cup provided For Ages 12 & Over Actual Bottle Size on Side Panel DO NOT TAKE DAYTIME AND NIGHTTIME PRODUCTS AT THE SAME TIME TAMPER EVIDENT: DO NOT USE IF PRINTED NECK WRAP IS BROKEN OR MISSING TAMPER EVIDENT: DO NOT USE IF IMPRINTED SAFETY SEAL UNDER CAP IS BROKEN OR MISSING 50844 ORG012303004336 Distributed by: CVS Pharmacy, Inc.
One CVS Drive, Woonsocket, RI 02895 © 2023 CVS/pharmacy CVS.com ® 1-800-SHOP CVS V-19849 ♥︎ 100% money back guaranteed. CVS.com/returnpolicy *This product is not manufactured or distributed by GlaxoSmithKline Consumer Healthcare Holdings (US) LLC, owner of the registered trademarks Robitussin ® Maximum Strength Cough + Chest Congestion DM and Robitussin ® Maximum Strength Nighttime Cough DM. PARENTS: Learn about teen medicine abuse www.StopMedicineAbuse.org Package Contains Two Bottles Actual Size CVS 44-030043 CVS 44-030043
Reported adverse events (FAERS)
Top reported reactions
Age at onset
Reporter sex
Serious outcomes
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About this NDC listing & data coverage
Kit / multi-component package
This NDC identifies a kit — a package containing more than one component. Structured data (pricing, ingredients, equivalents) is often reported per component rather than for the kit NDC itself, which can make this page look thinner than the components' own pages.
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | ✓ Available |
| Inactive ingredients (structured) | ✓ Available |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope. |
| HCPCS J-code billing crosswalk | — Not published for this NDC Most self-administered / retail products have no J-code — that is normal. |
| Medicaid utilization (CMS SDUD) | — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold. |