NDC 59779-0381-42 — CVS CAPSAICIN .1 g/100g Cream

🆔 Identity & classification

FDA NDC (as labeled) 59779-381-42

Product NDC 59779-381

11-digit billing NDC 59779038142

RxCUI 646333

UNII S07O44R1ZM

UPC 0050428266977

Application # M017

SPL Set ID 9b551fe3-3842-482a-9042-63de5ad39884

DEA schedule Non-controlled

Marketing category OTC MONOGRAPH DRUG

Marketing status On market

FDA listing status Listed (active directory)

Marketing start 2014-10-13

Route TOPICAL

Dosage form CREAM

Substance CAPSAICIN

Why two NDCs? The FDA registers this code as 59779-381-42 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 59779-0381-42. Same drug, same package — only the format differs.

Where does this data come from?

Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏷️ RxNorm drug class

This medicine belongs to the Capsaicin and similar agents class.

Drug family (ATC) Capsaicin and similar agents, Other local anesthetics

Where does this data come from?

Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

🏭 Manufacturer & labeler

LabelerCVS PHARMACY

FDA applicationM017 (OTC MONOGRAPH DRUG)

Labeler code59779

First marketedOct 2014

Product typeHuman Otc Drug

Portfolio550 products on file

🔎 All NDCs from CVS PHARMACY

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).

Where does this data come from?

Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

📗 Our plain-language guide HelloPharmacist

Yes, completely normal — and it actually means the medicine is working. Capsaicin activates the same pain-sensing receptors in your skin that respond to heat and spicy food. That b...
Why does capsaicin burn when I put it on? Is that normal?
For most OTC creams and ointments, you can apply up to 3 to 4 times a day. For OTC patches, apply to clean, dry skin and remove after no more than 8 hours — again, up to 3 to 4 tim...
How often should I apply capsaicin cream or use the patch?

📖 Read our full Capsaicin guide →

Patient education

📘 MedlinePlus patient leaflet ↗

Supplement & herbal interactions

Some supplements/herbs that may interact with Capsaicin (prescription drug) — tap one for details:

Dimethylsulfoxide (dmso)Moderate Turpentine OilModerate AlchemillaMinor

🌿 Every supplement checked against Capsaicin (prescription drug) (3 interactions) — ranked by severity →

Where does this data come from?

Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.

Where does this data come from?

Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?

No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.

Why might an inactive ingredient be missing?

Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.

Can inactive ingredients matter?

Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price system	Per g	Per package
Retail pharmacies payNADAC · weekly	Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo	No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly	No Part D plan price is available for this NDC in our data.

ℹ️

No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.

Where does this data come from?

NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

Product	Labeler	Pack	NADAC/unit	TE	Status	Price vs. this
Rugby Capsaicin Cream .1 g/100g 00536-1264-56	Rugby	1 tube	$0.202	—	Availability likely	—
Capsaicin .1 g/100g 50268-0198-42	AvPAK	1 tube	$0.202	—	Availability likely	—
Leader Capsaicin Pain Relief Cream .1 g/100g 70000-0549-01	Cardinal	1 tube	$0.202	—	Availability likely	—
Walgreens Arthritis Pain Relief Capsaicin Analgesic 1 mg/g 00363-0837-01	Walgreen	1 tube	—	—	FDA listed	—
Heat Pain Relief .1 g/100g 00363-6263-07	Walgreen	1 applicator	—	—	FDA listed	—
Earths Care Arthritis .1 g/100g 24286-1559-02	DLC	1 tube	—	—	FDA listed	—
Capzasin HP Arthritis Pain Relief .001 g/g 41167-7514-02	Chattem,	1 tube	—	—	FDA listed	—
Capsaicin .001 g/g 50268-0197-56	AvPAK	1 tube	—	—	FDA listed	—
Capsaicin 0.1 Percent .1 g/100g 50488-1060-06	Alexso,	60 g	—	—	FDA listed	—
Capsaicin 0.1% Cream 1 mg/g 59088-0242-08	Puretek	120 g	—	—	FDA listed	—
Cvs Capsaicin .1 g/100gthis 59779-0381-42	CVS	1 tube	—	—	FDA listed	—
Capsaicin HP Arthritis Pain Relief .1 g/100g 69375-0006-60	Nationwide	1 tube	—	—	FDA listed	—
Capsaicin Cream .1 g/100g 69396-0103-02	Trifecta	1 tube	—	—	FDA listed	—
Capzix .001 g/g 72847-0316-20	Toprail	1 tube	—	—	FDA listed	—
Capsaicin Cream .1 g/100g 73141-0558-02	A2A	1 tube	—	—	FDA listed	—
Capsaicin .1 g/100g 76420-0753-42	Asclemed	1 tube	—	—	FDA listed	—
Toast Screamin Hot .1 g/100g 78983-0102-05	IDEAZ,	148 g	—	—	FDA listed	—
Capsaicin Cream .1 g/100g 81533-0200-15	Noble	1 tube	—	—	FDA listed	—
NeroCare Capsaicin Neuropathy Relief Cream .1 g/100g 84066-0108-01	Guangzhou	100 g	—	—	FDA listed	—
Dr. Luke Capsaicin Cream Extra Strength .1 g/100g 87147-0003-01	DANOUS	114 g	—	—	Discontinued	—
Easment advanced absorption cream .12 g/120g 87352-0001-01	Easment	120 g	—	—	FDA listed	—
High Potency Pain Relief .1 g/100g 87773-0001-01	Xiamen	114 g	—	—	FDA listed	—

About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.

Where does this data come from?

Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️

2014

On the market since

Oct 2014

📍

2026

Currently FDA-listed

12 years listed

🔒

·

No generic listed yet

brand only

ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?

Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

📦 Packaging — all sizes for this product

Package NDC	Description	Marketing start	Status
59779-0381-42 You're viewing this	1 TUBE in 1 CARTON (59779-381-42) / 42 g in 1 TUBE	2014-10-13	Active

🧭 About this NDC listing & data coverage

Over-the-counter (OTC) product

What data is (and isn’t) available for this NDC — tap to expand

NDC identity (package / product / labeler codes)	✓ Available
Labeler	✓ Available
Product & package description	✓ Available
Marketing category & status	✓ Available
Active ingredient / dosage form / route	✓ Available
FDA label (SPL via DailyMed)	✓ Available
Package photos	— Not published for this NDC No photo available yet for this listing.
Inactive ingredients (structured)	— Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available.
NADAC pharmacy acquisition price (CMS)	— Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data	— Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk	— Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD)	— Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.

“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?

An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.

Why is there no price listed?

The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.

Is the NDC printed on the package the same as the 11-digit billing NDC?

Yes, they identify this exact package in different formats. The FDA registers it as 59779-381-42, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 59779-0381-42, written without dashes as 59779038142. The Identity section at the top of this page lists every form of this code.

What do the three segments of this NDC mean?

In 59779-0381-42, the first segment (59779) is the labeler code FDA assigned to CVS PHARMACY; the middle segment (0381) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (42) identifies this exact package size and type. Together they name one specific package of one specific product.

Is this package still being marketed?

Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by CVS PHARMACY. Listing status can change — the directory data on this page refreshes weekly.

Who lists this product with the FDA?

CVS PHARMACY is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.

Do I need a prescription for this product?

This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.

This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.

Where does this data come from?

Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.

🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 📦 Storage and Handling 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose

🎯 Indications and Usage 51 words ▾

Directions Adults and children over 18 years: use only as directed apply to affected area massage into painful area until thoroughly absorbed repeat as necessary, but no more than 3 to 4 times daily wash hands with soap and water after applying children under 18 years of age: ask a doctor

⏱️ Dosage and Administration 15 words ▾

Distributed by: CVS Pharmacy, Inc. One CVS Drive, Woonsocket, RI 02895 www.cvs.com Made in China

⚠️ Warnings 5 words ▾

Warnings For external use only

📦 Storage and Handling 24 words ▾

Other information store at room temperature Lot No. and Exp. Date: see box or crimp of tube save carton for complete Drug Facts information

🧪 Active Ingredient 6 words ▾

Active ingredient Purpose Capsaicin 0.1%........................................................................Topical analgesic

🧪 Inactive Ingredients 16 words ▾

Inactive ingredients benzyl alcohol, cetyl alcohol, isopropyl myristate, petrolatum, polyoxyl 40 stearate, water, sorbitan monostearate, sorbitol

🎯 Purpose 16 words ▾

For the temporary relief of minor pain associated with: Arthritis Simple backache Muscle strains Sprains Bruises

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

🔗 Related NDC lookups

🧪 All Capsaicin NDCsSame ingredient 🏭 All CVS labeler NDCsLabeler code 59779 📖 Read the Capsaicin drug informationUses, warnings & side effects