Rugby Capsaicin Cream .1 g/100g Cream, 1 tube
by Rugby Laboratories · 1 TUBE in 1 BOX (0536-1264-56) / 42.5 g in 1 TUBE
NDC 00536-1264-56
🏷️ FDA NDC (as labeled)
0536-1264-56
billing pads the labeler segment with a zero
OTC
On market
Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →
🆔 Identity & classification
FDA NDC (as labeled)
0536-1264-56
Product NDC
0536-1264
11-digit billing NDC
00536126456
NCPDP billing unit
GM — per gram (weight)
RxCUI
646333
UNII
S07O44R1ZM
UPC
0305361264567
Application #
M017
SPL Set ID
9eca34f1-e91a-3ac1-e053-2a95a90a9bd9
DEA schedule
Non-controlled
Marketing category
OTC MONOGRAPH DRUG
Marketing status
On market
FDA listing status
Listed (active directory)
Marketing start
2020-02-17
Route
TOPICAL
Dosage form
CREAM
Substance
CAPSAICIN
GPI-14
90850025003735
GPI class
Capsaicin
GCN Seq No
058057
GCN
23373
HICL code
002577
Ingredient (HICL)
Capsaicin
HIC1 code
L
Therapeutic class — broad (HIC1)
Skin/Subcutaneous Tissue
HIC2 code
L6
Therapeutic class — intermediate (HIC2)
Irritants
HIC3 code
L6A
Therapeutic class — specific (HIC3)
Irritants/Counter-Irritants
AHFS code
84:92.00.00
AHFS class
Skin And Mucous Membrane Agents, Misc.
FDB label name
CAPSAICIN 0.1% CREAM
FDB brand name
Capsaicin
Legend status
O — Over-the-counter (OTC) drug or device
Why two NDCs?
The FDA registers this code as 0536-1264-56 — a 4-4-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the labeler segment → 00536-1264-56. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.
🏷️ RxNorm drug class
This medicine belongs to the Capsaicin and similar agents class.
Drug family (ATC)
Capsaicin and similar agents, Other local anesthetics
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.
🏭 Manufacturer & labeler
LabelerRugby Laboratories
FDA applicationM017 (OTC MONOGRAPH DRUG)
Labeler code00536
First marketedFeb 2020
Product typeHuman Otc Drug
Portfolio149 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.
🩺 Clinical
Label name CAPSAICIN 0.1% CREAM Ingredient Capsaicin
📖 What it is MedlinePlus · NLM
Topical capsaicin is used to relieve minor pain in muscles and joints caused by arthritis, backaches, muscle strains, bruises, cramps, and sprains. Capsaicin is a substance that is found in chili peppers. It works by affecting nerve cells in the skin that are associated with pain, which results in decreased activity of these nerve cells and a reduced sense of pain.
Read the full MedlinePlus article ↗📗 Our plain-language guide HelloPharmacist
- Yes, completely normal — and it actually means the medicine is working. Capsaicin activates the same pain-sensing receptors in your skin that respond to heat and spicy food. That b...
- Why does capsaicin burn when I put it on? Is that normal?
- For most OTC creams and ointments, you can apply up to 3 to 4 times a day. For OTC patches, apply to clean, dry skin and remove after no more than 8 hours — again, up to 3 to 4 tim...
- How often should I apply capsaicin cream or use the patch?
Patient education
Supplement & herbal interactions
Some supplements/herbs that may interact with Capsaicin (prescription drug) — tap one for details:
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.
💬 Questions about Capsaicin?
Ask a pharmacist →
Ask a licensed pharmacist directly — free, answered by our team.
🧪 Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
-
UNII ZY81Z83H0X
Aloe vera leaf is a plant extract derived from the aloe plant. It is used in medicines as a natural moisturizer and skin-soothing agent in topical formulations.
-
UNII 2DMT128M1S
A waxy solid derived from plant or animal sources. It acts as an emulsifier to blend oil and water components, and also thickens the medicine to give it the right texture and consistency.
-
UNII 14255EXE39
Ethylparaben is a preservative, a chemical that stops bacteria and mold from growing in the medicine. It keeps the product safe and effective throughout its shelf life.
-
UNII PDC6A3C0OX
Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
-
UNII 230OU9XXE4
A waxy substance made from glycerin and stearic acid that acts as an emulsifier to blend oily and watery ingredients together. It also helps thicken and stabilize the medicine's texture.
-
UNII 002FR4N8OV
A surfactant derived from lauryl alcohol and ethylene oxide. It helps dissolve or mix oil-based and water-based ingredients together, and may aid in absorption or dispersion of the active drug in the formulation.
-
UNII T5L8T28FGP
Mineral oil is a clear, odorless liquid derived from crude oil. It acts as a lubricant and emollient in medications, helping pills slide smoothly during manufacturing and aiding moisture retention in topical products.
-
UNII 4T6H12BN9U
Petrolatum is a purified mineral oil-based jelly derived from petroleum. In medicines, it acts as an emollient, lubricant, and moisture barrier to soften skin, reduce friction, and help prevent water loss from formulations.
-
UNII 2KR89I4H1Y
Stearyl alcohol is a waxy, fatty substance derived from natural oils or made synthetically. It acts as an emulsifier and thickener in medicines, helping mix ingredients together and give the product the right texture.
-
UNII 059QF0KO0R
Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
10 inactive ingredients listed in the exact product block matched to this NDC.
The official label also statesAloe barbadensis leaf juice, Cetostearyl alcohol, Ethylparaben, Glycerin, Glyceryl monostearate, Mineral Oil, Petrolatum, Polyoxyethylene lauryl ether, Purified Water, stearic acid.
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed —
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.
💲 Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per g | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | $0.202 | $8.58 / 42.5 g |
| Medicaid paysCMS SDUD · 12 mo | $0.3304 | $14.04 / 42.5 g |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
NADAC price history (per g) — tap or hover for the price & month
▲ Up 2% over the last 12 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.
🔁 Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Rugby Capsaicin Cream .1 g/100gthis 00536-1264-56 | Rugby | 1 tube | $0.202 | — | Availability likely | — |
| Capsaicin .1 g/100g 50268-0198-42 | AvPAK | 1 tube | $0.202 | — | Availability likely | — |
| Leader Capsaicin Pain Relief Cream .1 g/100g 70000-0549-01 | Cardinal | 1 tube | $0.202 | — | Availability likely | — |
| Walgreens Arthritis Pain Relief Capsaicin Analgesic 1 mg/g 00363-0837-01 | Walgreen | 1 tube | — | — | FDA listed | — |
| Heat Pain Relief .1 g/100g 00363-6263-07 | Walgreen | 1 applicator | — | — | FDA listed | — |
| Earths Care Arthritis .1 g/100g 24286-1559-02 | DLC | 1 tube | — | — | FDA listed | — |
| Capzasin HP Arthritis Pain Relief .001 g/g 41167-7514-02 | Chattem, | 1 tube | — | — | FDA listed | — |
| Capsaicin .001 g/g 50268-0197-56 | AvPAK | 1 tube | — | — | FDA listed | — |
| Capsaicin 0.1 Percent .1 g/100g 50488-1060-06 | Alexso, | 60 g | — | — | FDA listed | — |
| Capsaicin 0.1% Cream 1 mg/g 59088-0242-08 | Puretek | 120 g | — | — | FDA listed | — |
| Cvs Capsaicin .1 g/100g 59779-0381-42 | CVS | 1 tube | — | — | FDA listed | — |
| Capsaicin HP Arthritis Pain Relief .1 g/100g 69375-0006-60 | Nationwide | 1 tube | — | — | FDA listed | — |
| Capsaicin Cream .1 g/100g 69396-0103-02 | Trifecta | 1 tube | — | — | FDA listed | — |
| Capzix .001 g/g 72847-0316-20 | Toprail | 1 tube | — | — | FDA listed | — |
| Capsaicin Cream .1 g/100g 73141-0558-02 | A2A | 1 tube | — | — | FDA listed | — |
| Capsaicin .1 g/100g 76420-0753-42 | Asclemed | 1 tube | — | — | FDA listed | — |
| Toast Screamin Hot .1 g/100g 78983-0102-05 | IDEAZ, | 148 g | — | — | FDA listed | — |
| Capsaicin Cream .1 g/100g 81533-0200-15 | Noble | 1 tube | — | — | FDA listed | — |
| NeroCare Capsaicin Neuropathy Relief Cream .1 g/100g 84066-0108-01 | Guangzhou | 100 g | — | — | FDA listed | — |
| Dr. Luke Capsaicin Cream Extra Strength .1 g/100g 87147-0003-01 | DANOUS | 114 g | — | — | Discontinued | — |
| Easment advanced absorption cream .12 g/120g 87352-0001-01 | Easment | 120 g | — | — | FDA listed | — |
| High Potency Pain Relief .1 g/100g 87773-0001-01 | Xiamen | 114 g | — | — | FDA listed | — |
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.
⏳ Availability & generic status
🏛️
2020
On the market since
Feb 2020
📍
2026
Currently FDA-listed
6 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.
🗺️ Medicaid utilization & spend
📍 This exact package only: Medicaid data is reported per full 11-digit NDC — labeler, product and pack size — so every number here is for 00536-1264-56, not the drug overall. Other pack sizes report separately.
💊 Pharmacy benefit only: These are Medicaid outpatient pharmacy claims, billed by NDC. They exclude the medical benefit — clinic- or hospital-administered drugs billed under HCPCS J-codes — so drugs used mostly that way (e.g. Avastin, Lucentis, Keytruda) can look low or missing here. That’s expected, not an error.
📅 Q1 2025 – Q4 2025 · 4 quarters of data
ⓘ The newest quarter is usually incomplete when first published; states restate recent quarters in later CMS releases, so the latest figures typically revise upward. State coverage-policy changes can also shift quarter-to-quarter totals.
Prescriptions last 4 qtrs
10.1K
Units reimbursed last 4 qtrs
464.5K
Gross reimbursed last 4 qtrs
$153.5K
Avg / prescription
$15.25
Avg / unit
$0.3304
Latest quarter Q4 2025
2.5KRx
Medicaid pays / g
$0.3304
gross reimbursed
vs
NADAC / g
$0.2018
acquisition cost
=
Spread
+$0.1286
+64% vs cost
What Medicaid paid per g (before rebates; includes the pharmacy’s dispensing fee) compared with NADAC — the average price pharmacies pay to buy the drug. A positive spread means Medicaid reimbursed more than the purchase price, before manufacturer rebates.
Fee-for-service vs managed care ⓘ
Fee-for-service · 4,968 Rx Managed care · 5,094 Rx
State Medicaid map
Units reimbursed · per 100k residents
29.6788
gray = no data reported ⓘ
Colors are per 100,000 residents, so big states don’t automatically dominate. Tap or hover a state for its actual totals.
Tap or hover a state
…for its Medicaid breakdown
Prescriptions—
Units—
Reimbursed—
🏆 Top states by units · per 100k residents
National units — by quarter
💵 About the dollar figures: “reimbursed” is what Medicaid paid pharmacies before confidential manufacturer rebates, so the program’s real net cost is lower than these numbers. Fee-for-service and managed-care claims are combined unless split above. Source: CMS State Drug Utilization Data; per-100k rates use 2023 Census population estimates.
🔬 Reported adverse events (FAERS)
Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Capsaicin — the ingredient across all brands.
Top reported reactions
Age at onset
Reporter sex
Male · 41%
Female · 59%
Unknown · 0%
Serious outcomes
Reports over time (by year) — tap or hover for the count & year
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.
📦 Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Status |
|---|---|---|---|
| 00536-1264-56 You're viewing this | 1 TUBE in 1 BOX (0536-1264-56) / 42.5 g in 1 TUBE | 2020-02-17 | Active |
📄 FDA label — Drug Facts FDA SPL
The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage
⏱️ Dosage and Administration
⚠️ Warnings
📦 Storage and Handling
🧪 Active Ingredient
🧪 Inactive Ingredients
🎯 Purpose
🎯 Indications and Usage ▾
Uses For the temporary relief of minor aches and pains of muscles and joints associated with: Arthritis Simple Backache Strains Sprains Bruises
⏱️ Dosage and Administration ▾
Directions Adults and Children over 18 years: Apply to affected area Massage into the painful area until thoroughly absorbed Repeat as necessary but not more than 3 to 4 times daily WASH HANDS WITH SOAP AND WATER AFTER APPLYING Children 18 years and younger: Ask a doctor
⚠️ Warnings ▾
Warnings For external use only: TEST FIRST ON SMALL AREA OF SKIN. When using this product: Use only as directed Do not apply to wounds, damaged, broken or irritated sin Do not use if you are allergic to capssicum or chili peppers Avoid contact with the eyes or mucous membranes A slight burning sensation may occur upon application, but generally disappears after several days of use If severe burning occurs, discontinue use Do not expose the treated area to heat or direct sunlight Do not bandage Do not use with heating pad
📦 Storage and Handling ▾
Other Information Store at room temperature 15°-30°F (59°-86°F)
🧪 Active Ingredient ▾
Active Ingredient Capsaicin 0.1%
🧪 Inactive Ingredients ▾
Inactive Ingredients Aloe barbadensis leaf juice, Cetostearyl alcohol, Ethylparaben, Glycerin, Glyceryl monostearate, Mineral Oil, Petrolatum, Polyoxyethylene lauryl ether, Purified Water, stearic acid.
🎯 Purpose ▾
Purpose Topical Analgesic
No label section mentions that — try another word, or open the full label on DailyMed below.
Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA.
Prefer the government’s original formatting? View this label on DailyMed ↗
For educational and professional reference only — not medical advice. Pricing reflects published
NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.