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Vcf Contraceptive NONOXYNOL-9 280 mg Film, Soluble — NDC 52925-0112-01 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

Vcf Contraceptive NONOXYNOL-9 280 mg Film, Soluble — NDC 52925-112-01 (Billing 52925-0112-01)

by APOTHECUS PHARMACEUTICAL CORP. · 9 POUCH in 1 BOX / 1 FILM, SOLUBLE in 1 POUCH

This is a package of Vcf Contraceptive NONOXYNOL-9 280 mg Film, Soluble from APOTHECUS PHARMACEUTICAL CORP., marketed since Jun 1988 and currently FDA-listed. It is the main listing for this product, which comes in 2 package sizes.

NDC 52925-0112-01
🏷️ FDA NDC (as labeled) 52925-112-01 billing pads the product segment with a zero
This package
Contains1 film, soluble in 1 pouch Pack sizes2 compare ↓
Main listing for product 52925-112 · Also comes in: 1 film 52925-112-25
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 52925-112-01 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
52925 labeler · 112 product · 01 package
Package marketed since
Jun 1, 1988
Sample package
No — commercial package
Listing certified through
Dec 31, 2026
Barcode (UPC-A, from the NDC)
3 5292511201 7
FDA record last changed
Jul 24, 2026
⚠️
Other active recalls for Nonoxynol-9 (different manufacturers) — 1 · tap to view
These affect other manufacturers’ products for the same ingredient — not necessarily the exact NDC on this page.
Class II · Nov 22, 2024 — CGMP deviations: out of specifications for assay (Apothecus Pharmaceutical Corp.) · FDA recall D-0151-2025
Each entry is an official FDA enforcement report — look up any recall number in the FDA recall database ↗
Past resolved recalls for this product (1)
Class II · Mar 21, 2024 · Terminated — cGMP Diviations (Apothecus Pharmaceutical Corp.) · FDA recall D-0427-2024

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 52925-112-01
Product NDC 52925-112
11-digit billing NDC 52925011201
NCPDP billing unit EA — each (per item)
RxCUI 1788958, 1788961
UNII 48Q180SH9T
Application # 505G(a)(3)
SPL Set ID 92f8eee8-2456-4baf-a85e-1335c80d7fcd
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 1988-06-01
Route VAGINAL
Dosage form FILM, SOLUBLE
Substance NONOXYNOL-9

Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification

GPI-14 55300010008228
GPI class VCF Vaginal Contraceptive
GCN Seq No 015903
GCN 11542
HICL code 001462
Ingredient (HICL) Nonoxynol 9
HIC1 code G
Therapeutic class — broad (HIC1) Female Genital System
HIC2 code G9
Therapeutic class — intermediate (HIC2) Intravaginal Antifertility Agents
HIC3 code G9A
Therapeutic class — specific (HIC3) Contraceptives,Intravaginal
AHFS code 32:00.00.00
AHFS class Nonhormonal Contraceptives
FDB label name VCF CONTRACEPTIVE FILM
FDB brand name Vcf
Legend status O — Over-the-counter (OTC) drug or device
Quick answers
  • GSN (GCN sequence number): 015903
  • GCN: 11542
  • GPI-14 (Medi-Span): 55300010008228
  • HICL (First Databank): 001462
  • AHFS class code: 32:00.00.00
  • RxCUI (RxNorm): 1788958
Why two NDCs? The FDA registers this code as 52925-112-01 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 52925-0112-01. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

Clinical

Label name VCF CONTRACEPTIVE FILM Ingredient Nonoxynol 9
🧪 What is this product?

This is an over-the-counter vaginal contraceptive film containing nonoxynol-9, a spermicide. The soluble film is placed in the vagina before intercourse, where it dissolves and is typically used as a barrier method to reduce the chance of pregnancy by immobilizing or destroying sperm. This product is marketed under the FDA's established monograph rules for over-the-counter contraceptive drugs.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eachPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 1 film
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
52925-0112-01 You're viewing this Main listing 9 POUCH in 1 BOX / 1 FILM, SOLUBLE in 1 POUCH 1988-06-01 — Active
52925-0112-25 52925-112-25 12 POUCH in 1 BOX / 1 FILM, SOLUBLE in 1 POUCH 1988-06-01 — Active

Pack size FAQ

What quantity is in this package?
This package is listed by the FDA — 9 pouch in 1 box / 1 film, soluble in 1 pouch.
What NDC number is used to bill for this package of Vcf Contraceptive NONOXYNOL-9 280 mg Film, Soluble?
Use the 11-digit billing form listed in the identifiers section of this page. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Vcf Contraceptive 280 mgthis 52925-0112-01 APOTHECUS 1 film — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
1988
On the market since
Jun 1988
📍
2026
Currently FDA-listed
38 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

What it looks like

Color White
One label can cover several strengths, so colors may be combined — always confirm a loose pill against the dispensed prescription label or a pharmacist.
Where does this data come from?
Physical description (imprint, shape, color, scoring, coating) from this product’s FDA Structured Product Labeling (SPL), mirrored from DailyMed / openFDA.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII PDC6A3C0OX
    Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
  • UNII 532B59J990
    Polyvinyl alcohol is a synthetic polymer made from plant-derived materials. It's used as a binder to hold ingredients together, a film-former in coatings, and a thickener in liquid formulations.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

3 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesglycerin, polyvinyl alcohol, purified water

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerAPOTHECUS PHARMACEUTICAL CORP.
FDA application505G(a)(3) (OTC MONOGRAPH DRUG)
Labeler code52925
First marketedJun 1988
Product typeHuman Otc Drug

More NDCs from APOTHECUS PHARMACEUTICAL CORP. labeler code 52925

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 📦 Storage and Handling 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Do Not Use 📄 When Using This Product 📄 Stop Use and Ask a Doctor If 📄 Keep Out of Reach of Children 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 6 words ▾

Use for the prevention of pregnancy

⏱️ Dosage and Administration 64 words ▾

Directions before using this product, read the enclosed package insert for complete directions and information be sure your fingers are dry before touching the film insert one film and place as far into the vagina as possible against the cervix insert VCF ® not less than 15 minutes and not more than 3 hours before intercourse use one film before each act of intercourse

⚠️ Warnings 124 words ▾

Warnings For Vaginal Use Only Not for rectal (anal) use Sexually transmitted disease (STDs) alert This product does not protect against HIV/AIDS or other STDs and may increase the risk of getting HIV from an infected partner. Do not use if you or your sex partner has HIV/AIDS. If you do not know if you or your sex partner is infected, choose another form of birth control When using this product you may get vaginal irritation (burning, itching or a rash) Stop use and ask a doctor if you or your partner get burning, itching, a rash, or other irritation of the vagina or penis Keep out of reach of children.

If swallowed, get medical help or contact a Poison Control Center right away.

📦 Storage and Handling 76 words ▾

Other information When used correctly every time you have sex, latex condoms greatly reduce, but do not eliminate, the risk of catching or spreading HIV, the virus that causes AIDS. Use a latex condom without nonoxynol-9 if you or your sex partner has HIV/AIDS, multiple sex partners, or other HIV risk factors. VCF ® is tested by independent laboratories for determination of sperm inactivating qualities, using the I.P.P.F. agreed protocol Store at 58° - 86°F (15°-30°C)

🧪 Active Ingredient 7 words ▾

Active ingredient (in each film) Nonoxynol-9, 28%

🧪 Inactive Ingredients 7 words ▾

Inactive ingredients glycerin, polyvinyl alcohol, purified water

🎯 Purpose 3 words ▾

Purpose Vaginal contraceptive

📄 Do Not Use 30 words ▾

Do not use if you or your sex partner has HIV/AIDS. If you do not know if you or your sex partner is infected, choose another form of birth control

📄 When Using This Product 14 words ▾

When using this product you may get vaginal irritation (burning, itching or a rash)

📄 Stop Use and Ask a Doctor If 24 words ▾

Stop use and ask a doctor if you or your partner get burning, itching, a rash, or other irritation of the vagina or penis

📄 Keep Out of Reach of Children 19 words ▾

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

📄 Questions or Comments 4 words ▾

Questions? 1-800-879-2393 (9-5 E.S.T.)

📄 Package Label / Principal Display Panel 55 words ▾

PRINCIPAL DISPLAY PANEL - 9 x 1 Film Pouch Box VCF ® Vaginal Contraceptive Film ® FOR PREVENTION OF PREGNANCY Begins to dissolve instantly Hormone free Kills sperm on contact Effective up to 3 hours! 9 SINGLE SEALED FILMS Contains the Spermicide Doctors Recommend Most Principal Display Panel - 9 x 1 Film Pouch Box

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by APOTHECUS PHARMACEUTICAL CORP.. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 1 other package presentation of this same product, including 1 film (52925-0112-25). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
APOTHECUS PHARMACEUTICAL CORP. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 52922-0001-01 · Ash 52925-0512-10 · APOTHECUS →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.