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Zestama Capsaicin .075 g/100mL Liquid, 89 mL — NDC 72835-0175-01 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

Zestama Capsaicin .075 g/100mL Liquid, 89 mL — NDC 72835-175-01 (Billing 72835-0175-01)

by V2 Pharma LLC · 89 mL in 1 BOTTLE, WITH APPLICATOR

This is a package of 89 mL of Zestama Capsaicin .075 g/100mL Liquid from V2 Pharma LLC, marketed since Apr 2025 and currently FDA-listed. It is this product's only package size.

NDC 72835-0175-01
🏷️ FDA NDC (as labeled) 72835-175-01 billing pads the product segment with a zero
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 8, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 72835-175-01 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
72835 labeler · 175 product · 01 package
Package marketed since
Apr 1, 2025
Sample package
No — commercial package
Listing certified through
Dec 31, 2026
Billing quantity
89 mL per package
Barcode (UPC)
0372835175018
FDA record last changed
Jul 24, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 72835-175-01
Product NDC 72835-175
11-digit billing NDC 72835017501
NCPDP billing unit ML — per mL (volume)
RxCUI 358922
UNII S07O44R1ZM
UPC 0372835175018
Application # M017
SPL Set ID c9b46759-b8df-4ff4-815e-8e032c2635c0
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2025-04-01
Route TOPICAL
Dosage form LIQUID
Substance CAPSAICIN

Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification

GCN Seq No 087615
GCN 57595
HICL code 002577
Ingredient (HICL) Capsaicin
HIC1 code L
Therapeutic class — broad (HIC1) Skin/Subcutaneous Tissue
HIC2 code L6
Therapeutic class — intermediate (HIC2) Irritants
HIC3 code L6A
Therapeutic class — specific (HIC3) Irritants/Counter-Irritants
AHFS code 84:92.00.00
AHFS class Skin And Mucous Membrane Agents, Misc.
FDB label name ZESTAMA 0.075% LIQUID ROLL-ON
FDB brand name Zestama
Legend status O — Over-the-counter (OTC) drug or device
Quick answers
  • GSN (GCN sequence number): 087615
  • GCN: 57595
  • HICL (First Databank): 002577
  • AHFS class code: 84:92.00.00
  • RxCUI (RxNorm): 358922
Why two NDCs? The FDA registers this code as 72835-175-01 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 72835-0175-01. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Capsaicin and similar agents class.

Drug family (ATC) Capsaicin and similar agents, Other local anesthetics
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

Label name ZESTAMA 0.075% LIQUID ROLL-ON Ingredient Capsaicin
📖 What it is MedlinePlus · NLM

Topical capsaicin is used to relieve minor pain in muscles and joints caused by arthritis, backaches, muscle strains, bruises, cramps, and sprains. Capsaicin is a substance that is found in chili peppers. It works by affecting nerve cells in the skin that are associated with pain, which results in decreased activity of these nerve cells and a reduced sense of pain.

Read the full MedlinePlus article ↗
📗 Our plain-language guide HelloPharmacist
  • Yes, completely normal — and it actually means the medicine is working. Capsaicin activates the same pain-sensing receptors in your skin that respond to heat and spicy food. That b...
  • Why does capsaicin burn when I put it on? Is that normal?
  • For most OTC creams and ointments, you can apply up to 3 to 4 times a day. For OTC patches, apply to clean, dry skin and remove after no more than 8 hours — again, up to 3 to 4 tim...
  • How often should I apply capsaicin cream or use the patch?
📖 Read our full Capsaicin guide →

Supplement & herbal interactions

Some supplements/herbs that may interact with Capsaicin (prescription drug) — tap one for details:

Dimethylsulfoxide (dmso)Moderate Turpentine OilModerate AlchemillaMinor
🌿 Every supplement checked against Capsaicin (prescription drug) (3 interactions) — ranked by severity →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
72835-0175-01 You're viewing this Main listing 89 mL in 1 BOTTLE, WITH APPLICATOR 2025-04-01 — Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Zestama .075 g/100mLthis 72835-0175-01 V2 89 ml — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2025
On the market since
Apr 2025
📍
2026
Currently FDA-listed
1 year listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

🧪 Avoiding an ingredient? See Capsaicin inactive ingredients by manufacturer: every current product's list side by side, so you can ask your pharmacy for the version that does not list it.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 3K9958V90M
    A liquid solvent derived from fermentation or chemical synthesis. In medicines, alcohol dissolves active ingredients, helps preserve the product, and improves how the body absorbs certain drugs.
  • UNII 344S277G0Z
    Allantoin is a naturally derived compound that helps soften and soothe skin. In medicines, it works as a skin-conditioning agent and may help support wound healing and reduce irritation in topical formulations.
  • UNII ZY81Z83H0X
    Aloe vera leaf is a plant extract derived from the aloe plant. It is used in medicines as a natural moisturizer and skin-soothing agent in topical formulations.
  • UNII OZ0E5Y15PZ
    A plant extract from arnica flowers, used as a flavoring agent or fragrance component in medicines. It may also provide mild soothing properties to certain topical formulations.
  • UNII FIW80T6P6V
    A plant extract from bamboo that acts as a natural filler and texture agent in medications. It helps give the product structure and consistency while being derived from plant material.
  • UNII Z17H97EA6Y
    A plant-derived mild cleanser made from natural sugars and oils. It acts as an emulsifier and surfactant to help mix water and oil-based ingredients together in the medicine.
  • UNII 92RU3N3Y1O
    Dimethicone is a silicone-based oil that acts as an anti-foaming agent and lubricant in medicines. It reduces gas bubbles in liquid formulations and helps coat and protect the stomach lining when ingested.
  • UNII YOW8V9698H
    Dimethyl sulfoxide is a clear liquid solvent derived from wood pulp. In medicines, it helps dissolve or carry active ingredients and improve how the body absorbs the drug.
  • UNII OS64WTR4KU
    Echinacea purpurea root is a plant extract used in supplements and some medicines. It typically serves as an active botanical ingredient rather than a traditional inactive filler or binder.
  • UNII 7FLD91C86K
    Edetate disodium is a chemical compound that binds and removes certain metal ions. In medicines, it acts as a preservative and stabilizer by preventing metals like calcium from interfering with the product's shelf life and consistency.
  • UNII 147D247K3P
    Ethylhexylglycerin is a synthetic preservative used to prevent bacteria and mold from growing in medicines and personal care products. It helps keep the product safe and stable throughout its shelf life.
  • UNII C5529G5JPQ
    Ginger is a plant-derived ingredient used as a flavoring agent to add taste and aroma to medicines. It may also provide mild soothing properties to support product palatability.
  • UNII 750W5330FY
    Glucosamine hydrochloride is an amino sugar derived from shellfish or produced synthetically. In medicines, it serves as an active nutritional ingredient rather than a typical inactive excipient, used to support joint and cartilage function.
  • UNII M825OX60H9
    Hydroxyethyl cellulose is a plant-derived thickener made by chemically treating cellulose. In medicines, it acts as a binder to hold ingredients together, a thickener to control texture, and sometimes a film-former for coatings.
  • UNII ZBP1YXW0H8
    A fragrant oil extracted from lavender plants, used as a flavoring and scent agent in medicines to improve taste and aroma.
  • UNII W4X7H8GYFM
    Polyethylene glycol (PEA) is a synthetic polymer derived from petroleum. It functions as a solvent, lubricant, and binder in medications to improve texture, reduce sticking, and help bind ingredients together.
  • UNII HIE492ZZ3T
    Phenoxyethanol is a synthetic preservative and antimicrobial agent used to prevent bacterial and fungal growth in medicines and cosmetic products, extending shelf life and maintaining product safety.
  • UNII 6DC9Q167V3
    Propylene glycol is a clear liquid derived from petroleum or vegetable sources. It acts as a solvent, humectant, and preservative in medicines, helping dissolve active ingredients and maintain product stability.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

19 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesWater Dimethicone Alcohol Dimethyl Sulfoxide Lavender Oil Decyl Glucoside Ginger Extract Bamboo Extract Pea Extract Glucosamine HCI Arnica Extract Propylene Glycol Phenoxyethanol Ethylhexylglycerin Hydroxyethyl Cellulose Allantoin Echinacea Extract Aloe Barbadensis Leaf Extract Disodium EDTA

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerV2 Pharma LLC
FDA applicationM017 (OTC MONOGRAPH DRUG)
Labeler code72835
First marketedApr 2025
Product typeHuman Otc Drug
Portfolio9 products on file

More NDCs from V2 Pharma LLC labeler code 72835

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 📦 Storage and Handling 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Do Not Use 📄 Stop Use and Ask a Doctor If 📄 Keep Out of Reach of Children 📖 Instructions for Use 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 19 words ▾

Uses Temporarily relieves minor aches and pains of muscles and joints associated with: simple backache arthritis strains sprains bruises

⏱️ Dosage and Administration 45 words ▾

Directions Adults and children 12 years of age and older: Apply Zestama using the touch free roll-on applicator to affected area liberally as needed for pain. Do not use more than 4 times per day. For children under 12 years of age, ask a doctor.

⚠️ Warnings 52 words ▾

Fore external use only Read all warnings and directions before use. Test first on small area of skin. When using this product you may experience a burning sensation and/or skin redness. The intensity of this reaction varies among individuals and may be severe. With regular use, this generally disappears after several days.

📦 Storage and Handling 8 words ▾

Store tightly closed in a cool dry place.

🧪 Active Ingredient 2 words ▾

Capsaicin 0.075%

🧪 Inactive Ingredients 34 words ▾

Water Dimethicone Alcohol Dimethyl Sulfoxide Lavender Oil Decyl Glucoside Ginger Extract Bamboo Extract Pea Extract Glucosamine HCI Arnica Extract Propylene Glycol Phenoxyethanol Ethylhexylglycerin Hydroxyethyl Cellulose Allantoin Echinacea Extract Aloe Barbadensis Leaf Extract Disodium EDTA

🎯 Purpose 2 words ▾

External analgesic

📄 Do Not Use 33 words ▾

Do not use: Near the face, eyes, or genetalia Immediately before or after bathing or swimming On wounds or damaged skin If you are allergic to capsicum or chili peppers Do not bandage

📄 Stop Use and Ask a Doctor If 35 words ▾

Stop use and ask a doctor or pharmacist if: Condition worsens or does not improve after regular use Severe burning persists or blistering occurs Treated area skin begins to scale or peel as if burnt

📄 Keep Out of Reach of Children 12 words ▾

If swallowed, get medical help or contact a Poison Control Center immediately.

📖 Instructions for Use 129 words ▾

Instructions for Zestama Touch Free Pain Relief: Lightly shake and invert bottle to allow product into applicator. Remove cap to expose applicator. Try not to touch any surfaces or liquids.

Avoid contact with the eyes, lips, nose, genetalia and other mucous membranes. Invert the bottle, then apply liberally to affected area 3 to 4 times daily. Do not use hands to rub in.

Place cap back on and Wash hands thoroughly with soap and water. Allow treated area to dry naturally for best results. Do not swim or bathe for at least 1 hour.

Do not tightly wrap or bandage the treated area Do not apply heat to the treated area immediately before or after use. Moisture and sweat can further “activate” the treated area and warm up more

📄 Package Label / Principal Display Panel 1 words ▾

Label

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Capsaicin — the ingredient across all brands.

Top reported reactions

Application Site Pain556
Pain494
Burning Sensation346
Pain In Extremity262
Fatigue234
Application Site Erythema153
Dyspnoea138

Age at onset

Child2
Adolescent4
Adult358
Elderly350

Reporter sex

3,943 reports
Male · 41%
Female · 59%
Unknown · 0%

Serious outcomes

Hospitalization779
Death191
Disabling136
Life-threatening80
Reports over time (by year) — tap or hover for the count & year
2019 2021 2023 2026 800 0
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by V2 Pharma LLC. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
V2 Pharma LLC is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 72835-0114-15 · V2 72835-0201-02 · V2 →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.