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Carbon Dioxide Compressed 990 mL/L Gas, 2.95 l — NDC 52374-0003-01 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

Carbon Dioxide Compressed 990 mL/L Gas, 2.95 l — NDC 52374-003-01 (Billing 52374-0003-01)

by MESSER GAS PUERTO RICO, INC · 2.95 L in 1 CYLINDER

This is a package of 2.95 l of Carbon Dioxide Compressed 990 mL/L Gas from MESSER GAS PUERTO RICO, INC, marketed since Jan 1965 and currently FDA-listed. It is the main listing for this product, which comes in 4 package sizes.

NDC 52374-0003-01
🏷️ FDA NDC (as labeled) 52374-003-01 billing pads the product segment with a zero
This package
Contains2.95 l Pack sizes4 compare ↓
Main listing for product 52374-003 · Also comes in: 22.37 l 52374-003-02 33.52 l 52374-003-03 59 l 52374-003-04
Rx only On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 52374-003-01 alone.

Record
FDA NDC Directory package listing · Human prescription drug
Code segments
52374 labeler · 003 product · 01 package
Package marketed since
Jan 1, 1965
Sample package
No — commercial package
Listing certified through
Dec 31, 2027
Barcode (UPC-A, from the NDC)
3 5237400301 0
FDA record last changed
Jul 24, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 52374-003-01
Product NDC 52374-003
11-digit billing NDC 52374000301
RxCUI 309004
UNII 142M471B3J
SPL Set ID 91a75727-30c2-4c6f-88d9-0c3f423ed01e
Established class (EPC) Radiographic Contrast Agent
Mechanism of action X-Ray Contrast Activity
DEA schedule Non-controlled
Marketing category UNAPPROVED MEDICAL GAS
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 1965-01-01
Route RESPIRATORY (INHALATION)
Dosage form GAS
Substance CARBON DIOXIDE
Quick answers
  • RxCUI (RxNorm): 309004
Why two NDCs? The FDA registers this code as 52374-003-01 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 52374-0003-01. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Radiographic Contrast Agent class.

Pharmacologic class Radiographic Contrast Agent
Drug family (ATC) Medical gases
How it works X-Ray Contrast Activity
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

📗 Our plain-language guide HelloPharmacist
📖 Read our full Carbon Dioxide guide →

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eachPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 22.37 l 33.52 l 59 l
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
52374-0003-01 You're viewing this Main listing 2.95 L in 1 CYLINDER 1965-01-01 — Active
52374-0003-02 52374-003-02 22.37 L in 1 CYLINDER 1965-01-01 — Active
52374-0003-03 52374-003-03 33.52 L in 1 CYLINDER 1965-01-01 — Active
52374-0003-04 52374-003-04 59 L in 1 CYLINDER 1965-01-01 — Active

Pack size FAQ

What quantity is in this package?
This package contains 2.95 l — 2.95 l in 1 cylinder.
How does this package differ from NDC 52374-0003-02?
Both are Carbon Dioxide Compressed 990 mL/L Gas — the drug itself is identical. This page's package is the 2.95 l one, while NDC 52374-0003-02 is the 22.37 l package.
What NDC number is used to bill for this package of Carbon Dioxide Compressed 990 mL/L Gas?
Use the 11-digit billing form listed in the identifiers section of this page. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Carbon Dioxide 990 mL/L 10014-0005-10 Aero 495 l — — FDA listed —
Carbon Dioxide 99 L/100L 10167-0500-01 Air 940 l — — FDA listed —
Carbon Dioxide 990 mL/L 10297-0020-01 A-OX 1683 l — — FDA listed —
Carbon Dioxide 990 mL/L 11324-0003-01 Linde 19056 l — — FDA listed —
Carbon Dioxide 990 mL/L 14961-0009-01 Haun 28.32 l — — FDA listed —
Carbon Dioxide 990 mL/L 17575-0104-05 AGL 12300 l — — FDA listed —
Carbon Dioxide 990 mL/L 21220-0123-01 General 12374 l — — FDA listed —
Carbon Dioxide 990 mL/L 34057-0501-01 Oxarc, 2 l — — Discontinued —
Carbon Dioxide 99 L/100L 42602-0006-01 Norco, 1380 l — — FDA listed —
Carbon Dioxide 990 mL/L 43621-0007-01 DJB 1745 l — — FDA listed —
Carbon Dioxide 990 mL/L 44076-0021-01 American 12375 l — — FDA listed —
Carbon Dioxide 990 mL/L 45149-0014-01 Messer 18770 l — — FDA listed —
Carbon Dioxide 990 g/kg 46123-0050-01 Roberts 1.13 kg — — FDA listed —
Carbon Dioxide 990 mL/L 46123-0240-01 Roberts 95042 l — — FDA listed —
Carbon Dioxide 990 mL/L 46362-0004-01 Red 2970380 l — — FDA listed —
Carbon Dioxide 990 mL/L 48273-0010-01 Keen 424.75 l — — FDA listed —
Carbon Dioxide 990 mL/L 49575-0005-05 Machine 1070.38 l — — FDA listed —
Carbon Dioxide 990 mL/L 51486-0005-01 ILMO 15840 l — — Discontinued —
Carbon Dioxide Compressed 990 mL/Lthis 52374-0003-01 MESSER 2.95 l — — FDA listed —
Carbon Dioxide 990 mL/L 52374-0103-01 MESSER 21000 l — — FDA listed —
Carbon Dioxide Refrigerated 990 mL/L 52438-0014-20 Messer 18770 l — — FDA listed —
Carbon Dioxide 990 mL/L 59578-0125-03 Linde 17000 l — — FDA listed —
Carbon Dioxide 990 mL/L 59579-0003-01 Linde 18068 l — — FDA listed —
Carbon Dioxide 990 mL/L 59788-0003-05 Arcet 1070.38 l — — FDA listed —
Carbon Dioxide 990 mL/L 65707-0002-01 Reliant 20000 l — — FDA listed —
Carbon Dioxide 990 mL/L 72276-0004-01 MITCHELL 16055 l — — FDA listed —
Carbon Dioxide 990 mL/L 84078-0003-01 WELDERS 1740 l — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
1965
On the market since
Jan 1965
📍
2026
Currently FDA-listed
61 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

A current SPL was checked, but it does not contain a structured or narrative inactive-ingredient list for this product. This does not mean the product has no inactive ingredients.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerMESSER GAS PUERTO RICO, INC
Labeler code52374
First marketedJan 1965
Product typeHuman Prescription Drug
Portfolio8 products on file

More NDCs from MESSER GAS PUERTO RICO, INC labeler code 52374

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

Full prescribing information FDA SPL

The complete FDA label for this product — the official prescribing information, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
📄 Package Label / Principal Display Panel
📄 Package Label / Principal Display Panel ~3 min read ▾

CARBON DIOXIDE, USP UN1013 CAS 124-38-9 MEDICAL GAS ℞ only. WARNING: Administration of Carbon Dioxide may be hazardous or contraindicated. For use only by or under the supervision of a licensed practitioner who is experienced in the use and administration of Carbon Dioxide and is familiar with the indications, effects, dosages, methods, and frequency and duration of administration, and with the hazards, contraindications and side effects, and the precautions to be taken.

WARNING: CONTAINS GAS UNDER PRESSURE; MAY EXPLODE IF HEATED. MAY DISPLACE OXYGEN AND CAUSE RAPID SUFFOCATION. MAY CAUSE FROSTBITE.

MAY INCREASE RESPIRATION AND HEART RATE. Obtain, read and follow all safety instructions before use. Avoid breathing contents.

Do not get in eyes, on skin, or on clothing. Use and store only outdoors or in a well-ventilated place. Wear protective gloves, protective clothing, and either eye or face protection.

Use a back flow preventive device in the piping. Close valve after each use and when empty. Use only with equipment rated for cylinder pressure.

Never put cylinders into unventilated areas of passenger vehicles. Do not open valve until connected to equipment prepared for use. Protect from sunlight when ambient temperature exceeds 52 C (125 F).

Read and follow the Safety Data Sheet (SDS) before use. FIRST AID: IF INHALED: Remove person to fresh air and keep comfortable for breathing. Get medical help if you feel unwell.

IF ON SKIN: Immediately thaw frosted parts with lukewarm water. Do not rub affected area. Get emergency medical help immediately.

Distributed by: MESSER GAS PUERTO RICO, INC. Road 869 Km

1.8Barrio Palmas Catano, PR 00962 787-641-7445 CONTENTS: Cylinder Pounds Type E 6.6LB K 50LB 100LB DO NOT REMOVE THIS PRODUCT LABEL. carbon dioxide compressed 2025

CARBON DIOXIDE, USP UN1013 CAS 124-38-9 DO NOT REMOVE THIS PRODUCT LABEL. MEDICAL GAS MESSER ℞ only. WARNING: Administration of Carbon Dioxide may be hazardous or contraindicated.

For use only by or under the supervision of a licensed practitioner who is experienced in the use and administration of Carbon Dioxide and is familiar with the indications, effects, dosages, methods, and frequency and duration of the administration, and with the hazards, contraindications and side effects, and the precautions to be taken. WARNING: CONTAINS GAS UNDER PRESSURE; MAY EXPLODE IF HEATED. MAY DISPLACE OXYGEN AND CAUSE RAPID SUFFOCATION.

MAY CAUSE FROSTBITE. MAY INCREASE RESPIRATION AND HEART RATE. Obtain, read and follow all safety instructions before use.

Avoid breathing contents. Do not get in eyes, on skin, or on clothing. Use and store only outdoors or in a well-ventilated place.

Wear protective gloves, protective clothing, and either eye or face protection. Use a back flow preventive device in the piping. Close valve after each use and when empty.

Use only with equipment rated for cylinder pressure. Never put cylinders into unventilated areas of passenger vehicles. Do not open valve until connected to equipment prepared for use.

Protect from sunlight when ambient temperature exceeds 52 C (125 F). Read and follow the Safety Data Sheet (SDS) before use. FIRST AID: IF INHALED: Remove person to fresh air and keep comfortable for breathing.

Get medical help if you feel unwell. IF ON SKIN: Immediately thaw frosted parts with lukewarm water. Do not rub affected area.

Get emergency medical help immediately. CONTENTS: Cylinder Pounds Type E 6.6LB K 50LB 100LB Distributed by: MESSER GAS PUERTO RICO INC. Road 869 Km

1.8 Barrio Palmas Catano, PR 00962 787-641-7445 carbon dioxide neck 2025

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Carbon Dioxide — the ingredient across all brands.

Top reported reactions

Air Embolism32
Subcutaneous Emphysema20
Post Procedural Complication9
Cardiac Arrest8
Hypotension7
Pneumoperitoneum7
Hypercapnia5

Age at onset

Adult1
Elderly2

Reporter sex

0 reports
Male · 31%
Female · 67%
Unknown · 2%

Serious outcomes

Hospitalization30
Life-threatening19
Death13
Disabling1
Reports over time (by year) — tap or hover for the count & year
2019 2021 2023 2026 8 0
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

About this NDC listing & data coverage

Finished prescription product Marketed without an FDA application

Listed without an FDA application

This product's marketing category indicates it is marketed without an approved FDA application (no NDA, ANDA, or BLA on file). Having an NDC does not by itself establish FDA approval — the NDC Directory is a listing system, not an approval decision. Approval-linked data such as Orange Book therapeutic-equivalence ratings therefore does not apply.

What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available.
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Unapproved Medical Gas". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by MESSER GAS PUERTO RICO, INC. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 3 other package presentations of this same product, including 22.37 l (52374-0003-02), 33.52 l (52374-0003-03), 59 l (52374-0003-04). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
MESSER GAS PUERTO RICO, INC is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as a prescription product, so it is dispensed under a prescriber's order. Your pharmacist can tell you whether any over-the-counter forms of the same medication exist.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 52374-0002-01 · Messer 52374-0006-03 · Messer →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.