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Nitrogen 995 mL/L Gas, 25000 l — NDC 52438-0016-20 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

Nitrogen 995 mL/L Gas, 25000 l — NDC 52438-016-20 (Billing 52438-0016-20)

by Messer LLC · 25000 L in 1 TANK

This is a package of 25,000 l of Nitrogen 995 mL/L Gas from Messer LLC, marketed since Jan 1960 and currently FDA-listed. It is this product's only package size.

NDC 52438-0016-20
🏷️ FDA NDC (as labeled) 52438-016-20 billing pads the product segment with a zero
Rx only Brand On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 52438-016-20 alone.

Record
FDA NDC Directory package listing · Human prescription drug
Code segments
52438 labeler · 016 product · 20 package
Package marketed since
Jan 1, 1960
Sample package
No — commercial package
Listing certified through
Dec 31, 2027
Barcode (UPC-A, from the NDC)
3 5243801620 8
FDA record last changed
Jul 24, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 52438-016-20
Product NDC 52438-016
11-digit billing NDC 52438001620
RxCUI 347021
UNII N762921K75
Application # NDA205766
SPL Set ID c6f2772a-e53a-c379-b99e-a4f7c3e82f60
DEA schedule Non-controlled
Marketing category NDA
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 1960-01-01
Route RESPIRATORY (INHALATION)
Dosage form GAS
Substance NITROGEN
Quick answers
  • RxCUI (RxNorm): 347021
Why two NDCs? The FDA registers this code as 52438-016-20 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 52438-0016-20. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Medical gases class.

Drug family (ATC) Medical gases
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

📗 Our plain-language guide HelloPharmacist
📖 Read our full Nitrogen guide →

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eachPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
52438-0016-20 You're viewing this Main listing 25000 L in 1 TANK 1960-01-01 — Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Nitrogen 995 mL/L 10218-0102-01 CEE-KAY 8500 l — — FDA listed —
Nitrogen 99.5 L/100L 10412-0095-01 Flint 145340 l — — FDA listed —
Nitrogen 995 mL/L 42241-0002-01 INDUSTRIAL 396 l — — FDA listed —
Nitrogen 995 mL/L 52374-0016-20 Messer 25000 l — — FDA listed —
Nitrogen 995 mL/Lthis 52438-0016-20 Messer 25000 l — — FDA listed —
Nitrogen 995 mL/L 53425-0002-01 IWS 396 l — — FDA listed —
Nitrogen 995 mL/L 53440-0002-01 Westair 240 l — — Discontinued —
Nitrogen 995 mL/L 53991-0002-01 SOUTHERN 230 l — — FDA listed —
Nitrogen 995 mL/L 58404-0002-01 Industrial 396 l — — FDA listed —
Nitrogen 995 mL/L 62273-0002-01 Metro 690 l — — FDA listed —
Nitrogen 995 mL/L 64169-0002-01 801576526 104347 l — — FDA listed —
Nitrogen 995 mL/L 70101-0002-01 Gas 180 l — — FDA listed —
Nitrogen 995 mL/L 70975-0002-01 Earlbeck 7220 l — — FDA listed —
Nitrogen 995 mL/L 71654-0003-01 SOUTHERN 396 l — — FDA listed —
Nitrogen 995 mL/L 72457-0005-01 UCG 1.5819 l — — FDA listed —
Nitrogen 995 mL/L 76349-0002-01 Southern 396 l — — FDA listed —
Nitrogen 995 mL/L 83746-0001-01 Gas 388 l — — FDA listed —
About this product: this is the brand-name version. We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
1960
On the market since
Jan 1960
📍
2026
Currently FDA-listed
66 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

A current SPL was checked, but it does not contain a structured or narrative inactive-ingredient list for this product. This does not mean the product has no inactive ingredients.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerMesser LLC
FDA applicationNDA205766 (NDA)
Labeler code52438
First marketedJan 1960
Product typeHuman Prescription Drug
Portfolio3 products on file

More NDCs from Messer LLC labeler code 52438

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

Full prescribing information FDA SPL

The complete FDA label for this product — the official prescribing information, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
📄 Package Label / Principal Display Panel
📄 Package Label / Principal Display Panel ~1 min read ▾

Plant 123 Messer St, Anytown, USA Certificate of Analysis - Stall 1 Product: Nitrogen NF Date: 10/27/2025 Lot#: 5138-1-1992-102725-04 Tare Weight: 31800 lbs. Gross Weight: 48500 lbs. Net Weight: 16700 lbs.

Net Volume: 230.51 kscf Batch #: AIT-81-6-102725-01 Logon Time: 2025-10-27 11:17:42 Analysis Finish: 2025-10-27 11:30:18 Logoff Time: 2025-10-27 11:31:57 Final Analysis Results Analyzer # Test/Units LIN1 Specs Analysis Results Limit of Detection Organoleptic Odor None None AIT-81-6 PPM O₂ ≤ 5.00 1.14

0.10AIT-81-2 PPM CO ≤ 10.00 0.35

0.10 LAB PPM CO₂ N/A NT

0.10 AIT-81-4A PPM H₂O N/A NT

0.10 AIT-80-2A PPM THC N/A NT

0.10 LAB PPM H₂ N/A NT

0.20Assay Results (by difference) Nitrogen Min % ≥ 99.0 (Messer Spec ≥ 99.999%) 99.99985 NT = Not Tested PPM O₂ Method Used: Electrochemical Manufacturer/Model#: Teledyne 3000TA-XL PPM CO Method Used: Infrared Manufacturer/Model#: Siemens Ultramat 6 These analyzers have been validated by Messer as acceptable alternatives to the official NF for Nitrogen Assay. Validation study documentation is maintained by Messer at the corporate office. LIN NDA: 205766, LIN NADA: 14136 This document contains an electronic signature.

Analyst Date Sample Results Obtained from Messer Validated Analyzers 10/27/2025 Quality Reviewer Date John Doe 10/27/2025 Should the material not be delivered to an NF customer, the material is "Not Approved for Human Drug Use" LOX1 LLC LIN GENERIC COA NEW TEMPLATE

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

About this NDC listing & data coverage

Finished prescription product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available.
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Messer LLC. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
Messer LLC is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as a prescription product, so it is dispensed under a prescriber's order. Your pharmacist can tell you whether any over-the-counter forms of the same medication exist.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 52438-0014-20 · Messer 52456-0022-01 · Rodial →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.