![Mineffect facial skin protectant and acne treatment solution Alumina, Calcarea Silicata, Ferrum Metallicum, Magnesia Sulphurica, Phosphorus, Sulphur, Titanium Metallicum, Zincum Metallicum 7 [hp_X]/118mL; 5 [hp_X]/118mL; 7 [hp_X]/118mL; 7 [hp_X]/118mL; 6 [hp_X]/118mL; 4 [hp_X]/118mL; 7 [hp_X]/118mL; 8 [hp_X]/118mL Spray — NDC 81488-0003-04 package photo](https://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=f6b3ea92-2382-4c3f-8ed9-31ea26fd47ee&name=81488003-04.jpg)
Mineffect facial skin protectant and acne treatment solution Alumina, Calcarea Silicata, Ferrum Metallicum, Magnesia Sulphurica, Phosphorus, Sulphur, Titanium Metallicum, Zincum Metallicum 7 [hp_X]/118mL; 5 [hp_X]/118mL; 7 [hp_X]/118mL; 7 [hp_X]/118mL; 6 [hp_X]/118mL; 4 [hp_X]/118mL; 7 [hp_X]/118mL; 8 [hp_X]/118mL Spray
by Kadesh Incoporation Co,Ltd · 1 BOTTLE, SPRAY in 1 BOX (81488-003-04) / 118 mL in 1 BOTTLE, SPRAY
NDC 81488-0003-04
🏷️ FDA NDC (as labeled)
81488-003-04
billing pads the product segment with a zero
OTC
On market
Non-controlled
🗂️ Data synced Sep 17, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →
🆔 Identity & classification
FDA NDC (as labeled)
81488-003-04
Product NDC
81488-003
11-digit billing NDC
81488000304
UNII
LMI26O6933, S4255P4G5M, E1UOL152H7, SK47B8698T, 27YLU75U4W, 70FD1KFU70 +2 more
SPL Set ID
f6b3ea92-2382-4c3f-8ed9-31ea26fd47ee
Established class (EPC)
Blood Coagulation Factor; Calculi Dissolution Agent; Cations; Inhi
Physiologic effect
Increased Coagulation Factor Activity; Increased Large Intestinal Motility; Inhibition Large Intestine Fluid/Electrolyte Absorption
Chemical class
Calcium; Divalent
DEA schedule
Non-controlled
Marketing category
UNAPPROVED HOMEOPATHIC
Marketing status
On market
FDA listing status
Listed (active directory)
Marketing start
2021-02-01
Route
TOPICAL
Dosage form
SPRAY
Substance
ALUMINUM OXIDE; CALCIUM SILICATE; IRON; MAGNESIUM SULFATE HEPTAHYDRATE; PHOSPHORUS; SULFUR; TITANIUM; ZINC
Why two NDCs?
The FDA registers this code as 81488-003-04 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 81488-0003-04. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.
🏭 Manufacturer & labeler
LabelerKadesh Incoporation Co,Ltd
Labeler code81488
First marketedFeb 2021
Product typeHuman Otc Drug
Portfolio12 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.
🩺 Clinical
🧪 What is this product?
Mineffect is a homeopathic spray product applied to facial skin. It contains eight mineral and elemental substances (aluminum oxide, calcium silicate, iron, magnesium sulfate, phosphorus, sulfur, titanium, and zinc) prepared according to homeopathic methods. In homeopathic practice, these ingredients are traditionally used to address skin concerns including acne and general skin protection, though homeopathic products are not evaluated by the FDA for effectiveness and are marketed based on homeopathic tradition rather than clinical evidence.
Patient education
Supplement & herbal interactions
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.
💬 Questions about Alumina, Calcarea Silicata, Ferrum Metallicum, Magnesia Sulphurica, Phosphorus, Sulphur, Titanium Metallicum, Zincum Metallicum?
Ask a pharmacist →
Ask a licensed pharmacist directly — free, answered by our team.
🧪 Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
-
UNII O3B55K4YKI
Calcium fluoride is a mineral compound used in pharmaceuticals as a filler and flow agent. It helps create proper tablet texture and ensures consistent powder movement during manufacturing.
-
UNII 0UV74P3R0J
A cerium-based chemical compound used as a colorant and opacifying agent in medications. It provides a white to off-white color and helps control light transmission in capsules and tablets.
-
UNII 0I2XIN602U
Ferric chloride hexahydrate is an iron compound used in medicine as a coagulant and hemostatic agent. It helps control bleeding by causing blood to clot, typically in topical formulations or solutions applied directly to wound sites.
-
UNII 91GQH8I5F7
Ferrosoferric phosphate is an iron compound used as a colorant and opacifying agent in medicines. It may give tablets or capsules a darker appearance and helps make them visually distinct.
-
UNII 24H4NWX5CO
Kaolin is a naturally occurring clay mineral. It's used in tablets and capsules as a filler and absorbent to add bulk, improve texture, and help bind ingredients together.
-
UNII 02F3473H9O
A mineral salt used in medications as a source of magnesium. It helps bind ingredients together, improve texture, and maintain the product's stability during storage.
-
UNII 8M4L3H2ZVZ
Sodium nitrate is a salt compound used in medicines as a preservative to prevent bacterial and fungal growth, and sometimes as a buffering agent to help maintain the product's pH balance.
-
UNII 059QF0KO0R
Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
8 inactive ingredients listed in the exact product block matched to this NDC.
The official label also statesAlumina Silicata, Calcarea Fluorica, Cerium Oxalicum, Distilled Water, Ferrum Muriaticum, Ferrum Phosphoricum, Magnesia Muriatica, Natrum Nitricum
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed —
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.
💲 Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per mL | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.
🔁 Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Mineffect facial skin protectant and acne treatment solution 7 [hp_X]/118mL; 5 [hp_X]/118mL; 7 [hp_X]/118mL; 7 [hp_X]/118mL; 6 [hp_X]/118mL; 4 [hp_X]/118mL; 7 [hp_X]/118mL; 8 [hp_X]/118mLthis 81488-0003-04 | Kadesh | 1 bottle | — | — | FDA listed | — |
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.
⏳ Availability & generic status
🏛️
2021
On the market since
Feb 2021
📍
2026
Currently FDA-listed
5 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.
📦 Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Status |
|---|---|---|---|
| 81488-0003-04 You're viewing this | 1 BOTTLE, SPRAY in 1 BOX (81488-003-04) / 118 mL in 1 BOTTLE, SPRAY | 2021-02-01 | Active |
🧭 About this NDC listing & data coverage
Over-the-counter (OTC) product
Homeopathic listing
About homeopathic listings
Mineffect facial skin protectant and acne treatment solution Alumina, Calcarea Silicata, Ferrum Metallicum, Magnesia Sulphurica, Phosphorus, Sulphur, Titanium Metallicum, Zincum Metallicum 7 [hp_X]/118mL; 5 [hp_X]/118mL; 7 [hp_X]/118mL; 7 [hp_X]/118mL; 6 [hp_X]/118mL; 4 [hp_X]/118mL; 7 [hp_X]/118mL; 8 [hp_X]/118mL SPRAY is listed under the homeopathic marketing category. An NDC listing in this category does not by itself establish FDA approval, and FDA does not evaluate homeopathic products for effectiveness. This page reports the listing data as published.
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | ✓ Available |
| Inactive ingredients (structured) | ✓ Available |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope. |
| HCPCS J-code billing crosswalk | — Not published for this NDC Most self-administered / retail products have no J-code — that is normal. |
| Medicaid utilization (CMS SDUD) | — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold. |
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.
Questions about this listing
Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Unapproved Homeopathic". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 81488-003-04, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 81488-0003-04, written without dashes as 81488000304. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 81488-0003-04, the first segment (81488) is the labeler code FDA assigned to Kadesh Incoporation Co,Ltd; the middle segment (0003) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (04) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Kadesh Incoporation Co,Ltd. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
Kadesh Incoporation Co,Ltd is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
📄 FDA label — Drug Facts FDA SPL
The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage
⏱️ Dosage and Administration
⚠️ Warnings
📦 Storage and Handling
🧪 Active Ingredient
🧪 Inactive Ingredients
🎯 Purpose
🎯 Indications and Usage ▾
Uses • For the treatment of acne • Helps keep skin clear of new acne blemishes, acne pimples and breakouts. • Temporarily protects and helps to relieve minor skin irritation and itching due to *rashes *eczema.
⏱️ Dosage and Administration ▾
Direction • Apply as needed during the day and night to keep the skin clear and fresh • Clean the skin thoroughly before applying this product. • Children under two years old, ask a doctor
⚠️ Warnings ▾
Warnings Do not Use *on broken skin *large area of the skin When using this product *Apply only to areas with acne *Do not get into eyes *Replace cap after using Stop use and ask a doctor *If condition worsens *If condition last more than 7days or clear up and occur again within a few days. If pregnant or breast-feeding , ask a health professional before use. Keep out of reach of children.
📦 Storage and Handling ▾
Other Information * Store at room temperature. * Tamper Evident: Do not use if neckband on bottle is broken or missing
🧪 Active Ingredient ▾
Active Ingredient Alumina 7X HPUS Calcarea Silicata 5X HPUS Ferrum Metallicum 7X HPUS Magnesia Sulphurica 7X HPUS Phosphorus 6X HPUS Sulphur 4X HPUS Titanium Metallicum 7X HPUS Zincum Metallicum 8X HPUS The letters HPUS indicate that this ingredients is officially included in the Homeopathic pharmacopoeia of the United States.
🧪 Inactive Ingredients ▾
Inactive Ingredients Alumina Silicata, Calcarea Fluorica, Cerium Oxalicum, Distilled Water, Ferrum Muriaticum, Ferrum Phosphoricum, Magnesia Muriatica, Natrum Nitricum
🎯 Purpose ▾
Purpose Dry, Itchy Skin Sensitive Skin Pimples Redness Pimples Redness Acne, Rash, Eczema Eczema Red, Itchy Skin
No label section mentions that — try another word, or open the full label on DailyMed below.
Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA.
Prefer the government’s original formatting? View this label on DailyMed ↗
For educational and professional reference only — not medical advice. Pricing reflects published
NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.