SHISEIDO BENEFIANCE WRINKLE SMOOTHING DAY AVOBENZONE, HOMOSALATE, OCTINOXATE, OCTOCRYLENE, and OXYBENZONE 1032 mg/50mL; 2580 mg/50mL; 3818 mg/50mL; 1548 mg/50mL; 774 mg/50mL Cream
🆔 Identity & classification
Where does this data come from?
🏭 Manufacturer & labeler
Where does this data come from?
🩺 Clinical
This is a topical day cream that contains five active ingredients commonly used as ultraviolet (UV) filters in sunscreen products. Avobenzone, homosalate, octinoxate, octocrylene, and oxybenzone are organic compounds that function to absorb UV radiation from the sun. The product is marketed as an over-the-counter monograph drug, meaning it follows established FDA guidelines for sunscreen formulations rather than undergoing individual product review. It is typically applied to the skin to help reduce sun exposure.
Patient education
Supplement & herbal interactions
Where does this data come from?
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🧪 Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
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UNII H4N855PNZ1
Alpha-tocopherol is a form of vitamin E, a fat-soluble antioxidant derived from natural or synthetic sources. In medicines, it prevents oils and fats from breaking down and becoming rancid, protecting the product's stability and shelf life.
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A synthetic form of vitamin E used as an antioxidant. It prevents oils and fats in the medicine from breaking down and becoming rancid, helping keep the product stable during storage.
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UNII 3K9958V90M
A liquid solvent derived from fermentation or chemical synthesis. In medicines, alcohol dissolves active ingredients, helps preserve the product, and improves how the body absorbs certain drugs.
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A plant extract from Angelica keiskei used as a natural flavoring agent and to add color to medicines. It may also provide antioxidant properties to help preserve the product's stability.
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Beheneth-20 is a surfactant derived from behenic acid, a fatty acid. It helps mix oil and water-based ingredients together in formulations and can act as an emulsifier or solubilizer.
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A synthetic waxy substance derived from plant oils, used as an emulsifier and thickener to help blend water and oil-based ingredients and improve the product's texture and stability.
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BHT is a synthetic antioxidant that prevents fats and oils in medicines from breaking down and becoming rancid. It helps keep the product stable and effective during storage.
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UNII 3XUS85K0RA
Butylene glycol is a clear liquid derived from petroleum or plants that acts as a humectant, solvent, and preservative booster in medicines. It helps keep formulations stable, dissolve active ingredients, and maintain moisture in topical products.
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UNII 3G6A5W338E
Caffeine is a natural stimulant compound commonly extracted from coffee beans and tea leaves. In medicines, it serves as an active booster in pain relievers and cold products to enhance alertness and improve the effectiveness of other ingredients.
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UNII 0A5MM307FC
A synthetic polymer that absorbs water and forms a thick, gel-like substance. In medicines, it works as a thickener and stabilizer to improve texture and help ingredients stay mixed together in creams, gels, and lotions.
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UNII K679OBS311
Carboxymethylcellulose sodium is a plant-derived thickening agent made from cellulose. In medicines, it acts as a binder to hold ingredients together, a disintegrant to help the tablet break apart, or a thickener in liquids.
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A green algae ingredient used as a natural colorant and nutritional filler in supplements and medications. It adds color and bulk to tablets and capsules.
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A weak organic acid derived from citrus fruits or made through fermentation. It works as a buffer to control pH, a preservative to extend shelf life, and a flavoring agent in medications.
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A natural plant extract from citrus junos seeds, used as a preservative and antioxidant to help maintain the medicine's stability and prevent degradation over time.
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Dimethicone is a silicone-based oil that acts as an anti-foaming agent and lubricant in medicines. It reduces gas bubbles in liquid formulations and helps coat and protect the stomach lining when ingested.
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Dipropylene glycol is a clear liquid made from propylene glycol. It acts as a solvent and humectant in medicines, helping dissolve active ingredients and retain moisture in the formulation.
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UNII 9G1OE216XY
Docosanol is a waxy, fatty alcohol derived from plant sources. It acts as an emollient and thickener in topical medicines, helping to soften the skin and improve product texture and stability.
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UNII 420IP921MB
A chelating agent derived from edetic acid that binds to metals in the formulation. It helps stabilize the medicine by preventing metal ions from causing breakdown or discoloration.
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Erythritol is a sugar alcohol derived from fermented fruits or grains. It's used as a sweetener and bulking agent in medicines to improve taste without adding significant calories.
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UNII 1K09F3G675
Ferric oxide red is an inorganic iron compound used as a colorant in medicines. It gives tablets, capsules, or other dosage forms a red or reddish tint for identification and appearance.
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Ferric oxide yellow is a naturally occurring iron compound used as a colorant in medications. It gives tablets, capsules, and other forms a yellow or golden hue for identification and appearance.
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A dark iron oxide compound that gives medicines their black or dark color. It's used as a colorant in tablets and capsules to help identify the product and make it visually distinctive.
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Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
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A plant extract from green tea leaves. It's used as an antioxidant ingredient to help preserve the medicine and maintain its stability during storage.
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A synthetic crosslinked polymer made by combining hexamethylene diisocyanate with trimethylol hexyllactone. It's used as a film-former and binder to help create protective coatings on tablets or capsules and improve product stability.
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Isododecane is a lightweight liquid hydrocarbon used as a solvent and spreadability agent in topical formulations. It helps dissolve active ingredients and makes the product easier to apply and absorb into the skin.
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Isohexadecane is a synthetic hydrocarbon oil used as an emollient and solvent in topical medicines. It helps dissolve active ingredients and improves spreadability and absorption through the skin.
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UNII G55HNL2C70
Jujube fruit is a natural plant extract used as a sweetener, flavor enhancer, and binder in medicines. It helps improve taste and texture while holding ingredients together in tablets or capsules.
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A waxy ester derived from myristic acid, used as an emollient and lubricant in topical formulations. It helps soften skin contact, reduce friction during application, and improve the texture and spreadability of creams and ointments.
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A synthetic liquid polymer made from ethylene and propylene compounds. It acts as a solvent and humectant to help dissolve active ingredients and maintain moisture in the formulation.
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A synthetic liquid polymer made from ethylene glycol and propylene glycol components. Used in medications as a solvent to dissolve active ingredients and improve how the medicine flows and mixes in liquid formulations.
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Phenoxyethanol is a synthetic preservative and antimicrobial agent used to prevent bacterial and fungal growth in medicines and cosmetic products, extending shelf life and maintaining product safety.
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Polyquaternium-51 is a synthetic polymer used in topical medicines and cosmetics. It acts as a film-former and conditioning agent, helping the product coat and adhere to skin or mucous membranes.
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Potassium hydroxide is a strong alkaline chemical used in medicines to adjust and maintain the pH level of liquid formulations, helping keep the product stable and the active ingredients effective.
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PPG-17 is a synthetic liquid polymer made from propylene glycol. It acts as a humectant and solvent in medicines, helping to dissolve active ingredients and maintain moisture in the product.
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Sapindus mukorossi fruit rind, also called soapnuts, is a natural plant material. It's used in formulations as a natural surfactant and foaming agent to help distribute and mix ingredients evenly.
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Silicon dioxide is a naturally occurring mineral used as a glidant and anti-caking agent. It helps powder ingredients flow smoothly and prevents clumping during manufacturing and storage.
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Sodium citrate is a salt derived from citric acid. It works as a buffer to maintain the medicine's pH level and may also help improve taste or act as a preservative in the formulation.
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Sodium metabisulfite is a preservative derived from sulfur compounds. It prevents microbial growth and oxidation in medicines, helping extend shelf life and maintain product stability.
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A salt derived from phosphoric acid, sodium polymetaphosphate acts as a sequestrant and buffering agent in medicines. It helps maintain stability and control acidity in liquid formulations.
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Sorbitol is a natural sugar alcohol derived from glucose. It serves as a sweetener, humectant, and bulking agent in medications to improve taste and help maintain moisture in the product.
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Stearyl alcohol is a waxy, fatty substance derived from natural oils or made synthetically. It acts as an emulsifier and thickener in medicines, helping mix ingredients together and give the product the right texture.
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UNII 856YO1Z64F
Turmeric is a natural spice derived from the turmeric plant root. It serves as a colorant in medicines, giving products a yellow or golden appearance, and may also provide mild flavoring.
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Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
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Xanthan gum is a thickening and stabilizing ingredient made from fermented corn or other sugars. It's added to medicines to improve texture, prevent separation of liquids and solids, and help the product stay consistent.
45 inactive ingredients listed in the exact product block matched to this NDC.
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
Why might an inactive ingredient be missing?
Can inactive ingredients matter?
💲 Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per g | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
Where does this data come from?
🔁 Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Shiseido Benefiance Wrinkle Smoothing Day 1032 mg/50mL; 2580 mg/50mL; 3818 mg/50mL; 1548 mg/50mL; 774 mg/50mLthis 58411-0439-50 | SHISEIDO | 1 jar | — | — | FDA listed | — |
Where does this data come from?
⏳ Availability & generic status
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
📦 Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Status |
|---|---|---|---|
| 58411-0439-50 You're viewing this | 1 JAR in 1 CARTON (58411-439-50) / 50 mL in 1 JAR | 2018-06-01 | Active |
🧭 About this NDC listing & data coverage
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | — Not published for this NDC No photo available yet for this listing. |
| Inactive ingredients (structured) | ✓ Available |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope. |
| HCPCS J-code billing crosswalk | — Not published for this NDC Most self-administered / retail products have no J-code — that is normal. |
| Medicaid utilization (CMS SDUD) | — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold. |
Questions about this listing
Is this NDC FDA-approved?
Why is there no price listed?
Is the NDC printed on the package the same as the 11-digit billing NDC?
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Do I need a prescription for this product?
Where does this data come from?
📄 FDA label — Drug Facts FDA SPL
🎯 Indications and Usage ▾
Uses helps prevent sunburn if used as directed with other sun protection measures (see Directions ), decreases the risk of skin cancer and early skin aging caused by the sun
⏱️ Dosage and Administration ▾
Directions For sunscreen use: apply liberally 15 minutes before sun exposure use a water resistant sunscreen if swimming or sweating reapply at least every 2 hours Sun Protection Measures . Spending time in the sun increases your risk of skin cancer and early skin aging. To decrease this risk, regularly use a sunscreen with a broad spectrum SPF of 15 or higher and other sun protection measures including: limit time in the sun, especially from 10 a.m. – 2 p.m. wear long-sleeve shirts, pants, hats, and sunglasses children under 6 months: Ask a doctor
⚠️ Warnings ▾
Warnings For external use only Do not use on damaged or broken skin When using this product keep out of eyes. Rinse with water to remove. Stop use and ask a doctor if rash occurs Keep out of reach of children. If product is swallowed, get medical help or contact a Poison Control Center right away.
📦 Storage and Handling ▾
Other information protect this product in this container from excessive heat and direct sun.
🧪 Active Ingredient ▾
Active ingredients Purpose AVOBENZONE 2.0% Sunscreen HOMOSALATE 5.0% Sunscreen OCTINOXATE 7.4% Sunscreen OCTOCRYLENE 3.0% Sunscreen OXYBENZONE 1.5% Sunscreen
🧪 Inactive Ingredients ▾
Inactive Ingredients WATER•GLYCERIN•DIPROPYLENE GLYCOL•BUTYLENE GLYCOL•BEHENYL ALCOHOL•SD ALCOHOL 40-B•SILICA•DIMETHICONE•ISODODECANE•ISOHEXADECANE•SORBITOL•BEHENETH-20•MYRISTYL MYRISTATE•PHYTOSTERYL MACADAMIATE•ERYTHRITOL•XANTHAN GUM•TOCOPHERYL ACETATE•PEG/PPG-14/7 DIMETHYL ETHER•PEG/PPG-17/4 DIMETHYL ETHER•CAFFEINE•SAPINDUS MUKOROSSI PEEL EXTRACT•ANGELICA KEISKEI LEAF/STEM EXTRACT•CAMELLIA SINENSIS LEAF EXTRACT•CITRUS JUNOS SEED EXTRACT•ZIZIPHUS JUJUBA FRUIT EXTRACT•EUCHEUMA SERRA/GRATELOUPIA SPARSA/SACCHARINA ANGUSTATA/ULVA LINZA/UNDARIA PINNATIFIDA EXTRACT•CURCUMA LONGA (TURMERIC) RHIZOME EXTRACT•POLYQUATERNIUM-51•SACCHARINA ANGUSTATA/UNDARIA PINNATIFIDA EXTRACT•CHLORELLA VULGARIS EXTRACT•PPG-17•STEARYL ALCOHOL•BEHENETH-30•ALCOHOL•CARBOMER•CELLULOSE GUM•TRISODIUM EDTA•HDI/TRIMETHYLOL HEXYLLACTONE CROSSPOLYMER•SODIUM CITRATE•BHT•SODIUM METAPHOSPHATE•POTASSIUM HYDROXIDE•CITRIC ACID•TOCOPHEROL•PPG-3 DIPIVALATE•SODIUM METABISULFITE•PHENOXYETHANOL•FRAGRANCE•IRON OXIDES•
🎯 Purpose ▾
Active ingredients Purpose AVOBENZONE 2.0% Sunscreen HOMOSALATE 5.0% Sunscreen OCTINOXATE 7.4% Sunscreen OCTOCRYLENE 3.0% Sunscreen OXYBENZONE 1.5% Sunscreen