SILVADENE silver sulfadiazine 10 mg/g Cream, 400 g
🆔 Identity & classification
Where does this data come from?
🏷️ RxNorm drug class
This medicine belongs to the Sulfonamide Antibacterial class.
Where does this data come from?
🏭 Manufacturer & labeler
Where does this data come from?
🩺 Clinical
Silver sulfadiazine, a sulfa drug, is used to prevent and treat infections of second- and third-degree burns. It kills a wide variety of bacteria. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Read the full MedlinePlus article ↗- Silver sulfadiazine cream is applied to second- and third-degree burn wounds to help prevent and treat serious infection. It's not a standalone treatment — your care team uses it a...
- After the wound is cleaned and any dead tissue is removed, the cream is spread in a thin layer — about 1/16 of an inch — directly over the burn area. It's applied once or twice a d...
- A temporary dip in white blood cells, especially a type called neutrophils, is actually one of the more commonly reported effects — it happens in roughly 1 in 5 patients. The good...
- My white blood cell count went down — should I be worried?
Patient education
Supplement & herbal interactions
Some supplements/herbs that may interact with Silver Sulfadiazine — tap one for details:
Where does this data come from?
Ask a licensed pharmacist directly — free, answered by our team.
🧪 Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
Where does this data come from?
IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
Why might an inactive ingredient be missing?
Can inactive ingredients matter?
💲 Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per g | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | $0.125 | $49.88 / 400 g |
| Medicaid paysCMS SDUD · 12 mo | $0.1286 | $51.44 / 400 g |
| Medicare drug plans payPart D · Q2 2026 | $0.4439 | $177.56 / 400 g |
Where does this data come from?
🔁 Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Silvadene 10 mg/gthis 61570-0131-40 | Pfizer | 400 g | $0.125 | AB | Availability likely | — |
| Silver sulfadiazine 10 mg/g 67877-0124-05 | Ascend | 50 g | $0.255 | AB | Availability likely | +105% |
| SSD Cream 10 g/1000g 43598-0210-25 | Dr | 25 g | $0.316 | AB | Availability likely | +153% |
| Silver Sulfadiazine 10 mg/g 59762-0131-00 | Mylan | 1 tube | $0.403 | AB | Availability likely | +223% |
| Silvadene 10 mg/g 50090-0230-00 | A-S | 1 tube | — | AB | FDA listed | — |
| Silver Sulfadiazine 10 mg/g 50090-0607-00 | A-S | 50 g | — | AB | FDA listed | — |
| Silver Sulfadiazine 10 mg/g 50090-0717-00 | A-S | 50 g | — | AB | FDA listed | — |
| Silver Sulfadiazine 10 mg/g 50090-0763-00 | A-S | 25 g | — | AB | FDA listed | — |
| Silver Sulfadiazine 10 mg/g 50090-2152-00 | A-S | 400 g | — | AB | FDA listed | — |
| Ssd 10 g/1000g 50090-7447-00 | A-S | 50 g | — | AB | FDA listed | — |
| SSD Cream 10 g/1000g 60760-0962-50 | St. | 50 g | — | AB | FDA listed | — |
| Silver Sulfadiazine 10 g/1000g 61919-0237-25 | DIRECT | 25 g | — | AB | FDA listed | — |
| Silver Sulfadiazine 10 mg/g 63187-0023-25 | Proficient | 25 g | — | AB | FDA listed | — |
| Silver Sulfadiazine 10 mg/g 63629-8768-01 | Bryant | 20 g | — | AB | Discontinued | — |
| Silver Sulfadiazine 10 mg/g 63629-8769-01 | Bryant | 25 g | — | AB | Discontinued | — |
| Silver Sulfadiazine 10 mg/g 63629-8770-01 | Bryant | 50 g | — | AB | Discontinued | — |
| Silver Sulfadiazine 10 mg/g 63629-8771-01 | Bryant | 50 g | — | AB | Discontinued | — |
| Silver Sulfadiazine 10 mg/g 63629-8772-01 | Bryant | 85 g | — | AB | Discontinued | — |
| Silver Sulfadiazine 10 mg/g 63629-8773-01 | Bryant | 400 g | — | AB | Discontinued | — |
| Silver Sulfadiazine 10 g/1000g 68071-2473-05 | NuCare | 50 g | — | AB | FDA listed | — |
| SSD Cream 10 g/1000g 68071-3867-05 | NuCare | 50 g | — | AB | FDA listed | — |
| Thermazene Silver Sulfadiazine 10 mg/g 68788-0600-02 | Preferred | 25 g | — | AB | FDA listed | — |
| SSD Cream 10 g/1000g 68788-8074-02 | Preferred | 25 g | — | AB | FDA listed | — |
| Silver Sulfadiazine 10 g/1000g 76420-0208-25 | Asclemed | 25 g | — | AB | FDA listed | — |
| Silver Sulfadiazine 10 mg/g 80425-0221-01 | Advanced | 50 g | — | AB | FDA listed | — |
| Silver Sulfadiazine 10 mg/g 87063-0078-05 | Asclemed | 50 g | — | AB | FDA listed | — |
Where does this data come from?
⏳ Availability & generic status
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
🗺️ Medicaid utilization & spend
💊 Medicaid utilization by pack size
📊 Medicare Part D spend CMS · PART D · 2026 (Q1)
🔬 Reported adverse events (FAERS)
Top reported reactions
Age at onset
Reporter sex
Serious outcomes
Where does this data come from?
📦 Packaging — all sizes for this product
| Package NDC | Description | Per unit | Per pack | Marketing start | Status |
|---|---|---|---|---|---|
| 61570-0131-20 | 1 TUBE in 1 CARTON (61570-131-20) / 20 g in 1 TUBE | $0.4328 / g | $8.66 | 1973-11-26 | Active |
| 61570-0131-25 | 1 TUBE in 1 CARTON (61570-131-25) / 25 g in 1 TUBE | $0.2886 / g | $7.21 | 2015-05-26 | Active |
| 61570-0131-40 You're viewing this | 400 g in 1 JAR (61570-131-40) | $0.1247 / g | $49.88 | 1973-11-26 | Active |
| 61570-0131-50 | 50 g in 1 JAR (61570-131-50) | $0.2447 / g | $12.24 | 1973-11-26 | Active |
| 61570-0131-55 | 1 TUBE in 1 CARTON (61570-131-55) / 50 g in 1 TUBE | $0.2447 / g | $12.24 | 2015-05-26 | Active |
| 61570-0131-85 | 1 TUBE in 1 CARTON (61570-131-85) / 85 g in 1 TUBE | $0.2732 / g | $23.22 | 1973-11-26 | Active |
| 61570-0131-98 | 1000 g in 1 JAR (61570-131-98) | — | — | 1973-11-26 | Active |
This pack has the lowest per-g cost of the 6 priced pack sizes ($0.1247 NADAC).
This pack accounts for about 6.5% of this product's recent Medicaid fills; the largest share goes to the 50 gs pack. See all packs ↓
Pack size FAQ
What quantity is in NDC 61570-0131-40?
What is the difference between NDC 61570-0131-40 and NDC 61570-0131-50?
What NDC number is used to bill for this package of SILVADENE silver sulfadiazine 10 mg/g Cream?
Prices are the latest CMS NADAC pharmacy acquisition cost per NDC; per-pack figures are per-unit × pack quantity, shown only when the pack is denominated in the same measure NADAC prices.
📄 Full prescribing information FDA SPL
🎯 Indications and Usage ▾
INDICATIONS AND USAGE SILVADENE Cream 1% (silver sulfadiazine) is a topical antimicrobial drug indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.
⏱️ Dosage and Administration ▾
DOSAGE AND ADMINISTRATION Prompt institution of appropriate regimens for care of the burned patient is of prime importance and includes the control of shock and pain. The burn wounds are then cleansed and debrided, and SILVADENE Cream 1% (silver sulfadiazine) is applied under sterile conditions. The burn areas should be covered with SILVADENE Cream 1% at all times.
The cream should be applied once to twice daily to a thickness of approximately 1/16 inch. Whenever necessary, the cream should be reapplied to any areas from which it has been removed by patient activity. Administration may be accomplished in minimal time because dressings are not required.
However, if individual patient requirements make dressings necessary, they may be used. Reapply immediately after hydrotherapy. Treatment with SILVADENE Cream 1% should be continued until satisfactory healing has occurred, or until the burn site is ready for grafting.
The drug should not be withdrawn from the therapeutic regimen while there remains the possibility of infection except if a significant adverse reaction occurs.
⛔ Contraindications ▾
CONTRAINDICATIONS SILVADENE Cream 1% (silver sulfadiazine) is contraindicated in patients who are hypersensitive to silver sulfadiazine or any of the other ingredients in the preparation. Because sulfonamide therapy is known to increase the possibility of kernicterus, SILVADENE Cream 1% should not be used on pregnant women approaching or at term, on premature infants, or on newborn infants during the first 2 months of life.
⚠️ Warnings ▾
WARNINGS Absorption of silver sulfadiazine varies depending upon the percent of body surface area and the extent of the tissue damage. Although few have been reported, it is possible that any adverse reaction associated with sulfonamides may occur. Some of the reactions, which have been associated with sulfonamides, are as follows: blood dyscrasias including agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, and hemolytic anemia; dermatologic and allergic reactions, including life-threatening cutaneous reactions [Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and exfoliative dermatitis]; gastrointestinal reactions; hepatitis and hepatocellular necrosis; CNS reactions; and toxic nephrosis.
There is potential cross-sensitivity between silver sulfadiazine and other sulfonamides. If allergic reactions attributable to treatment with silver sulfadiazine occur, continuation of therapy must be weighed against the potential hazards of the particular allergic reaction. Fungal proliferation in and below the eschar may occur.
However, the incidence of clinically reported fungal superinfection is low. The use of SILVADENE Cream 1% (silver sulfadiazine) in some cases of glucose-6-phosphate dehydrogenase-deficient individuals may be hazardous, as hemolysis may occur.
🤒 Adverse Reactions ▾
ADVERSE REACTIONS Several cases of transient leukopenia have been reported in patients receiving silver sulfadiazine therapy. 1,2,3 Leukopenia associated with silver sulfadiazine administration is primarily characterized by decreased neutrophil count. Maximal white blood cell depression occurs within 2 to 4 days of initiation of therapy.
Rebound to normal leukocyte levels follows onset within 2 to 3 days. Recovery is not influenced by continuation of silver sulfadiazine therapy. An increased incidence of leukopenia has been reported in patients treated concurrently with cimetidine.
Other infrequently occurring events include skin necrosis, erythema multiforme, skin discoloration, burning sensation, rashes, and interstitial nephritis. Reduction in bacterial growth after application of topical antibacterial agents has been reported to permit spontaneous healing of deep partial-thickness burns by preventing conversion of the partial thickness to full thickness by sepsis. However, reduction in bacterial colonization has caused delayed separation, in some cases necessitating escharotomy in order to prevent contracture.
🤰 Pregnancy ▾
Pregnancy Teratogenic Effects. A reproductive study has been performed in rabbits at doses up to three to ten times the concentration of silver sulfadiazine in SILVADENE Cream 1% and has revealed no evidence of harm to the fetus due to silver sulfadiazine. There are, however, no adequate and well-controlled studies in pregnant women.
Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly justified, especially in pregnant women approaching or at term (see CONTRAINDICATIONS ).
🧒 Pediatric Use ▾
Pediatric Use Safety and effectiveness in pediatric patients have not been established (see CONTRAINDICATIONS ).
🧓 Geriatric Use ▾
Geriatric Use Of the total number of subjects in clinical studies of SILVADENE Cream 1%, seven percent were 65 years of age and over. No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.
🧬 Clinical Pharmacology ▾
CLINICAL PHARMACOLOGY Silver sulfadiazine has broad antimicrobial activity. It is bactericidal for many gram-negative and gram-positive bacteria as well as being effective against yeast. Results from in vitro testing are listed below.
Sufficient data have been obtained to demonstrate that silver sulfadiazine will inhibit bacteria that are resistant to other antimicrobial agents and that the compound is superior to sulfadiazine. Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect.
Results of In Vitro Testing with SILVADENE ® Cream 1% (silver sulfadiazine) Concentration of Silver Sulfadiazine Number of Sensitive Strains/Total Number of Strains Tested Genus & Species 50 μg/mL 100 μg/mL Pseudomonas aeruginosa 130/130 130/130 Xanthomonas (Pseudomonas) maltophilia 7/7 7/7 Enterobacter species 48/50 50/50 Enterobacter cloacae 24/24 24/24 Klebsiella species 53/54 54/54 Escherichia coli 63/63 63/63 Serratia species 27/28 28/28 Proteus mirabilis 53/53 53/53 Morganella morganii 10/10 10/10 Providencia rettgeri 2/2 2/2 Providencia species 1/1 1/1 Proteus vulgaris 2/2 2/2 Citrobacter species 10/10 10/10 Acinetobacter calcoaceticus 10/11 11/11 Staphylococcus aureus 100/101 100/101 Staphylococcus epidermidis 51/51 51/51 β-Hemolytic Streptococcus 4/4 4/4 Enterococcus species 52/53 53/53 Corynebacterium- diphtheriae 2/2 2/2 Clostridium perfringens 0/2 2/2 Candida albicans 43/50 50/50 Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.
📦 How Supplied / Storage and Handling ▾
HOW SUPPLIED SILVADENE Cream 1% (silver sulfadiazine) is available in jars containing 50 g ( NDC 61570-131-50), 400 g ( NDC 61570-131-40), and 1000 g ( NDC 61570-131-98), and tubes containing 20 g ( NDC 61570-131-20), 25 g ( NDC 61570-131-25), 50 g ( NDC 61570-131-55) and 85 g ( NDC 61570-131-85). Store at Controlled Room Temperature 20° to 25°C (68° to 77°F).
📋 Description ▾
DESCRIPTION SILVADENE Cream 1% is a soft, white, water-miscible cream containing the antimicrobial agent silver sulfadiazine in micronized form, which has the following structural formula: Each gram of SILVADENE Cream 1% contains 10 mg of micronized silver sulfadiazine. The cream vehicle consists of white petrolatum, stearyl alcohol, isopropyl myristate, sorbitan monooleate, polyoxyl 40 stearate, propylene glycol, and water, with methylparaben 0.3% as a preservative. SILVADENE Cream 1% (silver sulfadiazine) spreads easily and can be washed off readily with water.
Chemical Structure