Home › NDC Lookup › Ingredients › Niacinamide, Adenosine › 73590-0073-02
🧴image loading
(from DailyMed)

COXIR INTENSIVE EGF PEPTIDE SERUM NIACINAMIDE, ADENOSINE 1 g/50mL; .02 g/50mL Liquid, 50 mL

by NOKSIBCHO cosmetic Co., Ltd. · 1 CONTAINER in 1 CARTON (73590-0073-2) / 50 mL in 1 CONTAINER (73590-0073-1)
NDC 73590-0073-02
🏷️ FDA NDC (as labeled) 73590-0073-2 billing pads the package segment with a zero
OTC On market Non-controlled
🗂️ Data synced Aug 27, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

🆔 Identity & classification

FDA NDC (as labeled) 73590-0073-2
Product NDC 73590-0073
11-digit billing NDC 73590007302
UNII 25X51I8RD4, K72T3FS567
SPL Set ID 03a97ef0-6ad1-47ef-a8f4-fd32fd02a199
Established class (EPC) Adenosine Receptor Agonist
Mechanism of action Adenosine Receptor Agonists
DEA schedule Non-controlled
Marketing category UNAPPROVED DRUG OTHER
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2021-07-01
Route TOPICAL
Dosage form LIQUID
Substance NIACINAMIDE; ADENOSINE
Why two NDCs? The FDA registers this code as 73590-0073-2 — a 5-4-1 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the package segment → 73590-0073-02. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏭 Manufacturer & labeler

LabelerNOKSIBCHO cosmetic Co., Ltd.
Labeler code73590
First marketedJul 2021
Product typeHuman Otc Drug
Portfolio44 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

🧪 What is this product?

This is an unapproved topical liquid serum containing adenosine and niacinamide as active ingredients. Adenosine is commonly used in skincare products for its role as an adenosine receptor agonist, typically intended to support skin hydration and reduce the appearance of fine lines. Niacinamide, also known as vitamin B3, is commonly included in topical skincare to help support skin barrier function and reduce redness. This product is marketed without an approved FDA application.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 3XUS85K0RA
    Butylene glycol is a clear liquid derived from petroleum or plants that acts as a humectant, solvent, and preservative booster in medicines. It helps keep formulations stable, dissolve active ingredients, and maintain moisture in topical products.
  • UNII PDC6A3C0OX
    Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

3 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesWater(Aqua), Butylene glycol, Glycerin, Alcohol, Propylene Glycol, 1,2-Hexanediol, PEG/PPG-18/4 Copolymer, Betaine, Phenoxyethanol, Triethanolamine, Carbomer, Allantoin, Ethylhexylglycerin, Glyceryl Acrylate/Acrylic Acid Copolymer, Parfum, PVM/MA Copolymer, Dipropylene Glycol, Thymus Vulgaris (Thyme) Extract, Camellia sinensis Callus Culture extracts, Bambusa Vulgaris Callus Culture Extract, Malva Sylvestris (Mallow) Flower Extract, Leontopodium alpinum extract, Snail Secretion Filtrate, Hydrolyzed Collagen, Sodium Benzoate, Potassium Sorbate, Citric Acid, Caprylyl Glycol, Punica Granatum Fruit Extract, Panax Ginseng Root Extract, Carthamus Tinctorius (Safflower) Flower Extract, Acanthopanax Senticosus (Eleuthero) Root Extract, Solanum Lycopersicum (Tomato) Fruit Extract, Nelumbo Nucifera Seed Extract, Lonicera Japonica (Honeysuckle) Flower Extract, Lilium Tigrinum Extract, Chrysanthemum Indicum Flower Extract, Tropolone, Copper Tripeptide-1, Oligopeptide-1

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Coxir Intensive Egf Peptide Serum 1 g/50mL; .02 g/50mLthis 73590-0073-02 NOKSIBCHO 50 ml — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2021
On the market since
Jul 2021
📍
2026
Currently FDA-listed
5 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
73590-0073-02 You're viewing this 1 CONTAINER in 1 CARTON (73590-0073-2) / 50 mL in 1 CONTAINER (73590-0073-1) 2021-07-01 Active

🧭 About this NDC listing & data coverage

Over-the-counter (OTC) product Marketed without an FDA application

Listed without an FDA application

This product's marketing category indicates it is marketed without an approved FDA application (no NDA, ANDA, or BLA on file). Having an NDC does not by itself establish FDA approval — the NDC Directory is a listing system, not an approval decision. Approval-linked data such as Orange Book therapeutic-equivalence ratings therefore does not apply.

What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos — Not published for this NDC No photo available yet for this listing.
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Unapproved Drug Other". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 73590-0073-2, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 73590-0073-02, written without dashes as 73590007302. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 73590-0073-02, the first segment (73590) is the labeler code FDA assigned to NOKSIBCHO cosmetic Co., Ltd.; the middle segment (0073) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (02) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by NOKSIBCHO cosmetic Co., Ltd.. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
NOKSIBCHO cosmetic Co., Ltd. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 17 words ▾

Uses ■ Intensive EGF peptide serum is formulated with EGF, peptide and collagen for brightening and firming.

⏱️ Dosage and Administration 18 words ▾

Directions ■ Can be used daily, AM and PM. Gently massage onto face in circular motions untill absorbed.

⚠️ Warnings 22 words ▾

WARNINGS For external use only. Avoid contact with eyes. Keep out of reach of children. Discontinue use if signs of irritation appear.

🧪 Active Ingredient 6 words ▾

ACTIVE INGREDIENTS NIACINAMIDE 2.0% ADENOSINE 0.04%

🧪 Inactive Ingredients 105 words ▾

INACTIVE INGREDIENTS Water(Aqua), Butylene glycol, Glycerin, Alcohol, Propylene Glycol, 1,2-Hexanediol, PEG/PPG-18/4 Copolymer, Betaine, Phenoxyethanol, Triethanolamine, Carbomer, Allantoin, Ethylhexylglycerin, Glyceryl Acrylate/Acrylic Acid Copolymer, Parfum, PVM/MA Copolymer, Dipropylene Glycol, Thymus Vulgaris (Thyme) Extract, Camellia sinensis Callus Culture extracts, Bambusa Vulgaris Callus Culture Extract, Malva Sylvestris (Mallow) Flower Extract, Leontopodium alpinum extract, Snail Secretion Filtrate, Hydrolyzed Collagen, Sodium Benzoate, Potassium Sorbate, Citric Acid, Caprylyl Glycol, Punica Granatum Fruit Extract, Panax Ginseng Root Extract, Carthamus Tinctorius (Safflower) Flower Extract, Acanthopanax Senticosus (Eleuthero) Root Extract, Solanum Lycopersicum (Tomato) Fruit Extract, Nelumbo Nucifera Seed Extract, Lonicera Japonica (Honeysuckle) Flower Extract, Lilium Tigrinum Extract, Chrysanthemum Indicum Flower Extract, Tropolone, Copper Tripeptide-1, Oligopeptide-1

🎯 Purpose 5 words ▾

PURPOSE Skin Brightening Anti wrinkle

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 73590-0072-02 · NOKSIBCHO 73590-0074-02 · NOKSIBCHO →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.