Clean and Clear Advantage Acne Spot Treatment Salicylic Acid 20 mg/mL Lotion — NDC 69968-0126-1 (Billing 69968-0126-01)
This is a package of Clean and Clear Advantage Acne Spot Treatment Salicylic Acid 20 mg/mL Lotion from Kenvue Brands LLC, marketed since Oct 2006 and currently FDA-listed. It is this product's only package size.
NDC database record
One package, one record: these facts belong to NDC 69968-0126-1 alone.
- Record
- FDA NDC Directory package listing · Human OTC drug
- Code segments
- 69968 labeler · 0126 product · 1 package
- Package marketed since
- Oct 1, 2006
- Sample package
- No — commercial package
- Listing certified through
- Dec 31, 2026
- Barcode (UPC)
- 0381370039914
- FDA record last changed
- Jul 24, 2026
Identity & classification
Regulatory identifiers FDA, NLM and CMS codes for this package
- RxCUI (RxNorm): 103568
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 8, 2026
- FDA label on DailyMed · label index refreshed Oct 6, 2026
- RxNorm (NLM RxNav) · catalog refreshed Oct 1, 2026
- Medi-Span GPI (licensed)
- First Databank (licensed) · refreshed Oct 8, 2026
RxNorm drug class
This medicine belongs to the Salicylic acid and derivatives class.
Where does this data come from?
- RxClass (NLM) · catalog refreshed Oct 1, 2026
Clinical
Topical salicylic acid is used to help clear and prevent pimples and skin blemishes in people who have acne. Topical salicylic acid is also used to treat skin conditions that involve scaling or overgrowth of skin cells such as psoriasis (a skin disease in which red, scaly patches form on some areas of the body), ichthyoses (inborn conditions that cause skin dryness and scaling), dandruff, corns, calluses, and warts on the hands or feet. Topical salicylic acid should not be used to treat genital warts, warts on the face, warts with hair growing from them, warts in the nose or mouth, moles, or b...
Read the full MedlinePlus article ↗- It is used in a facial routine for acne-prone and oil-prone skin. The routine includes a cleanser, serum, toner and emulsion. Salicylic acid helps loosen and shed dead skin cells.
- Use the cleanser morning and evening, and the serum in the morning after cleansing. Use the toner in the evening on dry skin, and the emulsion at night after cleansing. Avoid your...
- Mild stinging, burning, itching, dryness and extra peeling can happen. If dryness or peeling bothers you, try using the serum or toner every other day. If it gets excessive, stop a...
- It is best not to. Using another topical acne medication at the same time makes irritation and dryness more likely. If you get irritated, use only one at a time.
Patient education
Supplement & herbal interactions
Where does this data come from?
- MedlinePlus (NLM) · refreshed Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 6, 2026
Ask a licensed pharmacist directly — free, answered by our team.
Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per g | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
Where does this data come from?
- CMS NADAC weekly file
- CMS ASP pricing files · refreshed Sep 20, 2026
- CMS Medicaid State Drug Utilization Data · refreshed Oct 8, 2026
- CMS Part D plan pricing files · refreshed Sep 24, 2026
- VA National Acquisition Center price file
Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Marketing end | Status |
|---|---|---|---|---|
| 69968-0126-01 You're viewing this Main listing | 1 TUBE in 1 CARTON / 22 mL in 1 TUBE | 2006-10-01 | — | Active |
Therapeutic equivalents
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 8, 2026
- FDA Orange Book · refreshed Oct 3, 2026
- CMS NADAC weekly file
Availability & generic status
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
- FDA Orange Book · refreshed Oct 3, 2026
Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
🧪 Avoiding an ingredient? See Salicylic Acid Topical inactive ingredients by manufacturer: every current product's list side by side, so you can ask your pharmacy for the version that does not list it.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
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UNII 3K9958V90M
A liquid solvent derived from fermentation or chemical synthesis. In medicines, alcohol dissolves active ingredients, helps preserve the product, and improves how the body absorbs certain drugs.
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UNII 5138Q19F1X
Ammonia is a colorless gas made from nitrogen and hydrogen. It's used in medicines as a pH buffer to maintain the correct acidity level and help keep the product stable.
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UNII F5UM2KM3W7
Benzalkonium chloride is a chemical compound that works as a preservative and antimicrobial agent in medications. It prevents bacterial and fungal growth in liquid formulations to keep the product safe during storage and use.
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UNII 3XUS85K0RA
Butylene glycol is a clear liquid derived from petroleum or plants that acts as a humectant, solvent, and preservative booster in medicines. It helps keep formulations stable, dissolve active ingredients, and maintain moisture in topical products.
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UNII GC844VRD7E
A synthetic fatty acid ester derived from plant oils and lactic acid. It acts as an emulsifier and solvent to help mix oil and water-based ingredients and improve how the medicine dissolves or spreads in the body.
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UNII E4F12ROE70
A refined mineral oil derived from crude petroleum containing 13 to 14 carbon chains. It acts as a solvent, emollient, and carrier in topical formulations to help dissolve active ingredients and improve product texture and spreadability.
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UNII 8TY5YO42NJ
Capryloyl glycine is a mild, skin-conditioning ingredient made from a natural fatty acid and the amino acid glycine. In medicines, it acts as a surfactant and preservative booster, helping the product spread evenly and resist contamination.
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UNII ITP1Q41UPF
A plant extract from Atlas cedar bark used as a natural fragrance or flavoring agent in medicines. It may also help preserve the product or improve its sensory appeal.
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UNII A7EVH2RK4O
Cetyl lactate is a waxy compound made from lactic acid and cetyl alcohol. It works as an emulsifier and thickener to help mix oil and water ingredients and give the medicine the right texture.
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UNII XE54U569EC
A natural essential oil extracted from cinnamon bark. It's used as a flavoring agent to mask bitter tastes and improve the flavor of medicines.
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UNII H2KVQ74JM4
A compound derived from coconut oil that acts as a conditioning agent and surfactant. It helps stabilize and thicken liquid formulations while reducing static and improving texture in topical products.
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UNII 0THT5PCI0R
A silicone-based liquid that helps distribute active ingredients evenly throughout topical products. It acts as a solvent and emollient, allowing medicines to spread smoothly on skin while improving texture and absorption.
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UNII 63ZP7I1BQO
A plant-derived thickening agent made from xanthan gum that has been chemically modified. It helps give the medicine the right texture and consistency, and may act as a binder or stabilizer in tablets and liquids.
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UNII MP1J8420LU
A salt derived from edetic acid that binds to trace metals in medicines. It serves as a chelating agent and preservative to prevent metal-catalyzed breakdown of the drug and extend shelf life.
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UNII PDC6A3C0OX
Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
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UNII Z95S6G8201
A synthetic surfactant derived from lauryl alcohol and ethylene oxide. It helps dissolve and mix oily and watery ingredients in liquid formulations, and may improve how the medicine spreads or is absorbed.
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UNII HIE492ZZ3T
Phenoxyethanol is a synthetic preservative and antimicrobial agent used to prevent bacterial and fungal growth in medicines and cosmetic products, extending shelf life and maintaining product safety.
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UNII 7T1F30V5YH
A synthetic emulsifier derived from sorbitol and oleic acid. It helps mix oil and water-based ingredients together and keeps them from separating in liquid formulations.
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UNII BI6C7YO419
A synthetic oily liquid derived from petroleum-based materials. It functions as an emulsifier and solubilizer in medicines, helping blend water and oil-based ingredients and keeping them mixed throughout the product's shelf life.
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UNII 6DC9Q167V3
Propylene glycol is a clear liquid derived from petroleum or vegetable sources. It acts as a solvent, humectant, and preservative in medicines, helping dissolve active ingredients and maintain product stability.
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UNII M6S840WXG5
Purslane is a plant-derived ingredient used in pharmaceuticals as a natural source of beneficial compounds. It functions as an antioxidant and anti-inflammatory agent to help stabilize the formula and support product shelf life.
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UNII Z711V88R5F
Sarcosine is a small amino acid naturally found in foods and the body. In medicines, it acts as a buffer and pH regulator to keep the formulation stable and prevent unwanted chemical changes.
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UNII 059QF0KO0R
Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
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UNII 101I4J0U34
Witch hazel is a plant extract obtained from the leaves and bark of the North American shrub Hamamelis virginiana. It functions as an astringent and skin-conditioning agent in topical products, helping to tone and prepare the skin.
24 inactive ingredients listed in the exact product block matched to this NDC.
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.- FDA label on DailyMed · label index refreshed Oct 6, 2026
- FDA openFDA NDC Directory · synced Oct 8, 2026
Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
Why might an inactive ingredient be missing?
Can inactive ingredients matter?
Manufacturer & labeler
More NDCs from Kenvue Brands LLC labeler code 69968
- Neutrogena Healthy Skin Anti-Aging Perfector Sunscreen Broad Spectrum SPF 20 Medium to Deep 60 Octinoxate and Octisalate 70 mg/mL; 30 mg/mL Lotion NDC 69968-0081-1
- Mens Rogaine Extra Strength Unscented Minoxidil 50 mg/mL Solution NDC 69968-0089-1
- Womens Rogaine Unscented Minoxidil 20 mg/mL Solution NDC 69968-0090-1
- Neutrogena All in 1 Acne Control Daily Scrub Salicylic Acid 20 mg/mL Liquid NDC 69968-0092-4
- Neosporin Pain Itch Scar Bacitracin Zinc, Neomycin Sulfate, Polymyxin B Sulfate, and Pramoxine Hydrochloride 500 [iU]/g; 3.5 mg/g; 10000 [iU]/g; 10 mg/g Ointment NDC 69968-0093-1
- Neutrogena Beach Defense Water Plus Sun Protection Sunscreen Broad Spectrum SPF30 Avobenzone, Homosalate, Octisalate, Octocrylene, and Oxybenzone 30 mg/g; 30 mg/g; 40 mg/g; 20 mg/g; 50 mg/g Spray NDC 69968-0101-6
- Neutrogena Oil Free Acne Wash Cleanser Salicylic Acid 20 mg/mL Cream NDC 69968-0155-6
- Neutrogena On-the-Spot Acne Treatment Vanishing Formula Benzoyl Peroxide 25 mg/g Cream NDC 69968-0164-1
- Neutrogena Beach Defense Water Plus Sun Protection Sunscreen Broad Spectrum SPF70 Avobenzone, Homosalate, Octisalate, Octocrylene, and Oxybenzone 50 mg/g; 40 mg/g; 60 mg/g; 30 mg/g; 150 mg/g Aerosol, Spray NDC 69968-0169-6
- Neutrogena Ultra Sheer Body Mist Sunscreen Broad Spectrum SPF 70 Avobenzone, Homosalate, Octisalate, Octocrylene, and Oxybenzone 30 mg/g; 150 mg/g; 50 mg/g; 40 mg/g; 60 mg/g Aerosol, Spray NDC 69968-0171-5
- Listerine Total Care Fresh Mint Anticavity Sodium Fluoride .1 mg/mL Mouthwash NDC 69968-0178-1
- Neutrogena Oil Free Acne Moisturizer Pink Grapefruit Salicylic Acid 5 mg/mL Lotion NDC 69968-0193-1
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 8, 2026
- Drugs@FDA
FDA label — Drug Facts FDA SPL
🎯 Indications and Usage ▾
Use For the treatment of acne
⏱️ Dosage and Administration ▾
Directions clean the skin thoroughly before applying this product. cover the entire affected area with a thin layer one to three times daily because excessive drying of the skin may occur, start with one application daily, then gradually increase to two or three times daily if needed or as directed by a doctor if bothersome dryness or peeling occurs, reduce application to once a day or every other day
⚠️ Warnings ▾
Warnings For external use only. Flammable, keep away from open fire or flame. When using this product skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time. If eye contact occurs, flush thoroughly with water. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
📦 Storage and Handling ▾
Other Information Store at room temperature. Sunburn Alert This product contains an alpha hydroxy acid (AHA) that may increase your skin's sensitivity to the sun and particularly the possibility of sunburn. Use a sunscreen, wear protective clothing, and limit sun exposure while using this product and for a week afterwards.
🧪 Active Ingredient ▾
Active Ingredient Salicylic Acid (2%)
🧪 Inactive Ingredients ▾
Inactive Ingredients Alcohol Denat., Water, Hamamelis Virginiana (Witch Hazel) Water, Polyacrylamide, Glycerin, Cyclopentasiloxane, C13-14 Isoparaffin, C12-15 Alkyl Lactate, Alcohol, Phenoxyethanol, Cetyl Lactate, PPG-2 Isoceteth-20 Acetate, Cocamidopropyl PG-Dimonium Chloride Phosphate, Laureth-7, Polysorbate 20, Phenethyl Dimethicone, Fragrance, Dehydroxanthan Gum, Propylene Glycol, Benzalkonium Chloride, Ammonia, Tetrasodium EDTA, Butylene Glycol, Capryloyl Glycine, Sarcosine, Cinnamomum, Zeylanicum Bark Extract, Cedrus Atlantica Bark Extract, Portulaca Oleracea Extract
🎯 Purpose ▾
Purpose Acne Medication
📄 When Using This Product ▾
When using this product skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time. If eye contact occurs, flush thoroughly with water.
📄 Keep Out of Reach of Children ▾
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
📄 Questions or Comments ▾
Questions? Call toll‐free 1-877-754-6411 or 215-273-8755 (collect).www.cleanandclear.com
📄 Package Label / Principal Display Panel ▾
PRINCIPAL DISPLAY PANEL - 22 mL Tube Carton Clean & Clear ® advantage acne spot treatment salicylic acid acne medication OIL-FREE +WITCH HAZEL 100% of people showed clearer skin in just one day won't overdry skin
0.75FL. OZ. (22mL) Clean001
Medicare Part D spend CMS · PART D · 2026 (Q1)
About this NDC listing & data coverage
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | ✓ Available |
| Inactive ingredients (structured) | ✓ Available |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope. |
| HCPCS J-code billing crosswalk | — Not published for this NDC Most self-administered / retail products have no J-code — that is normal. |
| Medicaid utilization (CMS SDUD) | — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold. |