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Head and Shoulders Supreme Soothe and Strengthen Conditioner Pyrithione Zinc .5 g/100mL Lotion, 835 mL — NDC 69423-0349-83 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

Head and Shoulders Supreme Soothe and Strengthen Conditioner Pyrithione Zinc .5 g/100mL Lotion, 835 mL — NDC 69423-349-83 (Billing 69423-0349-83)

by The Procter & Gamble Manufacturing Company · 835 mL in 1 BOTTLE, PUMP

This is a package of 835 mL of Head and Shoulders Supreme Soothe and Strengthen Conditioner Pyrithione Zinc .5 g/100mL Lotion from The Procter & Gamble Manufacturing Company, marketed since May 2019 and currently FDA-listed.

NDC 69423-0349-83
🏷️ FDA NDC (as labeled) 69423-349-83 billing pads the product segment with a zero
This package
Contains835 mL Pack sizes2 compare ↓
Product page 69423-0349-27 Also comes in: 278 ml 69423-349-27
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 8, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 69423-349-83 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
69423 labeler · 349 product · 83 package
Package marketed since
Jan 15, 2023
Sample package
No — commercial package
Listing certified through
Dec 31, 2026
Barcode (UPC-A, from the NDC)
3 6942334983 8
FDA record last changed
Jul 24, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 69423-349-83
Product NDC 69423-349
11-digit billing NDC 69423034983
RxCUI 1043014, 1044465
UNII R953O2RHZ5
Application # M032
SPL Set ID 86abfdc2-d55b-4adb-e053-2991aa0a54b1
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2019-05-02
Route TOPICAL
Dosage form LOTION
Substance PYRITHIONE ZINC
Quick answers
  • RxCUI (RxNorm): 1043014
Why two NDCs? The FDA registers this code as 69423-349-83 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 69423-0349-83. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Other dermatologicals class.

Drug family (ATC) Other dermatologicals
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

🧪 What is this product?

Head and Shoulders Supreme Soothe and Strengthen Conditioner is a topical lotion applied to the hair and scalp. It contains pyrithione zinc, an active ingredient typically used in dandruff and seborrheic dermatitis products to help reduce flaking and itching of the scalp. This is an over-the-counter monograph drug, meaning it is marketed under FDA's established rules for this category of product rather than through an individual application review.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer gPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 278 ml
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
69423-0349-27 69423-349-27 Main listing 278 mL in 1 TUBE 2019-05-02 — Active
69423-0349-83 You're viewing this 835 mL in 1 BOTTLE, PUMP 2023-01-15 — Active

You're viewing the largest of 2 pack sizes for this product.

Pack size FAQ

What quantity is in this package?
This package contains 835 mL — 835 ml in 1 bottle, pump.
How does this package differ from NDC 69423-0349-27?
Both are Head and Shoulders Supreme Soothe and Strengthen Conditioner Pyrithione Zinc .5 g/100mL Lotion — the drug itself is identical. This page's package is the 835 mL one, while NDC 69423-0349-27 is the 278 ml package.
What NDC number is used to bill for this package of Head and Shoulders Supreme Soothe and Strengthen Conditioner Pyrithione Zinc .5 g/100mL Lotion?
Use the 11-digit billing form listed in the identifiers section of this page. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
CeraVe Anti-Dandruff Hydrating Conditioner 5 mg/mL 49967-0242-01 L'Oreal 266 ml — — FDA listed —
Pyrithione Zinc 0.5 2in1 Dandruff Conditioner .5 g/100mL 52000-0415-12 Universal 355 ml — — Discontinued —
Pyrithione Zinc 0.5 Dandruff .5 g/100mL 52000-0416-12 Universal 355 ml — — Discontinued —
13.5oz 2 In 1 Dandruff Hair Cleanse and Conditioner - Eucalyptus and Mint .5 g/100mL 57337-0178-01 Rejoice 400 ml — — FDA listed —
13.5oz 2 In 1 Dandruff Hair Cleanse and Conditioner - Shea and Cocoa Butter .5 g/100mL 57337-0179-01 Rejoice 400 ml — — FDA listed —
13.5oz 2 In 1 Dandruff Hair Cleanse and Conditioner - Eucalyptus and Mint .5 g/100mL 58503-0210-01 China 400 ml — — FDA listed —
13.5oz 2 In 1 Dandruff Hair Cleanse and Conditioner - Shea and Cocoa Butter .5 g/100mL 58503-0211-01 China 400 ml — — FDA listed —
Dove .5 g/100mL 64942-2447-01 Conopco 355 ml — — FDA listed —
WeCare Anti-Dandruff 5 g/1000mL 67777-0139-80 Dynarex 12 bottles — — FDA listed —
Head and Shoulders Conditioner Smooth and Silky .5 g/100mL 69423-0103-10 The 10 ml — — FDA listed —
Head and Shoulders Dry Scalp Care Hair and Scalp Conditioner .5 g/100mL 69423-0160-32 The 325 ml — — FDA listed —
Head and Shoulders Hair and Scalp Conditioner Green Apple .5 g/100mL 69423-0172-32 The 325 ml — — FDA listed —
Head and Shoulders White Charcoal Daily Hair and Scalp Conditioner .5 g/100mL 69423-0279-31 The 315 ml — — Discontinued —
Head and Shoulders Coconut Daily Hair and Scalp Conditioner .5 g/100mL 69423-0319-25 The 250 ml — — FDA listed —
Head and Shoulders Supreme Detox and Hydrate Conditioner .5 g/100mL 69423-0347-27 The 278 ml — — FDA listed —
Head and Shoulders Supreme Nourish and Smooth Conditioner .5 g/100mL 69423-0348-27 The 278 ml — — FDA listed —
Head and Shoulders Supreme Soothe and Strengthen Conditioner .5 g/100mLthis 69423-0349-83 The 835 ml — — FDA listed —
Head and Shoulders Supreme Color Protect Conditioner .5 g/100mL 69423-0350-27 The 278 ml — — FDA listed —
Royal Oils by head and shoulders Moisture Renewal Scalp Balancing Conditioner .5 g/100mL 69423-0571-40 The 400 ml — — FDA listed —
nioxin PRO CLINICAL SCALP RECOVERY moisturizing conditioner .5 g/100mL 82157-0012-10 Wella 1000 ml — — FDA listed —
Head and Shoulders Smooth and Silky Conditioner .5 g/100mL 84126-0234-31 The 315 ml — — FDA listed —
Mielle Lavender and Lychee Scalp Soothing Conditioner .5 g/100mL 84126-0258-35 The 355 ml — — FDA listed —
Head and Shoulders Deep Moisture Hair and Scalp Conditioner .5 g/100mL 69423-0197-31 The 315 ml — — Discontinued —
Head and Shoulders Shea Butter Hair and Scalp Conditioner .5 g/100mL 69423-0669-32 The 325 ml — — FDA listed —
Smooth And Soft Dandruff .5 g/100mL 52000-0452-12 Universal 355 ml — — FDA listed —
Everyday Clean Dandruff .5 g/100mL 76176-0131-01 NINGBO 355 ml — — FDA listed —
Smooth And Soft Dandruff .5 g/100mL 76176-0132-01 NINGBO 355 ml — — FDA listed —
TEA TREE Oil DANDRUFF .5 g/100mL 52000-0455-12 Universal 355 ml — — FDA listed —
Itchy Scalp Relief Dandruff .5 g/100mL 76176-0134-01 NINGBO 355 ml — — FDA listed —
Itchy Scalp Relief Dandruff .5 g/100mL 52000-0453-12 Universal 355 ml — — FDA listed —
Everyday Clean Dandruff .5 g/100mL 52000-0454-12 Universal 355 ml — — FDA listed —
TEA TREE Oil DANDRUFF .5 g/100mL 76176-0133-01 NINGBO 355 ml — — FDA listed —
Head and Shoulders Scalp Restore Nourishing Conditioner .5 g/100mL 84126-0906-31 The 315 ml — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2019
On the market since
May 2019
📍
2026
Currently FDA-listed
7 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 4V59G5UW9X
    Argan oil is a plant-derived oil from argan tree kernels. It's used in medicines as an emollient and skin-conditioning agent to help soften and moisturize the product's texture.
  • UNII X7GNG3S47T
    A quaternary ammonium compound used as an antistatic agent and emulsifier in pharmaceutical formulations. It helps reduce static electricity during manufacturing and improves texture or consistency in creams and lotions.
  • UNII LKG8494WBH
    Benzyl alcohol is a clear liquid used as a preservative and solvent in medicines. It helps prevent bacterial and fungal growth and dissolves other ingredients to create uniform liquid formulations.
  • UNII 936JST6JCN
    Cetyl alcohol is a waxy, fatty substance derived from plant or animal sources. It acts as an emulsifier and thickener in medicines, helping blend oil and water components and giving products a smooth, creamy texture.
  • UNII 92RU3N3Y1O
    Dimethicone is a silicone-based oil that acts as an anti-foaming agent and lubricant in medicines. It reduces gas bubbles in liquid formulations and helps coat and protect the stomach lining when ingested.
  • UNII DEL7T5QRPN
    A synthetic preservative that kills bacteria and fungi. It's added to medications to prevent microbial growth and extend shelf life, especially in liquid or topical formulations.
  • UNII 229D0E1QFA
    Methylisothiazolinone is a synthetic chemical preservative that prevents bacterial and fungal growth in liquid medicines and topical products. It helps keep the medication safe and extends shelf life during storage.
  • UNII HIE492ZZ3T
    Phenoxyethanol is a synthetic preservative and antimicrobial agent used to prevent bacterial and fungal growth in medicines and cosmetic products, extending shelf life and maintaining product safety.
  • UNII X8W61WUV70
    A natural extract from red rose petals used as a coloring agent and fragrance in medicines. It provides a pink or red hue and pleasant scent to tablets, liquids, or other formulations.
  • UNII 2KR89I4H1Y
    Stearyl alcohol is a waxy, fatty substance derived from natural oils or made synthetically. It acts as an emulsifier and thickener in medicines, helping mix ingredients together and give the product the right texture.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

11 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesWater, stearyl alcohol, behentrimonium chloride, cetyl alcohol, rosa gallica flower extract, argania spinosa kernel oil, dimethicone, fragrance, phenoxyethanol, benzyl alcohol, methylchloroisothiazolinone, methylisothiazolinone

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerThe Procter & Gamble Manufacturing Company
FDA applicationM032 (OTC MONOGRAPH DRUG)
Labeler code69423
First marketedMay 2019
Product typeHuman Otc Drug
Portfolio850 products on file

More NDCs from The Procter & Gamble Manufacturing Company labeler code 69423

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 When Using This Product 📄 Stop Use and Ask a Doctor If 📄 Keep Out of Reach of Children 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 11 words ▾

Uses helps prevent recurrence of flaking and itching associated with dandruff.

⏱️ Dosage and Administration 31 words ▾

Directions for best results use at least twice a week or as directed by a doctor. apply to wet hair after shampooing by gently massaging into hair and scalp, rinse well.

⚠️ Warnings 65 words ▾

Warnings For external use only. When using this product avoid contact with eyes. If contact occurs, rinse eyes thoroughly with water. Stop use and ask a doctor if condition worsens or does not improve after regular use of this product as directed. Keep this and all drugs out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

🧪 Active Ingredient 5 words ▾

Active ingredient Pyrithione zinc 0.5%

🧪 Inactive Ingredients 24 words ▾

Inactive ingredients Water, stearyl alcohol, behentrimonium chloride, cetyl alcohol, rosa gallica flower extract, argania spinosa kernel oil, dimethicone, fragrance, phenoxyethanol, benzyl alcohol, methylchloroisothiazolinone, methylisothiazolinone

🎯 Purpose 2 words ▾

Purpose Anti-dandruff

📄 When Using This Product 16 words ▾

When using this product avoid contact with eyes. If contact occurs, rinse eyes thoroughly with water.

📄 Stop Use and Ask a Doctor If 21 words ▾

Stop use and ask a doctor if condition worsens or does not improve after regular use of this product as directed.

📄 Keep Out of Reach of Children 23 words ▾

Keep this and all drugs out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

📄 Questions or Comments 4 words ▾

Questions (or comments)? 1-800-723-9569

📄 Package Label / Principal Display Panel 41 words ▾

PRINCIPAL DISPLAY PANEL - 278 mL Tube Label head & shoulders ® PYRITHION ZINC DANDRUFF SCALP & HAIR CONDITIONER SUPREME SOOTHE & STRENGTHEN WITH ARGAN OIL & ROSE ESSENCE FREE FROM SULFATES PARABENS PHTHALATES DYES

9.4 FL OZ (278 mL) HS

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by The Procter & Gamble Manufacturing Company. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 1 other package presentation of this same product, including 278 ml (69423-0349-27). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
The Procter & Gamble Manufacturing Company is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 69423-0348-27 · The 69423-0350-27 · The →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.